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All Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Rahmadewi Rahmadewi

Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Airlangga / Dr. Soetomo General Academic Hospital Surabaya

Author-ID : 3286949

Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 39 Documents Claim Missing Document

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Psoriasis Vulgaris in Human Immunodeficiency Virus Infected Patient: A Case Report Rahmadewi Rahmadewi; Maya Wardiana
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Psoriasis vulgaris (PV) is a chronic inflammatory skin disease characterized by erythematous thick scaly plaques. PV in human immunodeficiency virus (HIV) infected patient can give severe clinical features and challenging to treat since the treatment are immunosuppressive drugs. Purpose: To report a case of psoriasis vulgaris in HIV infected patient. Case: A 39 year-old man complained about scaly redness patches on his back and elbow that spread accompanied by burning sensation. From physical examination, on almost all over his body there were erythematous plaques sharply marginated with thick scales. Histopathologic examination from skin biopsy revealed parakeratosis, acanthosis, with psoriasiform hyperplasia and Munro’s microabscesses consistent to PV. The patient was treated with methotrexate tablets. After 8 days hospitalization, white plaque appeared on his tongue. Potassium hydroxide examination (KOH) 10% and 3 methods HIV test was done with positive result. Because of HIV positive methotrexate was stopped. Antiretroviral therapy (ART) was given and its combination with desoximetasone 0.25% cream after 10 days gave a good result for the PV. Discussion: The pathophysiology of PV in HIV infected patient seems to be conflicting due to the involvement of T cell lymphocyte in both diseases. Treatment for PV in HIV infected patient should consider the probability of the immunosuppressive effect of the drugs that can worsen the HIV infection. ART is recommended as the treatment for PV. Conclusion: Psoriatic lesion in this patient responded well to ART and desoximetasone 0.25% cream. PV in HIV infected patient requires certain management considering immunological status and immunosuppressive treatment. Early diagnosis of these comorbid condition help to determine appropriate management.

Kualitas Hidup Pasien Dewasa Muda dengan Akne Vulgaris Derajat Sedang di Indonesia Diah Mira Indramaya; Menul Ayu Umborowati; Amanda Gracia Manuputty; Ridha Ramadina Widiatma; Eva Lydiawati; Trisniartami Setyaningrum; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Akne vulgaris (AV) adalah penyakit inflamasi kronik yang menyerang unit pilosebasea yang paling banyak menyerang pasien dewasa muda di hampir seluruh negara. Pasien dengan akne vulgaris dapat mengalami tekanan psikologis sehingga memengaruhi kualitas hidup pasien. Tujuan: Mengevaluasi kualitas hidup pasien akne vulgaris derajat sedang. Metode: Merupakan penelitian potong lintang observasional dengan menggunakan kuesioner yang melibatkan pasien AV derajat sedang yang mendapatkan terapi AV standar dan penambahan fototerapi sinar biru pada periode Desember 2017 hingga Februari 2018 di Divisi Kosmetik Medik Unit Rawat Jalan Kesehatan Kulit dan Kelamin RSUD Dr.Soetomo Surabaya. Hasil: Sejumlah 40 pasien berusia 16 – 25 tahun dengan rata-rata 19,22 ± 2,76 tahun. Subjek merasakan AV berefek berat terhadap kualitas hidupnya (65%), diikuti dengan yang merasakan berefek sedang (20%), berefek ringan (10%), berefek sangat berat (2,5%), dan tidak ada efek terhadap kualitas hidup (2,5%). Skor total kuesioner Dermatology Life Quality Index (DLQI) dianalisis korelasi dengan variabel lama sakit dan usia subjek menggunakan uji Spearman’s rho. Analisis tersebut menunjukkan adanya korelasi yang bermakna antara skor DLQI total dengan lamanya subjek menderita AV (p = 0,037; CI 95%). Kekuatan korelasi antar kedua variabel (r) negatif lemah. Hal tersebut berarti semakin lama durasi menderita AV maka semakin kecil skor DLQI total. Skor DLQI total dikatakan tidak berkorelasi dengan usia subjek (p = 0,318; CI 95%). Simpulan: Penelitian ini menunjukkan penurunan kualitas hidup pada pasien akne derajat sedang, dan kualitas hidup berkorelasi dengan lama durasi menderita AV.

Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging Retha Retha; Sawitri Sawitri; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Evy Ervianti; Linda Astari; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.1-6

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.

Chickenpox Mimicking Monkeypox in Adult with Diabetes Mellitus and Acute Kidney Injury: Diagnosis and Management Maya Wardiana; Rahmadewi Rahmadewi; Dwi Murtiastutik; Sawitri Sawitri; Damayanti Damayanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.213-223

Background: Chickenpox caused by the varicella-zoster virus (VZV) in diabetes mellitus patients might exhibit similar clinical features with monkeypox, caused by monkeypox virus (MPXV). In May 2019, Singapore notified World Health Organization (WHO) of one laboratory-confirmed case of monkeypox. Considering Singapore is located near Indonesia, awareness about the possibility of an outbreak in Indonesia should be raised. Purpose: To report a case of chickenpox mimicking monkeypox in an adult with diabetes mellitus and acute kidney injury. Case: A 51-year-old male with poorly controlled diabetes mellitus was suspected to have a chickenpox differential diagnosis with monkeypox. His chief complaint was multiple blisters on his body and vomiting. There was a history of feeding a monkey. From dermatological status on facial, trunk, and extremities there were multiple pleomorphic vesicles. Laboratory results showed elevated renal function. Polymerase chain reaction (PCR) examination using VZV as primer revealed a positive result in the range of 810 bp. He was treated with intravenous acyclovir for 3 days and oral acyclovir for 7 days then discharged with improvement in skin lesions and normal renal function. Discussion: Chickenpox in adult and diabetes mellitus patients can give severe clinical manifestation mimicking monkeypox. PCR has a significant role especially when diagnosis could not be established from the physical examination. Acyclovir can be given as the therapy. Conclusion: Adult and poorly controlled diabetes mellitus are important risk factors associated with the severity and complication of chickenpox. A careful diagnostic approach and management are needed.

In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients Eva Lydiawati; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Rahmadewi Rahmadewi; Cita Rosita Sigit Prakoeswa; Christina Avanti; Endang Wahyu Fitriani; Erwin Astha Triyono; Linda Astari; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.189-194

Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp. Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P < 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.

Antifungal Activity of Rosmarinus Officinalis Essential Oil and Nystatin on Store Isolate of Candida species from HIV/AIDS Patients with Oral Candidiasis Bernadya Yogatri Anjuwita; Iskandar Zulkarnain; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Pepy Dwi Endraswari; Damayanti Damayanti; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.167-173

Background: Oral candidiasis is caused by the mycotic activity of Candida albicans present in the oral cavity, and it is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/acquired immune deficiency syndrome (AIDS). The growing resistance and side effects to common antifungal drugs have promoted herbal essential oils as antifungal agents in recent years. In this study, essential oils (EO) of Rosmarinus officinalis (Lamiaceae) were examined for in vitro antifungal activity against Candida species. Purpose: To evaluate the antifungal activity of essential oils of Rosmarinus officinalis (Lamiaceae) and nystatin using the microdilution technique by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of Candida spesies. Methods: This was an experimental laboratory study with a post-test-only design conducted in Dr. Soetomo General Academic Teaching Hospital, Surabaya. Forty isolates consisted of twenty isolates of Candida albicans and twenty isolates of Candida non-albicans were collected. The isolates were tested for antifungal activity using the microdilution on 96-well plates. Result: There was a significant difference from the results of the MIC concentration of rosemary essential 100% to 6.25% microdilution method between nystatin and rosemary essential oil (p < 0.05). Conclusion: The antifungal activity of rosemary essential oil was better than nystatin that the lowest MIC value, which was 6.25%, has been obtained the microdilution method. The minimum fungicidal concentration of rosemary essential oil was 25%, while the minimum fungicidal concentration nystatin was higher than 100%.

