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All Journal International Journal of Public Health Science (IJPHS) Jurnal Gizi dan Pangan JURNAL GIZI INDONESIA Journal of Nutrition College Journal of Biomedicine and Translational Research Sari Pediatri Medical Laboratory Technology Journal GIZI INDONESIA AcTion: Aceh Nutrition Journal Amerta Nutrition Jurnal Kesehatan Journal of Telenursing (JOTING) Journal of Health and Nutrition Research Sports Medicine Curiosity Journal Holistik Jurnal Kesehatan Poltekita: Jurnal Ilmu Kesehatan Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)

Adriyan Pramono

Department Of Science Nutrition, Faculty Of Medicine, Diponegoro University

Author-ID : 344431

Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Kandungan Antioksidan pada Suplemen Daun Kelor terhadap Kadar Acyl Ghrelin pada Subjek Obesitas Mahabatillah, Desty; Afifah, Diana Nur; Pramono, Adriyan
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9218

This study aims to explore the effect of antioxidant content on acyl ghrelin levels in obese subjects. This research method is a systematic literature review approach by searching for journal articles in the PubMed database. Inclusion criteria were articles published in the last 10 years using RCT methods on experimental animals and humans with obese nutritional status and providing Moringa leaf intervention. The research results showed that of 69 articles identified, only 7 articles met the inclusion criteria. The findings obtained indicate that the high antioxidant content of Moringa leaves has great potential as a functional food source and is beneficial for body health. The conclusion of the research is that the antioxidant content in Moringa leaves has an effect on obesity and still needs to be studied for its effect on acyl ghrelin. Keywords: Acyl ghrelin, Moringa Leaf Supplements, Antioxidants, Obesity

Nutritional Status Related to Work Fatigue in Police Officers at the Traffic Police Directorate of East Java Antika, Karinda Kennia; Pramono, Adriyan
Sports Medicine Curiosity Journal Vol 1 No 1 (2022): May 2022
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/smcj.v1i1.58516

Work fatigue can cause a decrease in performance which can lead to work accidents. Fatigue can be caused by several factors including nutritional status and work environment. This study aimed to determine the relationship between nutritional status and work environment with work fatigue of Police Officer at The Traffic Police Directorate of East Java. The design of this study was cross sectional, with 44 subjects aged 21-40 years. Data collection includes body weight and body height, subject identity data and work fatigue levels with the Industrial Fatigue Research Committee (IFRC) questionnaire. The independent variables were nutritional status and work environment and the dependent variables was work fatigue. Spearman’s Rank and Kolmogorov Smirnov test was used to analyze the relationship between nutritional status and work environment variables with work fatigue on the subjects. The correlation analysis between nutritional status and work fatigue was p = 0,000. The analysis between work environment and work fatigue was p = 1,000. There was a relationship between nutritional status and work fatigue, but there was no relationship between work environment and work fatigue of Police Officer at The Traffic Police Directorate of East Java.

Intervensi kukis tempe gembus terhadap kadar trigliserida dan tekanan darah pada pasien diabetes melitus tipe 2 Karimah, Asma; Afifah, Diana Nur; Pramono, Adriyan; Seno, Khristophorus Heri Nugroho Hario; Legowo, Anang Mohamad
Holistik Jurnal Kesehatan Vol. 18 No. 6 (2024): Volume 18 Nomor 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v18i6.421

