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Journal : Universa Medicina

Long-COVID neurological symptoms are associated with D-dimer levels in COVID-19 patients Diah Kurnia Mirawati; Pepi Budianto; Rivan Danuaji; Subandi Subandi; Ira Ristinawati; Hanindia Riani Prabaningtyas
Universa Medicina Vol. 41 No. 2 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.169-175

Abstract

Background Coronavirus disease 2019 (COVID-19) is a disease designated as a global pandemic by the WHO that can manifest clinically as neurological disorders that can occur in the acute phase or after the acute phase (long COVID-19), such as headache, myalgia, anosmia, and cognitive impairment. These neurological disorders as symptoms of long COVID-19 are presumably caused by hypercoagulable conditions characterized by an increase in D-dimer level. This study aims to determine the correlation of long COVID-19 neurological symptoms with hypercoagulable conditions and the role of D-dimer as a biomarker of long COVID-19 neurological symptoms. MethodsThis was a cross-sectional study involving 31 patients with long COVID-19 symptoms. Admitted long COVID-19 cases with recorded D-dimer levels and definitive outcomes were included consecutively. Long COVID-19 neurological symptoms were collected. D-dimer level was measured using immunofluorescence assay and reported in fibrinogen equivalent units (ìg/mL). The correlation between D-dimer levels and neurological clinical manifestations was assessed by using ordinal regression analysis. The p-value of <0.05 was considered statistically significant. ResultsThe mean age of the subjects was 38.81 ± 11.58 years and 18 (58.06%) were female. Long COVID neurological symptoms comprised myalgia, anosmia and cephalgia, and most subjects complained of myalgia (80.65%). On multivariable analysis, long-COVID-19 neurological symptoms were significantly correlated with D-dimer [odds ratio (OR) = 1.05; p=0.020]. ConclusionThe number of neurological long COVID symptoms were significantly correlated with level of D-Dimer. Ultimately, more clarity is needed on the neurological impact of COVID-19, its diagnosis, and its treatment.
The effect of listening to Holy Quran recitation on stress among healthy adults: a non-blinded randomized controlled trial Hanafi, Muchtar; Rahmatillah, Arif; Wiyono, Nanang; Mirawati , Diah Kurnia
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.61-68

Abstract

BackgroundStress is the body’s inability to reach a balance between physical or psychological demands and the ability to meet them. Failure to meet these demands has a crucial impact which includes physical, emotional, and behavioral disorders. Recitation of the Quran is believed to cause relaxation by lowering adrenocorticotropic and cortisol hormonal levels. This study aimed to assess the effects of Quran recitation on stress levels using the biofeedback indicators electromyogram, skin conductance, and heart rate among healthy adults. MethodsThis study used a pre- and post-test group design involving 40 males between 19 and 23 years of age, randomized into two groups, i.e. control group (n=20) and Quran recitation listeners (n=20). The subjects were conditioned in a quiet room for 30 minutes before the stress level measurements were taken. The stress level measurements by means of electromyogram, skin conductance, and heart rate were performed with biofeedback before and after giving the stressor tests’ protocol. Statistical analysis using independent t-test was then performed. ResultsThe baseline comparative measurement using biofeedback between control and treatment groups revealed nonsignificant between-group differences in electromyogram, skin conductance, and heart rate (p=0.150; p= 0.389; and p=0.985 respectively). After applying the stress protocol followed by the intervention, the independent t-test revealed significant between-group differences in electromyogram and skin conductance (p= 0.042 and p=0.030), but not in heart rate (p=0.741). ConclusionsOur study demonstrated that Quran recitation has a significant effect in relieving stress levels assessed using biofeedback parameters (electromyogram and skin conductance) among healthy adults.
Co-Authors . Suroto Achmad Arman Subijanto Achmad Arman Subijanto, Achmad Arman Afifah Syifaul Ummah Apriyanto, Arif Arif Apriyanto Astrida Fesky Febrianty B, Benedictus Baarid Lukman Hamidi Baarid Luqman Hamidi Baarid Luqman Hamidi Bagus Dwi Prasetyo Bambang Purwanto Benedictus Benedictus Budianto, Pepi Damayanti, Elok Dewi Hayu Kirana Dewi, Endang Kusuma Dhiandra Dwi Hapsari Dono Indarto Endang Kusuma Dewi Endang Sutisna Sulaeman Endang Sutisna Sulaeman Ervina Arta Jayanti Hutabarat Faizal Muhammad Farida Aisyah Fauzi Novia Isnaening Tyas Fauzi Novia Isnaening Tyas Fillisita Chandramalina Dewayani Gia Noor Pratami Ginong Pratidina Wijnaputri Hafizhan, Muhammad Hambarsari, Yetty Hamidi, Baarid Lukman Hamidi, Baarid Luqman Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindya Riani Prabaningtyas Hanindya Riani Prabaningtyas Hapsari, Maria Yosita Ayu Hutabarat, Ervina Arta Jayanti Ida Ayu Putu Sri Widnyani Ida Untari Ida Untari Ilhamsyah, Rudi Ira Ristinawati Kenneth Tan Lawly Arrel Dionnie Greatalya Lestari Handayani Lucia Pancani Anggraeni Muchtar Hanafi Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad, Faizal Nanang Wiyono Novian Anindito Santosa Novian Anindito Santosa Nyono Dedi Prabowo Pepi Budianto Pepi Budianto Pepi Budianto Prabaningtyas, Hanindia Riani Prabaningtyas, Hanindya Prabaningtyas, Hanindya Riani Putri, Puspita Sari Sugiyarto Raden Ajeng Hanindia Riani Prabaningtyas Raden Andi Ario Tedjo Raden Andi Ario Tedjo Rahmatillah, Arif Rakhma, Titian Ristinawati, Ira Rivan Danuaji Rivan Danuaji Rivan Danuaji Rivan Danuaji Rivan Danuaji Rivan Danuaji Rivan Danuaji Setyo Sri Rahardjo Soetrisno Stefanus Erdana Putra Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Sulistyani Sulistyani Sulistyani Sulistyani SUROTO Suroto . Suroto Suroto Suroto Suroto Suroto Suroto Susilo, Wahyu Agung Tan, Kenneth Teddy Tejomukti Tedjo, Raden Andi Ario Tejomukti, Teddy Vitri Widyaningsih Vivienne Tjung Wahyu Agung Susilo Widhianingsih, Nella Lusti Yetty Hambarsari Yetty Hambarsari