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Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure Shauma, Claradhita Ayu; Fulyani, Faizah; Pramono, Adriyan; Mahati, Endang; Putri, Sylvia Rahmi; Maulana, Reza Achmad; Anjani, Gemala
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.44-52

Abstract

Background: vitamin D (25(OH)D) is a fat-soluble vitamin that is unstable in the gastrointestinal environment and has low bioavailability. A protein-lipid complex (liprotide) can be used as a shell to increase vitamin D stability and bioavailability. Liprotide can also serve as a delivery system for transporting vitamin D to its intended site. Little attention has been paid to utilizing liprotide as a delivery system for vitamin D and evaluating its functional activity.Objective: to investigate the effect of liprotide-encapsulated vitamin D3 on PTH levels and bone microstructure in vitamin D and calcium (VD-Ca) deficient rats.Materials and Methods: an overall of 24 Wistar rats had been divided into four groups, a normal control group (K), a VD-Ca group without treatment (K-), a VD-Ca group with 180 IU/200 gBW/day free vitamin D3 (FVD3), and a VD-Ca group with 180 IU/200 gBW/day liprotide-encapsulated vitamin D3 (LVD3). Before and after 28 days of vitamin D intervention, blood samples were taken and analysed for serum PTH levels. The microstructure of the bone was analyzed using the Scanning Electron Microscope (SEM).Results: the VD-Ca rats supplemented with vitamin D3 (FVD3 and LVD3) had a significant decrease in serum PTH levels (p<0.001) and improved bone microstructure (p<0.05) compared to the (K-) group. The reduction of PTH in the LVD3 group was higher compared to the FVD3 group. The bone microstructure between the FVD3 and LVD3 groups is significantly different, as seen in the Ct.Wi parameter, with the LVD3 group having a higher Ct.Wi than the FVD3 group.Conclusion: liprotide-encapsulated vitamin D3 improves the serum PTH level and bone microstructure in a rat model of vitamin D and calcium deficiency.
PENGARUH KONSUMSI KUKIS ’MANGPIS’ TERHADAP PEMERIKSAAN GULA DARAH PERIVER DAN VENA SUBJEK OBESITAS Nawai, Fatmayanti; Syauqy, Ahmad; Pramono, Adriyan; Afifah, Diana Nur; Noer, Etika Ratna
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 46 No. 2 (2023): PGM VOL 46 NO 2 TAHUN 2023
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/pgm.v46i2.751

Abstract

Dietary fiber, resistant starch, bioactive compounds, phenolic antioxidants, flavonoids, and inulin are found in mangrove and banana flour. The combination of the two flours is expected to produce cookies that increase the metabolism of obesity. This study aims to identify the chemical characteristics, level of preference, and glycemic index of mangrove and banana flour cookies (mangpis) to increase metabolism in obese subjects. This study consists of three stages. The first stage of chemical characteristic analysis and preference level using a Completely Randomized Design (CRD) design with 4 treatments with 2 repetitions. The second stage of the best and selected formula from the level of preference tests its glycemic index value and glycemic load using a Completely Randomized Design. and the third stage of steamed intervention using Pre-Post Randomized Control Group Design. The results showed that F1 had the highest air, dietary fiber, crude fiber, and resistant starch content, while F0 had the highest protein, energy, and carbohydrate content. F2 cookies had the highest fat content. The glycemic index of steamed F2 was included in the medium category with a low glycemic load. The 28-day F2 intervention reduced triglycerides but did not affect fasting blood sugar or insulin levels.
Food Consumption in Relation to Hyperglycemia in Middle-Aged Adults (45−59 years): A Cross-Sectional National Data Analysis Syauqy, Ahmad; Mattarahmawati, Siti Andhini; Pramono, Adriyan
Jurnal Gizi dan Pangan Vol. 17 No. 3 (2022)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.85 KB) | DOI: 10.25182/jgp.2022.17.3.187-194

Abstract

The study aimed to investigate the association between food consumption with hyperglycemia among middle-aged adults in Indonesia. This cross-sectional study utilized secondary data from the 2018 Indonesia Basic Health Survey (IBHS). A total of 8,477 subjects met the inclusion criteria and included in this study. Fasting Blood Glucose (FBG) was analyzed in the laboratory using an enzymatic analysis. The fasting blood glucose was categorized as hyperglycemia (≥126 mg/dl) and normal (<126 mg/dl). A food frequency questionnaire was used to assess the food intake. Multiple logistic regression was used to analyze the association of food consumption and hyperglycemia. Our results found that the prevalence of hyperglycemia in this population was 43%. The mean FBG was 104.68±31.99 mg/dL for male and 110.75±43.92 mg/dl for female subjects. Frequent consumption of sweet desserts (OR=1.265; CI=1.132, 1.413), Sugar-Sweetened Beverages (SSB) (OR=1.433; 95% CI:1.263−1.626), salty foods (OR=1.189; 95% CI=1.079−1.311), fried foods (OR=1.172; 95% CI=1.033−1.331), and instant foods (OR=1.186; 95 % CI=1.088−1.293) were significantly associated with increased odds of hyperglycemia. There was a significant association between food consumption and hyperglycemia among middle-aged adults in Indonesia.
Analisis Prediksi Body Roundness Index untuk Prediabetes pada Orang Dewasa di Indonesia: Assessing the Predictive Accuracy of the Body Roundness Index for Prediabetes in Indonesian Adults Pramono, Adriyan; Nursari, Elia Nawang; Dieny, Fillah Fithra; Kurniawati, Dewi Marfu'ah; Rahadiyanti, Ayu
Amerta Nutrition Vol. 9 No. 4 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i4.2025.689-697

