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Deni Firmansyah
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Peran Aktivitas Fisik dalam Mencegah Penyakit Degeneratif pada Lansia Jannah, Raudatul; Firmansyah, Deni; Ariyadi, Ariyadi
Journal of Medical and Health Sciences Vol. 1 No. 3: Journal of Medical and Health Science, December 2025
Publisher : Gema Cendekia Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71094/jmhs.v1i3.288

Abstract

Increasing life expectancy has resulted in a growing elderly population, making them vulnerable to various degenerative diseases. Diseases such as musculoskeletal, cardiovascular, metabolic, and neurodegenerative disorders pose a major challenge in maintaining the quality of life of the elderly. Physical activity is considered an effective and sustainable non-pharmacological preventive strategy to reduce the risk of these degenerative diseases. This study aims to comprehensively examine the role of physical activity in preventing degenerative diseases in the elderly, based on the latest scientific evidence. This study used a systematic literature review design with a descriptive-analytical approach. Data were obtained from fully open-access national and international journal articles published within the last ten years. The literature analyzed encompassed various research designs, focusing on physical activity and its impact on the health of the elderly. The research process involved identification, selection, data extraction, and thematic analysis and synthesis of findings. The study results indicate that regular physical activity appropriate to the abilities of the elderly plays a significant role in preventing degenerative diseases. Physical activity has been shown to improve musculoskeletal function, cardiovascular health, metabolic control, and support mental health and cognitive function in the elderly. Furthermore, physical activity contributes to increased independence and quality of life in the elderly. The conclusion of this study confirms that physical activity is a crucial component of promotive and preventive health efforts for the elderly, and it needs to be integrated into health care and community empowerment programs.
Liposomal Gel of Centella asiatica: Antioxidant Activity and Release Profile Indriaty, Sulistiorini; Firmansyah, Deni; Utami, Mima Eliestya; Karlina, Nina; Suharyani, Ine; Haidar, Hilal; Safitri, Amanda; Setiawati, Elis
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404437