A Retrospective Study: Characteristics and Management of Gonorrhea Indah Purnamasari; Dwi Murtiastutik; Muhammad Yulianto Listiawan; Evy Ervianti; Rahmadewi Rahmadewi; Budiono Budiono; Astindari Astindari; Maylita Sari; Septiana Widyantari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.1-7

Background: Gonorrhea (GO) is a sexually transmitted infection that remains an important clinical and public health problem worldwide. Its incidence tends to increase both in males and females. Given the scale of the public health impact of GO, the selection of appropriate therapy is essential. Purpose: This study aimed to evaluate the characteristics, management, and recovery of gonorrhea patients. Methods: The research material was obtained from the medical record of gonorrhea patients at the Sexually Transmitted Infections (STI) Outpatient Clinic, Dermatology and Venerelogy Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya, from January 2016 to December 2018. Result: We found 84 new GO patients (0.02%) out of the total new outpatients at the Dermatology and Venereology Department, Dr. Soetomo General Academic Teaching Hospital, Surabaya. Most of them were males (92.9%), 17–25 years age group (52.4%), unmarried (67.9%), and heterosexual (90.5%). The majority of therapy is dual therapy, was combination of doxycycline and cefixime (78%). Only 34 patients (40.5%) attended the follow-up visits, and 94.1% of them recovered, and 5.9% presented with cystitis. Conclusion: The characteristics features of GO varies in each variable. One of important to control GO is provide effective and appropriate treatment and routinely clinical and laboratories were needed control.

The Comparison of Candida spp. Colonization on Psoriasis Vulgaris Patient and Control Amanda Gracia Manuputty; Dwi Murtiastutik; Sawitri Sawitri; Muhammad Yulianto Listiawan; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Pepy Dwi Endraswari; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.40-47

Background: Psoriasis is an inflammatory, chronic, and recurring skin disease that affects patient’s quality of life. Environment, drugs, and infections in the form of antigen and toxin such as Candida spp. are assumed responsible for triggering and exacerbating psoriasis. Purpose: To compare the prevalence of skin colonization of Candida spp. on psoriasis vulgaris patient and control. Methods: This study was observational analytic research involving 33 psoriasis vulgaris patients and 33 healthy individuals. They were matched up based on sex, age, and lesion location. Swab of skin lesions on the Koebner area of both groups was cultured on CHROMagar media. Candida spp. was later identified and the colonization was calculated. Result: Candida spp. was found on 51.5% of lesions in psoriasis vulgaris patients and 21.2% in the control group with a significant difference of p < 0.05. The average colony number of Candida spp. in psoriasis vulgaris group was lower than the control group with no significant difference of p > 0.05. The predominant Candida spp. in the psoriasis vulgaris and control groups was Candida krusei, which were 35.5% and 85.6%, respectively. No significant difference between sex, age, period of complaints, age onset, degree of severity (Psoriasis Area and Severity Index), and therapy history, with positive culture of Candida spp. Conclusion: There was no difference in the number of Candida spp. colonization in the psoriasis vulgaris group and the control group. However, the culture positivity of Candida spp. in the psoriasis vulgaris patients was higher than in the control group.

Skin Aging Profile in Tertiary Hospital: a Descriptive Study Tasya Wikassa; Damayanti Damayanti; Irfiansyah Irwadi; Trisniartami Setyaningrum; Rahmadewi Rahmadewi; Diah Mira Indramaya; Menul Ayu Umborowati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.36-45

Background: Skin aging is a physiological process that involves changes in skin cells and tissues due to abnormal mechanisms and decreased tissue function caused by both intrinsic and extrinsic factors. Skin aging has different clinical manifestations in each individual, which were classified using Glogau's photoaging classification. Purpose: The objective of this descriptive observational study is to evaluate the profile of skin aging patients at Dr. Soetomo General Hospital Surabaya from January – December 2019. Methods: This study utilized a total sampling technique from data obtained from the patients' medical records, which included age, gender, occupation, anamnesis, physical examination, diagnosis, and treatment received by patients. This research has been reviewed by the Ethics Committee at Dr. Soetomo General Hospital Surabaya (0438/KEPK/XII/2021). Result: Based on data obtained from medical records, 415 samples of skin aging patients were collected. The highest number of cases occurred among patients aged 45 - < 60 years. Most patients were female, and the majority of patients’ occupations were private employees. History taking findings include the most common complaint, namely dull skin, with the most precipitating factors discovered in patients, namely exposure to sunlight and pollution. Wrinkles were the most common physical examination finding in patients, with Glogau's photoaging III being the most common diagnosis. Most patients were treated with photoprotection in the form of sunscreen. Conclusion: With the increase of public awareness about appearance, as well as human health and quality of life, skin aging is receiving adequate attention nowadays, with sun exposure being the most common precipitating factor.

