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All Journal Alchemy : Journal of Chemistry Journal of Mathematical and Fundamental Sciences Public Health of Indonesia ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Pharmaceutical And Biomedical Sciences Journal (PBSJ) Pharmaceutical Sciences and Research (PSR) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia
Ofa Suzanti Betha
Department Of Pharmacy, Faculty Of Health Sciences, Syarif Hidayatullah State Islamic University, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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The Effect of Gelatin and Propylene Glycol on the Penetration Rate of Asiaticoside from Centella asiatica (L.) Urb Leaf Extract Geleaf Extract Gel Sabrina Dahlizar; Yuni Anggraeni; Atina Munfarikhatin; Nelly Suryani; Ofa Suzanti Betha; Zilhadia; Sofa Fajriah; Abdi Wira Septama; Maulina Handayani; Herdini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/w7prk175

Abstract

Centella asiatica (L.) Urb. is a plant known for its potential in scar treatment due to the presence of asiaticoside, a compound capable of promoting skin cell tissue repair. However, the large molecular size of asiaticoside hinders its penetration through the skin. This study aims to evaluate the effect of gelatin and propylene glycol on the transdermal penetration of asiaticoside from a gel formulation containing Centella asiatica leaf extract. Four different formulations were tested: a control (F1, without gelatin or propylene glycol); one with 15% propylene glycol (F2); one with 4% gelatin (F3); and one with 4% gelatin and 15% propylene glycol (F4). The physical characteristics of the formulations were assessed using several parameters: organoleptic properties, pH, homogeneity, centrifugation, spreadability, viscosity, and rheological behaviour. Penetration studies were performed using a Franz Diffusion Cell with a Whatman No. 1 membrane (pre-coated with Spangler solution) for 360 minutes. The penetration data were analyzed using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) with a C18 BEH column (2.1 × 50 mm; 1.8 μm particle size). The results showed that each formulation exhibited distinct characteristics. The study findings indicated that both gelatin and propylene glycol, as well as their combination, significantly influenced the penetration of asiaticoside in the gel formulation. Propylene glycol, functioning as a penetration enhancer, was found to increase the penetration of asiaticoside in both gelatin-based and liquid formulations.              
Physical Stability Test and Total Phenolic Content Determination of Spray Gel Formulation with Ethanol 70% Melinjo Leaf (Gnetum gnemon L.) Extract with Combination of Carbopol 940 and HPMC as Gelling Agent Nelly Suryani; Vivi Anggia; Halimah Dewi; Rosa Adelina; Sabrina Dahlizar; Ofa Suzanti betha; Estu Mahanani Dhilasari; Ismiarni Komala; Yardi Saibi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.45975

Abstract

The stability of a pharmaceutical preparation is very important in formulation to ensure product efficacy and safety. This research aims to test the physical stability and total phenolic content of a spray gel preparation made from 70% ethanol extract of melinjo leaves (Gnetum gnemon L.) with a combination of Carbopol 940 and HPMC as gelling agents. Antioxidant activity was tested using the DPPH method, while total phenolic content was measured using the Folin-Ciocalteu reagent and expressed in gallic acid equivalents (mgGAE/g). The results analysis of total phenolic content in the 70% ethanol extract of melinjo leaves showed a value of 46.237 mg GAE/g. Meanwhile, the total phenolic content in the spray gel formulation of the 70% ethanol extract of melinjo leaves was recorded at 0.88 mg GAE/g."Based on evaluation, the best formula is a combination of Carbopol and Hidroxypropyl methylCellulosa, HPMC (0.4%:0.4%), but the stability test results show physical instability. Further modifications are required to produce a physically stable formula.  
Perilaku Manajemen Diri dan Profil Temperamen pada Karyawan Universitas Prediabetes: Studi Kuantitatif Deskriptif Barita Juliano Siregar; Almahdy A; Dedy Almasdy; Ofa Suzanti betha; Edi Rohaedi; Rafly Syah Putra
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.47019

Abstract

This descriptive study (n = 39) investigated diabetes self‑management Questionnaire (DSMQ) and temperament profiles among university employees with prediabetes risk. DSMQ subscales (glucose management, dietary control, physical activity, healthcare use) were assessed alongside 75‑g OGTT categories (IFG/IGT) using ADA‑standard definitions. Most participants had low DSMQ scores (79.5%), with dietary control and physical activity as the weakest domains. Overweight/obesity was highly prevalent (BMI ≥ 23 kg/m²; 85%), and routine check‑ups were infrequent. BMI correlated with prediabetes (r = 0.436; p = 0.005) and hypertension (r = 0.466; p = 0.003). Dominant temperament was associated with 2‑hour plasma glucose during OGTT (ρ = 0.321; p = 0.045), whereas subdominant temperament was not significant (ρ = 0.285; p = 0.071). We clarified DSMQ structure (16 items; reverse‑coded items; sum scale) and standardized IFG/IGT/75‑g OGTT terms in line with ADA 2025. Findings highlight the need for workplace multicomponent programs integrating nutrition education, structured physical activity, weight management, and temperament‑informed counseling. Limitations include descriptive design (n = 39), purposive sampling, potential confounding, and the non‑causal nature of correlations. In settings with low health service utilization, pragmatic screening and regular follow‑up combined with personalized behavior change strategies may help prevent progression to type 2 diabetes.
Formulation and Stability of Miana Leaf Extract Spray Gel with Antioxidant Nelly Suryani; Rachmadi Wibowo; Rosa Adelina; Vivi Anggia; Tania Sabarini; Sabrina Dahlizar; Ofa Suzanti Betha; Estu Mahanani Dhilasari
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.100561.179-190

