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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Majalah Farmasetika JSMARTech : Journal of Smart Bioprospecting and Technology Pelita: Jurnal Pengabdian kepada Masyarakat Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy Indonesian Journal of Jamu Jurnal Pengabdian Masyarakat Inovatif
Nina Herlina
Program Studi Farmasi FMIPA Universitas Pakuan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Sosialisasi dan Pelatihan Deteksi Dini Kanker Payudara di Lingkungan Dosen dan Karyawan Universitas Pakuan Nhestricia, Nhadira; Wardatun, Sri; Herlina, Nina
KENDURI : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 3 No. 3 (2023): Desember
Publisher : Yayasan Darussalam Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62159/kenduri.v3i3.1012

Abstract

Kanker payudara (KPD) merupakan keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Kanker payudara merupakan salah satu jenis kanker terbanyak di Indonesia. Lebih 80% kasus ditemukan berada pada stadium yang lanjut, dimana upaya pengobatan sulit dilakukan. Pemahaman masyarakat terutama yang berada di lingkungan dosen dan karyawan Universitas Pakuan yang menganggap dirinya sehat, seringkali melupakan bahwa kanker payudara sewaktu-waktu juga dapat menyerang dirinya. Hal ini yang menyebabkan tingkat kesadaran masyarakat untuk memeriksa payudara sendiri secara rutin juga rendah, sehingga jika segala sesuatunya sudah terjadi maka semuanya serba terlambat. Oleh karena itu perlu adanya upaya pencegahan, diagnosis dini, pengobatan kuratif maupun paliatif serta upaya rehabilitasi yang baik, agar pelayanan pada penderita dapat dilakukan secara optimal. Kegiatan pencegahan atau prevensi terdiri dari pencegahan primer dan sekunder. Pencegahan primer merupakan usaha agar tidak terkena kanker payudara dengan mengurangi atau meniadakan faktor-faktor risiko yang diduga sangat erat kaitannya dengan peningkatan insiden kanker payudara. Pencegahan primer atau supaya tidak terjadinya kanker secara sederhana adalah mengetahui faktor -faktor risiko kanker payudara, seperti yang telah disebutkan di atas, dan berusaha menghindarinya. Kegiatan sosialisasi dan pelatihan deteksi dini di lingkungan Universitas Pakuan merupakan kegiatan pengabdian untuk mendeteksi secara dini terjadinya kanker payudara. Kegiatan ini dilakukan bekerjasama dengan dengan Yayasan Love pink. Love pink merupakan Organisasi nirlaba yang berfokus pada kegiatan sosialisasi deteksi dini dengan cara SADARI (Periksa Payudara Sendiri), SADANIS (Periksa Payudara Secara Klinis), dan pendampingan bagi sesama perempuan dengan kanker payudara. Lovepink bergerak dengan basis komunitas survivors yang bekerja secara sukarela untuk mendukung visi dan misi organisasi. Diharapkan kegiatan ini dapat menurunkan resiko kejadian kanker payudara..
Toksisitas Akut dan Efek Penurunan Tekanan Darah Formula Daun Mangga arumanis (Mangifera indica L.), Lemon (Citrus limon) dan Cabe Jawa (Piper retrofractum Vahl.) Setiani, Lusi Agus; Herlina, Nina; Widya Sopyan, Sonia
Majalah Farmasetika Supl. 9 No. 1, Tahun 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i7.58847

