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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Jurnal Respirasi (JR) Jurnal Ners CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL CRJIM (Clinical and Research Journal in Internal Medicine) Narra J Caring : Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Jurnal Kedokteran Komunitas (Journal of Community Medicine) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal of Law, Education and Business Indonesian Journal of Biomedicine and Clinical Sciences Deka in Medicine

Syifa Mustika

Brawijaya University

Author-ID : 326467

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Platelet-Lymphocyte Ratio and Neutrophil-Lymphocyte Ratio as Early Mortality Predictors for Patients with End-Stage Chronic Liver Disease Syifa Mustika; Affa Kiysa Waafi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Chronic liver disease (CLD) often results in fatal complications. Child-Turcotte-Pugh (CTP) score is the earliest predictor of mortality but the Model for End-Stage Liver Disease (MELD) score is more objective. Studies showed platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) could become mortality predictors for chronic liver disease. We aimed to investigate NLR and PLR as early mortality predictors for CLD, in comparison with CTP and MELD scores. Method: This was a retrospective observational cohort study. We recruited patients with CLD (liver cirrhosis and hepatocellular carcinoma), from Saiful Anwar Hospital, Indonesia. Data regarding PLR, NLR, CTP, and MELD scores were obtained from the medical records. Participants were followed for 30 days to determine survival. Results: Ninety patients were recruited in the study. There were 31 deaths (34.4%) in 30 days. Mortality was higher in HCC patients than liver cirrhosis. Although NLR had similar sensitivity with CTP (51.6%), neither PLR (p 0.956) nor NLR (p 0.087) could significantly better predict mortality than CTP (p 0.001) or MELD scores (p 0.002). In opposite to PLR, NLR had a positive correlation with MELD and CTP scores. Conclusion: On the contrary to the PLR, the NLR positively correlated with the severity of the disease, NLR had the potential as a predictor of early mortality for patients with chronic liver disease as compared to CTP and MELD scores. But PLR could not substitute both CTP and MELD scores.

Reactivation of Hepatitis B Infection During the Cause of Non Hodgkin's Lymphoma Chemotherapy Diana Jeni H; Syifa Mustika
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 2 (2014): VOLUME 15, NUMBER 2, August 2014
Publisher : The Indonesian Society for Digestive Endoscopy

Hepatitis due to hepatitis B virus (HBV) reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. Frequently used combination regimens in Non-Hodgkin’s lymphoma are cyclophosphamide, hydroxydaunomycin (adriamycin), vincristine (oncovin), and prednison (CHOP). The use of rituximab, a monoclonal antibody targeting CD20 antigen present in benign and malignant B-cells, in combination with systemic chemotherapy has resulted in an improved duration of remission and survival for this patients. Rituximab is a HBV reactivation risk factor even greater than corticosteroids in a series of patients with lymphoma treated with combined-modality treatment (CMT).A 43 years old female patient who already diagnosed with Non-Hodgkin’s lymphoma, came with chief complain nausea and vomiting for three weeks. The patient recently got hospitalized with icteric and known have positive HBsAg. She received chemotherapy rituximab CHOP (R-CHOP) for four times and got rituximab in the last chemotherapy. Previously she had icteric and increased liver function test. After exclude other possibility causes this symptom and sign, it was concluded this is HBV reactivation. The chemotherapy was postponed until this reactivation of hepatitis B resolved and start giving lamivudine two weeks before reintroduce chemotherapy.Keywords: antiviral treatment, chemotherapy, hepatitis B virus, reactivation

