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All Journal Jurnal Ilmiah Farmasi Pendidikan Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Current Biochemistry Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Keperawatan BSI Adi Widya : Jurnal Pengabdian Masyarakat Pharmasipha Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Indonesia INTEGRITAS : Jurnal Pengabdian Community Empowerment Jurnal Farmasi Proceeding Biology Education Conference Prosiding University Research Colloquium Journal Prima Health Science Herbal Medicine Journal SWAGATI: Journal of Community Service Jurnal Sains dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET) Sabar : Jurnal Pendidikan Agama Kristen dan Katolik Jurnal Hukum, Administrasi Publik dan Negara
Desi Purwaningsih
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Farmasi

 1 
FORMULASI DAN UJI ANTIJAMUR Candida albicans KRIM EKSTRAK RIMPANG KENCUR (Kaempferiae galanga Linn.) DENGAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Irawan, Ira; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 2 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i2.220

Abstract

 Senyawa aktif yang terdapat pada rimpang kencur (Kaempferia galanga Linn.) antara lain alkaloid, flavonoid, dan tanin digunakan sebagai antijamur. Penelitian ini bertujuan untuk mengetahui pengaruh variasi asam stearat dan trietanolamin terhadap mutu fisik dan stabilitas sediaan krim dan aktivitasnya terhadap Candida albicans ATCC 10231 serta formula sediaan krim dengan mutu fisik yang paling baik dan memiliki aktivitas antijamur. Ekstrak rimpang kencur diperoleh dengan maserasi menggunakan etanol 70%, diformulasi dengan konsentrasi ekstrak 12% serta variasi asam stearat dan trietanolamin dengan perbandingan yaitu (10:7, 13:5, 16:3). Formulasi sediaan krim dilakukan dengan mencampurkan fase minyak dan fase air kemudian dilakukan mutu fisik meliputi uji organoleptis, homogenitas, daya sebar, daya lekat, pH, viskositas, dan Cycling test. Penelitian ini menggunakan metode difusi cakram untuk mengetahui aktivitas antijamur serta one way ANOVA untuk analisis staitistik. Hasil penelitian diperoleh diameter zona hambat ekstrak sebesar 13,17 mm. Variasi asam stearat dan trietanolamin berpengaruh terhadap mutu fisik dan aktivitas antijamur sediaan krim. Sediaan krim memiliki aktivitas antijamur terhadap Candida albicans ATCC 10231. Formula terbaik adalah formula 1 dengan variasi asam stearat : trietanolamin (10:7) yang memiliki mutu fisik paling baik, dengan diameter zona hambat sebesar 13,00 mm yang tergolong kuat dalam menghambat pertumbuhan jamur.
OPTIMASI GELLING AGENT PADA SEDIAAN GUMMY CANDY PARASETAMOL DENGAN METODE SIMPLEX LATTICE DESIGN Pradana, Arsita; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol 13, No 1 (2024)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v13i1.274

Abstract

Sediaan parasetamol yang beredar di pasaran saat ini berbentuk tablet, tablet kunyah, sirup, suspensi dan emulsi. Ketersediaan formula obat parasetamol untuk anak di Indonesia masih terbatas. Tujuan dari penelitian ini untuk melakukan suatu pengembangan sediaan parasetamol yang acceptable atau mudah diterima oleh masyarakat dalam bentuk sediaan permen kenyal yaitu gummy candy.            Rancangan formula gummy candy parasetamol untuk di optimasi dengan metode Simplex Lattice Design (SLD) kemudian pembuatan 8 run gummy candy variasi konsentrasi gelatin dan karagenan. Pengujian mutu fisik masing-masing formula gummy candy meliputi pengujian organoleptik, kekenyalan, pH dan kadar air. Validasi metode analisis dengan parameter akurasi, presisi, spesifitas, linearitas dan LOD LOQ kemudian dilanjutkan dengan pengujian keseragaman kandungan sediaan gummy candy parasetamol dengan menggunakan spektrofotometer UV-Vis.            Hasil penelitian konsentrasi gelatin dan karagenan berpengaruh terhadap kekenyalan, pH dan kadar air sediaan gummy candy parasetamol. Gelatin berpengaruh dominan terhadap peningkatan kekenyalan, karagenan berpengaruh dominan terhadap peningkatan pH dan kadar air. Formula optimum didapatkan dengan proporsi gelatin 599,226 mg dan karagenan 400,774 mg.
Formulasi Mouthwash Ekstrak Kulit Buah Nanas (Ananas comosus (L.) Merr) dengan Variasi Konsentrasi Gliserin sebagai Antibakteri Terhadap Streptococcus mutans ATCC 25175 Maharani, Novita; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 2 (2021): Jurnal Farmasi (Journal of Pharmacy), October 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dental caries is a major disease in problems in the oral cavity especially in the teeth. The main cause of dental caries is the bacterium Streptococcus mutans which is a normal inhabitant of the oral cavity. Dental caries can be overcome using a mouthwash preparation containing antibacterial substances. Pineapple skin (Ananas comosus (L.) Merr) is one of the plants that contains substances that have antibacterial activity. The purpose of this study was to determine the physical quality and stability, and activity antibacterial of mouthwash pineapple skin extract. Pineapple skin extract was made in three mouthwash formulations using various concentrations of glycerin 5%, 10%, and 15%. Mouthwash were tested for physical quality and stability. Antibacterial activity test against Streptococcus mutans ATCC 25175 using the well method. The data obtained are presented in the form of tables and graphs processed with SPSS ver22 with the Paired T-Test method for testing viscosity and testing pH and ANOVA for measuring the diameter of the inhibition zone. The results showed that mouthwash preparations in all formulas with organoleptic physical qualities, viscosity, and stability produced good preparations, while in testing the physical quality of the pH did not meet the pH requirements of mouthwash preparations because of the influence of pineapple skin extract (Ananas comosus (L.) Merr). In testing the antibacterial activity of mouthwash, the diameter of the inhibition zone was obtained the base 0 mm; F1 11.08 mm; F2 13.08 mm; F3 15.08 mm; and control positive 16,75 mm.
OPTIMASI SEDIAAN GUMMY CANDY PARASETAMOL DENGAN VARIASI KONSENTRASI GELATIN DAN GLISERIN MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN Nisa, Zaitun; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 11 No. 2 (2022): Jurnal Farmasi (Journal of Pharmacy), October 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/35yaf041