Abstract

Daun mangga arumanis, lemon dan buah cabe jawa adalah tanaman lokal Indonesiayang banyak dimanfaatkan oleh masyarakat serta memiliki potensi sebagai agenpenurun tekanan darah. Namun, potensi ini perlu didukung oleh bukti ilmiah yangmencakup uji keamanan dan efektivitas. Penelitian ini bertujuan untuk mengevaluasiefek antihipertensi dan toksisitas akut dari campuran daun mangga arumanis, lemondan cabe jawa (MLC). Tikus diinduksi hipertensi selama 21 hari menggunakanprednison (1,5 mg/kgBB) dan natrium klorida (2%). Hewan dikelompokkan menjaditujuh kelompok: kontrol normal, kontrol negatif (Na CMC 0,05%), kontrol positif I(Captopril 0,45 mg/200 gBB), kontrol positif II (ramuan jamu 14,4 mg/200 gBB), sertatiga kelompok MCL dengan dosis berbeda: MLC I (6 mg:10 mg:4,2 mg/200 gBB), MLCII (3 mg:5 mg:2,1 mg/200 gBB), dan MLC III (12 mg:10 mg:4,2 mg/200 gBB). Tekanandarah diukur setiap 7 hari selama 35 hari menggunakan CODA® Blood Pressure,mencakup parameter utama tekanan darah sistolik dan diastolik serta parameterpendukung seperti Mean Arterial Pressure (MAP) dan Heart Rate (HR). Uji toksisitasakut dilakukan dengan metode fixed dose yang dimodifikasi menggunakan pemberianMLC dengan perbandingan formula 1:1 dosis 300 mg/kgBB dan 2000 mg/kgBB. Hasilpenelitian menunjukkan bahwa formula MLC memiliki efek signifikan dalammenurunkan tekanan darah. Selain itu, nilai LD50 formula MLC berada di atas 2000mg/kgBB, yang dikategorikan sebagai tidak toksik. Hasil penelitian menunjukkanpotensi formula MLC sebagai kandidat agen antihipertensi yang aman dan efektif.
Effectiveness of nutmeg flesh extract (Myristica fragrans H) as an immunomodulator using the carbon clearance method in mice (Mus musculus) Rokhmah, Nisa Najwa; Herlina, Nina; Ananda, Syindi Yulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1517

Abstract

Nutmeg (Myristica fragrans H) is composed of secondary metabolite compounds, among which flavonoids significantly contribute to its immunomodulatory properties. Using the carbon clearance method, this study aims to determine the efficacy of nutmeg flesh extract (NFE) as an immunomodulator. Negative control (Na-CMC 0.5%), normal control (Na-CMC 0.5%), immunostimulant positive control (Imboost® Force 0.91mg/20 g BW of mice), immunosuppressant positive control (methylprednisolone® 0.015 mg/20 g BW of mice), dose I (5 mg/20 g BW of mice), dose II (10 mg/20 g BW of mice), and dose III (20 mg/20 g BB mice) comprised the seven groups of 35 white male mice (DDY). The assessed parameters included organ index, absorbance, and the phagocytosis constant and index. The immunostimulant effect of NFE was demonstrated by the phagocytosis index values of 1.225 (indicating moderate immunostimulation), 1.512 (indicating moderate immunostimulation), and 2.202 (indicating strong immunostimulation) for NFE dose I, II, and III, respectively. The lymphoid organ index may have increased among the three NFE treatment groups, according to the results of organ index measurements. We can conclude, Nutmeg Flesh Extract (NFE) has an immunomodulatory effect in the immunostimulant category, as well as increased phagocytosis activity and lymphoid organ index.
The Effect of Javanese Chili (Piper retrofractum) and Lemon (Citrus limon) Formula on Total Cholesterol Levels in Male White Rats Setiani, Lusi Agus; Herlina, Nina; Ramadhani, Friska Noerfitria
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.8688

