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The Relationship Between Cognitive Function And Stroke Severity In Bethesda Hospital, Yogyakarta Pinzon, Rizaldy Taslim; Marpaung, Refianda Olivia Febrianti; Sugianto
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 12 No. 2 (2024): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v12i2.28936

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Background: Stroke is a clinical manifestation of impaired brain function, both focally and globally, which can be severe and last for 24 hours. Damage to brain cells can cause cognitive, sensory and motoric dysfunction and hinder functional abilities from daily activities to communication caused by brain cells in stroke patients. Aims this study to determine the relationship between cognitive function and stroke severity at Bethesda Hospital, Yogyakarta. Methods: This study used a retrospective cohort method in 118 ischemic stroke patients with mild to moderate levels of cognitive function within 1-3 months after the first attack using secondary stroke registry. The patient's cognitive function was measured by the MMSE when the patient was discharged from hospital and stroke severity was measured by the NIHSS when the patient was first admitted to the hospital. Results: Of the 118 patients, the majority of patients in this study were male (59.3%), aged ≥ 60 years (57.6%). In this study, no significant relationship was found between cognitive function and stroke severity (p = 0.106). Gender, age, history of hypertension, history of diabetes mellitus, history of dyslipidemia, and the patient's education level did not find a significant association with cognitive function as assessed by the MMSE score and the severity of stroke as assessed by the NIHSS score. Conclusion: There was no significant relationship between cognitive function as assessed by the MMSE score and stroke severity as assessed by the NIHSS score. Keywords: Cognitive function, Stroke severity, Stroke, MMSE, NIHSS, Disability.
Drug Induced Gingival Overgrowth In Elderly Stroke : A Case Report Pinzon, Rizaldy Taslim; Nathanael, Hanshel Everad
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 12 No. 2 (2024): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v12i2.30215

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Background: Drug-induced gingival overgrowth has been reported as adverse effect of certain medication, including amlodipine, in susceptible individuals. The exact mechanism of gingival hypertrophy remains unclear and may be related with multifactorial factors. Gingival hypertrophy related with speech and mastication problem, poor oral hygiene and aesthetic appearance. Case Presentation: We report the case of a 64-year-old male with post stroke and hypertension who developed gum hypertrophy following amlodipine use for 3 years. Maintenance of oral hygiene and substitution of offending medication was performed as the first step in management. Conclusion: A case of DIGO associated with amlodipine on post stroke patient with hypertension that causing difficulties in mastication and diffuse gingival enlargement. After the amlodipine was substituted with candesartan and oral hygiene was performed, leading to significant alleviation of the symptoms Keywords: Gingival hypertrophy; Amlodipin; DIGO; Adverse event
ASSOCIATION BETWEEN COGNITIVE IMPAIRMENT AND 6-12 MONTHS QUALITY OF LIFE IN ISCHEMIC STROKE Kadex Reisya Sita Damayanti; Pinzon, Rizaldy Taslim
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.22

Abstract

Background: Stroke is a major contributor to deaths and disabilities worldwide. Impaired cognitive function is often found in ischemic stroke patients. Disability due to stroke causes functional impairment in various quality of life domains. Cognitive function is one of the predictors of the quality of life. There are still not many studies on cognitive impairment and quality of life in ischaemic stroke patients in Indonesia. Objective: To compare the average quality of life of 6-12 months of stroke patients at the Bethesda Hospital Yogyakarta Neurology Center based on the presence of cognitive impairment Methods: The study used a retrospective cohort study design. Subject data were obtained from the Bethesda Hospital Yogyakarta stroke registry. All risk factor data (laboratory and clinical) and medication were obtained during admission. Cognitive impairment was measured using the Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT). The questionnaire used was World Health Organization Quality Of Life BREF (WHOQOL-BREF). Results: From 113 patients, average quality of life of patients in domain 1, domain 2, and domain 3 was not significant (p > 0.05). A significant mean difference between cognitive impairment and quality of life was found in domain 4 (p = 0.025). Analysis of the confounding variables showed that a history of hypertension, National Institute of Health Stroke Scale (NIHSS) score, diabetes, and atrial fibrillation also had an effect on the patient's quality of life. Conclusion: Cognitive impairment does not have a significant effect on quality of life, especially in the domains of physical health, psychological health, and social relations, but has a significant effect on the environmental health domain of ischemic stroke patients.
ANALISIS KORELASI SKOR GEJALA TOTAL, NYERI, DAN KUALITAS HIDUP SETELAH PENGOBATAN VITAMIN B1, B6, DAN B12 DOSIS TINGGI PADA NEUROPATI PERIFER Hakim, Manfaluthy; Kurniani, Nani; Pinzon, Rizaldy; Tugasworo, Dodik; Basuki, Mudjiani; Haddani, Hasnawi; Pambudi, Pagan; Fithrie, Aida; Wuysang, Audry Devisanty
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 2 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i2.3

