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Effectiveness of synbiotic red dragon fruit yogurt on glucose and oxidative stress in metabolic syndrome rats Rustanti, Ninik; Armelinda, Nyoman Putri Ari; Febriandina, Kharisma Dwi; Ardiaria, Martha; Rahadiyanti, Ayu; Susilo, Mursid Tri; Pramono, Adriyan
AcTion: Aceh Nutrition Journal Vol 10, No 1 (2025): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i1.2231

Abstract

Metabolic syndrome is still a global health problem, especially in Indonesia. Oxidative stress is related to metabolic syndrome because it is triggered by hyperglycemia. Synbiotic yogurt containing the whole red dragon fruit has antioxidant and synbiotic potential. This study aimed to determine the effect of synbiotic yogurt with whole red dragon fruit on fasting blood glucose (FBG) and malondialdehyde (MDA) levels in rats with metabolic syndrome. The design of this study was true-experimental, with a pre-post test and randomized control group design. A total of 24 male Sprague Dawley rats were divided into four groups (K-, K+, P1, P2). Groups K+, P1, and P2 were fed a high-fat, high-fructose diet (HFHFD) for 2 weeks. Groups P1 and P2 were administered synbiotic yogurt intervention of 0,009 mL/gBB/day and 0,018 mL/gBB/day, respectively, for 4 weeks. GOD-PAP method for FBG analysis and TBARS method for MDA analysis.  Data were analyzed using the paired t-test and One-Way ANOVA test. The P1 and P2 groups experienced a significant decrease in FBG levels by 63,45% and 76,07%, respectively (p<0,001), and a significant decrease in MDA by 26,1% and 37,2%, respectively (p<0,001). In conclusion, the administration of synbiotic yogurt at 0,018 mL/gBB/day (200 mL/day for humans) for four weeks was effective in reducing FBG and MDA levels.
Association of food consumption and physical activity with metabolic syndrome according to central obesity status in Indonesian adults: A cross-sectional study Permatasari, Mayang Januarti; Syauqy, Ahmad; Noer, Etika Ratna; Pramono, Adriyan; Tjahjono, Kusmiyati
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.31-35

Abstract

Background: Previous studies have reported that the risk of metabolic syndrome differs between obese and non-obese individuals based on food consumption and physical activity.Objective: This study aims to analyze differences in the association of food consumption and physical activity with the incidence of metabolic syndrome in individuals with and without central obesity.Materials and Methods: This cross-sectional study examined individuals aged 19 to 64 years using Riskesdas 2018 data. Sample characteristics, including smoking habits, alcohol consumption, food consumption, physical activity, anthropometric data, clinical data, and biochemical data were collected for univariate, bivariate, and multivariate analyses. Logistic regression was used as a multivariate analysis to investigate the association of food consumption and physical activity with the risk of metabolic syndrome in individuals with and without central obesity. Results: In this study, individuals with and without central obesity significantly increased risk of metabolic syndrome (p<0.05) due to consuming nearly all kinds of unhealthy foods (sweet foods, savory foods, fatty/cholesterol-rich/fried foods, grilled foods, processed meat/chicken/fish, soft drinks/carbonated drinks, energy drinks, and instant noodles/other instant foods). However, only individuals without central obesity who frequently consume seasonings (OR=1.519, 95% CI: 1.241-1.859) have a significant association with an increased risk of metabolic syndrome. Meanwhile, only individuals with central obesity who often consume sugary drinks (OR=1.315, 95% CI: 1.132-1.529) are significantly associated with an increased risk of metabolic syndrome. In addition, inadequate consumption of fruits and vegetables as well as lack of physical activity also significantly increase the risk of metabolic syndrome in individuals with and without central obesity (p<0.05).Conclusion: Only the consumption of seasonings and sugary drinks shows a different relationship to the risk of metabolic syndrome in individuals with and without central obesity.
Liprotide-encapsulated vitamin D3 modulates circulated PTH levels and improved bone microstructure Shauma, Claradhita Ayu; Fulyani, Faizah; Pramono, Adriyan; Mahati, Endang; Putri, Sylvia Rahmi; Maulana, Reza Achmad; Anjani, Gemala
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.44-52