Abstract

Hypercholesterolemia, defined as blood cholesterol levels exceeding 200 mg/dL, is a significant risk factor for cardiovascular disease. Traditional Indonesian medicinal plants, such as Javanese chili (Piper retrofractum) and lemon (Citrus limon), have long been recognized for their potential lipid-lowering properties. This study aimed to scientifically evaluate the hypocholesterolemic effect of a combined P. retrofractum and C. limon extract in a hypercholesterolemic rat model. Thirty male Sprague-Dawley rats were randomly assigned to seven groups: a normal control, a negative control (Na-CMC), a positive control (simvastatin 0.018 mg/200 g BW), a scientific herbal formula (0.18 g/200 g BW), and three treatment groups receiving P. retrofractum and C. limon in ratios of 1:1, 1:2, and 2:1. Hypercholesterolemia was induced using a cholesterol-cholate-thiouracil (CCT) mixture alongside a high-fat diet. Total cholesterol levels were quantified using the Cholesterol Oxidase-Peroxidase Aminoantipyrine (CHOD-PAP) method. After 21 days of treatment, all P. retrofractum and C. limon-treated groups demonstrated a statistically significant reduction in total cholesterol compared to the negative control (p <0.05). Notably, the 1:1 and 1:2 ratios of P. retrofractum to C. limon yielded the most substantial cholesterol reductions (44% and 43%, respectively), comparable to the scientific herbal formula and superior to simvastatin (30%). In contrast, the 2:1 ratio showed a comparatively lower reduction (38%), suggesting a potential inhibitory effect of excessive P. retrofractum on C. limon's lipid-lowering properties. These findings collectively highlight the promising potential of optimized P. retrofractum and C. limon combinations, particularly at 1:1 and 1:2 ratios, as effective natural interventions for managing hypercholesterolemia.
Phytochemical Profile and Pharmacological Mechanisms of Pandanus tectorius Fruit: A Comprehensive Review Setiani, Lusi Agus; Herlina, Nina; Wahyuningrum, Cyntia; Putri, Nabilah Yuliana
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.374

Abstract

The fruit of Pandanus tectorius, commonly known as screw pine or sea pandan, contains various secondary metabolites with significant therapeutic potential but remains underutilized in clinical applications. This review summarizes findings from 2014 to 2025 regarding its phytochemical composition and pharmacological effects. Sixteen bioactive compounds have been identified, including pandanusin A, bergapten, scoparone, scopoletin, several lignans, isoamericanin A, kaempferol, chrysin, phenolic acids, betulinic acid, and β-sitosterol. These constituents demonstrate antioxidant, anti-inflammatory, analgesic, antidiabetic, antimicrobial, and anticancer activities. Mechanistic actions include inhibition of alpha-glucosidase, reduction of oxidative stress, and induction of cytotoxicity in cancer cells. The ethyl acetate fraction, in particular, exhibits strong activity against HeLa cells. Novel delivery systems, such as nanoemulsions, are being explored to enhance solubility and bioavailability. Additionally, preclinical studies suggest roles in immune modulation, wound healing, and pain relief. Although promising, further clinical validation and formulation standardization are needed. This review highlights the potential of P. tectorius fruit as a candidate for evidence-based phytotherapeutic development.
Cardioprotective Effects of Red Ginger Extracted Using Natural Deep Eutectic Solvent on Lipid Profile in Atherosclerotic Rats Yulianita; Herlina, Nina; Tri Retno Handayani, Marybet; Al Aziz, Novan Masis; Safitri, Aditiya; Pamungkas, Ragil Raihan
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.410

Abstract

Atherosclerosis, a leading cause of cardiovascular disease, is closely related to dyslipidemia. This study evaluated the cardioprotective effects of red ginger (Zingiber officinale var. rubrum) extracted using a Natural Deep Eutectic Solvent (NADES) on lipid profiles and the risk of atherosclerosis in rats induced with an atherogenic diet and lipopolysaccharide (LPS). Thirty male Sprague-Dawley rats were divided into five groups: normal control, negative control, positive control (Simvastatin), and two treatment groups receiving red ginger extract at 25 mg/kg and 50 mg/kg body weight (BW). After 24 days of treatment, the 25 mg/kg BW dose significantly reduced total and LDL cholesterol while increasing HDL levels compared with the negative control (p < 0.05), showing comparable effects to Simvastatin. The 50 mg/kg BW dose did not significantly reduce total and LDL cholesterol but produced the highest HDL level. All treatment groups showed a significantly lower Atherogenic Index of Plasma (AIP) than the negative control, with the lowest AIP in the 50 mg/kg BW group. These findings demonstrate the cardioprotective potential of red ginger extracted with NADES as a natural, environmentally friendly approach to preventing dyslipidemia and atherosclerosis.
Education and Training on Making Probiotic Drinks to Help Improve Health and Immunity in Bantarsari Village Wulandari, Asri; Wulandari, Cyntia; Nurhikmah, Wilda; Koniah, Eni; Tri Retno, Marybet; Permanasari, Anna; Oktaviani, Emy; Herlina, Nina; Ashura Rizkiyani, Nanda
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 1 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i1.55