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CORRELATION ANALYSIS OF TOTAL SYMPTOM SCORE, PAIN, AND QUALITY OF LIFE POST HIGH DOSE VITAMIN B1, B6, DAN B12 TREATMENT IN PERIPHERAL NEUROPATHYABSTRACTIntroduction: Peripheral neuropathy (PN) is a clinical condition in which nerves of the peripheral nervous system are damaged and is associated with various symptoms affecting the patients’ quality of life (QoL).Aims: To understand the  effect of Vitamin B1, B6, and B12 combination in mild to moderate PN.Methods: This is a prospective, open label, multicenter, single arm observational study involved 399 subjects with PN of different etiology. Subjects received the vitamin B1, B6, and B12 combination tablet orally once daily and were observed for 3 months. Total symptom score (TSS), visual analog score (VAS) and QoL were assessed, and the correlation between these parameters was analyzed.Results: Clinically significant reductions were observed from baseline to subsequent visits for TSS and VAS. Positive correlation  was observed between TSS and components of VAS. The study treatment was associated with a significant improvement in QoL parameters. Inverse correlation was observed between QoL and TSS as well as QoL and components of VAS. The study treatment was found to be well tolerated.Discussion: The correlation  analysis between different outcome measures demonstrated the beneficial effect of combination of vitamin B1, B6, and B12 in relief from symptoms and improvement in QoL of PN.Keyword: Correlation analysis, peripheral neuropathy, SF-8, TSS, VAS, vitamin B1, B6, and B12ABSTRAKPendahuluan: Neuropati perifer (NP) merupakan kondisi klinis akibat kerusakan pada sistem saraf tepi yang memengaruhi kualitas hidup (quality of life/QoL) pasien.Tujuan: Mengetahui efek pemberian kombinasi vitamin B1, B6, and B12 pada NP ringan hingga sedang.Metode: Penelitian observasional dan prospektif secara open label, multisenter, dan single arm, yang melibatkan 399 subjek penderita neuropati perifer dengan etiologi yang berbeda-beda. Subjek mengonsumsi tablet kombinasi vitamin B1, B6, and B12 secara oral satu kali sehari dan diamati selama 3 bulan. Dilakukan penilaian skor gejala total (total symptom score/TSS), visual analog scale (VAS), dan QoL, serta korelasi antara parameter-parameter tersebut.Hasil: Terdapat penurunan TSS dan VAS yang bermakna secara klinis antara baseline (awal) dengan kunjungan berikutnya. Terdapat korelasi yang positif antara TSS dengan komponen-komponen VAS. Pemberian perlakuan dalam penelitian berkorelasi secara bermakna dengan perbaikan parameter dalam QoL. Teramati juga adanya hubungan terbalik antara QoL dengan TSS serta QoL dan komponen VAS. Pengobatan pada penelitian ini juga terbukti dapat ditoleransi dengan baik.Diskusi: Analisis korelasi antara berbagai macam metode pengukuran yang berbeda menunjukkan manfaat dari pemberian kombinasi vitamin B1, B6, and B12 dalam mengurangi gejala dan perbaikan QoL pada pasien PN.Kata kunci: Analisis korelasi, neuropati perifer, kualitas hidup, SF-8, TSS, VAS, vitamin B1, B6, and B12
PAINFUL NEURALGIA RELATED RAMSAY HUNT SYNDROME: A CASE REPORT Pinzon, Rizaldy Taslim; Pandita, Felicia Dara Puspitaning
Journal of Pain, Headache and Vertigo Vol. 6 No. 1 (2025): March
Publisher : PERDOSNI (Perhimpunan Dokter Spesialis Neurologi Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2025.006.01.01