Clinical Profile and Treatment of Acne Vulgaris Patients M. Yulianto Listiawan; Farah Meriana Fajrin; Rahmadewi Rahmadewi; Afif Hidayati; Sawitri Sawitri; Diah Mira Indramaya; Rebekah Juniati Setiabudi; Maya Wardiana
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.156-161

Background: Acne vulgaris (AV) is not a deadly condition may affect one’s quality of life. Treatment of AV includes topical and oral, depending on the severity. Antibiotics as oral treatment should not be given alone because it can precipitate resistance. Purpose: To describe the clinical characteristics of AV in a tertiary hospital in Indonesia and evaluate the treatment given. Methods: This is a descriptive, retrospective study with a cross-sectional design. The study subject was classified based on severity according to Plewig and Kligman’s acne grading. Further evaluation was made according to the type of lesion, the risk factortopical and oral treatment in subjects with grades 2, 3, and 4. This research was conducted at the Cosmetic Medic Division, Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital Surabaya based on medical records from the period of 2017 to 2019. Result: From 2017 to 2019, there were 525 (1.1%) new AV patients out of a total of 45,754 new patients. AV was the major diagnosis in the Cosmetic Medic division. AV grades 2, 3, and 4 were found in 167 patients (32.0%). The most common lesion was papulopustular (75.4%) and the most common risk factor was hormonal (58.7%). All the patients received tretinoin, clindamycin gel 1.2%, and sunscreen for topical treatment. Doxycycline was the most common oral antibiotic used (98.2%) Conclusion: The most common AV grade in this study was mild AV. Oral antibiotics were given to moderate-to-severe AV patients in combination with topical treatment to prevent resistance.

Co-Authors Afif Hidayati Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ayu Ardhaninggar Agustina Tri Pujiastuti Alfrid Asditya Amanda Gracia Manuputty Amanda Gracia Manuputty Anggraeni, Sylvia Astindari Astindari Astindari Astindari, Astindari Bagus Haryo Kusumaputra, Bagus Haryo Bernadya Yogatri Anjuwita Budi Utomo Budiono Budiono Budiono Budiono Christina Avanti Cita Rosita Prakoeswa Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Dewi Kusumawati Dhita Karina, Dhita Diah Mira Indramaya Dwi Murtiastutik DYAH FAUZIAH, DYAH Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Eva Lydiawati Evy Ervianti Fajrin, Farah Meriana Farah Meriana Fajrin Geani, Silvani Hari Sukanto Indah Purnamasari INDROPO AGUSNI Irma Tarida Listiyawati Irmadita Citrashanty, Irmadita Irwadi, Irfiansyah Iskandar Zulkarnain Leli Asih Linda Astari, Linda Lynoora, Eko Rianova M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani, Marina Maya Wardiana Maya Wardiana Maya Wardiana Maylita Sari Maylita Sari, Maylita Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Nurina Dhani Rahmayanti Pedia Primadiarti, Pedia Pepy Dwi Endraswari, Pepy Dwi Pramitha, Riezky Januar Putri Hendria Wardhani Rebekah Setiabudi, Rebekah Retha Retha Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Rubianti, Marissa Astari Ryski Meilia Novarina Sarah Fauzia Saut Sahat Pohan Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri SEPTIANA SEPTIANA Septiana Widyantari Sunarso Suyoso Sunarso Suyoso, Sunarso Tasya Wikassa Tengku Riza Zarzani N Trisniartami Setyaningrum Veithzal Rivai Zainal Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yusuf Wibisono

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