The Prevalence, Profile, and Risk Factor of Patients with Ulcerative Colitis at Dr. Saiful Anwar Malang General Hospital Syifa Mustika; Nanik Triana
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Background: The prevalence ulcerative colitis (UC) in RSCM Jakarta in 1991-1995 is 2.5%. The disease affects men and women at similar rates or slightly more common in women than in men. Age of onset follows a bimodal pattern, with a peak at 15-25 years and a smaller one at 55-65 years, although the disease can occur in people of any age. The precise etiology of UC is not well understood. UC is precipitated by a complex interaction of environmental (cigarretes, diet, non-steroidal anti-inflammatory drug/NSAID, etc), genetic, and immunoregulatory factors. This study aimed to identify the prevalence, profile and risk factor of ulcerative colitis in Dr. Saiful Anwar General Hospital Malang.Method: This is a retrospective survey analysis from medical record which was taken from 2170 patients who underwent colonoscopy in Dr. Saiful Anwar General Hospital Malang from January 2010 to December 2014. Demographic setting (sex, age), clinical features, lifestyle, diagnosis based on colonoscopy were analyzed as the variables.Results: Total patients with UC was 176 patients. The prevalence of UC during 2010-2014 was 8.2% at Dr. Saiful Anwar General Hospital. There was a similar prevalence of sex between male and female patients, in which 95 (53.4%) were male and 81 (46.6%) were female. The average age of patients with UC was 41,6 years. Most patients were presented with abdominal pain (32.90%) and weight loss (42.1%). The diagnosis based on colonoscopy were pancolitis (36%), proctosigmoiditis/proctitis (31.81%), and left-sided colitis (21.9%). The risk factors of UC identified in this study were current smoker, use of NSAIDs/traditional herbs/potion and fiber diet. Majority of ulcerative colitis study samples were non-smoker (75%), not consuming herbal treatment/NSAID (60.22%), and rarely consuming fiber (36.93%). There is a significan correlation between frequency of fiber diet and UC (r = -0.106, p = 0.000).Conclusion: The prevalence of UC was 8.2% in our hospital with men and women were equally affected, and average age was 41.6 years. Patients presented with various clinical symptoms, most are abdominal pain and weight loss. The most frequent diagnosis were pancolitis, proctosigmoiditis/proctitis, and leftside colitis. There is a significant correlation between frequency of fiber diet and UC (r = -0.106, p = 0.000).Keywords : ulcerative colitis, prevalence, profile, risk factors

Correlation of Aerobic Exercise and High Nitrate Diet with Population of Eschericia Coli in the Digestive Tract of Liver Cirrhosis Individuals Retti Nurlaili; Syifa Mustika
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 3 (2017): VOLUME 18, NUMBER 3, DECEMBER 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Background: In liver cirrhosis, the population of E coli is increased. conditions such as reduced intestinal). Escherichia coli with 2 enzyme nitrate reductase (NRF and Nir) reduce nitrate to nitrite and subsequently converted to ammonia (99%) and nitric oxide (1%) in anaerobic condition. Regular aerobic exercise 2-3 times/week for 30 minutes resulted in increased 2,3-DPG which reduces the activity of E. coli to reduce nitrate to nitrite and ammonia, which only works on the anaerobic state. High Nitrate Diets lead to increased nitrate reducing bacteria such as E. coli resulting in the reduction of nitrate excess produce nitrite and ammonia in large quantities. Probiotic Lactobacillus spp. can suppress the growth of bacterial endotoxins and pathogens such as E. coli and other Enterobacteriaceae. This study aimed to determine the correlation of aerobic exercise and a high nitrate diet in gastrointestinal populations of Escherichia coli gastrointestinal tract in patient with liver cirrhosis.Method: This was a descriptive-experimental study in liver cirrhosis patients Child Pugh A/B in outpatient clinic Saiful Anwar Hospital in August 2015. Respondents were asked to fill out a questionnaire with information about the demographic data, the nitrate diet, aerobic exercise, other medical data and sanitation, and stool samples were taken for faecal culture. Eta Correlation statistical test was used to determine the correlation of aerobic exercise and a high nitrate diet high in population of E. coli. The significant difference are indicated by p 0.005.Results: A total of 36 patients diagnosed with liver cirrhosis Child Pugh A/B, 14 (39%) underwent aerobic exercise 3x /week, as many as 25 (70%) consume a high nitrate diet. There was a strong relationship between aerobic exercise and high nitrate diet with population of E. coli (Ƞ = 0.725; p 0.05).Conclusion: There was a strong relationship between aerobic exercise and high nitrate diet with a population of E. coli in liver cirrhosis. Giving probiotics in patients with liver cirrhosis suppressed the population of E. coli.

Prevalence of Hepatitis B Infection Among Male Prisoners in Malang Syifa Mustika; Daya Daryadijaya
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 20, No 1 (2019): VOLUME 20, NUMBER 1, April 2019
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Hepatitis B virus (HBV) infection is a global public health problem. Prison populations are at high risk for HBV transmission. In Prison, there is very rare to perfom screening for hepatitis B. This study aims to determine the prevalence of HBV infection among male prisoners in Malang, East Java Province of Indonesia.Method: In this cross sectional study, a total of 165 male prisoners were screened using rapid test (DiaSpot® test kit) for detection of HbsAg in serum samples.Results: The risk factors for HBV transmission were had permanent tattoo (11.32%), multiple sex partner (6.67%), injecting drug users (24.32%), history of blood tranfusion (4.76%), and family history of hepatitis (9.37%). There are 101 subjects (61.2%) for negative anti-HBs result. Positive result for HBsAg and anti-HBs were 7.8% and 30.9% respectively.Conclusion: The prevalence of HBV infection among male prisoners was 7.8%. It is suggested to perfom HBV infection screening on high risk population routinely.

