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All Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Rahmadewi Rahmadewi

Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Airlangga / Dr. Soetomo General Academic Hospital Surabaya

Author-ID : 3286949

Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Penatalaksanaan Alopecia Areata (Treatment of Allopecia Areata) Agatha Anindhita Ayu Ardhaninggar; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Alopecia Areata (AA) is a disease characterized by loss of hair from the scalp of a sudden. The main principle of treatment of AA that inhibit or alter the immunological response by modulating the inflammatory process that occurs around hair follicles. There are several options in the treatment of AA Purpose: provide insight into a variety of existing AA management. Review: AA is a form of autoimmune disease mediated by T lymphocytes that attack hair follicles and hair loss is characterized by chronic and recurrent. Based on the latest research results, the onset and severity of AA are determined by the interaction between genetic factors and environmental factors of the originator. Currently the hypothesis of AA focuses on the collapse of immune privilege status of a hair follicle and presentation of self-antigens that cause active lymphocytes. Several factors such as genetics, autoantigen, immune cell activity, and stress factors played a role in the pathogenesis of AA. The basic principle of treatment of AA, can be divided into two, namely Immunosuppressant and immunomodulatory will manipulate the inflammatory process intrakutan. Conclusion: Several therapeutic options in the AA include the injection of corticosteroids, minoxidil, immunotherapies, photochemotherapy, calcineurin inhibitors, metrotrexate, sulfasalazzine, azatioprine, laser therapy, PRP therapy, and therapy with stem cellsKey word: allopecia areata, treatment

Profile of Fungal and Bacterial Infections in Inguinal Erythrosquamous Dermatoses Irma Tarida Listiyawati; Sunarso Suyoso; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Erythrosquamous dermatoses are diseases of the skin, characterized with the erythematous changing accompanied with scales. Usually, the patients were treated with antifungal and antibiotic, but there were no data to support this therapy. Purpose: To describe the profile of fungal and bacterial infections in erythrosquamous dermatoses. Methods: This is a descriptive cross-sectional study in patient with inguinal erythrosquamous dermatoses in Dermatology and Venereology Outpatient Department, Dr. Soetomo General Hospital 2016. Subjects have been collected through consecutive sampling, and the amount of subject were determined as total sampling from May – August 2016 Results: The profile of fungal infections were tinea kruris (57.14%) and intertriginous candidiasis (9.52%). Fungal infections as a trigger were seborrheic dermatitis (14.29%) and erythema intertrigo (14.29%). Profile of bacterial infections were erythrasma (4.76%). Result of fungal culture were T. mentagrophytes (52.38%), C. parapsilosis (9.52%), S. ciferii (4.76%), C. albicans (4.76%), T. inkin (4.76%), Malaszesia spp (9.52%), and negative result (14.28%). Result of gram positive bacterial culture were S. aureus (38.10%), S. epidermidis (9.52%), S. lentus, S. haemolyticus, S. hominis 4.76%. Mixed gram positive bacteria were S. aureus-S. haemolyticus dan S. lentus-E. faecalis 4.76%. Gram positive and gram negative bacteria were S. aureus-A. baumanii, S. aureus-S. haemolyticus-A. baumanii 4.76% each. Gram negative bacteria were A. baumanii and K. pneumoniae 4.76% each and contamination 9.52%. Conclusion: The profile of fungal and bacterial infections in inguinal erythrosquamous dermatoses mostly were tinea cruris. The result of fungal culture mostly were T. mentagrophytes. The result of bacterial culture mostly were gram positive bacteria, consist of S. aureus, S. epidermidis, S. lentus, S. haemolyticus, S. hominis, E. faecalis.

Profile of Serum Interferon Gamma Induced Protein 10 in Borderline Leprosy Patients with and without Type 1 Leprosy Reaction Agustina Tri Pujiastuti; Indropo Agusni; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred. Purpose: To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction. Methods: This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria. Results: Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123 ± 327,628 pg/mL and 331,648 ± 101,819 pg/mL in groups without reaction. Conclusions: Serum IP10 levels in borderline leprosy patient with type 1 reaction is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Further studies are needed to reveal the role of IP`10 in type 1 leprosy reaction.