Background: Diabetes mellitus (DM) type 2 is a non-communicable disease that is a global health problem. The cause can be low daily fiber intake, so high-fiber diet intervention is recommended in its treatment. Tempe gembus which contains high fiber, is expected to provide sufficient fiber supply for people with DM type 2. Purpose: To analyze the effect of consuming tempe gembus cookies on triglyceride (TG) levels and blood pressure (systolic and diastolic) in patients with DM type 2. Methods: An experimental study with a pre-post randomized control group design was conducted in December 2023-March 2024 in Banyumas Regency involving 36 patients with DM type 2. Participants were randomly divided into two groups (control and intervention). The intervention group consumed 30 g/day of tempe gembus cookies as a substitute for snacks supported by standard DM type 2 care for 28 days. Data analysis used an independent t-test or with 80% power and 95% confidence interval, p value <0.05 indicates a statistically significant difference. Results: There was no statistically significant difference between the two groups in the mean changes in TG levels and blood pressure after the intervention (p = 0.093) for TG levels, p = 0.852 (systolic blood pressure) and p = 0.864 (diastolic blood pressure). However, clinically the intervention was able to reduce TG levels by 71 mg/dL (p = 0.039) and diastolic blood pressure by 4.62 mmHg, this decrease was better when compared to the control group. Conclusion: High-fiber dietary interventions accompanied by consistent lifestyle changes can help manage TG levels and blood pressure, especially in patients with DM type 2. Keywords: Blood Pressure; Diabetes Mellitus Type 2; Tempe Gembus Cookies; Triglycerides. Pendahuluan: Diabetes melitus (DM) tipe 2 merupakan penyakit tidak menular yang menjadi permasalahan kesehatan secara global. Penyebabnya dapat berupa asupan serat harian yang rendah, sehingga intervensi diet tinggi serat disarankan dalam penanganannya. Tempe gembus yang mengandung serat tinggi, diharapkan dapat menyediakan pasokan serat yang mencukupi untuk pasien DM tipe 2. Tujuan: Untuk menganalisis pengaruh konsumsi kukis tempe gembus terhadap kadar trigliserida (TG) dan tekanan darah (sistolik dan diastolik) pada pasien DM tipe 2. Metode: Studi eksperimental dilakukan menggunakan desain pre-post randomized control group, dilakukan pada bulan Desember 2023-Maret 2024 di Kabupaten Banyumas yang melibatkan 36 pasien DM tipe 2.partisipan dibagi menjadi dua kelompok secara acak (kontrol dan intervensi). Kelompok intervensi mengonsumsi kukis tempe gembus sebanyak 30 g/hari sebagai pengganti makanan selingan didukung dengan perawatan standar untuk DM tipe 2 selama 28 hari. Analisis data menggunakan independen t-test atau dengan daya 80% dan derajat kepercayaan 95%. Nilai p <0.05 menunjukkan adanya perbedaan yang bermakna secara statistik. Hasil: Tidak ada perbedaan yang bermakna secara statistik dari kedua kelompok dalam perubahan rerata kadar TG dan tekanan darah setelah intervensi (p=0.093) untuk kadar TG, p =0.852 (tekanan darah sistolik) dan p =0.864 (tekanan darah diastolik). Namun, secara klinis intervensi mampu mengurangi kadar TG sebesar 71 mg/dL (p =0.039) dan tekanan darah diastolik sebesar 4.62 mmHg, penurunan ini lebih baik jika dibandingkan kelompok kontrol. Simpulan: Intervensi diet tinggi serat disertai dengan perubahan gaya hidup secara konsisten dapat membantu pengelolaan kadar TG dan tekanan darah, terutama pada pasien dengan DM tipe 2. Kata Kunci: Diabetes Melitus Tipe 2; Kukis Tempe Gembus; Tekanan Darah; Trigliserida.

Additional vitamin D supplementation does not affect muscle strength in the older women: A double-blind randomized controlled trial Nurahmatika, Prisma; Noer, Etika Ratna; Ngestiningsih, Dwi; Susanto, Hardhono; Pramono, Adriyan; Supatmo, Yuswo
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 2 (2024): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.2.101-107

Background: The elderly, aged 60 and above, are expected to increase in number in the coming years. Aging brings about various changes, impacting both physical and mental health. Proper protein intake and exercise can boost muscle protein synthesis, while maintaining optimal vitamin D levels is crucial. Research is necessary to explore vitamin D's impact on elderly muscle mass.Objective: This study aims to investigate the effect of adding vitamin d supplementation to protein and exercise on handgrip strength in healthy elderly.Materials and Methods: 24 participants were randomized in a double-blinded, pilot study ages 60- 80 years Subjects were divided into two groups. Group 1 was given interventions of vitamin D supplementation 1000 UI/day combining soy + oats milk as a protein and exercise. The second group was given intervention of soy+ oats milk protein, and exercise. The intervention program was administered for 8 weeks. Data comparison whitin and between groups were analyzed by Independent T-test, Mann-Whitney, and Paired T-testResults: Data from all participants was analyzed, before and after interventions of handgrip was increased in both of groups from a mean of 17.18kg to 18.06kg for the right hand and 15.17kg to 18.26kg for the left hand in Group 1, 13.80kg to 16.86kg for the right hand and 15.45kg to 17.32kg for the left hand in Group 2. Results of the difference test analysis between the two groups (ANOVA t = 0.548, P= 0172) showed no difference between group 1 and group 2.Conclusion: In this study, there was no effect of adding vitamin D supplementation on handgrip at healthy elderly participants.

