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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Rural and Urban Community Empowerment Indonesian Journal of Cancer Media Penelitian dan Pengembangan Kesehatan
Sri Melati Munir
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Abstract

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital. 
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
PENYULUHAN KESEHATAN TENTANG BAHAYA MEROKOK TERHADAP RISIKO TERJADINYA KANKER PARU SERTA UPAYA YANG DILAKUKAN UNTUK DETEKSI DINI KANKER PARU DI KELURAHAN SIALANG SAKTI KECAMATAN TENAYAN RAYA KOTA PEKANBARU Munir, Sri Melati; Lasmaria, Rohani; Zahtamal, Zahtamal
Journal of Rural and Urban Community Empowerment Vol. 2 No. 1 (2020): Desember
Publisher : Fakultas Perikanan dan Kelautan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/96ttnf25

Abstract

Kanker paru merupakan penyebab utama keganasan di dunia, telah mencapai hingga 13 persen dari semua diagnosis kanker. Kanker paru juga merupakan penyebab kematian dari 1/3 kematian laki-laki di dunia akibat kanker. Kegiatan penyuluhan kesehatan tentang Bahaya Merokok Terhadap Risiko Terjadinya Kanker Paru Serta Upaya Yang Dilakukan Untuk Deteksi Dini Kanker Paru di Kelurahan Sialang Sakti Kecamatan Tenayan Raya. Kegiatan penyuluhan dilakukan di Kelurahan Sialang Sakti Kecamatan Tenayan Raya dan sekitarnya yang persertanya adalah ibu- ibu yang berjumlah 50 peserta yang bertempat tinggal di Kelurahan Sialang Sakti Kecamatan Tenayan Raya. Para peserta penyuluhan yang mengikuti kegiatan ini hampir semuanya mempunyai keluarga di rumah yang masih merokok ataupun sudah berhenti merokok. Peserta juga diberikan leaflet yang bisa dibaca oleh semua anggota keluarga di rumah. Setelah penyuluhan diharapkan peserta penyuluhan dapat mengajak keluarganya yang merokok ataupun yang terkena pajanan asap rokok untuk memeriksakan dirinya sebagai salah satu usaha deteksi dini kanker paru. Dengan dilakukannya acara pengabdian kepada masyarakat di Kelurahan Sialang Sakti Kecamatan Tenayan Raya diharapkan dapat memberikan pengetahuan yang bermanfaat bagi masyarakat terutama bahaya merokok terhadap risiko terjadinya kanker paru serta upaya deteksi dini kanker paru.
Profile of Underdiagnosis Lung Cancer with Pulmonary Tuberculosis at Arifin Achmad General Hospital, Pekanbaru Munir, Sri Melati; Aulia, Ananda Febriani; Simatupang, Elvando Tunggul Mauliate; Tanlie, Veghasanah
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1293

Abstract

Background: Lung cancer and pulmonary tuberculosis are respiratory issues that collectively account for the world’s leading cause of mortality. Indonesia, being a nation endemic for Pulmonary Tuberculosis, frequently encounters instances of diagnosis overlap with lung cancer. Delays in the diagnosis of both pulmonary tuberculosis and lung cancer have a global impact on morbidity and mortality. Based on this, this study aims to determine the profile of Lung Cancer patients who were previously diagnosed as pulmonary tuberculosis as an initial diagnosis that can provide new criteria in establishing a diagnosis between pulmonary tuberculosis and lung cancer.Method: This study is a descriptive cross-sectional study using total sampling collected over 1 year. The inclusion criteria were lung cancer patients previously diagnosed with clinical pulmonary tuberculosis, with or without anti-tuberculosis drugs obtained from medical record data. All results are presented in the form of a distribution table. Results: Twenty seven patients diagnosed with adenocarcinoma, with the highest prevalence among males (77.78%). The duration of delay was less than 6 months (62.96%), being the highest rate in this study. Due to the delay in diagnosis, all patients diagnosed with lung cancer were at stage IV. Discussion: Adenocarcinoma is the most common form of lung cancer in men and individuals over 40 years old. Lung cancer with a latency duration of 6 months is typically diagnosed at stage IV. Clinical pulmonary tuberculosis must be investigated further if no clinical improvement is observed after one month of anti-tuberculosis drug treatment.Conclusion: Diagnostic delays of lung cancer significantly impact patient survival. Screening for suspected lung cancer in clinical pulmonary tuberculosis is crucial to reduce morbidity and mortality. Sputum cytology and low-dose CT scan may be utilized as screening modalities.
PENYULUHAN KESEHATAN TENTANG BAHAYA MEROKOK TERHADAP RISIKO TERJADINYA KANKER PARU SERTA UPAYA YANG DILAKUKAN UNTUK DETEKSI DINI KANKER PARU DI KELURAHAN SIALANG SAKTI KECAMATAN TENAYAN RAYA KOTA PEKANBARU Munir, Sri Melati; Lasmaria, Rohani; Zahtamal, Zahtamal
Journal of Rural and Urban Community Empowerment Vol. 2 No. 1 (2020): Desember
Publisher : Fakultas Perikanan dan Kelautan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/

