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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Pro Food Jurnal Penelitian Kesehatan Suara Forikes Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Ilmu Kefarmasian Indonesia Scripta Biologica Jurnal Gema Ngabdi Jurnal Abdi Insani Jurnal Kesehatan Tambusai Journal of Multidisciplinary Applied Natural Science Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Warta Desa (JWD) Prosiding Konferensi Nasional PKM-CSR Jurnal Pijar MIPA Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Kefarmasian Indonesia Lombok Medical Journal Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Candra Dwipayana Hamdin
Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : scripta biologica

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EFEK HIPOGLIKEMIK INFUSA DAUN TANAMAN MAKASAR, Brucea javanica (L) Merr, PADA TIKUS HIPERGLIKEMIK YANG DIINDUKSI ALOKSAN Handa Muliasari; Candra Dwipayana Hamdin; Muhsinul Ihsan
Scripta Biologica Vol 4, No 4 (2017)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.87 KB) | DOI: 10.20884/1.sb.2017.4.4.620

Abstract

Brucea javanica (L) Merr is a local plant used traditionally for diabetic medication in Lombok Island. The B. javanica seed has been recognized to have an antidiabetic effect, while the impact of the leave extract was understudied. The purpose of this research was to determine the effect of B. javanica leaves infusion on the blood glucose level of alloxan-induced diabetic rats. B. javanica leaves extract were applied by soaking leaves into hot water (95°C) to obtain the extract concentration of 5% (w/v). This experiment provides four treatments to rats within 15 days with five replicates for each treatment. The treatments for rats were K1 a positive control, K2 a negative control, K3 a healthy control, and P1 treated with leave infused water. The diabetic condition for K1, K2, and P1 was induced with an intravenous injection of 125 mg/kgBW alloxan monohydrate to the rats. After stable diabetic condition, K1 rats were treated with Glibenclamide (0,25 mg/kgBW), K2 rats were untreated, P1 rats were administered with leaves infused water of B. javanica (L) Merr 3 ml/day. K3 rats were uninduced and untreated. The hypoglycemic effect was observed by estimating the fasting blood glucose level of the rats every three days. After 15 days of treatments, P1 rats blood glucose level reduced by the 13,30%, while K1 rats 22,04%. The decrease in blood glucose level of both K1 and P1 rats have not reached the average blood glucose level of healthy rats. The result of the statistical analysis showed the infused extract effect was not significantly differed compared to positive control (P < 0.05).
Co-Authors Adila Rizkika Agus Dwi Ananto, Agus Aini, Siti Rahmatul Alamanda, Baiq Irzana Putri Alfiah Hayati Almando Geraldi Almira Amini Alsifah Nurhidayati Amini, Almira Ananta, Muhammad Naufal Farras Andriliana Trihastuty Arief Nurrochmad Baiq Citra Azzahra Qotrunnada Baiq Ressa Puspita Rizma Candra Eka Puspitasari Dandiko Galanova Dandiko Galanova Devy Shandra Purwati Dhea Syafitri Dwiyanti Dheni Cahyo Dheny Cahyo Saputro Diouf Maulana Dwi Putranto Dyke Gita Wirasisya Dzakiyyah Sulthanah Ahmad Faolananda Qurrota A&#039;yun Faturrahman Fawwaz Aqila Putri Febriana Putri Rohmayani Febriana Putri Rohmayani Firli Rahmah Primula Dewi Ghina Salsabila Gusti Ayu Pratitha Devinta Putri Gusti Ayu Putu Sri Erwinayanti Hajar, Versa Rachmania Halimatussakdiyah Halimatussakdiyah Handa Muliasari Hasina, Raisya Haulya Razkianita Hudaynu Patya Putri I MADE SUDARMA Ida Bagus Putra Manuaba Ika Puspitasari Ima Arum Lestarini Iman Surya Pratama Ivan Mambaul Munir Jingga Rusyesyah Padli Karlina Dwi Febrianingsih Kattari, Raisah Putri Lalu Rifqi Azami Lim, Vuanghao Lisnasari, Baiq Risky Wahyu M. M. Samdya Aripansy Mahacita Andanalusia Mahdiyyah Husna Nihar Manikya Pramudya Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Nadia Magfira Nurmalasanti Nadya Arianita Turisia Naya Wahyu Anindiya Naya Wahyu Anindiya Ni Made Amelia Ratnata Dewi Ningsih, Fitriani Putri Eka Puji Elok Dzakirah Putri, Dheden Nurhani Bija Raisya Hasina Retno Zahara Ria Hapsari Risma Fitriani Riza Rusyiana Romi Juniawan Sabila Rosyada Sabita Tarinda Sabita Tarinda Saputra, Yoga Dwi Shafira Khansa Haiba Silhiyatun Mayada Sinta wahyu utami Siti Maesarah Siti Maesarah Siti Rahmatul Aini Siti Rahmatul Aini Steve Pratama Tanjaya Syahrani Febrianti Ulya, Tuhfatul Vania Aisyah Aulia Syahda Haris Vania Aisyah Aulia Syahda Haris Wahida Hajrin Widia Nila Risnadewi Windah Anugrah Subaidah Wiwin Azariani Yazid Maula Zaskia Rizky Maulana Zaskia Rizky Maulana `Mustofa, Laila Al Azizi