Sensibility Test of Candida species against Nystatin, Ketoconazole, and Fluconazole on Oral Candidiasis with HIV/AIDS using Disc Diffusion Method Cut Shelma Maharani; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.221-231

Background: Oral candidiasis is one of the most common infections in Human Immunodeficiency Virus/Acquired Immuno Deficiency Syndrome (HIV/AIDS) patients. Some studies have reported an increased number of resistances of Candida sp. against several antifungal therapies. Purpose: To evaluate the pattern of Candida sp. causing oral candidiasis and the pattern of resistance among the Candida sp. against nystatin, ketoconazole, and fluconazole in oral candidiasis patients with HIV/AIDS infection. Methods: This was a descriptive observational study conducted at the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo General Academic Teaching Hospital. Candida sp. was identified using conventional methods, while the sensibility test was done by using disc diffusion methods. Result: There were 26 subjects with 50 isolates of Candida sp. that had been cultured successfully. Non-albicans Candida sp. was the most common species, which was observed in 28 subjects (56%). The results of the sensibility test on Candida sp. against nystatin, ketoconazole, and fluconazole were 0 (0%), 3(6%), dan 23(46%) respectively. Conclusion: The increased resistance among Candida sp. against antifungal drugs, especially fluconazole, could raise awareness in drug prescription, especially for HIV/AIDS patients.

Erythema Annulare Centrifugum mimicking tinea corporis: A Case Report Rahmadewi Rahmadewi; Riyana Noor Oktaviyanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Erythema annulare centrifugum (EAC) is a rare cutaneous disease characterized by erythematous and violaceous annular plaques that usually involved the thighs and the legs with unknown etiology. EAC has a clinical similar to tinea corporis but different in terms of therapy. Case: A 52-year-old woman was complain redness patches on her both legs and abdomen since 2 month. Redness patches appeared suddenly. Firstly, small patch like insect bite appeared in her abdomen, but rapidly spread into her extremities especially at lower legs accompanied with itchy. She never complains about pain and burning sensation on his rash. No complain about ear, nose and throat disturbances, She has complain about toothache since 3 month ago. Physical examination showed on extremities inferior dextra and sinistra, there were erythematous macules sharply marginated that is varying in size. Regio abdomen and extremitas superior there were hyperpigmentasi macule sharply marginated that is varying in size. A potassium hydroxide microscopic, examination showed a negative result for a fungal infection. A skin biopsy was performed and the histologic examination revealed epidermis with spongiosis and in dermis with infiltration hystiosit, eosinofil and lymphosit on capiler blood vessel. The clinical and histopathological features, with a supportive history of recurrent lesions, led to the diagnosis of EAC. We give patient with dexamethasone and cetirizine, the lesions regressed spontaneously 3 months after onset. Discussion: The main differential diagnosis in our patient include tinea corporis. Histopathology of the skin lesions was classical for EAC. EAC resolves either spontaneously or once the underlying disease has been successfully treated. Systemic glucocorticoids usually suppress EAC, but recurrence is common when these drugs are stopped.

Pediculosis Capitis with Complication Sepsis and Anemia In Elderly Patient: A Case Report Rahmadewi Rahmadewi; Riyana Noor Oktaviyanti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 2 (2019): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Pediculosis is an ectoparasitic infestation of human scalp. Infestation is characterized by intense itching, secondary infection, and anemia in cases of severe infestation, and inadequate diet. Treatment of head lice includes physical methods, topical pediculicides, and oral agents. Purpose: To report a case of pediculosis capitis with complication of sepsis and anemia in elderly patient Case: A women, 80 year-old, body weight 45 kilograms, came to Emergency Room of Dr. Soetomo General Hospital with complaint about malaise, low appetite, and sometimes fever since 1 week ago. Patient also complained about itchy sensation on her scalp appeared since 3 months ago. There were many lices on her scalp. Itchy sensation was felt all day. Patient took a bath only once daily, and spent her time on bed because patient had a hemiparese since 6 months ago. History of the same disease in the family, her grandson also had the same complaint (lice on scalp). No history of bleeding or gastrointestinal bleeding. Patient had a low appetite. There were so many lices on her scalp, with erosion and crustae. Patient was treated with systemic antibiotic ceftriaxone injection 2 times 1 gram daily, metronidazole drip 3 times 500 mg, Packed Red Cell (PRC) transfusion 2 kolf /day until Hb more than10 g/dl, permethrin 1 % (Peditox). The treatments gave a good result. Discussion: Head-to-head contact is by far the most common route of lice transmission. We assumed that the infestation could stem directly from hair in hair contact, or indirectly, e.g. towels, which may have been already used by infected people. The source of contagious in this case could be from her grandson who also had the same complaint (lice on scalp). Treatment of pediculosis is permethrin 1%, other options if these treatments don’t work include malathion, benzyl alcohol, spinosad, and topical ivermectin. Conclusion: This patient was successfuly treated with permethrin 1 % (Peditox) and repeated treatment after 7 days gave good results and in this case there were no side effects. Patient education is the key in preventing pediculosis capitis and also reminding patients that they can help to prevent the spread of these parasites.

