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All Journal Majalah Kedokteran Bandung JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Journal of Dentomaxillofacial Science MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Jurnal Respirasi (JR) Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Jurnal Pengabdian Masyarakat Formosa (JPMF) Indonesian Journal of Cancer Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Ika Kustiyah Oktaviyanti
Departemen Patologi Anatomi Fakultas Kedokteran, Universitas Lambung Mangkurat, Banjarmasin, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : The Indonesian Biomedical Journal

 1 
The Effects of Administration of Mangosteen Pericap's Ethanolic Extract and Xanthone on Angiogenesis of Gastric Ulcer Healing in Wistar Rats Observed Through the Increase in the level of NO and VEGF and CD-31 Expressions Ika Kustiyah Oktaviyanti; Djanggan Sargowo; Mohammad Aris Widodo; Karyono Mintaroem
The Indonesian Biomedical Journal Vol 3, No 3 (2011)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v3i3.150

Abstract

BACKGROUND: NSAIDs can cause gastric ulcer or may delay the healing of it. Upon exposure to indomethacin, gastric ulcer can occur due to oxidants. Mangosteen rind contains xanthone, which is a natural antioxidant. Administration of this antioxidant may increase angiogenesis that can accelerate healing of gastric ulcer.METHODS: This study used an experimental method with randomized post test control only design using Wistar rats. The rats were put on fasting for 24 hours, then a single dose of 30mg/kg body weight (BW) Indomethacine was given. The rats were divided into control group and treatment group. The treatment group was further divided into two subgroups: one group was given a daily 200 mg/kg BW mangosteen pericap extract, and the other group was given 35 mg/kg BW Xanthone. Both the control group and treatment group were decapitated on the 3rd day, 6th day and 12th day, respectively. After decapitation, the stomach of each rat was taken and divided into two portions, one portion was used for NO examination by ELISA, and the other portion for hispathological examination and immunohistochemical analysis for assessing CD 31 and VEGF expressions.RESULTS: Administration of mangoosteen pericap and xanthone could accelerate healing of gastric ulcers as compared with the control, as shown by the decrease in the severity level of the ulcers. Mangoosteen pericap and xanthone could also increase NO, VEGF expression, and CD-31 as compared with the control, especially on the 3rd day of treatment. Explanation of this finding might be that the antioxidants contained in the mangoosteen pericap or in xanthone could bind with radical superoxide and accelerate release of free NO. The increase of NO caused increase of VEGF and CD-31 that could accelerate angiogenesis, which eventually could accelerate healing of the gastric ulcers.CONCLUSIONS: The effect of mangosteen pericap's extract and xanthone can improve healing of gastric ulcers by increasing nitric oxide and also can increase angiogenesis as shown by the increase of VEGF and CD-31 expressions.KEYWORDS: mangosteen, healing, gastric Ulcer, angiogenesis
Co-Authors AA Sudharmawan, AA Achmad Rudijanto Agung Ary Wibowo Agung Ary Wibowo Agung Ary Wibowo Agung Ary Wibowo, Agung Ary Ahmad Marzuki Rifki Hanafi Ahmad Marzuki Rifki Hanafi, Ahmad Marzuki Rifki Al Hasani, Siti Atthahirah Alfi Yasmina Ali Assagaf Alifah Nadia Ambarita, Winona Vida Vita Nathania Anak Agung Istri Sri Wiadnyani Arganita, Fidya Rahmadhany Ariska Endariantari Asnawati Asnawati Asnawati Asnawati Brian Hansen Efraim Sitompul Budiwinata, Winardi Desi Rahmawaty Dewi Nurdiana Diani, Holly Dini Desviana Rahmayanti Dini Desviana Rahmayanti, Dini Desviana Djanggan Sargowo Djanggan Sargowo Eka Yudha Rahman Eka Yudha Rahman Eka Yudha Rahman Eko Suhartono Eko Suhartono Erna Yulida Fahrina Ulfah Fatmathalia Ranti Gading Aurora Puspita Kencana Hafidza, Fadhil Haryati Haryati Hasfira, Fairuz Izdihar Hendra Sutapa Hendra Sutapa Heni Pujiastuti Hery Poerwosusanta Hery Poerwosusanta Hidayat Sujuti Hilda Ayu Setyawati Hilda Ayu Setyawati, Hilda Ayu Ida Yuliana Ida Yuliana Ira Nurrasyidah Irfan Maulana Irfan Maulana, Irfan Isa Ansori Isa, Mohamad Isnaini Isnaini Istiana Istiana Istiana Istiana Juliana, Adies Kanessha Winola Sunata Karyono Mintaroem Karyono Mintarum Khairini Putri Khatimah, Husnul Kusumawardhani, Erna Lena Rosida Lena Rosida Lena Rosida Madargerong, Vincentius Adrian Maharani Laillyza Apriasari Maria Ulfah Mohammad Aris Widodo Muhammad Abianovan Ramadhan Muhammad Ajib Nuzula Muhammad Ali Faisal Muhammad Rizki Syabana Muhammad Sahal Imaduddin Muhammad Sahal Imaduddin, Muhammad Sahal Muthmainah, Noor Nazwa Salsabila Hadni Nikmah, Elok Hikmatun Nurdiana Dewi Nurrafi Aliya Khasanah Oscar Tri Joko Putra Prenggono, Muhamad Darwin Priyono, Sasongko Hadi Rahmiati Rahmiati Rosmitha Monikayani Salma Nurul Ahyati Sasongko Hadi Priyono Sukses Hadi Syafa’ah, Irmi Tenri Ashari Wanahari Triawanti Triawanti Triawanti Ulfah, Fahrina Wahyuni, Dina Widodo, Firman Aprilianto Widya Noor Haliza Widya Shoffa Rosyida Widya Wulan Fitri Winardi Budiwinata Winardi Budiwinata Zakia, Sukma Dina