Abstract

The extract of Miana leaves (Coleus scutellarioides L.) is recognized for possessing potent antioxidant Action. This research aimed to develop a physically stable spray gel incorporating miana leaf extract and to evaluate its antioxidant potential through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. Three formulations with different proportions of Carbopol and hydroxypropyl methylcellulose (HPMC) were evaluated for stability under room-temperature storage and during cycling tests, with organoleptic characteristics and viscosity as assessment parameters. The extract alone exhibited very strong antioxidant Action (IC₅₀ = 47.71 ppm). In comparison, the spray gel formulations showed IC₅₀ values of 141.18 ppm (FE1, 1%), 113.72 ppm (FE2, 3%), and 80.90 ppm (FE3, 5%), corresponding to moderate, moderate, and strong Action, respectively. Among these, FE2 (3% extract) demonstrated the most favorable physical stability.
Mikroenkapsulasi Daun Pala Menggunakan Maltodekstrin dan Gom Arab dengan Teknik Spray Drying Sabrina Dahlizar; Della Irsalina; Nelly Suryani; Ofa Suzanti Betha; Estu Mahanani Dhilasari; Sofa Fajriah; Maulina Handayani; Mutia Sari Wardana
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.46181

Abstract

Nutmeg leaves (Myristica fragrans H.) are a rich source of various types of phenolic compounds that have exhibited a strong correlation with antioxidant capacity. The inherent instability of phenolic compounds poses significant challenges for their application in the pharmaceutical sector. Spray–drying microencapsulation has emerged as a promising strategy to overcome these challenges. The research aims to evaluate the physicochemical properties and the antioxidant activity of the spray-dried microcapsule of nutmeg leaves. There are variations in extract: encapsulant concentration, including FM-1 (1:2), FM-2 (1:3), and FM-3 (1:4), with a 1:1 encapsulant ratio between maltodextrin and gum arabic. The spray-dried nutmeg leaves were evaluated for morphology, particle size distribution, yield, moisture content, flowability, angle of repose, and encapsulation efficiency. Additionally, antioxidant activity tests were conducted using the DPPH method. The research showed that microcapsules of each formula have spherical and wrinkled shapes. The characteristics of the microcapsules for each formula yield 29.63%, 33.23%, and 33.85%, with moisture content of 7.31%, 9.32%, and 10.01%. The particle sizes measured were 4.58 μm, 5.55 μm, and 7.16 μm; flow rates were 0.59 g/s, 0.75 g/s, and 1.04 g/s; angles of repose were 41.71 °, 37.7 °, and 36.72 °, respectively (FM-1, FM-2, FM-3). The encapsulation efficiencies were 46.63%, 34.32%, 25.66%, respectively. The nutmeg leaves extract exhibited very strong antioxidant activity, with an IC50 value of 36.1 ppm. In contrast, the antioxidant activity of the microcapsules was relatively weak, with IC50 values of 239.07 ppm, 555.29 ppm, and 755.84 ppm, respectively (FM-1, FM-2, FM-3). This study showed that the spray-dried microcapsules of nutmeg leaves from the three formulas have morphologies, particle size distribution, angle of repose, and moisture content that met the requirements. However, the yield, flow rate, and encapsulation efficiency have not met the requirements.
Impact of self-care training on prediabetes prevention among UIN Jakarta employees: The Role of Public Health Pharmacy in Education and Monitoring Barita Juliano Siregar; Almahdy A; Dedy Almasdy; Syamsudin A; Ofa Suzanti Betha; Edi Rohaedi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.206-216.2025

Abstract

Prediabetes is a preclinical condition with a high risk of progressing to type 2 diabetes. This study evaluated an eight-week self-care training program among UIN Jakarta employees, facilitated by Public Health Pharmacy and integrating Avicenna’s classical health principles with WhatsApp-based digital education. A quasi-experimental pre–post design without a control group was applied to 39 participants meeting prediabetes criteria. Clinical parameters assessed included random blood glucose (RBG), systolic blood pressure (SBP), body mass index (BMI), and waist circumference (WC), along with self-care practices using the Indonesian version of the Diabetes Self-Management Questionnaire (DSMQ). Data were analyzed using Wilcoxon signed-rank test and Cohen’s dz effect size. Significant improvements were observed in SBP (dz = -0.530), BMI (dz = -0.253), WC (dz = -0.320), and DSMQ score (dz = +0.793), while RBG showed no significant change. These findings support a culturally relevant, cost-effective model for workplace-based prediabetes prevention. In line with American Diabetes Association (ADA) 2025 Standards of Care, the approach emphasizes person-centered Diabetes Self-Management Education and Support (DSMES) and team-based support; European Society of Cardiology (ESC) 2024 guidelines align the observed SBP reduction with recommended targets after lifestyle intervention. Future programs should extend duration and adopt hybrid delivery for optimal glycemic control.
Model Konseptual Pendidikan Farmasi Berbasis Worldview Islam dan Tibb Nabawi Ofa Suzanti Betha; Maemunah Sa'diyah; Budi Handrianto
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.49190