Primary Hepatic Lymphoma in a 32-year-old Male Nurria Betty Indriyaningrum; Syifa Mustika
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 1 (2017): VOLUME 18, NUMBER 1, April 2017
Publisher : The Indonesian Society for Digestive Endoscopy

A 32-year-old male came with right upper abdominal pain with a mass increasing in size since the last 6 months, with no other typical symptoms. The physical findings revealed right upper abdominal mass, rubbery consistence, irregular surface, rounded edge, unclear border, immobile, without any tenderness. Other physical examination revealed normal findings, without any lymphadenopathy at another site. The laboratory findings revealed non-reactive hepatitis B and C markers, normal AFP, slightly increased LDH. Plain chest X-ray showed elevated right hemidiaphragm, and a large mass sized ± 14.18 x 8.56 x 12.56 cm compressing the liver. We’ve done biopsy with ultrasound guiding on the mass, and the histological examination revealed that it was lymphoma with negative CD20. The diagnosis was established as primary hepatic lymphoma and the patient was then given chemotherapy.

Non Cirrhotic Portal Vein Thrombosis: Diagnostic and Therapeutic Challenge Syifa Mustika; Pratista Adi Krisna
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 1 (2021): VOLUME 22, NUMBER 1, April 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Portal vein thrombosis (PVT), the second most common cause of portal hypertension, can be found in cirrhosis and non-cirrhosis patients. Various factors can cause non-cirrhosis PVT, such as biliary infection. Upper gastrointestinal bleeding without sign of liver failure, must be considered as non-cirrhosis PVT manifestation. Combining physical, laboratory, endoscopic and radiological examination is needed to establish the diagnosis of PVT. The principle of PVT management consists of 3 keypoints. They are prevention and treatment of gastrointestinal bleeding, prevention of recurrent thrombosis and portal cholangiopathy therapy. Many aspect should be considered regarding the administration of anticoagulants in PVT patients, especially chronic PVT with cavernomas.

Prevalence of Hepatitis B and C Infection Among Street Children Community in Malang City Syifa Mustika; Charisma Dian Simatupang
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Background: World Health Organization (WHO) announced that during 2017, 325 million people worldwide were infected with the hepatitis B virus (HBV) or hepatitis C virus (HCV). Street children community is a part of society that is susceptible to HBV and HCV transmission, yet no data available about the prevalence. The purpose of this study was to determine the prevalence of hepatitis B and hepatitis C infections in street children community of Malang during 2017.Method: This cross-sectional study was conducted in September 2017 with subjects of street children who were members of the East Java Humanitarian Network (EJHN) group. They were interviewed, got vital signs examined, and performed HBsAg and anti HCV tests using the ECLIA method.Results: There were 90 subjects, with more male than female (60%). The most frequent age range was between 21 to 30 years (35.6%). Most of them do not have permanent jobs (37.8%). The level of education varied, with 30% were at the level of primary education and 56.7% were married. There were 4.4% hepatitis B positive and 1.1% of hepatitis C positive among the subjects. Subjects with positive results had history of free sex, tattoos, and intravenous drugs abuse as the risk factors of HBV and HCV transmission.Conclusion: The prevalence of Hepatitis B and Hepatitis C in the population of street children in Malang city, East Java, were 1.1% and 4.4%, respectively. The most common risk factors were free sex and tattoos.

The Relationship of Diarrhea in COVID-19 Patients With Transaminitis, Severity, and Mortality Amanda C Wowor; Supriono Supriono; Bogi Pratomo; Syifa Mustika
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 2 (2021): VOLUME 22, NUMBER 2, August 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Coronavirus disease 2019 (COVID-19) is a pandemic that causes various types of symptoms. Diarrhea is a gastrointestinal symptom that is hypothesized to be associated with patient morbidity and mortality. Research on the relationship between diarrhea and the incidence of transaminitis, severity and mortality has never been carried out, so further research is neededMethod: Descriptive-analytic research design with a case-control study approach. Sampling using consecutive sampling on patients in the inpatient installation of dr. Saiful Anwar, Malang. Research data on diarrhea incidence, transaminitis, severity, and mortality were obtained from secondary data on COVID-19 patients. Data were analyzed using chi-square with a significance level p 0.05Results: The incidence of diarrhea in COVID-19 patients with transaminitis was 45.8% and significantly associated (p = 0.025). Diarrhea in COVID-19 patients was associated with severity (p = 0.046) and patient mortality (p = 0.028).Conclusion: There is a relationship between the incidence of diarrhea in COVID-19 patients with trasnsaminitis, severity and mortality

