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Fajar Budi Lestari
Departement Of Bioresources Technology And Veterinary, Vocational College, Universitas Gadjah Mada, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Public Health Veterinary

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Combined molecular and clinicopathologic characterization of feline coronavirus infection in cats from a multicat shelter Amalia, Fia; Wasissa, Madarina; Salasia, Siti Isrina Oktavia; Lestari, Fajar Budi
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.259-271

Abstract

Molecular detection of feline coronavirus (FCoV) is essential for diagnosing feline infectious peritonitis (FIP). This study aimed to confirm FCoV infection in clinically suspected cats and to describe the associated hematological and cytological changes. Reverse transcriptase polymerase chain reaction (RT-PCR), targeting the N gene, was performed on 20 cats exhibiting clinical signs consistent with FCoV infection, including vomiting, diarrhea, abdominal effusion, rhinitis, uveitis, and ataxia, yielding the expected 386 bp amplicon in all cases. Ascitic fluid was preferred for RT-PCR when available, whereas blood samples were analyzed for hematology. Hematologic profiles revealed consistent inflammatory changes. The mean total leukocyte count was 22.8 ± 12.1 × 10³/µL, and the mean platelet count was 769 ± 505 × 10³/µL. Neutrophilia and leukocytosis were the most common abnormalities, observed in 55% (11/20) of cats, followed by monocytosis in 15% (3/20), lymphopenia in 5% (1/20), and lymphocytosis in 30% (6/20). Platelet counts showed marked variation, ranging from severe thrombocytopenia in 40% (8/20) to extreme thrombocytosis in 35% (7/20). Cytologic examination of ascitic fluid from five cats revealed macrophage-predominant exudates with moderate numbers of neutrophils and few lymphocytes. Macrophages were often vacuolated and contained phagocytosed debris, whereas some neutrophils appeared degenerated. The background consisted of proteinaceous material consistent with a high-protein effusion. The integration of molecular, hematologic, and cytologic findings provides a multimodal diagnostic approach that improves diagnostic reliability. These findings emphasize the importance of combining PCR with clinicopathological data to enhance the early and accurate detection of FIP in multicat environments.
Co-Authors Achmad Fauzi Achmad Fauzi Achmad Yoga Sundava Alhadz, Ghias Ghifari Amalia, Fia Andita, Aretta Safa Anggraini, Mila Putri Basy, Lukman La Budiyanto, Yohanes Wawan Christin Marganingsih Santosa Clara Ajeng Artdita Clara Ajeng Artdita Clara Ajeng Artdita, Clara Ajeng Dewi, Vira Kartika Donny Widianto Endah Purwati Endah Purwati Erian Pemila Ayu Tanzila Fatiha, Azzahra Jasmine Fatkhanuddin Aziz, Fatkhanuddin Febri Ariyanti Fitriana, Fauziah Haryadi, Fathur Rohman Hidayah, Nurulia Hidayat, Rochmad Hidayatullah, Muhammad Fatan Ida Tjahajati Kurniyawan, Farid Firnanda Kustika, Estha Gusmalia Latifah, Khilda Tsania Madarina Wasissa Maharani, Ananda Peurine Syafira Maharani, Vidya Maulana, Husni Maulina, Tifa Restyka Mitra Slipranata Morsid Andityas Muhammad Novrizal Abdi Sahid Nara Husnal Aufa Novra Arya Sandi Novra Arya Sandi Nugroho, Muhammad Arif Nurbani Aziz NURULIA HIDAYAH Pangestu, M. Mukhlis Aditya Pinesthy, Meiandra Ragil Prihanani, Nur Ika Putri Rousan Nabila Putri, Shafira Amalia Rahmayanti, Desyah Rarastoeti Pratiwi Rini Widayanti Risa Ummami, Risa Safitri, Nuril Qolbi Sarah Nuraida S Sarah Nuraidah Sari, Anjar Ruspita Setyaningrum, Maria Advensia Eka Setyorini, Dian Ritma Singgih Utomo Siti Isrina Oktavia Salasia Siti Isrina Oktavia Salasia Siti Isrina Oktavia Salasia Siti Isrina Oktavia Salasia Sukoco, Hendro Surya, Nur Jannah Permata Suryanto Suryanto Syazwina, Alvina Meita Wahyuningtyas, Helfi Wasissa, Madarina Yenni, Latifah Yosyana, Alyaa Rifqoh Putri Yuliawati, Priskilla Sandi