Abstract

Background: vitamin D (25(OH)D) is a fat-soluble vitamin that is unstable in the gastrointestinal environment and has low bioavailability. A protein-lipid complex (liprotide) can be used as a shell to increase vitamin D stability and bioavailability. Liprotide can also serve as a delivery system for transporting vitamin D to its intended site. Little attention has been paid to utilizing liprotide as a delivery system for vitamin D and evaluating its functional activity.Objective: to investigate the effect of liprotide-encapsulated vitamin D3 on PTH levels and bone microstructure in vitamin D and calcium (VD-Ca) deficient rats.Materials and Methods: an overall of 24 Wistar rats had been divided into four groups, a normal control group (K), a VD-Ca group without treatment (K-), a VD-Ca group with 180 IU/200 gBW/day free vitamin D3 (FVD3), and a VD-Ca group with 180 IU/200 gBW/day liprotide-encapsulated vitamin D3 (LVD3). Before and after 28 days of vitamin D intervention, blood samples were taken and analysed for serum PTH levels. The microstructure of the bone was analyzed using the Scanning Electron Microscope (SEM).Results: the VD-Ca rats supplemented with vitamin D3 (FVD3 and LVD3) had a significant decrease in serum PTH levels (p<0.001) and improved bone microstructure (p<0.05) compared to the (K-) group. The reduction of PTH in the LVD3 group was higher compared to the FVD3 group. The bone microstructure between the FVD3 and LVD3 groups is significantly different, as seen in the Ct.Wi parameter, with the LVD3 group having a higher Ct.Wi than the FVD3 group.Conclusion: liprotide-encapsulated vitamin D3 improves the serum PTH level and bone microstructure in a rat model of vitamin D and calcium deficiency.
PENGARUH KONSUMSI KUKIS ’MANGPIS’ TERHADAP PEMERIKSAAN GULA DARAH PERIVER DAN VENA SUBJEK OBESITAS Nawai, Fatmayanti; Syauqy, Ahmad; Pramono, Adriyan; Afifah, Diana Nur; Noer, Etika Ratna
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 46 No. 2 (2023): PGM VOL 46 NO 2 TAHUN 2023
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/pgm.v46i2.751

Abstract

Dietary fiber, resistant starch, bioactive compounds, phenolic antioxidants, flavonoids, and inulin are found in mangrove and banana flour. The combination of the two flours is expected to produce cookies that increase the metabolism of obesity. This study aims to identify the chemical characteristics, level of preference, and glycemic index of mangrove and banana flour cookies (mangpis) to increase metabolism in obese subjects. This study consists of three stages. The first stage of chemical characteristic analysis and preference level using a Completely Randomized Design (CRD) design with 4 treatments with 2 repetitions. The second stage of the best and selected formula from the level of preference tests its glycemic index value and glycemic load using a Completely Randomized Design. and the third stage of steamed intervention using Pre-Post Randomized Control Group Design. The results showed that F1 had the highest air, dietary fiber, crude fiber, and resistant starch content, while F0 had the highest protein, energy, and carbohydrate content. F2 cookies had the highest fat content. The glycemic index of steamed F2 was included in the medium category with a low glycemic load. The 28-day F2 intervention reduced triglycerides but did not affect fasting blood sugar or insulin levels.
PROFIL STATUS GIZI DAN KOMPOSISI TUBUH REMAJA SANTRIWATI BERDASARKAN JENIS KEBIASAAN PUASA Dieny, Fillah Fithra; Nur Aini, Fadhilah; Fauzia, Ria; Pramono, Adriyan; Susilo, Mursid Tri; Widyastuti, Nurmasari; Wijayanti, Lilis; Wijayanti, Hartanti Sandi
Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Vol. 47 No. 2 (2024): PGM VOL 47 NO 2 TAHUN 2024
Publisher : Persagi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/pgm.v47i2.797