ASUPAN SENG, KADAR SERUM SENG, DAN STUNTING PADA ANAK SEKOLAH DI PESISIR SEMARANG Pramono, Adriyan; Panunggal, Binar; Anggraeni, Neni; Rahfiludin, Mohammad Zen
Jurnal Gizi dan Pangan Vol. 11 No. 1 (2016)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

The purpose of this study is to determine prevalence of at risk inadequate intake of dietary zinc, and to analyze differences of zinc serum level between dietary zinc quintile and stunting status. A cross sectional study was conducted to 70 school children (9-12 years) selected by simple random sampling. Height was measured by stadiometer and weight was measured using calibrated digital weight-scale. Zinc serum level was analyzed by Atomic Absorbance Spectrophotometry (AAS) method, and dietary intake of zinc and iron was obtained using semi-quantitative Food Frequency Questionnaire (FFQ). Data were analyzed using Anova test. Seventy percent subjects were at risk inadequate intake of dietary zinc based on Estimated Average Requirement (EAR) cut off and zinc serum levels among all subjects in this study were <65 μg/dl. There were 47.1% stunting children found in this study. Mean zinc serum levels significantly differences between dietary zinc quintile (p=0.000) and between stunting status (p=0.000). At risk inadequate dietary zinc still contributed to zinc deficiency in coastal school children population. Zinc status was significantly different between stunted and normal children.Keywords: coastal area, dietary zinc, EAR, stunting, zinc serum levels

Striped catfish oil and turmeric extract reduces inflammation in metabolic syndrome rats Mambaya, Helvi Desi; Muniroh, Muflihatul; Afifah, Diana Nur; Anjani, Gemala; Pramono, Adriyan; Sulchan, Mohammad
International Journal of Public Health Science (IJPHS) Vol 14, No 2: June 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i2.24984

Metabolic syndrome is a growing global health problem. Long-term treatment for metabolic syndrome causes side effects. Therefore, the use of nutraceuticals could also be considered. This study analyzed the effect of the administration of striped catfish oil and turmeric extract on tumor necrosis factor-α (TNF-α) levels and homeostasis model assessment of insulin resistance (HOMA-IR) in metabolic syndrome rats. Metabolic syndrome was induced in rats by administration of high fat fructose diet (HFFD) containing 3 g pork fat (15%), 2 g duck egg yolk (10%), 15 g standard diet (75%), and 2 ml fructose (1%). Thirty rats were randomized into five groups: C1 (normal control group), C2 (metabolic syndrome control group without treatment), P1 (striped catfish oil at 0.08 ml/200 g BW/day), P2 (turmeric extract at 5.04 mg/kg BW/day), P3 (combination of striped catfish oil at 0.08 ml/200 gBW/day and turmeric extract at 5.04 mg/kg BW/day). There was a significant decrease (p<0.05) in TNF-α levels and HOMA-IR in treatment groups (P1, P2, P3) compared to C2. The P3 group had the lowest TNF-α levels. Treatment groups had the same potential effect in reducing HOMA-IR. Striped catfish oil, turmeric extract, and their combination reduce inflammation and insulin resistance in metabolic syndrome rats.

Short Chain Fatty Acid Concentrations in the Cecum of Obese Rats after Giving Dangke (Fermented Milk) from Enrekang Magfirah, Ariel; Diana Nur Afifah; Endang Sri Lestari; Pramono, Adriyan; Rustanti, Ninik
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 4 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i4.3774

