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All Journal Jurnal Tumbuhan Obat Indonesia Biota Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Pharmed: Journal of Pharmaceutical Science and Medical Research Pharmademica: Jurnal Kefarmasian dan Gizi Jurnal Sains dan Kesehatan
Weka Sidha Bhagawan
Universitas PGRI Madiun
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Metabolite Profiling of Eleutherine palmifolia (L.) Merr. By HPTLC-Densitometry and its Correlation with Anticancer Activities and In Vitro Toxicity Mutiah, Roihatul; Hadya, Chorida Muhjatul; Ma'arif Z.A, Burhan; Bhagawan, Weka Sidha; Annisa, Rahmi; Indrawijaya, Yen Yen Ari; Huwaida, Fadhila Isma; Ramadhani D.A., Ria; Susilowati, Retno; Taufik, Imam
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1608.73 KB) | DOI: 10.14499/indonesianjpharm30iss3pp157

Abstract

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is a plant that used as raw material for herbal medicines. The difference of growing location the medicinal plants affects the difference of metabolite content, It also affects the pharmacological activity and toxicity of the plant. This study aims to determine the profile of metabolites (metabolite fingerprinting), anticancer profiles, toxicity/safety profiles from several different regions in Indonesia for the purpose of authentication, efficacy, safety and quality control of these plants. Samples were sampled from 6 different locations in Indonesia, they were West Java, Central Java, East Java, East Borneo, Central Borneo, and South Borneo. Metabolite fingerprinting was determined by HPTLC-densitometry method, the profile of anticancer activity and toxicity was known by the MTT-ELISA method. The difference between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA). Whereas the relation between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Partial Least Square (PLS). The results of the metabolite profile analysis with PCA showed that E. palmifolia from 6 different locations gave different metabolite profiles and there were 3 metabolites that had a significant effect on cluster formation. samples are Rf 055, 059, and 044. The results of the HCA analysis showed that the 6 regions are in one cluster the same one. The analysis of PLS-DA showed that the metabolites for anticancer activity are found in Rf 059, 076, 093 and Rf 034. While the metabolites for toxicity are Rf 002, Rf 044 and Rf 059.
Co-Authors . Waris Agnis Pondineka Ria Aditama Aissyah Nurfatma Amaranto, Jennifer Anik Listiyana Annisa, Rahmi Arum Suproborini Arum Suproborini Asri Wido Mukti Asti Rahayu Atiqah, Sri Nur Atiza Fajrin Maulidya Bhagawan, Weka Burhan Ma'arif Burhan Ma’arif Cicilia Novi Primiani Cicilia Novi Primiani Devi Safrina Dewi Ratih Tirto Sari Dian Susanti Donato, Percival Faisal Akhmal Muslikh Fidia Rizkiah Inayatilah Firsta Roisatul Islamiyah Hadya, Chorida Muhjatul Heni Pujiastuti Hison, Jade Huwaida, Fadhila Isma Irawati, Santia Izza Nailia Shirvi Jauhar Maknun Septaza Rahmandika Krisnamurti, Gabriella Chandrakirana Kurniawan Hidayat Perdana Putra Lestari, Nia Ayu Lisniawati Lisniawati M Bakti Samsu Adi Ma'arif Z.A, Burhan Ma'arif, Burhan Ma'arif, Burhan Mandalawati, Titin Maritha, Vevi Mochammad Amrun Hidayat Muhammad Evy Prastiyanto Norachuriya, Zedny Nur Rahmawati Wijaya Nurfatma, Aissyah Octavia, Nur Ika Peria, Jo Prasetyo, Yona Primiani, Cicilia Novi Primiani, Cicilia Novi Primiani Pujiati Pujiati Pujiati Putra, Aditya Dwi Permana Rahmawati, Eka Diana Rahmi Annisa Ramadhani D.A., Ria Ramdhani, Alfina Widya Retno Susilowati Ria Ramadhani Dwi Atmaja Rina Nurmaulawati Rivera, Alice Rizal Maarif Rukmana, Rizal Maarif Rizkiah, Fidia Roihatul Mutiah Roihatul Mutiah Safitri, Rusiana Yulia Santos, Gema Silfarohana, Rantika Suproborini, Arum Tanghal, Analiza Taufik, Imam Teguh Pamungkas, Rizki Putra Ubaidillah Abdel Barsyaif Yanuar Ashari Cahyaningrum Yaya Sulthon Aziz Yen Yen Ari Indrawijaya Zatalini, Dioni Zatalini, Dioni Fadia