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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal SOLMA JMBI UNSRAT (Jurnal Ilmiah Manajemen Bisnis dan Inovasi Universitas Sam Ratulangi) Jurnal Pengabdian Magister Pendidikan IPA Jurnal Farmagazine Community Empowerment Jurnal Development Medimuh : Jurnal Kesehatan Muhammadiyah Jurnal Patria Bahari Medical Sains : Jurnal Ilmiah Kefarmasian GENIUS JOURNAL (General Nursing Science Journal) Jurnal Pustaka Aktiva : Pusat Akses Kajian Akuntansi, Manajemen, Investasi, dan Valuta Jurnal Abdi Masyarakat Kita Jurnal Farmasi Sains dan Praktis Sciences of Pharmacy Jurnal Informatika Ekonomi Bisnis Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Jurnal Pendidikan Guru Sekolah Dasar InJEBA : International Journal of Economics, Business and Accounting Journal of Scientific Insights Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Media Penelitian dan Pengembangan Kesehatan Global Leadership Organizational Research in Management Baktimu : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah Journal of Medical and Health Science
Deni Firmansyah
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Liposomal Gel of Centella asiatica: Antioxidant Activity and Release Profile Indriaty, Sulistiorini; Firmansyah, Deni; Utami, Mima Eliestya; Karlina, Nina; Suharyani, Ine; Haidar, Hilal; Safitri, Amanda; Setiawati, Elis
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404437

Abstract

Centella asiatica (L.) Urban contains flavonoids and triterpenoids with strong antioxidant activity; however, its topical bioavailability is limited by poor solubility. This study aimed to formulate and evaluate liposomal gel systems containing a 70% ethanol extract of C. asiatica to enhance dermal penetration while preserving antioxidant activity. The extract was incorporated into liposomes using a lecithin–cholesterol ratio of 9:1 and formulated into gels at concentrations of 0.3% (FG1) and 0.5% (FG2). Physicochemical characterization showed mean particle sizes of 119.8 ± 7.21 nm (FG1) and 101.3 ± 6.55 nm (FG2), with polydispersity index values of 0.410 and 0.306, respectively, indicating acceptable vesicle homogeneity across three independent replicates (n = 3). The formulations were physically stable for two weeks at 4 °C but exhibited instability at elevated temperatures. Antioxidant activity evaluated using the DPPH assay yielded IC₅₀ values of 13.87 ± 0.02 µg/mL for FG1 and 13.97 ± 0.06 µg/mL for FG2, which were not significantly different (p > 0.05) from vitamin C (9.16 ± 0.06 µg/mL), indicating preservation of radical-scavenging capacity. In vitro permeation studies using Franz diffusion cells demonstrated cumulative quercetin penetration of 280.86 ± 1.12 µg/cm² for FG1 and 314.40 ± 0.93 µg/cm² for FG2 over 4 h, with FG2 showing significantly higher flux (p < 0.05). Release kinetics followed a zero-order model (R² = 0.9881–0.9914), suggesting controlled release behavior. Overall, liposomal gel formulations show potential for improving topical delivery of C. asiatica without overstating long-term stability or therapeutic superiority.
Penyuluhan Mengenai DAGUSIBU pada Ibu-ibu Rumah Tangga untuk Meningkatkan Pengetahuan mengenai Penggunaan dan Penanganan Obat di Rumah Suharyani, Ine; Firmansyah, Deni; Sulastri, Lela; Noviani, Lusy; Lestari, Trisna; Nabila, Seilefa Putri; Wahyu, Muhammad; Meilina, Meri
Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2026): Edisi Maret 2026
Publisher : FKIP Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/amalilmiah.v7i1.783