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Ramsay Hunt Syndrome is a rare case.  This syndrome is a severe complication of the reactivation of varicella zoster virus in the geniculate ganglion. Facial paralysis is the main clinical presentation.  We present a rare case Ramsay Hunt Syndrome in a 48 year old female that referred to neurology clinic with very painful herpetic neuralgia, left ear discomfort, and facial palsy. The patient came after two weeks eruption of herpetic rash in the second and third branch of trigeminal nerve. Treatment as antiviral, steroid, gabapentin, and amitriptyline showed improvement and significantly reduced the pain in this patient.
Subdural Hematoma in Chronic Myelocytic Leukaemia Pinzon, Rizaldy Taslim; Fedora, Gusti Ayu Jacinda Amanda
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.100-103

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Chronic subdural hematoma is an old collection of blood between the arachnoid and dura mater that covers the brain surface. This condition is a common neurological emergency and commonly caused by craniocerebral trauma. Chronic subdural hematoma caused by leukaemia was rarely reported, and its pathogenesis and strategies for clinical treatment remain controversial. We report a rare case of chronic subdural hematoma caused by chronic myelocytic leukaemia (CML) in blast crisis. The patient was diagnosed as CML 8 months ago after ischemic stroke. The bone marrow cytology, flow cytology, and haematology consultation suggested chronic myelocytic leukaemia. The patient admitted again with headache and right side weakness. The routine blood examination showed blast crisis. The emergency neurosurgical consultation was performed, but the patient's condition deteriorated quickly after admission. The platelet levels continued to decrease after admission. In this case, early diagnosis and multidisciplinary treatment are important to minimalized the outcome and poor prognosis.
DEVELOPMENT AND VALIDATION TEST OF DISINI (DISTAL SYMETRIC NEUROPATHY) IN DIABETES MELLITUS PATIENTS Maharani, Anyelir Dewi; Pinzon, Rizaldy Taslim; S, Sugianto
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.06

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Background: Diabetic neuropathy is a complication of diabetes mellitus that may lead to ulceration and potentially amputation of the feet in affected individuals. This may result in elevated rates of morbidity and mortality. Although certain health care facilities lack access to essential neuropathy screening equipment (e.g., 128 Hz tuning forks, reflex hammers, and monofilaments), alternative methods must be developed to ensure early detection of diabetic neuropathy. Objective: To determine the development and measure the validity of the DISINI (Distal Symmetric Neuropathy) questionnaire in diabetes mellitus patients. Methods: A quantitative cross-sectional analysis was conducted at Bethesda Hospital Yogyakarta utilising secondary data obtained from DISINI and DN4 examinations of 64 individuals diagnosed with diabetes mellitus. Utilising the ROC curve, AUC value, Pearson correlation test, and Spearman rank correlation, the acquired data were analysed. Results: Analysis of the ROC Curve and AUC values showed that the cut off for the DISINI questionnaire was ≥ 3. The diagnostic value of the DISINI questionnaire included sensitivity 91.84%, specificity 60.00%, positive predictive value (NPP) 88.24%, negative predictive value (NPN) 69, 23%, positive likelihood ratio (LR (+)) 2.30, and negative likelihood ratio (LR (-)) 0.14. The correlation test DISINI with DN4 shows that there is a relationship between the scores of the DISINI  and DN4 (p = 0.001). The correlation test between DISINI and DNE shows that there is a relationship between the DISINI and DNE scores (p = 0.013). The correlation test DISINI with DNS shows that there is a relationship between the scores of the DISINI and DNS (p = 0.007). The correlation test DISINI with Monofilament showed that there was no relationship (p = 0.318). Conclusion: The validation test of the DISINI (Distal Symmetric Neuropathy) questionnaire in diabetes mellitus patients had a sensitivity of 91.84% and a specificity of 60.00% using the gold standard DN4 (Douleur Neuropathique en 4 Questions).
Pengembangan dan Validasi Awal dari Algoritma Sederhana untuk Menilai Disabilitas Paska Stroke Pinzon, Rizaldy Taslim; Al Jody, Abraham
Jurnal Kesehatan Vol 13 No 1 (2025): In Press
Publisher : STIKES Bethesda Yakkum