Abstract

Female students in Islamic boarding school are one of the vulnerable groups to experience nutritional problems caused by several factors, one of which is because there are traditions that can change eating patterns. Changes in eating patterns can be caused by fasting traditions, such as Daud and Ngrowot. Objectives: This study aims to analyze the differences in nutritional status and body composition among female students based on type of fasting habits. This research is an observational analytical study with a cross sectional design at API Asri Syubbanul Wathon Islamic Boarding School Tegalrejo, Magelang in female students aged 16-18 years who were selected using stratified random sampling techniques. Subjects were divided into the Daud (n=34), Ngrowot (n=30), Daud and Ngrowot (33), and without Daud Ngrowot (n=31) groups. Data were analyzed using One-Way ANOVA and Kruskall-Wallis test. Most subjects had been fasting for 3 years and the majority of subjects who practiced Daud and Daud Ngrowot fasting rarely did sahur. However, the eating habits of the four groups did not different significantly. The majority of subjects eating twice a day and rarely exercising. Most of the subjects in the four groups had normal nutritional status, muscle mass, and body water percentage, but most subjects had above normal body fat percentage. There was no difference in nutritional status based on BMI/A (p=0.707), MUAC (p=0.594), WC (p=0.372), and WHR (p=0.201) and body composition such as body fat percentage (p=0.393), muscle mass (p=0.403), and total body water percentage (p=0.346) in the four groups. Nutritional status based on BMI/A, MUAC, WC, WHR, body fat percentage, muscle mass, and total body water percentage did not differ significantly between Daud, Ngrowot, Daud with Ngrowot, and without Daud Ngrowot groups.
Food Consumption in Relation to Hyperglycemia in Middle-Aged Adults (45−59 years): A Cross-Sectional National Data Analysis Syauqy, Ahmad; Mattarahmawati, Siti Andhini; Pramono, Adriyan
Jurnal Gizi dan Pangan Vol. 17 No. 3 (2022)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.85 KB) | DOI: 10.25182/jgp.2022.17.3.187-194

Abstract

The study aimed to investigate the association between food consumption with hyperglycemia among middle-aged adults in Indonesia. This cross-sectional study utilized secondary data from the 2018 Indonesia Basic Health Survey (IBHS). A total of 8,477 subjects met the inclusion criteria and included in this study. Fasting Blood Glucose (FBG) was analyzed in the laboratory using an enzymatic analysis. The fasting blood glucose was categorized as hyperglycemia (≥126 mg/dl) and normal (<126 mg/dl). A food frequency questionnaire was used to assess the food intake. Multiple logistic regression was used to analyze the association of food consumption and hyperglycemia. Our results found that the prevalence of hyperglycemia in this population was 43%. The mean FBG was 104.68±31.99 mg/dL for male and 110.75±43.92 mg/dl for female subjects. Frequent consumption of sweet desserts (OR=1.265; CI=1.132, 1.413), Sugar-Sweetened Beverages (SSB) (OR=1.433; 95% CI:1.263−1.626), salty foods (OR=1.189; 95% CI=1.079−1.311), fried foods (OR=1.172; 95% CI=1.033−1.331), and instant foods (OR=1.186; 95 % CI=1.088−1.293) were significantly associated with increased odds of hyperglycemia. There was a significant association between food consumption and hyperglycemia among middle-aged adults in Indonesia.
Analisis Prediksi Body Roundness Index untuk Prediabetes pada Orang Dewasa di Indonesia: Assessing the Predictive Accuracy of the Body Roundness Index for Prediabetes in Indonesian Adults Pramono, Adriyan; Nursari, Elia Nawang; Dieny, Fillah Fithra; Kurniawati, Dewi Marfu'ah; Rahadiyanti, Ayu
Amerta Nutrition Vol. 9 No. 4 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i4.2025.689-697