Uji Kepekaan Antibiotik Oral terhadap Bakteri Propionilbacterium acnes Pasien Akne Vulgaris Derajat Sedang Berat Alfrid Asditya; Iskandar Zulkarnain; Rahmadewi Rahmadewi; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Akne vulgaris (AV) merupakan penyakit kulit yang sering terjadi terutama pada usia remaja dan dapat berlanjut pada usia dewasa. Peningkatan penggunaan antibiotik menyebabkan pola bakteri Propionilbacterium acnes yang berubah, sehingga dilaporkan adanya resistensi terhadap beberapa antibiotik Tujuan: Mengevaluasi kepekaan antibiotik oral doksisiklin, klindamisin, azitromisin, dan eritromisin yang digunakan pada akne vulgaris derajat sedang-berat terhadap bakteri Propionilbacterium acnes. Metode: Deskriptif observasional, dengan 37 pasien AV baru dan lama yang memenuhi kriteria inklusi dan eksklusi. Sampel diambil dari lesi pustula akne vulgaris kemudian ditanam di media kultur anaerob, diidentifikasi dengan VITEK® 2, dan tes kepekaan antibiotik dengan metode disk difusi. Hasil: Akne vulgaris derajat sedang-berat terbanyak pada laki-laki usia 18-25 tahun dengan tingkat pendidikan sekolah lanjutan tingkat atas (SLTA), hasil uji kultur dan identifikasi menunjukkan terbanyak adalah bakteri Propionilbacterium acnes. Tiga puluh tujuh sampel isolat menunjukkan antibiotik yang memiliki kepekaan terhadap Propionilbacterium acnes adalah sebagai berikut: doksisiklin (100%), azitromisin (86%), klindamisin (76%), dan eritromisin (73%). Simpulan: Kepekaan antibiotik terhadap bakteri Propionilbacterium acnes menunjukkan yang pertama adalah doksisiklin, azitromisin, klindamisin, dan kepekaan paling rendah adalah eritromisin.

Psoriasis Vulgaris in Human Immunodeficiency Virus Infected Patient: A Case Report Rahmadewi Rahmadewi; Maya Wardiana
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Psoriasis vulgaris (PV) is a chronic inflammatory skin disease characterized by erythematous thick scaly plaques. PV in human immunodeficiency virus (HIV) infected patient can give severe clinical features and challenging to treat since the treatment are immunosuppressive drugs. Purpose: To report a case of psoriasis vulgaris in HIV infected patient. Case: A 39 year-old man complained about scaly redness patches on his back and elbow that spread accompanied by burning sensation. From physical examination, on almost all over his body there were erythematous plaques sharply marginated with thick scales. Histopathologic examination from skin biopsy revealed parakeratosis, acanthosis, with psoriasiform hyperplasia and Munro’s microabscesses consistent to PV. The patient was treated with methotrexate tablets. After 8 days hospitalization, white plaque appeared on his tongue. Potassium hydroxide examination (KOH) 10% and 3 methods HIV test was done with positive result. Because of HIV positive methotrexate was stopped. Antiretroviral therapy (ART) was given and its combination with desoximetasone 0.25% cream after 10 days gave a good result for the PV. Discussion: The pathophysiology of PV in HIV infected patient seems to be conflicting due to the involvement of T cell lymphocyte in both diseases. Treatment for PV in HIV infected patient should consider the probability of the immunosuppressive effect of the drugs that can worsen the HIV infection. ART is recommended as the treatment for PV. Conclusion: Psoriatic lesion in this patient responded well to ART and desoximetasone 0.25% cream. PV in HIV infected patient requires certain management considering immunological status and immunosuppressive treatment. Early diagnosis of these comorbid condition help to determine appropriate management.