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

 Stroke menyebabkan kematian dan disabilitas jangka panjang di seluruh dunia, termasuk di Indonesia. Alat ukur derajat disabilitas yang ada memiliki durasi pengerjaan yang lama dan belum disesuaikan dengan konteks budaya lokal. Penelitian ini mengembangkan algoritma cepat untuk menilai disabilitas penyintas stroke di Indonesia. Penelitian potong lintang ini dilaksanakan di RS Bethesda, Yogyakarta, Indonesia. Kami mengumpulkan data demografi dan klinis subyek. Derajat disabilitas dinilai dengan algoritma baru dan modified Rankin Scale (mRS). Validitas criterion dievaluasi melalui perhitungan sensitivitas, spesifisitas, nilai prediktif positif (PPV), dan nilai prediktif negatif (NPV). Kami merekrut 22 subjek. Sebanyak 64% subyek adalah laki-laki dan 73% berusia ≥60 tahun. Dyslipidemia dialami oleh 82% subyek dan fibrilasi atrial pada 9%. Algoritma yang baru memiliki sensitivitas 93,3%, spesifisitas 85,7%, PPV 93,3%, dan NPV 85,7% Algoritma ini memiliki akurasi setara dengan instrumeninstrumen standar. Validasi lanjutan dengan penelitian yang lebih besar, di lebih dari satu tempat penelitian, dan pada pasien dengan disabilitas berat diperlukan sebelum penerapan secara luas.
Hubungan Antara Tingkat Kepatuhan Minum Obat Antiplatelet Aspirin Dengan Kejadian Stroke Iskemik Berulang Di RS Bethesda Yogyakarta Putra, I Dewa Gde Rainey Chrisananta; Pinzon, Rizaldy Taslim; Pramudita, Esdras Ardi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i1.5742

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Stroke menduduki urutan ketiga terbesar penyebab kematian setelah penyakit jantung dan kanker, dengan laju mortalitas 18 % sampai 37 % untuk stroke pertama dan 62 % untuk stroke berulang. Diperkirakan 25 % orang yang sembuh dari stroke yang pertama akan mendapatkan stroke berulang dalam kurun waktu 5 tahun. Stroke berulang merupakan stroke yang terjadi lebih dari satu kali. Ketidakpatuhan minum obat memberikan peluang untuk terjadinya stroke berulang 4,39 kali dibandingkan dengan penderita stroke yang teratur berobat. Tujuan penelitian ini untuk melihat hubungan antara tingkat kepatuhan minum obat anti-platelet aspirin dengan kejadian stroke iskemik berulang digunakan  penelitian analitik dengan metode kasus kontrol. Penelitian menggunakan sampel sebanyak 112 data yang diambil dari data primer pasien. Kelompok kasus sebanyak 56 pasien stroke berulang dan kelompok kontrol sebanyak 56 pasien stroke tidak berulang dengan menanyakan riwayat stroke dan kepatuhan minum obat aspirin tahun 2016 kebelakang. Analisis terhadap 112 subyek yang memenuhi kriteria penelitian menunjukkan bahwa terdapat hubungan antara tingkat kepatuhan sedang dan rendah minum obat anti-platelet Aspirin dengan kejadian stroke iskemik berulang dengan p >0,05 (OR : 28,52, 95%CI: 12,657-88,762, p: < 0,001) Hasil menunjukkan bahwa terdapat hubungan antara tingkat kepatuhan minum obat anti-platelet aspirin dengan kejadian stroke iskemik berulang di Rumah Sakit Bethesda Yogyakarta. Kata kunci : Stroke, kepatuhan minum obat antiplatelet aspirin
PENGGUNAAN EPERISONE HYDROCLORIDE UNTUK MENGURANGI NYERI PASIEN NYERI PUNGGUNG BAWAH AKUT DI RUMAH SAKIT BETHESDA YOGYAKARTA Widyantanti, Maria Atika Sukmana; Pinzon, Rizaldy Taslim
Media Farmasi: Jurnal Ilmu Farmasi Vol 14, No 2 : September 2017
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v14i2.11243