Abstract

Background: Anthropometric measurements for identifying body fat could be used to screen individuals with prediabetic risk. Objectives: To evaluate and compare the diagnostic accuracy of body roundness index (BRI), conicity index (C-index), body mass index (BMI), waist circumference, and waist-to-height ratio (WHtR) as predictors of prediabetes in the adult population of Indonesia. Methods: This study employs a cross-sectional design and uses secondary data from the Baseline Health Research (Ind: Riskesdas) 2018. As many as 12.327 samples were subjected to descriptive analysis, and the area under the curve (AUC) was utilised to assess the diagnostic potential of anthropometric measures in predicting prediabetes. Results: The five anthropometric parameters have a very weak ability as a prediabetic predictor. The WHtR and BRI (AUCmen=0.571; AUCwomen=0.573) were significantly better than the other anthropometric parameters. In contrast, the C-index values for women (AUCwomen=0.548) were considerably lower than other anthropometric parameters. However, there was no significant difference between the C-index for men (AUCmen=0.560) and the waist circumference (AUC=0.564) and BMI (AUC=0.559) values. Conclusions: The body roundness index has the same ability to predict prediabetes with WHtR, while the C-index in women is weaker than waist circumference and BMI.
Socioeconomic, demographic, and lifestyle factors associated with adolescent obesity in Indonesia: Analysis of Indonesia Health Survey 2023 data Widyastuti, Paula Agung; Noer, Etika Ratna; Nuryanto, Nuryanto; Margawati, Ani; Pramono, Adriyan
AcTion: Aceh Nutrition Journal Vol 11, No 1 (2026): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v11i1.2553

Abstract

Adolescent obesity is an increasing public health problem in Indonesia, influenced by economic disparities, demographic factors, and lifestyle changes. This study aimed to analyze the socioeconomic, demographic, and lifestyle factors associated with adolescent obesity using data from the 2023 Indonesia Health Survey (IHS). This cross-sectional study involved 46,432 adolescents aged 10–19 years, classified as obese based on BMI-for-age z-scores using total sampling. The variables examined included age, sex, education, wealth index, place of residence, consumption of sweet, salty, and fatty foods, soft drinks, energy drinks, instant noodles, physical activity, and smoking. Data were analyzed univariately and bivariately using chi-square tests and multivariately using logistic regression. The results showed that wealth index and instant noodle consumption were significantly associated with obesity (p < 0.05). Consumption of fatty, fried, and cholesterol-rich foods (p = 0.032; OR = 0.956) and energy drinks (p = 0.034; OR = 1.104) were identified as significant risk factors. In conclusion, high-fat dietary patterns and energy drink consumption increase the risk of obesity. The widespread availability of unhealthy foods in both urban and rural areas poses challenges to obesity prevention. Therefore, interventions that promote healthy eating behaviors among adolescents, such as school-based nutrition education, social media campaigns, and community-based initiatives are essential.
The Effect of Moringa Leaf Powder and Egg Supplementation on Nutritional Status and Appetite: A Quasi-Experimental Study in Undernourished Children Putri, Luti Bilqisthi; Pramono, Adriyan; Muis, Siti Fatimah; Mahati, Endang; Afifah, Diana Nur
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.1080