Obesity is one of the main causes of metabolic syndrome. This incident is triggered by an imbalance in the intestinal microbiota, resulting in inflammation, impaired tissue function and insulin resistance. Lactic acid bacteria, which are probiotics capable of balancing the gut microbiota, are present in fermented milk. The purpose of this study is to evaluate the variations in SCFA concentrations following dangke administration. The method in this research was a true experimental design, specifically a completely randomized, post test only design with a control group. This study used thirty male Sprague Dawley rats were split up into five equal groups, obesity intervention (X1, X2 and X3), obese control (P1), and health control (P0). A high fat sucrose diet (HFSD) was used to promote obesity in P1, X1, X2 and X3, whereas (P0) served as a healthy control group. Additionally, the X1, X2, and X3 groups received doses of L-Bio at 0,018 g/200 g body weight, dangke at 1,8 g/200 g bodyweight, and dangke at 3,6 g/200 g bodyweight, respectively for 28 days. Data were analyzed statistically with One Way Anova test and significant data (<0.05) were further tested using Bonferroni Post Hoc test. The result of this study showed the highest SCFA Acetate, Propionat, Butirat, and Total of SCFA (P0> X3> X2> X1, P1) (p=0.000). The conclusion of this study found that giving a dose of 3.6 g/ 200 g body weight of dangke could elevate SCFA levels thereby, dangke can enhance obesity management by boosting the synthesis of SCFA.

Narrative Literature Review on MC4R rs17782313 Gene-Nutrient Interaction and Obesity Risk Yocku, Monica H.S. Otline; Pramono, Adriyan
Jurnal Kesehatan Vol 16 No 1 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i1.4893

The Melanocortin 4 Receptor (MC4R) gene plays a critical role in appetite regulation and energy balance. The single nucleotide polymorphism (SNP) rs17782313, located near the MC4R gene, has been widely associated with an increased risk of obesity, primarily through its influence on appetite control and energy homeostasis. Understanding how this genetic variant interacts with dietary intake can offer valuable insights into the pathophysiology of obesity and inform personalized nutritional strategies. This study aims to investigate the role of SNP rs17782313 in dietary factors and obesity risk, with a particular focus on the underlying molecular mechanisms. A narrative literature review was conducted, synthesizing findings from molecular, genetic, and epidemiological studies. The review highlights how rs17782313 may influence MC4R function and how macronutrient intake, particularly carbohydrates, proteins, and fats, modulates this effect. Evidence suggests that nutritional factors can affect gene expression or interact directly with the MC4R pathway, influencing energy intake, metabolic responses, and body weight regulation. Observational studies in various populations confirm the global relevance of these gene-diet interactions. The findings highlight the need for an integrative approach that combines genetics and nutrition to develop individualized interventions for obesity prevention and treatment. Understanding these interactions may contribute to more effective management of obesity and related metabolic disorders by tailoring dietary recommendations to genetic profiles.

The Effects of Fermented Buffalo Milk (Dadih) Fortified with Red Dragon Fruit and Selenium on Adiponectin and Tumor Necrosis Factor-Alpha Levels in Obese Rats Wulandari, Fitri; Rustanti, Ninik; Pramono, Adriyan
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.639

The increasing prevalence of obesity and its associated complications necessitates the exploration of functional foods as therapeutic interventions. This study aimed to analyze the effects of fermented buffalo milk (dadih) fortified with red dragon fruit (Hylocereus polyrhizus) and selenium on adiponectin and Tumor Necrosis Factor-Alpha (TNF-α) levels in obese rats. This experimental study employed a pretest-posttest control group design involving 20 Wistar rats divided into four groups: K1 (healthy control), K2 (obese control), P1, and P2 (obese intervention). K2, P1, and P2 were in obesity conditions induced by a high-fat-fructose diet (HFFD) for 28 days, and K1 was a healthy control group. Furthermore, dadih only and dadih fortified with red dragon fruit and selenium at 1.8 g/200 g body weight/day were administered to P1 and P2 groups, respectively. Treatment using dadih fortified with red dragon fruit and selenium significantly reduced weight gain (p=0.000) compared to K2 and P1. In addition, the P2 group showed increased adiponectin levels and decreased TNF-α levels (p=0.000) compared to the K2 and P1 groups. A strong negative correlation was found between adiponectin levels and TNF-alpha and body weight, while TNF-alpha and body weight showed a strong positive correlation. To conclude, fortifying dadih with red dragon fruit and selenium is more effective in improving the metabolic condition of obese rats compared to non-fortified dadih. This fortification significantly enhances adiponectin levels and reduces TNF-alpha levels. These findings suggest that functional food fortification could be a promising approach for managing obesity-related inflammation and metabolic disorders in humans, highlighting the potential application of dadih in dietary interventions.

