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All Journal Dentino: Jurnal Kedokteran Gigi Dentin Prosiding Konferensi Nasional PKM-CSR
I Wayan Arya Krishnawan Firdaus
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Humanities Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Nursing Public Health Social Sciences

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TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RAT KIDNEY (Rattus norvegicus) Hengki Robiyansyah; I Wayan Arya Krishnawan Firdaus; Deby Kania Tri Putri; Bayu Indra Sukmana; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20401

Abstract

Background: Excessive free radicals cause oxidative stress which is dangerous for the body. The number of free radicals in the body can be controlled with the presence of antioxidants. Kelakai leaves (Stenochlaena palustris.) are known to have activity as an antioxidant which has the potential to become an ingredient in herbal medicine. Purpose: To prove whether there is a toxic effect of administering kelakai leaf extract on the kidneys of Wistar rats based on analysis of blood urea and creatinine levels. Method: A pure experimental study with a posttest-only with control group design method, there were 4 groups consisting of 1 negative control group and 3 treatment groups who were given kelakai leaf extract orally for 28 days and then analyzed the blood urea and creatinine levels of the Wistar rats. Results: The average values of urea and creatinine levels in the three treatment groups were still within the normal range. There was a significant difference in the urea levels of all groups (p<0.05), and there was no significant difference in the creatinine levels of treatment groups 2 and 3 (p>0.05). Conclusion: Kelakai leaf extract given orally for 28 days did not cause toxic effects on the kidneys of Wistar rats based on analysis of blood urea and creatinine levels.
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Krisna Erlangga Putra Ramadhani; I Wayan Arya Krishnawan Firdaus; Yusrinie Wasiaturrahmah; Didit Aspriyanto; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
Co-Authors Ahda Ahda Annisa Amalia Noviyanti Amy Nindia Carabelly Annisa Fitri Yuniar Anugrah Qatrunnada Hakim Asphia Rahmah Aspriyanto, Didit Aulia Azizah Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Bimo Gondo Arum Danika Dita Maharani Debby Saputera, Debby Della Isnadya Noor Destri Khusnul Khotimah Dewi Nurdiana Dewi Puspitasari Dhiya Salma Azminida Diana Wibowo Diza Afira Hutasuhut Erida Wydiamala Erisa Lidiya Fachriani Fachriani Fidya Mariam Fransiska Uli Arta Panjaitan Fransiska Uli Artha Panjaitan Gusti Erysa Nur Tsaniya Hatta, Isnur Hengki Robiyansyah Hilyatul Auliya Ika Kusuma Wardani Ina Rezki Rahmasari Ismi Natasya Salwa Krisna Erlangga Putra Ramadhani M. Ridhotama Wibowo Maharani Laillyza Apriasari Maharani Lailyza Apriasari Mahmud Muhlisin Marthia Eka Nurdila Melisa Budipramana, Melisa Mery Novita Muhammad Genadi Askandar Muhammad Ikhlasul Amal Sangadji Namira Fathya Salsabila Nurul A&#039;idah Rahmad Arifin Renie Kumala Dewi Rosihan Adhani, Rosihan Setyawardhana, Raden Harry Dharmawan Shaula Chintyasari Siti Denty Rizqita Stevani Stevani Tri Putri, Deby Kania Utami, Juliyatin Putri Yusrinie Wasiaturrahmah