Abstract

Background: Anthropometric measurements for identifying body fat could be used to screen individuals with prediabetic risk. Objectives: To evaluate and compare the diagnostic accuracy of body roundness index (BRI), conicity index (C-index), body mass index (BMI), waist circumference, and waist-to-height ratio (WHtR) as predictors of prediabetes in the adult population of Indonesia. Methods: This study employs a cross-sectional design and uses secondary data from the Baseline Health Research (Ind: Riskesdas) 2018. As many as 12.327 samples were subjected to descriptive analysis, and the area under the curve (AUC) was utilised to assess the diagnostic potential of anthropometric measures in predicting prediabetes. Results: The five anthropometric parameters have a very weak ability as a prediabetic predictor. The WHtR and BRI (AUCmen=0.571; AUCwomen=0.573) were significantly better than the other anthropometric parameters. In contrast, the C-index values for women (AUCwomen=0.548) were considerably lower than other anthropometric parameters. However, there was no significant difference between the C-index for men (AUCmen=0.560) and the waist circumference (AUC=0.564) and BMI (AUC=0.559) values. Conclusions: The body roundness index has the same ability to predict prediabetes with WHtR, while the C-index in women is weaker than waist circumference and BMI.
Ramadan Fasting and Anthropometric Parameters: The Role of MC4R rs17782313 Genotype in Adults Semarang, Indonesia Kurniawan, Kezia Yunandra; Yocku, Monica Hermina Sharon Otline; Savitri, Rachmania Anggita; Haq, Arynal; Maharani, Nani; Fulyani, Faizah; Noer, Etika Ratna; Pramono, Adriyan
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.29501

Abstract

Background: The melanocortin-4 receptor (MC4R) gene regulates energy balance and food intake. The rs17782313 variant has been linked to altered homeostasis and eating behavior, and may also affect anthropometric and body composition responses during Ramadan fasting.Objective: To examine the effects of Ramadan fasting on anthropometric parameters, body composition, and macronutrient intake across different MC4R genotypes in adults.Methods: Thirty-five subjects were genotyped and grouped into recessive (TT, n=15) and dominant (TC+CC, n=20) allele carriers. Anthropometric and body composition measurements, dietary intake (SQ-FFQ), and physical activity (IPAQ-SF) were assessed before, during, and after Ramadan. Genetic data for rs17782313 were obtained from a prior investigation. Repeated Measures ANCOVA, adjusted for energy intake and physical activity, evaluated genotype and time effects.Results: The recessive group (TT) showed higher values than the dominant group (TC+CC), with significant differences in body weight, BMI, hip circumference, and visceral fat across all time points (p<0.05). Waist circumference differed significantly during and after Ramadan, while BMR differed only before fasting (p<0.05). Macronutrient intake and physical activity did not differ significantly, although protein and fat intake changes post-Ramadan were notable (p<0.05). A significant time–activity interaction was found for body weight (p=0.041). TT carriers experienced greater anthropometric benefits from Ramadan fasting compared to TC+CC carriers.Conclusion: Ramadan fasting significantly influences anthropometric parameters, body composition, and macronutrient intake across MC4R genotypes. Greater responses were observed in recessive carriers (TT), although fasting outcomes were also shaped by nutrition and physical activity. These findings highlight the interplay of genetic and environmental factors in energy regulation during Ramadan.
Co-Authors A.Savitri, Rachmania Afida Soucha Towil, Afida Soucha Ahmad Syauqy Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Anang M Legowo Andri C Kumoro Anggraeni, Neni Anggriany, Nissa Ani Margawati Anjani, Gemala Antika, Karinda Kennia Aryanti Setyaningsih Ayu Rahadiyanti Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Dewi Marfu’ah Kurniawati Diana N Afifah Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Endang Mahati Endang Sri Lestari Etika R Noer Etika Ratna Noer Faizah Fulyani Fika Noviandini Putri Sari Fillah Fithra Dieny Finta Wahdania Fitra Aprilindo Sase Fitri Wulandari Fitriyono Ayustaningwarno Fulyani, Faizah Galuh Hardaningsih Gisi Sari Bestari Haq, Arynal Hardhono Susanto Hardhono Susanto Hertanto Wahyu Subagio Karimah, Asma Kura, Stefyne Sonya Yohana Kurniawan, Kezia Yunandra Kusmiyati Tjahjono Latifah Rachmawati Latifatul Khoir Hidayati Liska Widiyastuti, Liska M Mexitalia Magfirah, Ariel Mahabatillah, Desty Mambaya, Helvi Desi Maria Mexitalia Mattarahmawati, Siti Andhini Maulana, Reza Achmad Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Mukarromah, Tsamaroh Azzah Muniroh, Muflihatul Nani Maharani Nawai, Fatmayanti Neni Anggraheni, Neni Niken Puruhita Ninik Rustanti Novita Kurnia Sari Nur Ahmad Habibi Nurahmatika, Prisma Nurmasari Widyastuti Nursari, Elia Nawang Nuryanto Nuryanto Permatasari, Mayang Januarti Putri, Sylvia Rahmi Rahmawati, Eka Rina Regie Febriansyah, Regie Rina Pratiwi Rinta Amalia Safitri, Ulan Savitri, Rachmania Anggita Seno, Khristophorus Heri Nugroho Hario Shauma, Claradhita Ayu Siti Fatimah Muis Sylvia Rahmi Putri Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari Yocku, Monica Hermina Sharon Otline Yuswo Supatmo