Case Report: A 31-year-old Post Cesarean Section Women with Intrahepatic Cholestasis of Pregnancy and Post Partum Bell’s Palsy Syifa Mustika; RC Tarigan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 3 (2018): VOLUME 19, NUMBER 3, December 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Intrahepatic cholestasis of pregnancy (ICP) is cholestasis condition characterized by pruritus, elevated serum aminotransferase and bile acid levels with onset in the second or third trimester of pregnancy. Estimated of ICP prevalence only 0.001% to 0.3%. Bell's Palsy is a neurological disorder that causes facial muscles on one side of the face to suddenly weaken or become paralyzed. Bell's Palsy is more common in young adults, older people, diabetics and pregnant women. A 31-year-old women with major complaint is yellow eyes. She got itching in all over the body. Patient was in second pregnancy with gestational age was 39-40 weeks. She suffered from unable to close her eyelid or blink. Patient was diagnosed with cholestasis intrahepatal in pregnancy and Bell’s palsy post partum. Diagnosis was established concluded from anamnesis, physical examination and hepar biopsy. The result of a liver biopsy showed intrahepatic cholestasis. From Fibroscan examination was visible with F2 category or Moderate Fibrosis. The main management of this patient is cesarean section with UDCA and corticosteroid therapy. Patient was administrated with antiviral therapy for her Bell’s Palsy condition. After 1 week hospitalization, patient was discharged with improvement of her major complaint.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Rudijanto Adam Adam Ade Rahmawati Affa Kiysa Waafi Amalia, Dinda Amanda C Wowor Anton Komala Arifah, Nina Nur Bayu Eka Nugraha Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Brahmantyo, Herwindo Pudjo Budi Herlianto Budi Herlianto Budiarto, Andika Agus Caesar Ahmad Tidel Camoya Gersom Charisma Dian Simatupang Daryadijaya, Daya Daya Daryadijaya Dewi Santosaningsih Dewi Santosaningsih Dian Handayani Dian Handayani Dian Hasanah Diana Jeni H Diana Jeni H, Diana Jeni edy susanto Endang S. Rahayu Erlina B Fachrureza, Mochamad Fachrurrezza, Mochammad Faridah, Amirah Fathoni, Alfan Fiqih Faruz Gatya, Mifta Harijono Achmad Harijono Achmad Harijono Achmad Harijono Ahmad Hartaya, Arsy Hanandya Imroatussholihah, Al Indriyaningrum, Nurria Betty Indriyaningrum, Nurria Betty Jonny K. Fajar Kenty Wantri Anita, Kenty Wantri Komala, Anton Kongkam, Pradermchai Larasati, Putu Anissa Lia Sasmithae Lutfiyanto Nurhidayat M. Farid Rakhman Mariyatun Mariyatun, Mariyatun Marzuki, Mochammad Jalalul Michaela, Cleine Muli Yaman Muthiah, Mark Nabila Ramadhani Nabila, Salsala Sifa Nanik Triana Nasution, Muhammad Imanuddin Nina Nur Arifah Novita Apramadha Kartika Sari Nugraha, Bayu Eka Nugroho, Rama Tiar Nurlaili, Retti Nurmalita, Shafira Nurria Betty Indriyaningrum Pandu Tridana Sakti, Pandu Tridana Pramesi, Putrika C. Pratista Adi Krisna Pratomo , Bogi Prayitno, Tia Rahmi Priyanto, Tia Rahmi Putri, Dinda Amalia Eka Putri, Fildzah Karunia Rakhmadhan, Iraky Ramadi Satryo Wicaksono Ratnaningtyas, Yosefin RC Tarigan Renny Tandya Retti Nurlaili Reyhan , Muhammad Rosita, Firdha Ruliana Ruliana, Ruliana Rulli Rosandi Safira, Zahra Sagala, Ida Samichah Samichah Sasmithae, Lia Satiti, Ika Sembiring, Frinny Sholihah, Al Imroatus Sigit Triyus Priyantoro Sigit Triyus Priyantoro, Sigit Triyus Sopacua , Andre Supriono Supriono ., Supriono Supriono Supriono Supriono Supriono Supriono Supriono Susanti, Lia Susanto, Jefri P. Suyoso Suyoso Tarigan, RC Tiar Oktavian Effendi Triana, Nanik Vianty , Liku Wibowo, Bogi Pratomo Wijayanti Saputri, Nur Estu Yuni Rahmawati

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Journal : The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy