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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Jurnal Matematika & Sains Indonesian Journal of Tropical and Infectious Disease UNEJ e-Proceeding Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Food and Pharmaceutical Sciences Bulletin of Chemical Reaction Engineering & Catalysis Journal of Bio-molecule Research And Engineering Andan Jejama: Indonesian Journal Of Community Engagement
Nanik Siti Aminah
Departemen Kimia, Fakultas Sains Dan Teknologi, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total dan Fenolik Total Ekstrak Sidaguri (Sida rhombifolia L.) Asma Asma; Abdul Rohman; Djoko Santosa; Mohamad Rafi; Nanik Siti Aminah; Muhamad Insanu; Irnawati Irnawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4955

Abstract

Sidaguri atau Sida rhombifolia L. telah digunakan oleh masyarakat sebagai obat tradisional, yaitu: penghilang rasa nyeri, radang, asam urat, penyakit kuning, muntah darah, dan sakit gigi. Faktor yang mempengaruhi produksi kandungan metabolit sekunder adalah kondisi lingkungan seperti tempat tumbuh, iklim, interaksi intra dan inter-spesifik serta waktu panen. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan serta kadar flavonoid dan fenolik total ekstrak sidaguri berdasarkan tempat tumbuh. Sampel diekstraksi dengan ultrasonic-assisted extraction (UAE) dan diuji penangkapan radikal bebas menggunakan metode 2,2’-difenil-1-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3-diethyl4benzothiazoline-6-sulfonic acid) (ABTS), serta penetapan kadar flavonoid total dan kandungan fenolik total. Hasil uji aktivitas antioksidan sidaguri dari Cangkringan dan Ngemplak memiliki aktivitas antioksidan tertinggi baik pada metode penangkapan radikal DPPH dengan nilai IC50 masing-masing sebesar 0,400±0,004 dan 0,403±0,004 mg/mL, maupun metode ABTS dengan nilai TEAC masing-masing sebesar 40,733±0,240 dan 35,598±0,153 mg/g serbuk sidaguri, dengan kadar flavonoid total masing-masing sebesar 10,095±0,068 dan 12,066±0,025 mg/g serbuk sidaguri dan kadar fenolik total masing-masing sebesar 56,45±0,068 dan 31,502±0,025 mg/g serbuk sidaguri.
Identification of Sida rhombifolia from Its Related Plants Using Thin-Layer Chromatographic Analysis Mohamad Rafi; Sefni Reza Yolanda; Dewi Anggraini Septaningsih; Maria Bintang; Nanik Siti Aminah; Muhamad Insanu; Abdul Rohman
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.73077

Abstract

Sida rhombifolia belongs to the Malvaceae family and is often used to treat gout in Indonesia. S. rhombifolia has many efficacies and contains many different chemical components. The abundance and variation of chemical content and chemical compounds in this medicinal plant are challenging factors in ensuring medicinal plants' safety and quality control. Thin-layer chromatography (TLC) fingerprint analysis derived from S. rhombifolia extract can also be used for the medicinal plant's quality control. This research aimed to develop the optimum condition for the chemical fingerprint analysis of S. rhombifolia using a TLC fingerprint analysis. A total of 11 bands were produced with optimum separation using silica gel 60 F254 TLC plate, a mixed mobile phase condition with chloroform, ethyl acetate, and methanol (6.5:2:1.5). This fingerprint analysis performed an excellent separation in the TLC plate at 366 nm with sulfuric acid as reagent derivatization. In general, the results of the analysis validation, including stability, specificity, precision, and robustness of TLC fingerprints, met the acceptance criteria. The TLC fingerprint of S. rhombifolia can be distinguished from 2 related plants with similar leaf shapes, Turnera ulmifolia L. and Hibiscus rosa-sinensis. The developed method was validated, so it could be used to control S. rhombifolia quality.
UHPLC-Q-Orbitrap HRMS-based Untargeted Metabolomics of Sida rhombifolia Leaves and Stem Extracts Alfi Hudatul Karomah; Mohamad Rafi; Dewi Anggraini Septaningsih; Auliya Ilmiawati; Utami Dyah Syafitri; Nanik Siti Aminah; Muhamad Insanu; Abdul Rohman
HAYATI Journal of Biosciences Vol. 30 No. 4 (2023): July 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.4.770-778

Abstract

Sida rhombifolia, also known as sidaguri in Indonesia, is a medicinal plant commonly used as a herbal medicine because of its metabolite and biological activities. One of the several factors that affect plant metabolite composition and concentration is the use of plant parts. In this study, the experiment aimed to identify the metabolite profile in the leaves and stem extracts of S. rhombifolia using UHPLC-Q-Orbitrap HRMS-based untargeted metabolomics. The samples were distinguished by principal component analysis (PCA). Extraction of metabolites was conducted by sonication for approximately 30 min with 70% ethanol as the extraction solvent; 28 metabolites were identified. Seven metabolites were identified only in the leaves, three were identified only in the stems, and 18 other metabolites were identified in both the leaves and stems. These metabolites were categorized as flavonoids, triterpenoids, alkaloids, coumarins, phenolic aldehydes, phenolic acids, ecdysteroids, fatty acids, and monoterpene lactones. Based on the classification results, PCA grouped the leaves and stem extracts of S. rhombifolia using the peak area variables of the identified metabolites.
ISOLATION AND STRUCTURE ELUCIDATION OF SECONDARY METABOLITE COMPOUNDS FROM Curcuma aeruginosa Alsya Firdausi Nuzula; Alfinda Novi Kristanti; Nanik Siti Aminah; Yoshiaki Takaya; Marisa Nur Sahadatin; Andika Pramudya Wardana
Jurnal Kimia Riset Vol. 8 No. 1 (2023): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v8i1.44073

Abstract

Black turmeric (Curcuma aeruginosa) is Indonesian medicinal plant belonging to the Zingeberaceae family, mostly found on Java. This study aimed to determine the new molecular structures of the compounds isolated from black turmeric originating from Indonesia. Isolation of the secondary metabolite compounds was initiated by solid-liquid extraction using the maceration method with ethanol solvent, followed by liquid-liquid extraction using the partition method with n-hexane and dichloromethane as solvents. Separation and purification were carried out using vacuum liquid chromatography (VLC) and gravity column chromatography (GCC). The isolated compounds were characterized using spectroscopic methods, including UV-Vis, IR, and NMR spectroscopy. The isolation resulted in three sesquiterpenoid compounds, (E)-7-isopropyl-4,10-dimethylcyclodec-10-ene-5,8-dione (curdione), (1R,10R)-Epoxy-(-)-1,10-dihydrocurdione, and zedoalactone B, together with two common terpenes, ethyl tetradecanoate and 1-hexadecene.
Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total dan Fenolik Total Ekstrak Sidaguri (Sida rhombifolia L.) Asma Asma; Abdul Rohman; Djoko Santosa; Mohamad Rafi; Nanik Siti Aminah; Muhamad Insanu; Irnawati Irnawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4955

Abstract

Sidaguri atau Sida rhombifolia L. telah digunakan oleh masyarakat sebagai obat tradisional, yaitu: penghilang rasa nyeri, radang, asam urat, penyakit kuning, muntah darah, dan sakit gigi. Faktor yang mempengaruhi produksi kandungan metabolit sekunder adalah kondisi lingkungan seperti tempat tumbuh, iklim, interaksi intra dan inter-spesifik serta waktu panen. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan serta kadar flavonoid dan fenolik total ekstrak sidaguri berdasarkan tempat tumbuh. Sampel diekstraksi dengan ultrasonic-assisted extraction (UAE) dan diuji penangkapan radikal bebas menggunakan metode 2,2’-difenil-1-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3-diethyl4benzothiazoline-6-sulfonic acid) (ABTS), serta penetapan kadar flavonoid total dan kandungan fenolik total. Hasil uji aktivitas antioksidan sidaguri dari Cangkringan dan Ngemplak memiliki aktivitas antioksidan tertinggi baik pada metode penangkapan radikal DPPH dengan nilai IC50 masing-masing sebesar 0,400±0,004 dan 0,403±0,004 mg/mL, maupun metode ABTS dengan nilai TEAC masing-masing sebesar 40,733±0,240 dan 35,598±0,153 mg/g serbuk sidaguri, dengan kadar flavonoid total masing-masing sebesar 10,095±0,068 dan 12,066±0,025 mg/g serbuk sidaguri dan kadar fenolik total masing-masing sebesar 56,45±0,068 dan 31,502±0,025 mg/g serbuk sidaguri.
Modification of Turen Bentonite with AlCl3 for Esterification of Palmitic Acid Abdullah Abdulloh; Siti Maryam; Nanik Siti Aminah; Triyono Triyono; Wega Trisunaryanti; Mudasir Mudasir; Didik Prasetyoko Didik Prasetyoko
Bulletin of Chemical Reaction Engineering & Catalysis 2014: BCREC Volume 9 Issue 1 Year 2014 (April 2014)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.9.1.5513.66-73

Abstract

Natural Turen bentonite has been modified and applied as catalyst for palmitic acid esterification. Modification of natural Turen bentonite was conducted by cation exchange method using AlCl3 solution. Catalyst characterization was performed on X-ray Fluoroscence, X-ray Diffraction, nitrogen adsorption-desorption and infrared spectroscopy techniques. The catalytic activity test in the esterification reaction of palmitic acid with methanol was conducted by bath at 65 °C with a variation of reaction time of 1, 2, 3, 4 and 5 h. Catalytic activity has been observed qualitatively using GC-MS and quantitatively by changes in acid number. The analysis showed the formation of Al3+-bentonite. Observation on the elements has shown that the presence of calcium decreased from 10.2% to 4.17%, with an increase of aluminium content from 9.9% to 13%. Diffraction line at 2θ 5.7379º became 5.6489º, along with changes in d-spacing of 15.3895 Å to 15.6319 Å. The surface area increased from 83.78 m2/g to 91.26 m2/g, while Brönsted acid sites increased from 10.2 µmol/g to 67.5 µmol/g and Lewis acid sites increased from 94.9 µmol/g to 132 µmol/g. Furthermore, Al3+-bentonite has showed as active catalyst in the esterification reaction of palmitic acid with palmitic acid with conversion of 78.78% for 5 h. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
THE EFFECTIVENESS OF HERBAL MOSQUITO COILS "MORIZENA” AGAINST Aedes Aegypti DEATH Susilowati, Rina Priastini; Darmanto, Win; Aminah, Nanik Siti
Indonesian Journal of Tropical and Infectious Disease Vol. 7 No. 2 (2018)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.03 KB) | DOI: 10.20473/ijtid.v7i2.7324

Abstract

It has been successfully found new herbal mosquito coils called "Morizena” made from Passiflora foetida leaf extract (40%), Chrysantemum cinerariaefolium flowers seed extract (40%), essential oils of  leaves-stems of Cymbopogon nardus (20%). The herbal mosquito coils are more effective to kill Aedes aegypti compared to commercial synthetic mosquito coils made from Transfluthrin. Treatment of exposure to herbal mosquito coils "Morizena” on Aedes aegypti for 8 hours/day with concentration 500 ppm (P1), 1000 ppm (P2), 2000 ppm (P3), 3000 ppm (P4), 4000 ppm (P5) and treatment of exposure to synthetic mosquito coils Transfluthrin 2500 ppm (K1) as a positive control, and without treatment of exposure to mosquito coils (K0) as a negative control. Experimental animals used were adult Ae. aegypti mosquito with 25 mosquitoes in each treatment. Experimental design used is one-way Anova test with linear regression to calculate its LC50 and LC90. The results of test to herbal mosquito coils "Morizena” given for 8 hours/day obtained mortality of Ae. aegypti by 92% to a concentration of 3000 ppm (P4) and 100% to a concentration of 4000 ppm (P5) and 100% for test to synthetic mosquito coils transfluthrin 2500 ppm (K1). Ae. aegypti LC50 and LC90 value for treatment of exposure to herbal mosquito coils "Morizena” are 999 ppm and 2977 ppm. Treatment of herbal mosquito coils "Morizena” with graded doses up to 4000 ppm and synthetic mosquito coils Transfluthrin 2500 ppm causing an increase in the enzyme acetylcholinesterase activity of Ae. aegypti. The conclusion is based on the Ae. aegypti  LC90 value is 2977 ppm, which means the effective dose of herbal mosquito coils "Morizena” to kill Ae. aegypti is 2977 ppm.
The comparative of free energy binding between Pyrimethamine-pDHFR double mutant and Pyrimethamine-pDHFR quadruple mutant: Structure-based approach Abdjan, Muhammad Ikhlas; Aminah, Nanik Siti; Kristanti, Alfinda Novi; Takaya, Yoshiaki; Siswanto, Imam
Journal of Bio-Molecule Research and Engineering Vol 1 No 2 (2022)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbiome.v1i2.43982

Abstract

Structure-based was performed to understand the mechanism inhibition of pyrimethamine (CP6) against Plasmodium Falciparum mutants at the molecular level. A molecular docking process was carried out to obtain the initial conformation of each system. The data showed in the form of RMSD values, hydrogen bonds, and grid scores. The results show that the RMSD value in the redocking process meets the criteria of the CP6-1J3J and WRA-1J3K complexes with a value of ≤ 2 í…. Several hydrogen bonds bind to receptor-active sites, including Ile14, Asp50, Ile164, and Asn108. Additionally, the grid score (kcal/mol) binds well on the active site: CP6-1J3J (-46.86), WRA-1J3K (-65.40), and CP6-1J3k (-44.71). Furthermore, molecular dynamics simulation was carried out to determine the free energy (∆Gbind) of each complex using the MM/GBSA approach. The results show ∆Gbind (kcal/mol) in each complex, namely CP6-1J3J (-28.24), WRA-1J3K (-36.62), and CP6-1J3k (-24.23). Information on this research was expected to provide molecular insight into pyrimethamine as an antimalaria inhibitor.
THE INTEGRATION OF COMPUTATIONAL CHEMISTRY TO SUPPORT INTERACTIVE LEARNING MEDIA FOR SENIOR HIGHSCHOOL: AN INNOVATIVE STRATEGY TO IMPLEMENT ‘KURIKULUM MERDEKA’ Haq, Kautsar Ul; Kristanti, Alfinda Novi; Suwito, Hery; Aminah, Nanik Siti; Rusdipoetra, R. Aryabraga; Alfian, Fariz Rizky; Asyura, Syarifah
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 4 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i4.2024.526-536

Abstract

Simulation or chemical modeling with computers is a major topic in computational chemistry. This subject is not covered in high school material, however, this method can be applied to support a more interactive learning process. Computational chemistry can be used as a virtual teaching aid and can also be used to help explain or predict chemical reactivity. The aim of this Community Service is to improve teachers' understanding of computational chemistry, both in theory and practice, according to the curriculum. The training activities were conducted using two methods: Lectures and practical sessions. Avogadro 1.2.0 and MOPAC2016 software were used for this training. The outcome of this program were evaluated using quantitative and qualitative analysis. The sustainability of the program was analyzed from the assignments regarding the plan to integrate the material provided into the learning process at schools. Based on the evaluation results, participants felt that the training they had received met their teaching needs. After participating in this training, the participants had various ideas for integrating computational chemistry into learning activities.
TRAINING ON FOOD PACKAGING FOR MSMEs SENDEN VILLAGE TRENGGALEK BY UNAIR TEAM & PARTNER UNIVERSITIES Aminah, Nanik Siti; Kristanti, Alfinda Novi; Ramadhan, Rico; Hendradi, Rimuljo; Takaya, Yoshiaki; Khoso, Mir Hasan; Baharin, Siti Nor Atika; Abdjan, Muhammad Ikhlas
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 9 No. 2 (2025): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v9i2.2025.238-248