Abstract

Program DAGUSIBU dilakukan secara berkesinambungan untuk memberikan pemahaman terhadap ibu-ibu rumah tangga mengenai cara penggunaan dan penanganan obat di rumah, karena hasil riskesdas menunjukkan banyaknya rumah tangga yang menyinpan obat sisa resep maupun obat persediaan di rumah. Kegiatan penyuluhan dilakukan di Desa Sigong, dengan sasaran ibu-ibu rumah tangga. Kegiatan ini dilakukan dengan metode penyampaian materi dan diskusi yang interaktif. Tingkat pengetahuan peserta sebelum dan setelah penyuluhan diukur melalui pre-test dan post-test. Pada hasil pre-test, peserta paling banyak menjawab salah pertanyaan mengenai beyond used date (BUD) dari tetes mata, tanggal pembuatan obat, serta cara membuang sisa obat baik sediaan padat maupun sirup antibiotik, sementara pada hasil post-test terlihat sehingga setengah pertanyaan dari kuesioner dijawab benar oleh semua peserta (100%), dan hanya 2 pertanyaan yang dijawab benar oleh 83,33% peserta. Secara kumulatif, peningkatan rata-rata jawaban benar meningkat dari 65% menjadi 90.83%. Selain dari aspek pengguna, perlu dilakukan pertimbangan bagi produsen untuk memberikan sign atau tulisan penting dalam Bahasa Indonesia, agar pengguna obat memahami tulisan dalam sediaan farmasi, terutama untuk suplemen atau vitamin yang umumnya dikonsumsi secara mandiri tanpa bantuan tenaga kesehatan.
Co-Authors AA Sudharmawan, AA Aan Kunaedi Ade Irma Suryani Adelia, Dinda Adelisa Mulyani Adinda Haya Zhafirah Adinda Haya Zhafirah Adiputra, I Komang Hedi Pramana AHMAD FAISOL Ahmad Soleh Albianto, Deranito Langlang Paresa Alfaidah, Hani Alfi Oktavia Alya Najmatul Laila Amanda Aulia Azahrah Angelica Alma Sera Anggaina, Mira Ariyadi, Ariyadi Arzety, Adelia Vita Asmarani, Sri Utami Asrini Asrini Auderina Aliza Zahra Fathin Aunila, Nandita Syafa Auril Amaliah Auril Amaliah Ayu Endang Purwati Ayuni Arzalia Putri Ayuni Arzalia Putri Bachtiar, Arsyad Bella Putri Firanti Cahyaningsih, Nur Putri Dahlia Dahlia Dahlia Daniel, Prima Audia Delia Dwitiyani Destri Putri Ramadhanti Dewi, Kurnia Dhea Aulia Ramadhani Dhea Aulia Ramadhani Dhiyaa Anisah Diah Rodiah Diah, Muhammad Diana Amelia Putri Didi Rohadi Didin Ahidin Dinda Aprilia Gumilang Dinda Eka Febriani Dinda Eka Febriani Dwitiyani, Delia Eka Mardiyani Elinawati Elis Setiawati, Elis Emi Safrina Ernawati Ernawati Erni Yuningsih Fajar Willy Ahzami Fatih Nandika Hakim Faturrahman, Muhammad ilham Fauziah, Diny Nur FAUZIYAH Fidella Nuraini Fidella Nuraini Firmansyah, Andan Fitri Ernalis Fitri, Nazifa Fitriani, Fipit Gianto, Vinie Regina Putri Gina Khairunisah Habibty, Hamda Liyan Haidar, Hilal Haryani Haryani Hasani, Salsabila Henri Setiawan Hilmy, Mochammad Husnul Khotimah Husnul Khotimah IIN INDAWATI Inayatul Fajriyah Indah Setyaningsih Indri Berliani Indri Berliani Islamiyyah Nur Aini Ohorella Islamiyyah Nur Aini Ohorella Jacinta Winarto Juwita Sari, Amelia Khairunisah, Gina Lailatul Salamah Lani Sheha Rachmany Lela Sulastri, Lela Lestari, Trisna Lilis Lismayanti Liyan Habibty, Hamda M. Haidar Ar Rasyid Maharani Susilowati Mahendra, Putu Gede Pasek Suparta Meilina, Meri Meisa, Ade Michelle, Vanessa Moch. Saiful Bachri Moch. Saiful Bachri Mochammad Hilmy Muhammad Diah Muhammad Hafidin Muhammad Hafidin Muhammad Wahyu, Muhammad Muhammad Yani Zam Zam Muhammad Yani Zamzam Mulyani, Adelisa Mulyati, Lia Mustaniroh, Laila Mutiara Agustianti Nabila, Seilefa Putri Nahdia Fajri Mahmudah Neysa Elvira Neysa Elvira Nina Karlina Nina Karlina Noviani, Lusy Nur Rahmi Hidayati, Nur Rahmi Nurjannah, Nida Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurpadilah, Demita Nurwijayanti Pamungkas, Muhamad Bagja Prasasty Ramadhani, Septya Prasetyo, Ery Teguh Putri Sabhika Imany Putri, Elisa Nabila Raif Pradifa Adhikara Raif Pradifa Adhikara Ramadhani, Septya Prasasty Rani Dwi A Ratih Rosita raudatul jannah Renny Amelia Rima Yulia Senja, Rima Yulia Rizqia Shafa Fauziah RR. Ella Evrita Hestiandari Rr. Erlina Rukmana, Ika Ruliyanti Safitri, Amanda Samsuri Samsuri Sari, Amelia Juwita Setyaningsih, Indah Siagian, Friska Monika Sari Sidik Lingga Kusuma Siti Nurhasanah Siti Pandanwangi TW Sri Murniyanti Suci Nurlia Suharyani, Ine Sulistiorini Indriaty Syifa, Nabila Aulia Tiara Ramadhani Tiara Ramadhani Titin Sumarni Utami, Mima Eliestya Vanessa Michelle Wardani, Amellia Wiarta, Iqra Wijayanto, Danuja Yasmin Zahiyah Yayan Rizikiyan Zahra Kirana Fadillah Zahra Kirana Fadillah Zamzam, Muhammad Yani Zuraidah Tharo