Kualitas Hidup Pasien Dewasa Muda dengan Akne Vulgaris Derajat Sedang di Indonesia Diah Mira Indramaya; Menul Ayu Umborowati; Amanda Gracia Manuputty; Ridha Ramadina Widiatma; Eva Lydiawati; Trisniartami Setyaningrum; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Akne vulgaris (AV) adalah penyakit inflamasi kronik yang menyerang unit pilosebasea yang paling banyak menyerang pasien dewasa muda di hampir seluruh negara. Pasien dengan akne vulgaris dapat mengalami tekanan psikologis sehingga memengaruhi kualitas hidup pasien. Tujuan: Mengevaluasi kualitas hidup pasien akne vulgaris derajat sedang. Metode: Merupakan penelitian potong lintang observasional dengan menggunakan kuesioner yang melibatkan pasien AV derajat sedang yang mendapatkan terapi AV standar dan penambahan fototerapi sinar biru pada periode Desember 2017 hingga Februari 2018 di Divisi Kosmetik Medik Unit Rawat Jalan Kesehatan Kulit dan Kelamin RSUD Dr.Soetomo Surabaya. Hasil: Sejumlah 40 pasien berusia 16 – 25 tahun dengan rata-rata 19,22 ± 2,76 tahun. Subjek merasakan AV berefek berat terhadap kualitas hidupnya (65%), diikuti dengan yang merasakan berefek sedang (20%), berefek ringan (10%), berefek sangat berat (2,5%), dan tidak ada efek terhadap kualitas hidup (2,5%). Skor total kuesioner Dermatology Life Quality Index (DLQI) dianalisis korelasi dengan variabel lama sakit dan usia subjek menggunakan uji Spearman’s rho. Analisis tersebut menunjukkan adanya korelasi yang bermakna antara skor DLQI total dengan lamanya subjek menderita AV (p = 0,037; CI 95%). Kekuatan korelasi antar kedua variabel (r) negatif lemah. Hal tersebut berarti semakin lama durasi menderita AV maka semakin kecil skor DLQI total. Skor DLQI total dikatakan tidak berkorelasi dengan usia subjek (p = 0,318; CI 95%). Simpulan: Penelitian ini menunjukkan penurunan kualitas hidup pada pasien akne derajat sedang, dan kualitas hidup berkorelasi dengan lama durasi menderita AV.

Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging Retha Retha; Sawitri Sawitri; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Evy Ervianti; Linda Astari; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.1-6

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.

Co-Authors Afif Hidayati Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ayu Ardhaninggar Agustina Tri Pujiastuti Alfrid Asditya Amanda Gracia Manuputty Anak Agung Gede Sugianthara Anggraeni, Sylvia Astindari Astindari Astindari Astindari, Astindari Bagus Haryo Kusumaputra, Bagus Haryo Bernadya Yogatri Anjuwita Budi Utomo Budiono Budiono Christina Avanti Cita Rosita Prakoeswa Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Damayanti Dewi Kusumawati Dhita Karina Dhita Karina, Dhita Diah Mira Indramaya Dian Kistiani Irawaty Dwi Murtiastutik DYAH FAUZIAH, DYAH Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Eva Lydiawati Evy Ervianti Fajrin, Farah Meriana Farah Meriana Fajrin Geani, Silvani Hari Sukanto, Hari Helmi Safitri Indah Purnamasari INDROPO AGUSNI Irma Tarida Listiyawati Irmadita Citrashanty Irmadita Citrashanty, Irmadita Irwadi, Irfiansyah Iskandar Zulkarnain Kartika Paramita Kemal N. Siregar Leli Asih Linda Astari, Linda Lynoora, Eko Rianova M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani Marina Rimadhani, Marina Maya Wardiana Maya Wardiana Maya Wardiana Maylita Sari Maylita Sari, Maylita Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Milla Herdayati, Milla Nurina Dhani Rahmayanti Pedia Primadiarti Pedia Primadiarti, Pedia Pepy Dwi Endraswari, Pepy Dwi Putri Hendria Wardhani Rebekah Setiabudi, Rebekah Retha Retha Ridha Ramadina Widiatma Riezky Januar Pramitha Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Rubianti, Marissa Astari Ryski Meilia Novarina Sarah Fauzia Saut Sahat Pohan Saut Sahat Pohan Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri SEPTIANA SEPTIANA Septiana Widyantari Siswahyudianto Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso, Sunarso Tasya Wikassa Tengku Riza Zarzani N Tris Eryando Trisniartami Setyaningrum Veithzal Rivai Zainal Yusuf Wibisono

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