Abstract

This study aimed to evaluate the effects of purified gambir (Uncaria gambir Roxb.), vitamin C, and their combination on AST levels in male mice subjected to maximal physical activity. Twenty-five male albino mice were randomly divided into five groups (n=5/group): normal control, maximal physical activity control, purified gambir 200 mg/kg body weight + maximal physical activity, vitamin C 65 mg/kg body weight + maximal physical activity, and a combination of purified gambir 100 mg/kg body weight and vitamin C 32.5 mg/kg body weight + maximal physical activity. Treatments were administered orally for 7 days. On day 8, maximal physical activity was induced by forced swimming for approximately 15 min. Serum AST levels were measured photometrically at 340 nm. Data were analyzed using the Shapiro-Wilk test, Levene’s test, Kruskal-Wallis test, and exploratory Mann-Whitney U test. The mean serum AST levels in Groups I, II, III, IV, and V were 141.4 ± 5.98, 146.6 ± 6.88, 122.6 ± 14.26, 124.8 ± 9.96, and 118.8 ± 6.46 IU/L, respectively. The Kruskal-Wallis test showed a significant overall difference among groups (p=0.007). Descriptively, the purified gambir, vitamin C, and combination groups showed lower AST levels than the maximal physical activity group. The combination group showed the lowest mean AST level; however, no significant difference was found between the combination group and the single-treatment groups in exploratory pairwise analysis. Purified gambir, vitamin C, and their combination were associated with lower serum AST levels in male mice subjected to maximal physical activity compared with the physical activity-only group. Although the combination treatment showed the lowest mean AST level, its statistical superiority over purified gambir alone or vitamin C alone was not demonstrated. These findings suggest a potential protective effect against exercise-associated tissue stress, although further studies using larger sample sizes and more specific biomarkers are needed.
Co-Authors . Nurmeilis Abdi Wira Septama Abdi Wira Septama Addina Syahida Afifah Nurnishrina Azzahra Afifah Nurul Izzah Akhsani, Luthfia Wikhdatul Alifa Nurulhusna Almahdy A Almahdy A Amelia, Puteri Annisa Triana Yusman Anwar, Vidia Arliani Atina Munfarikhatin Azzahra, Afifah Nurnishrina Barita J. Siregar Bayyinah Bayyinah Bayyinah, Bayyinah Boy Reynaldi Noor Budi Handrianto Dedy Almasdy Della Irsalina Djamain, Nelly Suryani Edi Rohaedi Edi Rohaedi Eka Putri Estu Mahanani Dhilasari Fakhrun Nisa' Farida Kusumaningrum Fathmah Syafiqoh Ghilman Dharmawan Halimah Dewi Herdini Herdini , Herdini Herman Suryadi Ismiarni Komala Kusumaningrum, Farida Maemunah Sa'diyah Maulina Handayani Maulina Handayani Maulina Handayani Mida Fahmi Mochamad Iqbal Nurmansyah Moethia Moethia Mufidah, Syarifatul Muhamad Beny Setiawan Muhammad Fikry Awaludin Muhammad Reza Munfarikhatin, Atina Mutia Sari Wardana Nelly Suryani Nelly Suryani Nelly Suryani Nelly Suryani Nelly Suryani Noni Tri Utami Nurhasni Nurhasni Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhayati Putri Indriyani Nurkholiza, Zahara Faiziah Nurkhyati Putri Indriyani Putri Hayati Nufus Qurry Mawaddana Rachmadi Wibowo Rafly Syah Putra RAHMAT, DENI Rosa Adelina Rosa Adelina Rurynta Ferly Shavira Sabrina Dahlizar Sabrina Dahlizar Sabrina Dahlizar Sabrina Dahlizar Sabrina Dahlizar Sabrina Dahlizar Saibi, Yardi Yardi Sangadji, Sarah Nahdah Zhaafirah Sarah Nahdah Zhaafirah Sangadji Siregar, Barita Juliano Siswa Setyahadi Siswa Setyahadi Sofa Fajriah Sofa Fajriah Sofa Fajriah Suci Ahda Novitri Supandi Supandi Supandi Supandi Supandi Supandi Supandi Syafiqoh, Fathmah Syamsudin A Tania Sabarini Tengku Riza Zarzani N Tri Yuliana Agustiani Ummi Habibah Vidia Arliani Anwar Vivi Anggia Vivi Anggia Wafa Wafa Yardi Saibi Yardi Yardi Yardi Yardi Yetika Alvionita Yuni Anggraeni Yuni Anggraeni Yuni Anggraeni Zilhadia Zilhadia Zilhadia Zilhadia