Abstract

Undernutrition among children under five remains a major public health problem in Indonesia, particularly in East Nusa Tenggara Province. According to the 2024 Health Profile of East Nusa Tenggara Province, the prevalence of undernourished (wasted) children in South Central Timor Regency increased from 5.1% in 2019–2020 to 9.7% in 2024, indicating a persistent burden of acute malnutrition. While plant-based, nutrient-dense foods such as Moringa oleifera leaf powder have been widely promoted, evidence on their effectiveness when combined with high–biological-value animal protein, particularly eggs, remains limited. This study aimed to assess the effect of combined moringa leaf powder and egg supplementation on appetite and nutritional status among undernourished children aged 36–59 months. A quasi-experimental study with a control group was conducted from May to July 2025 in the Batuputih Health Center area. Forty undernourished children (weight-for-age Z-score −3 to −2 SD) were allocated to an intervention group (15 g/day moringa leaf powder plus one egg) or a control group (one egg only) for 60 days. Appetite was assessed using the Children’s Eating Behaviour Questionnaire (CEBQ), and nutritional status was evaluated using WHO anthropometric indices Significant improvements in weight-for-age and weight-for-height were observed in both groups (p < 0.05). However, a significant increase in appetite was found only in the intervention group (p = 0.039), while no significant change was observed in height-for-age. The integration of moringa leaf powder with egg-based animal protein effectively improves appetite and short-term nutritional status, supporting weight-for-age and appetite as the most sensitive indicators for short-term nutrition programs, while linear growth requires longer intervention periods.
Co-Authors A.Savitri, Rachmania Afida Soucha Towil, Afida Soucha Ahmad Syauqy Ainun Anindita Rahadyani Aisya Maulida, Aisya Amanda Umihani, Amanda Anang M Legowo Andri C Kumoro Anggraeni, Neni Anggriany, Nissa Ani Margawati Anjani, Gemala Antika, Karinda Kennia Armelinda, Nyoman Putri Ari Aryanti Setyaningsih Ayu Rahadiyanti Bagoes Widjanarko Binar Panunggal Deny Yudi Fitranti Dewi Marfu’ah Kurniawati Diana N Afifah Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Astuti Farikha, Dwi Astuti Dwiningsih Dwiningsih Endang Mahati Endang Mahati Endang Sri Lestari Etika R Noer Etika Ratna Noer Faizah Fulyani Fauzia, Ria Febriandina, Kharisma Dwi Fika Noviandini Putri Sari Fillah Fithra Dieny Finta Wahdania Fitra Aprilindo Sase Fitri Wulandari Fitriyono Ayustaningwarno Fulyani, Faizah Galuh Hardaningsih Gisi Sari Bestari Hardhono Susanto Hardhono Susanto Hartanti Sandi Wijayanti Hertanto Wahyu Subagio Karimah, Asma Kura, Stefyne Sonya Yohana Kusmiyati Tjahjono Latifah Rachmawati Latifatul Khoir Hidayati Lilis Endang Wijayanti, Lilis Endang Liska Widiyastuti, Liska M Mexitalia Magfirah, Ariel Mahabatillah, Desty Mambaya, Helvi Desi Maria Mexitalia MARTHA ARDIARIA Mattarahmawati, Siti Andhini Maulana, Reza Achmad Mohammad Sulchan Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muflihatul Muniroh Mukarromah, Tsamaroh Azzah Muniroh, Muflihatul Mursid Tri Susilo Nawai, Fatmayanti Neni Anggraheni, Neni Niken Puruhita Ninik Rustanti Novita Kurnia Sari Nur Ahmad Habibi Nur Aini, Fadhilah Nurahmatika, Prisma Nurmasari Widyastuti Nursari, Elia Nawang Nuryanto Nuryanto Permatasari, Mayang Januarti Putri, Luti Bilqisthi Putri, Sylvia Rahmi Rahmawati, Eka Rina Regie Febriansyah, Regie Rina Pratiwi Rinta Amalia Safitri, Ulan Seno, Khristophorus Heri Nugroho Hario Shauma, Claradhita Ayu Siti Fatimah Muis Sylvia Rahmi Putri Untari Wardana, Ruliansyah Kusuma Widya Ayu Wulandari Widyastuti, Paula Agung Yocku, Monica H.S. Otline Yuswo Supatmo