Abstract

Kanker paru merupakan penyebab utama keganasan di dunia, telah mencapai hingga 13 persen dari semua diagnosis kanker. Kanker paru juga merupakan penyebab kematian dari 1/3 kematian laki-laki di dunia akibat kanker. Kegiatan penyuluhan kesehatan tentang Bahaya Merokok Terhadap Risiko Terjadinya Kanker Paru Serta Upaya Yang Dilakukan Untuk Deteksi Dini Kanker Paru di Kelurahan Sialang Sakti Kecamatan Tenayan Raya. Kegiatan penyuluhan dilakukan di Kelurahan Sialang Sakti Kecamatan Tenayan Raya dan sekitarnya yang persertanya adalah ibu- ibu yang berjumlah 50 peserta yang bertempat tinggal di Kelurahan Sialang Sakti Kecamatan Tenayan Raya. Para peserta penyuluhan yang mengikuti kegiatan ini hampir semuanya mempunyai keluarga di rumah yang masih merokok ataupun sudah berhenti merokok. Peserta juga diberikan leaflet yang bisa dibaca oleh semua anggota keluarga di rumah. Setelah penyuluhan diharapkan peserta penyuluhan dapat mengajak keluarganya yang merokok ataupun yang terkena pajanan asap rokok untuk memeriksakan dirinya sebagai salah satu usaha deteksi dini kanker paru. Dengan dilakukannya acara pengabdian kepada masyarakat di Kelurahan Sialang Sakti Kecamatan Tenayan Raya diharapkan dapat memberikan pengetahuan yang bermanfaat bagi masyarakat terutama bahaya merokok terhadap risiko terjadinya kanker paru serta upaya deteksi dini kanker paru.
Hematologic and Non-Hematologic Side Effects in Lung Cancer Patients Post Chemotherapy at Arifin Achmad General Hospital Oinike, Irene; Munir, Sri Melati
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.186

Abstract

Background: Lung cancer is the second-highest cause of malignancy in the world, with a prevalence of 11.4% of all types of cancer. The majority of lung cancer patients are diagnosed at an advanced stage; therefore, chemotherapy acts as palliative therapy without curative therapy options. Chemotherapy drugs have various side effects, both hematologic and non-hematologic. Thus, monitoring side effects should be notable to improve the quality of life for patients with lung cancer undergoing chemotherapy. Method: This research was a descriptive study with a total sampling data collection technique. Samples were collected for 6 months according to the inclusion criteria, and the results were presented in the form of a distribution table. Results: During August 2023 to January 2024, 29 lung cancer patients met the inclusion criteria at Arifin Achmad General Hospital. Of these 29 patients, 25 (86.21%) were men and 4 (13.79%) were women. The hematologic side effects were observed in 16 (55.17%) patients, while non-hematologic side effects were found in 18 (62.07%) patients. The most common hematologic side effect is anemia, and the most common non-hematologic side effect is gastrointestinal disorders. Conclusion: The chemotherapy regimen used for lung cancer patients caused both hematologic and non-hematologic side effects. The non-hematologic side effects were more common than the hematologic.
Aspergillosis in Lung Cancer: A Narrative Literature Review Yarsy, Pofi Risanti; Sri Melati Munir
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.935

Abstract

Aspergillosis is one of the complications of lung cancer and lung cancer treatment. Diagnosis of Aspergillosis in lung cancer, in general, is still a challenge because clinical symptoms and examination results are not typical, and risk factors often go unnoticed. To simplify the diagnosis of Aspergillosis, several criteria have been created based on the patient's condition, clinical and radiological features, and mycological laboratory examination. Doctors' vigilance still needs to be increased, examination facilities are still limited in certain cities, and diagnostic services have not been integrated, so management is not optimal. This literature review aims to increase doctors' knowledge and awareness regarding aspergillosis in lung cancer, which is an important step to improve the appropriate management of this disease.
The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Abstract