Abstract

Infectious diseases are still a global problem, including in Indonesia. Immunity is an important factor in preventing infectious diseases. Probiotics are living organisms that are able to provide beneficial effects for maintaining health, namely being able to maintain the health of the digestive tract so that the body's immunity becomes better. The purpose of this community service is to provide information and increase knowledge about the role of probiotics in helping improve health and body immunity to mothers who live in Bantarsari Village, Rancabungur District, Bogor Regency. The method used is initial pretest followed by providing education about probiotics, giving brochures about probiotics, demonstrating the manufacture of probiotics and closing with post test to see the final ability of the participants. The result of the community service activity is an increase in the knowledge of the participant mothers about the importance of probiotics, types of probiotics and an increase in the ability to make probiotic drinks. The activity went well and was attended by the target group community and followed by village officials.
Health services in an effort to control degenerative diseases in the Pakansari Cibinong sub-district Andini, Septia; Najwa Rokhmah, Nisa; Nurmala, Sara; Fatmi, Mindiya; Ambarwati, Rini; Herlina, Nina; Nurhikmah, Wilda; Wahyuningrum, Cyntia
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 2 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i2.70

Abstract

Health is one of the basic human needs that is important to maintain. With good health conditions, humans can carry out activities and fulfill other life needs well. Health services are a dynamic activity in the form of helping the community in monitoring the scale of their health. Health services are efforts carried out jointly to maintain and improve health, prevent and cure disease, and increase public attention to their health conditions. Degenerative is a group of diseases in which there is a change in the function of certain parts of the body. As age increases, body function also decreases, so that degenerative diseases cannot be avoided. The dominant risk factor for degenerative diseases is heredity. Exercise habits and the habit of consuming balanced nutrition will also help with a healthy and good aging process. The aim of this service activity is so that people in the Pakansari Cibinong sub-district who take part in the activity can know the importance of knowing their health conditions and also raise awareness among the people in the Pakansari Cibinong sub-district regarding their health conditions. Activities carried out at community service events for the community in Cibinong sub-district are general health checks, Body Mass Index (BMI) checks, blood pressure checks, blood sugar checks and uric acid checks. There were 38 people who took part in the activity, including 26.3% men and 73.7% women. From the results of the examination, it was found that 39.5% of participants had a normal BMI, 47.4% were overweight and 13.2% were obese. Hypertensive conditions were found to be dominant in pre-hypertensive conditions, namely with a percentage of 29.7%. Blood sugar conditions were found to be hypertension, namely with a percentage of 86.5% and uric acid conditions were dominated by participants who had normal conditions with a percentage of 64.9%.
Comparison of the Effectiveness of Jackfruit Banana Peel Extract, Kepok Banana Peel and Uli Banana Peel on Reducing Uric Acid Levels Najwa Rokhmah, Nisa; Herlina, Nina; Andhika Riyantama, Alfi
JSMARTech: Journal of Smart Bioprospecting and Technology Vol. 6 No. 2 (2025): Vol. 6 No. 2 (2025): JSMARTech Volume 6, No 2, 2025
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2025.006.02.01

