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Efri Mardawati
Faculty Of Agricultural Industrial Technology, Universitas Padjadjaran, Jalan Raya Bandung- Sumedang KM 21, Jatinangor 45363, Indonesia
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Journal : International Journal of Science and Environment

 1 
Exploration of Antifungal Tests Based on Δ-Guaiene From Subang Patchouli Oil Rahmawati, Rahmi; Nurjanah, Sarifah; Rialita, Tita; Mardawati, Efri; Filianty, Fitry
International Journal of Science and Environment (IJSE) Vol. 5 No. 3 (2025): August 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijse.v5i3.194

Abstract

Guaiene is a derivative compound produced as a byproduct in the production of patchouli alcohol from patchouli oil (Pogostemon cablin Benth.). This study aims to evaluate the antifungal activity of δ-guaiene extracted from patchouli oil originating from Subang against four types of skin pathogenic fungi: Aspergillus niger, Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. The method used was a laboratory experiment, with the main parameters observed including Inhibition Zone Diameter (IZD), Minimum Inhibitory Concentration (MIC), and Minimum Fungicidal Concentration (MFC). The results showed that δ-guaiene inhibited the growth of C. albicans at a concentration of 40%, with an IZD of 0.15 mm. Against A. niger, the compound demonstrated an inhibition zone of 1.4 mm at a 20% concentration and had an MFC of 20%. For T. mentagrophytes, an IZD of 0.4 mm was observed, with both MIC and MFC at 20%. Activity against gypseum showed an IZD of 0.25 mm, with MIC and MFC also at 20%. These findings suggest that δ-guaiene from patchouli oil has potential as a candidate antifungal agent derived from local resources, supporting the development of natural bioactive compounds and sustainability.
Co-Authors Abil Fadila Ade Moetangad Kramadibrata Adiyaksa, Narendra Bagus Agung Tri Mulyono Agus Try Hartono Agustien, Shilvya Dewi Ahmad Fadhlul Kamal Aisyah Hanifah Alifa Putri Anarghya Amaliyah, Putri Rizqi Amelia Hariry Amelia Hariry Anas Bunyamin Andi Trirakhmadi Anggraini, Sulistina Anindya Rahmana Fitri Anting Wulandari Anting Wulandari Anting Wulandari Arina Sabila Nurhidayat Asri Widyasanti Asri Widyasanti Awaly Ilham Dewantoro Bambang Nurhadi Budi Mandra Harahap Budi Mandra Harahap Dara Nadira Daulay Dedy Prijatna Desy Nurliasari Desy Nurliasari Desy Nurliasari Desy Nurliasari Suparno Diah Meilany Dwi Purnomo Dwi Wahyuda Wira Dwi Wahyudha Wira Edy Suryadi Een Sukarminah Efatmi, Fajri Eki Dwiyan Saputra Eko Heri Purwanto Eko Heri Purwanto Elazmanawati Lembong Elni Hazar Indriantini Emanuela Rae Alodia Emilda Ayu Febrianti Endah Wulandari Endah Wulandari Fadhlurrahmah, Jauhar faizal syahmurman Fajri Efatmi Fathia Salsabila Emmaputri Fauzan, Muklis Fitry Filianty Ghina Haura Tsamarah Hana Nur Fitriana Handarto Hanifah, Aisyah Hanni Listia Furi Harahap, Budi Mandra Hariry, Amelia Haryono Haryono Hendri Hermawan Adinugraha Herlina Marta Hilda Ayu Aulia Imas Siti Setasih Imas Siti Setiasih In-In Hanidah Indah Mayangsari Putri Setiawan Indah Mega Kartini Insy Alimatun Hasanah Irfan Ardiansah Ismiatun Ismiatun Januardi Kasbawati Kasbawati Lubis, Muhammad Adly Rahandi M. Ade Moetangad Kramadibrata M.T.A.P. Kresnowati Marleen Herudiyanto Maulid, Muhammad Rifqi Maulida Rahmah, Devi Meilanny Budi Santoso Mimin Muhaemin Mochamad Djali Mohammad Djali Muhammad Saukat Mulyono, Agung Tri Munajat Munajat Nadya Maharani Nanang Masruchin Nanang Masruchin Nandi Sukri Natasha Putri Siahaan Norisca Aliza Putriana Norisca Aliza Putriana Norisca Aliza Putriana, Norisca Aliza Nurliasari, Desi Nurliasari, Desy Nurlilasari, Puspita Nurriyanti, Anggita Halimah Nurul Afifah Octaviana Nofiarno Putri Okta Paulia Panguji Raja Sinurat Pareira Prawiranegara, Boy Macklin Puji Lestari Puntigavere Dante R. Sheila Kusumawardhani Rafli, Muhammad Rahadatul 'Aisy Rahmawati, Rahmi Ratih Siswanina Putri Rifaldy, Dhifal Dui Riska Surya Ningrum Rizika Wulandari Rizki Sendi, Cahyani Robi Andoyo Roby Andoyo Roni kastaman Roni Kastaman Rosalinda, s S. Rosalinda S. Rosalinda, S. Saefudin, Saefudin Samsul Huda Samsul Huda Santoso, Meilanny Budi Sarifah Nurjanah Sarinarulita Rosalinda Selly Harnesa Putri Setasih, Imas Siti Setiadi, Tjandra Shidqi Syauqi Silvia Oktavia Nur Yudiastuti Silvia Yudiastuti Siti Nurhasanah Sri Suhartini, PhD Sumanti Debby Moody Sumirat, Riska Surya Martha Pratiwi Tensiska, Tensiska Tita Rialita Totok Herwanto Totok Pujianto Tri Yuliana Wahyu Daradjat Yana Cahyana Yazid Bindar Yazid Bindar Yoga Windu Wardhana Yunita Hasnah Devina