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.
Lung Cancer In Former Tuberculosis Patients at Arifin Achmad General Hospital, Riau Province Martarita, Evitrie; Erdayani, Rita; Munir, Sri Melati; Fauzi, Zarfiardy Aksa; Simanjuntak, Arya Marganda
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.97

Abstract

Background: There is ongoing discussion over the connection between lung cancer and pulmonary tuberculosis (TB). Future lung cancer cases in Indonesia, which has the second-highest TB case burden, are a cause for concern. The purpose of this study is to ascertain the connection between TB and LC at Arifin Achmad General Hospital in the province of Riau. Method: From 2015 to 2018, we looked back on lung cancer patients at Arifin Achmad General Hospital in Riau Province who had received pulmonary tuberculosis and anti-tuberculosis treatment (ATT). Results: From 203 patients, 24 patients (11.8%) had histories of TB. The patients' ages were from 41 years to 60 years. The most prevalent pathological findings were adenocarcinoma in 13 patients (54.0%). The most common cancer stage was advanced stage IIIB in 7 patients (29.2%) Conclusion: The cases of TB infections were apparent in lung cancer patients, approximately around 11% of lung cancer cases. Therefore, it is necessary to assess the history of TB in lung cancer patients.
Risk Factors for EGFR (Epidermal Growth Factor Receptor) Gene Mutations in Lung Adenocarcinoma Patients at Arifin Achmad Hospital, Riau Province Riensya, Bayu Aulia; Munir, Sri Melati; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.484

Abstract

Background: Lung cancer is the first cause of oncological death worldwide. Guidelines made by various cancer associations, including PDPI-IASTO, regarding NSCLC recommend that all advanced stages of NSCLC undergo target genetic testing, such as EGFR mutations. The incidence of EGFR mutations in Asian populations is quite high.Methods: This was a retrospective observational analytic study with a cross-sectional study design.Results: The most unmodifiable risk factors were age ≥45 years (81.4%), male sex (70.6%), location of lung cancer on the right (52.9%), cancer size of ≥5 cm (100%), M1a metastases (57.8%), and no family history of malignancy (97.1%). The smoking status (ex-smoker) (P=0.022; OR=4.3; 95% CI=1.24-15.57), sex (male) (P=0.007; OR=3.409; 95% CI=1.406-8.268), and metastatic status (M1a) (P=0.025; OR=0.203; 95% CI=0.05-0.821) were the dominant risk factors that affected the incidence of EGFR mutations in patients with lung adenocarcinoma at Arifin Achmad Hospital.Conclusion: Male, ex-smokers, and metastatic status (M1a) were the dominant risk factors for the incidence of EGFR mutations in lung adenocarcinoma patients at Arifin Achmad Hospital. 
Co-Authors Adrianison, Adrianison Amarudin, Amarudin Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Arfiansyah, Mochammad Aris Arif Santoso Aulia Wiradi Aulia, Ananda Febriani Ayu Warma Darmawi . Duyen, Natalie Dwipa Dhurandhara Eka Bebasari Elisna Syahruddin Erdayani, Rita Ermayanti, Sabrina Erwin Christianto Esha, Indi Faisal Yunus Fendro Zibetra, Fendro Gurning, Andi Sarikawan Hanif, Muhammad Alfin Haryati Haryati Hidayat, Moulid Ida Ayu Jasminarti Dwi Kusumawardani Iklima Asiah INDRA YOVI Indriani, Sri Indah Infianto, Andreas Jasminarti, Ida Ayu Khairani, Muhammad Kurniawan, Ferry Dwi Laksmi Wulandari Lasmaria, Rohani Lim, Darren Wan-Teck Martarita, Evitrie Muthmainnah " Noni Novisari Soeroso Novita Andayani, Novita Oinike, Irene Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putra, Andika Chandra Riensya, Bayu Aulia Rohani Lasmaria Simbolon, Rohani Lasmaria Santoso, Andintia Aisyah Setyawan, Ungky Agus Simanjuntak, Arya Marganda Simatupang, Elvando Tunggul Mauliate Suyanto " Tanlie, Veghasanah Tuti Restuastuti Uci Tama Azilla Widya Syah Fitri Wijaya, Dewi Wina Astari Putri Wiwit Ade Fidiawati Yarsy, Pofi Risanti Zahtamal Zahtamal Zaini, Jamal Zarfiardy Aksa Fauzi