Abstract

This study aimed to compare the anti-hyperuricemia effects of ethanolic extracts from the peels of nangka, kepok, and uli bananas in male Sprague Dawley rats. Twenty-five rats (5–7 weeks old; 150–200 g) were randomly divided into five groups (n = 5 per group): a negative control (0.5% CMC-Na), a positive control (allopurinol 2.52 mg/200 g BW), and three treatment groups receiving 70 mg/200 g BW of each banana peel extract. The banana peels were extracted using the Ultrasound-Assisted Extraction (UAE) method with 70% ethanol. Hyperuricemia was induced for 10 days by oral administration of chicken liver juice (2 ml/kg body weight) for nine consecutive days, followed by a single intraperitoneal injection of potassium oxonate (50 mg/kg body weight) on the tenth day.  Uric acid levels were measured using the uricase-PAP method and quantified with a microplate reader at 570 nm. Blood samples were collected from the tail vein and analyzed to determine uric acid concentration before and after treatment. Data were analyzed using a randomized block design (RBD), followed by ANOVA and Duncan’s post hoc test (α ≤ 0.05). The kepok banana peel extract showed the highest uric acid reduction (93.60%), followed by nangka (90.21%) and uli (81.26%). These results suggest that all three banana peel extracts possess significant anti-hyperuricemic activity, with kepok peel extract demonstrating the greatest potential for uric acid reduction.   Keywords: Jackfruit Peel Extract, Cavendish Banana Peel Extract, Plantain Peel Extract, Anti-Hyperuricemia, Uric Acid
KOMUNIKASI, INFORMASI, EDUKASI PENYAKIT HIPERTENSI SEBAGAI STRATEGI UNTUK MENINGKATKAN PENGETAHUAN MASYARAKAT DI KELURAHAN PAKANSARI CIBINONG, KABUPATEN BOGOR Herlina, Nina; Fatmi, Mindiya; Ambarwati, Rini; Andini, Septia; Rokhmah, Nisa Najwa; Nurmala, Sara; Nurhikmah, Wilda; Wahyuningrum, Cintya; Rikkit
BESIRU : Jurnal Pengabdian Masyarakat Vol. 1 No. 11 (2024): BESIRU : Jurnal Pengabdian Masyarakat, November 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/yb6wck91

Abstract

Hypertension is a significant health issue in Indonesia, with a prevalence of 30.8%. This community service activity aims to enhance the knowledge of residents in Pakansari Village regarding hypertension and its management through education on dietary patterns and using fruits and vegetables. The methods employed in this activity include Information and Education Activities, which consist of presentations, discussions, practical sessions on making healthy juices from local ingredients, and counseling. The results indicate an improvement in participants' knowledge, with an average post-test score reaching 95%, compared to a pre-test score of 88%. Additionally, participants successfully practiced making healthy beverages that can be incorporated into their daily routines to help control blood pressure. This activity will positively impact community health and encourage healthier lifestyle changes.
Co-Authors . Yulianita, . Al Aziz, Novan Masis Ambarwati, Rini Ananda, Putri Ananda, Syindi Yulia Andhika Riyantama, Alfi Anna Permanasari Ashura Rizkiyani, Nanda Asri Wulandari Bina Lohita Sari Chyntia Wahyuningrum Dwi Indriati Dwi Indriati Elsa Fitria Elsa Mareta Emy OKTAVIANI Fitri Aninda Fitria, Elsa Ike Yulia Wiendarlina Indriati, Dwi Koniah, Eni Lusi Agus Setiani Mindiya Fatmi Mulyati Mulyati Effendi Mulyati Effendi Najwa Rokhmah, Nisa Nhestricia, Nhadira Nurhikmah, Wilda Pamungkas, Ragil Raihan Putri Ananda Putri, Nabilah Yuliana Ramadhani, Friska Noerfitria Rikkit Safitri, Aditiya Salma Hanunah Ulfa Sara Nurmala Septia Andini Siti Sadiah Sri Wardatun Tri Retno Handayani, Marybet Tri Retno, Marybet Wahyuningrum, Cintya Wahyuningrum, Cyntia Widya Sopyan, Sonia Wilda Nurhikmah Wilda Nurhikmah Wulandari, Cyntia Yulianita Yulianita Zaldy Rusli