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All Journal Alchemy : Journal of Chemistry Journal of Mathematical and Fundamental Sciences Public Health of Indonesia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Pharmaceutical And Biomedical Sciences Journal (PBSJ) Pharmaceutical Sciences and Research (PSR) Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Kefarmasian Indonesia
Ofa Suzanti Betha
Pharmacy Department, Faculty Of Health Sciences, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Indonesia. Jl. Kertamukti No 5, Pisangan Ciputat 15419 Tangerang Selatan, Banten Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Suryani, Nelly; Anwar, Vidia Arliani; Saibi, Yardi; Dhilasari, Estu Mahanani; Dahlizar, Sabrina; Betha, Ofa Suzanti; Komala, Ismiarni; Azzahra, Afifah Nurnishrina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Abstract

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.
Co-Authors Abdi Wira Septama Addina Syahida Afifah Nurul Izzah Akhsani, Luthfia Wikhdatul Alifa Nurulhusna Amelia, Puteri Annisa Triana Yusman Anwar, Vidia Arliani Azzahra, Afifah Nurnishrina Barita J. Siregar Bayyinah Bayyinah Bayyinah, Bayyinah Boy Reynaldi Noor Djamain, Nelly Suryani Eka Putri Estu Mahanani Dhilasari Fakhrun Nisa' Farida Kusumaningrum Fathmah Syafiqoh Ghilman Dharmawan Herdini Herdini , Herdini Herman Suryadi Ismiarni Komala Komala, Ismiarni Kusumaningrum, Farida Maulina Handayani Mida Fahmi Mochamad Iqbal Nurmansyah Moethia Moethia Mufidah, Syarifatul Muhamad Beny Setiawan Muhammad Fikry Awaludin Muhammad Reza Munfarikhatin, Atina Nelly Suryani Nelly Suryani Nisa', Fakhrun Noni Tri Utami Nurhasni Nurhasni Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurkhayati Putri Indriyani Nurkholiza, Zahara Faiziah Nurkhyati Putri Indriyani Nurmeilis Nurmeilis Putri Hayati Nufus Qurry Mawaddana RAHMAT, DENI Rurynta Ferly Shavira Sabrina Dahlizar Saibi, Yardi Yardi Sangadji, Sarah Nahdah Zhaafirah Sarah Nahdah Zhaafirah Sangadji Siregar, Barita Juliano Siswa Setyahadi Siswa Setyahadi Sofa Fajriah Suci Ahda Novitri Supandi Supandi Supandi Supandi Supandi Supandi Supandi suryani, nelly Syafiqoh, Fathmah Tengku Riza Zarzani N Tri Yuliana Agustiani Ummi Habibah Wafa Wafa Yardi Yardi Yardi Yardi Yetika Alvionita Yuni Anggraeni Yuni Anggraeni Zilhadia Zilhadia Zilhadia