Selenium-Fortified Red Dragon Fruit Dadih Improves Obesity Markers in Rats Induced by a High-Fat, High-Fructose Diet Safitri, Ulan; Wulandari, Fitri; Mukarromah, Tsamaroh Azzah; Rustanti, Ninik; Pramono, Adriyan
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.443

Obesity is a growing global health problem linked to metabolic disorders. Functional foods have emerged as a potential non-pharmacological approach to support obesity management. Dadih, a traditional Indonesian fermented buffalo milk product, contains probiotics but has limited antioxidant capacity. This study aimed to evaluate the effects of selenium-fortified red dragon fruit dadih on obesity markers namely body weight and Lee Index and its functional characteristics in rats induced with a high-fat, high-fructose diet (HFFD). A true experimental design with randomized controlled groups was conducted using 24 male Sprague-Dawley rats divided into four groups: healthy control (K−), obesity control (K+), dadih (Di), and selenium-fortified red dragon fruit dadih (Di+). After 28 days of HFFD induction, Di and Di+ groups received 2 mL /200 g BW/day of dadih for 28 days. At the end of the intervention, the Di+ group exhibited significantly moderated body weight gain (from 278.4 ± 3.36 g to 316.6 ± 2.40 g, p = 0.000) and the lowest Lee Index (296.1), compared to Di (329.8 ± 2.58 g to 316.6 ± 2.40 g, Lee Index: 299.0) and K+ (281.2 ± 2.58 g to 364.4 ± 3.50 g, Lee Index: 343.4). Functional analysis showed that Di+ had higher lactic acid bacteria (7.7 × 10⁸ CFU/g) and antioxidant activity (19.54%) than Di. These findings demonstrate that the combination of probiotics, red dragon fruit bioactives, and selenium synergistically improved metabolic regulation. In conclusion, selenium-fortified red dragon fruit dadih improved the functional quality of the product and showed potential to regulate obesity markers. This formulation offers a promising functional food innovation for obesity management and warrants further clinical investigation.

Co-Authors A.Savitri, Rachmania Afida Soucha Towil, Afida Soucha Ahmad Syauqy Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Anang M Legowo Andri C Kumoro Anggraeni, Neni Anggriany, Nissa Ani Margawati Anjani, Gemala Antika, Karinda Kennia Armelinda, Nyoman Putri Ari Aryanti Setyaningsih Ayu Rahadiyanti Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Dewi Marfu’ah Kurniawati Diana N Afifah Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Endang Mahati Endang Sri Lestari Etika R Noer Etika Ratna Noer Faizah Fulyani Fauzia, Ria Febriandina, Kharisma Dwi Fika Noviandini Putri Sari Fillah Fithra Dieny Finta Wahdania Fitra Aprilindo Sase Fitri Wulandari Fitriyono Ayustaningwarno Fulyani, Faizah Galuh Hardaningsih Gisi Sari Bestari Hardhono Susanto Hardhono Susanto Hartanti Sandi Wijayanti Hertanto Wahyu Subagio Karimah, Asma Kura, Stefyne Sonya Yohana Kusmiyati Tjahjono Latifah Rachmawati Latifatul Khoir Hidayati Lilis Endang Wijayanti, Lilis Endang Liska Widiyastuti, Liska M Mexitalia Magfirah, Ariel Mahabatillah, Desty Mambaya, Helvi Desi Maria Mexitalia MARTHA ARDIARIA Mattarahmawati, Siti Andhini Maulana, Reza Achmad Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Mukarromah, Tsamaroh Azzah Muniroh, Muflihatul Mursid Tri Susilo Nawai, Fatmayanti Neni Anggraheni, Neni Niken Puruhita Ninik Rustanti Novita Kurnia Sari Nur Ahmad Habibi Nur Aini, Fadhilah Nurahmatika, Prisma Nurmasari Widyastuti Nursari, Elia Nawang Nuryanto Nuryanto Permatasari, Mayang Januarti Putri, Luti Bilqisthi Putri, Sylvia Rahmi Rahmawati, Eka Rina Regie Febriansyah, Regie Rina Pratiwi Rinta Amalia Safitri, Ulan Seno, Khristophorus Heri Nugroho Hario Shauma, Claradhita Ayu Siti Fatimah Muis Sylvia Rahmi Putri Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari Widyastuti, Paula Agung Yocku, Monica H.S. Otline Yuswo Supatmo

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