Abstract

Centella asiatica (L.) Urban contains flavonoids and triterpenoids with strong antioxidant activity; however, its topical bioavailability is limited by poor solubility. This study aimed to formulate and evaluate liposomal gel systems containing a 70% ethanol extract of C. asiatica to enhance dermal penetration while preserving antioxidant activity. The extract was incorporated into liposomes using a lecithin–cholesterol ratio of 9:1 and formulated into gels at concentrations of 0.3% (FG1) and 0.5% (FG2). Physicochemical characterization showed mean particle sizes of 119.8 ± 7.21 nm (FG1) and 101.3 ± 6.55 nm (FG2), with polydispersity index values of 0.410 and 0.306, respectively, indicating acceptable vesicle homogeneity across three independent replicates (n = 3). The formulations were physically stable for two weeks at 4 °C but exhibited instability at elevated temperatures. Antioxidant activity evaluated using the DPPH assay yielded IC₅₀ values of 13.87 ± 0.02 µg/mL for FG1 and 13.97 ± 0.06 µg/mL for FG2, which were not significantly different (p > 0.05) from vitamin C (9.16 ± 0.06 µg/mL), indicating preservation of radical-scavenging capacity. In vitro permeation studies using Franz diffusion cells demonstrated cumulative quercetin penetration of 280.86 ± 1.12 µg/cm² for FG1 and 314.40 ± 0.93 µg/cm² for FG2 over 4 h, with FG2 showing significantly higher flux (p < 0.05). Release kinetics followed a zero-order model (R² = 0.9881–0.9914), suggesting controlled release behavior. Overall, liposomal gel formulations show potential for improving topical delivery of C. asiatica without overstating long-term stability or therapeutic superiority.
Co-Authors AA Sudharmawan, AA Aan Kunaedi Ade Irma Suryani Adelia, Dinda Adelisa Mulyani Adinda Haya Zhafirah Adinda Haya Zhafirah Adiputra, I Komang Hedi Pramana AHMAD FAISOL Ahmad Soleh Albianto, Deranito Langlang Paresa Alfaidah, Hani Alfi Oktavia Alya Najmatul Laila Amanda Aulia Azahrah Angelica Alma Sera Anggaina, Mira Ariyadi, Ariyadi Arzety, Adelia Vita Asmarani, Sri Utami Asrini Asrini Auderina Aliza Zahra Fathin Aunila, Nandita Syafa Auril Amaliah Auril Amaliah Ayu Endang Purwati Ayuni Arzalia Putri Ayuni Arzalia Putri Bachtiar, Arsyad Bella Putri Firanti Cahyaningsih, Nur Putri Cheryl Anjanette Ganidi, Abigail Dahlia Dahlia Dahlia Daniel, Prima Audia Delia Dwitiyani Destri Putri Ramadhanti Dewi, Kurnia Dhea Aulia Ramadhani Dhea Aulia Ramadhani Dhiyaa Anisah Diah Rodiah Diah, Muhammad Diana Amelia Putri Didi Rohadi Didin Ahidin Dinda Aprilia Gumilang Dinda Eka Febriani Dinda Eka Febriani Dwitiyani, Delia Eka Mardiyani Elinawati Elis Setiawati, Elis Emi Safrina Ernawati Ernawati Erni Yuningsih Fajar Willy Ahzami Fatih Nandika Hakim Faturrahman, Muhammad ilham Fauziah, Diny Nur FAUZIYAH Fidella Nuraini Fidella Nuraini Firmansyah, Andan Fitri Ernalis Fitri, Nazifa Fitriani, Fipit Gianto, Vinie Regina Putri Gina Khairunisah Habibty, Hamda Liyan Haidar, Hilal Haryani Haryani Hasani, Salsabila Hendra Kurniawan Henri Setiawan Hilmy, Mochammad Husnul Khotimah Husnul Khotimah IIN INDAWATI Inayatul Fajriyah Indah Setyaningsih Indri Berliani Indri Berliani Islamiyyah Nur Aini Ohorella Islamiyyah Nur Aini Ohorella Jacinta Winarto Juwita Sari, Amelia Khairunisah, Gina Lailatul Salamah Lani Sheha Rachmany Lela Sulastri, Lela Lilis Lismayanti Liyan Habibty, Hamda M. Haidar Ar Rasyid Maharani Susilowati Mahendra, Putu Gede Pasek Suparta Meisa, Ade Michelle, Vanessa Moch. Saiful Bachri Moch. Saiful Bachri Mochammad Hilmy Muhammad Diah Muhammad Hafidin Muhammad Hafidin Muhammad Yani Zam Zam Muhammad Yani Zamzam Mulyani, Adelisa Mulyati, Lia Mustaniroh, Laila Mutiara Agustianti Nahdia Fajri Mahmudah Neysa Elvira Neysa Elvira Nina Karlina Nina Karlina Nina Karlina Nur Rahmi Hidayati, Nur Rahmi Nurjannah, Nida Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurpadilah, Demita Pamungkas, Muhamad Bagja Prasasty Ramadhani, Septya Prasetyo, Ery Teguh Putri Sabhika Imany Putri, Elisa Nabila Raif Pradifa Adhikara Raif Pradifa Adhikara Ramadhani, Septya Prasasty Rani Dwi A Ratih Rosita raudatul jannah Renny Amelia Restu Wardhani, Arie Rima Yulia Senja, Rima Yulia Rizqia Shafa Fauziah RR. Ella Evrita Hestiandari Rr. Erlina Rukmana, Ika Ruliyanti Safitri, Amanda Samsuri Samsuri Sari, Amelia Juwita Setyaningsih, Indah Siagian, Friska Monika Sari Sidik Lingga Kusuma Siti Nurhasanah Siti Pandanwangi TW Sri Murniyanti Suci Nurlia Suharyani, Ine Sulistiorini Indriaty Syifa, Nabila Aulia Thie, Freddy Tiara Ramadhani Tiara Ramadhani Titin Sumarni Ulva Theana, Vera Utami, Mima Eliestya Utomo, Dwi Vanessa Michelle Wardani, Amellia Wiarta, Iqra Wijayanto, Danuja Yasmin Zahiyah Yayan Rizikiyan Zahra Kirana Fadillah Zahra Kirana Fadillah Zamzam, Muhammad Yani Zuraidah Tharo