Abstract

The International Community Services program (ICS) at Universitas Airlangga, part of the Tri Dharma of the university focusing on community service, aims to enhance human resource capacities within communities. In 2024, the program targeted Senden Village, Kampak sub-District, Trenggalek District, East Java, Indonesia, to assist its MSMEs in overcoming packaging challenges that hinder market interest. Collaborating with domestic and international universities, including Universitas Mayjen Sungkono, SMBBMU University Larkana Pakistan, UiTM Negeri Sembilan Malaysia, UM Malaysia, and Meijo University Japan, the program provided intensive training on innovative and functional packaging techniques. This program was chosen and considered urgent because processed food products produced by local MSMEs are still sold in bulk and packaged haphazardly. Therefore, a touch of hygienic and "eye-catching" packaging technology is needed. Attractive and hygienic packaging technology is expected to increase the selling power of these processed food products. The training included theoretical sessions, focus group discussion (FGD) demonstrations, and the introduction of plastic vacuum sealers to improve product packaging and branding. Food packaging workshop held on July 15, 2024, where participants engaged in hands-on training, group discussions, and label design, resulting in tangible improvements in product marketability. The initiative of this activity is not only to increase the visibility and attractiveness of Senden Village products but also to introduce the natural exotism of the village and local products to the national and international community, encouraging cultural and knowledge exchange. The collaboration of this program strengthens international collaboration and provides invaluable experience for students and lecturers. The successful implementation of this program confirms Airlangga University's commitment to community service and its goal of creating a sustainable positive impact on the village community, which ultimately contributes to the development of better human resources. The training has been carried out very well and each training participant has their own brand with an attractive logo and is hygienically packaged with vacuum technology. All training participants were satisfied with this activity as well as head of village, head of PKK, and all the team involved. They hope that next year's activities can be carried out with other innovations for the progress of Senden village.
Co-Authors Abdjan, Muhammad Ikhlas Abdul Rohman Abdul Rohman Abdul Rohman Abdul Rohman Abdullah Abdulloh Abdulloh Abdulloh Alfa Akustia Widati Alfi Hudatul Karomah Alfian, Fariz Rizky Alfinda Novi Kristanti Alsya Firdausi Nuzula Alsya Firdausi Nuzula Ana Firdausyah Andika Pramudya Wardana Andika Pramudya Wardana Asefin Nurul Ikhtiarini Asma Asma Auliya Ilmiawati Azalea Rahma Septianti Baharin, Siti Nor Atika Budi Prasetyo, Antonius Choirotul Isma Citra Putri Pramitha Didik Prasetyoko Didik Prasetyoko Didik Prasetyoko Djoko Santosa Emilia L. Ghisalberti Euis Holisotan Hakim Euis Holisotasn Hakim Ganden Suprianto Giman Giman Haq, Kautsar Ul Hariyanto, Geraldo Figo Hery Suwito Imam Siswanto Irnawati Irnawati Irnawati Irnawati Khoso, Mir Hasan Khusnul Wardah Mukharomah Lia Dewi Juliawaty Mahmiah Maria Bintang Marisa Nur Sahadatin Marisa Nur Shahadatin Masatake Niwa Mochamad Zakki Fahmi Mohamad Rafi Mohamad Rafi Mohamad Rafi Mohamad Rafi Mudasir Mudasir Mudasir Mudasir Muhamad Insanu Mulyadi Tanjung Nita Citrasari NUrina Fitriani, NUrina Qonitah Labibah Rico Ramadhan, Rico Rimuljo Hendradi Rusdipoetra, R. Aryabraga Satya Candra Wibawa Sakti Sefni Reza Yolanda Septaningsih, Dewi Anggraini Setyaningsih, Widiastuti Siti Maryam Siti Maryam Sjamsul Arifin Achmad Sjamsul Arifin Achmad Suhaili, Suhaili Susilowati, Rina Priastini Syarifah Asyura, Syarifah Takaya, Yoshiaki Taufik Taufik Tio Christiawan Bramayudha Tokok Adiarto Triyono Triyono Triyono Triyono Utami Dyah Syafitri Wardana, Andika Pramudya Wega Trisunaryanti Wega Trisunaryanti Win Darmanto Yana Maolana Syah Yaung Kwee Yoshiaki Takaya Yoshiaki Takaya