Abstract

Nyeri punggung bawah (NPB) akut merupakan keluhan umum yang dirasakan pada punggung bawah, dapat menjalar sampai dengan kaki, terjadi kurang dari 12 minggu atau nyeri timbul kembali setelah 6 bulan bebas nyeri. Obat yang digunakan untuk mengatasi NPB salah satunya eperisone hydrochloride. Tujuan dari penelitian ini mengukur efek eperisone hydrocloride dalam menurunkan rasa nyeri pada pasien NPB akut dilihat dari nilai Visual Analog Scale (VAS). Metode  yang digunakan dalam penelitian ini adalah observasional analitik dengan rancangan penelitian kohort. Subjek penelitian, pasien NPB akut yang dikelompokkan berdasarkan terapi yang digunakan, kelompok eperisone hydrocloride 50 mg dua kali sehari dan non-eperisone hydrocloride. Data diperoleh melalui kuisioner nilai VAS dan wawancara. Hasil penelitian ini didapatkan 45 pasien NPB akut yang terdiri dari 16 laki-laki (35,60%), 29 perempuan (64,40%). Sebanyak 15 pasien masuk kelompok eperisone hydrocloride dan 30 pasien masuk kelompok non-eperisone hydrocloride, dengan rata–rata umur pasien 53,53±14,94 dan 59,53 ±14,0 tahun. Hasil analisis statistik menunjukkan terdapat perbedaan bermakna dari penurunan nilai VAS sebelum dan sesudah menerima terapi pada kelompok eperisone hydrocloride (p=0,004), outcome berupa penurunan rasa nyeri saat beraktivitas (p=0,456) dan juga efek samping yang muncul saat pemberian terapi (p=1,000). Kesimpulan dari penelitian ini adalah eperisone hydrocloride  dapat menurunkan nilai nyeri dan mencapai outcome.
Co-Authors Adnyana, Kadek Sinthia Grahita Agung Endro Nugroho Agung Wiwiek Indrayani Agustinus Rudolf Phyma, Agustinus Rudolf Al Jody, Abraham Al Jody, Abraham Alexxander Alexxander, Alexxander Alfi Yasmina Alfi Yasmina Amboro, Wisnu Anak Agung Gede Sugianthara Angela, Angela Ardiani, Birgitta Lisbethiara Bagaskara, Arya T Basuki, Mudjiani Budi Harsana, Mary Rose Angelina Bustami, Mursyid Ciptasari, Debora Purwasista Daniel Mahendra Krisna, Daniel Mahendra Desyandri Desyandri Digdoyo, Ananda Dodik Tugasworo Erna Kristin Esdras Ardi Pramudita, Esdras Ardi Fedora, Gusti Ayu Jacinda Amanda Ferdy Firmansyah Firdaus Hafidz As Shidieq Fithrie, Aida Fransiska Theresia Meivy Babang, Fransiska Theresia Meivy Gelgel, Putu Clara Shinta Hakim, Manfaluthy Hardi Astuti Witasari Hariatmoko Hariatmoko, Hariatmoko Hidayat, Muh. Faris I Putu Eka Widyadharma Ika Puspitasari Iwan Dwiprahasto Jarir At Thobari Jesisca, Jesisca Johan Budiman Kadex Reisya Sita Damayanti Kriswanto Widyo, Kriswanto Kushartanti, Bernadeta Margareta Wara Lailla Affianti Fauzi Laksmi Asanti, Laksmi Lucas Meliala Maharani, Anyelir Dewi Maharani, Regina Vika Marpaung, Refianda Olivia Febrianti Mitasari, Pradita S Mugiono, Iroen Muhammad Hasnawi Haddani Muslimah Muslimah Nani Kurniani Nathanael, Hanshel Everad Novita Intan Arovah Nugraha, Boya Padma, Radha Govinda Pagan Pambudi Pandita, Felicia Dara Puspitaning Paramitha, Dessy Pratiwi, Woro Rukmi Priskila, Loury Purwaka, Barlaam Bagus Purwaka Purwandityo, Ayuningtyas Galuh Purwantiningsih, Purwantiningsih Putra, I Dewa Gde Rainey Chrisananta Ratih Puspita Febrinasari Rendra, Andreas K. Renita Sanyasi, Rosa De Lima Renita Sanyasi, Rosa De Lima Renita, Rosa De Lima Rosa De Lima Renita Sanyasi, Rosa De Lima Renita Sari, Efrilia Setyawan, Irfanianta Arif Sinaga, Ruth Vanessa Gloria Sudharmadji Sugianto Sugianto s Sugianto Sugianto Susanto, Agnes Susi Susanti Sutejo, Mianti Nurrizky Thomas Eko Purwata Tri Murti Andayani Trijayanti, Christiana Vania Rau, Chiquita Putri Veronica, Vanessa Widyantanti, Maria Atika Sukmana Wijaya, Vincent Ongko Wijono, Andre Dharmawan Wuysang, Audry Devisanty Y, Yudiyanta Yolanda Dyah Kartika Zalukhu, Marta Lisnawati