Abstract

Paracetamol gummy candy is a chewy candy that is composed of a mixture of sweeteners and hydrocolloid components containing paracetamol and is designed to crumble and melt on the tongue. This study aims to see the effect of variations in the concentration of gelatin and glycerin on the physical quality of paracetamol gummy candy preparations, and to determine the best concentration of gelatin and glycerin to obtain paracetamol gummy candy preparations with optimum physical properties. Preparation of the preparation using the casting method and using 8 formula designs from Design Expert Simplex Lattice Design with a ratio of gelatin and glycerin concentrations. The results of the physical quality test with the critical parameters of elasticity and moisture content were analyzed using the Simplex Lattice Design method. This method can be used to optimize the dosage formula in various variations in the amount of material composition, so as to produce the optimum formula with the expected physical characteristics. The results showed that gelatin had more effect on elasticity and glycerin had more effect on the water content of paracetamol gummy candy. The proportions of gelatin 998,723 mg and glycerin 51.277 mg resulted in the optimum formula with the best elasticity and water content of gummy candy paracetamol.
FORMULASI DAN UJI ANTIJAMUR Candida albicans KRIM EKSTRAK RIMPANG KENCUR (Kaempferiae galanga Linn.) DENGAN VARIASI ASAM STEARAT DAN TRIETANOLAMIN Irawan, Ira; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 12 No. 2 (2023): Jurnal Farmasi (Journal of Pharmacy), October 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/qzxj1g27

Abstract

The active compounds contained in the rhizome of kencur (Kaempferia galanga Linn.) include alkaloids, flavonoids, and tannins which are used as antifungals. This study aims to determine the effect of variations of stearic acid and triethanolamine on the physical quality and stability of cream preparations and their activity against Candida albicans ATCC 10231 and cream formulation formulas with the best physical quality and have antifungal activity. Kencur rhizome extract was obtained by maceration using 70% ethanol and formulated with an extract concentration of 12% and variations of stearic acid and triethanolamine with a ratio of (10:7, 13:5, 16:3). The formulation of the cream preparation was carried out by mixing the oil phase and the water phase and then physical quality was carried out including organoleptic tests, homogeneity, spreadability, adhesion, pH, viscosity, and Cycling test. This study used the disc diffusion method to determine antifungal activity and one way ANOVA for statistical analysis. The results showed that the diameter of the extract inhibition zone was 13.17 mm. Variations of stearic acid and triethanolamine affect the physical quality and antifungal activity of cream preparations. Cream preparations have antifungal activity against Candida albicans ATCC 10231. The best formula is formula 1 with variations of stearic acid : triethanolamine (10:7) which has the best physical quality, with an inhibition zone diameter of 13.00 mm which is strong in inhibiting fungal growth.
OPTIMASI GELLING AGENT PADA SEDIAAN GUMMY CANDY PARASETAMOL DENGAN METODE SIMPLEX LATTICE DESIGN Pradana, Arsitya; Aisiyah, Siti; Purwaningsih, Desi
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 1 (2024): Jurnal Farmasi (Journal of Pharmacy), April 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/p6a5c155

Abstract

The dosage form of paracetamol gummy candy has several advantages compared to other paracetamol preparations circulating in Indonesia, including fast onset, high bioavailability, pleasant taste, practical to use, easy to serve, acceptable to children, so can increase the impact of taking the drug. The aim of this research was to determine the effect of varying concentrations of gelatin and carrageenan on the elasticity, pH and air content of paracetamol gummy candy preparations and to determine the proportion of gelatin and carrageenan in the optimum formula using the Simplex Lattice Design method. The paracetamol gummy candy formula design from Design Expert SLD produced 8 runs with varying concentrations of gelatin and carrageenan. Critical parameters in determining the optimum formula include elasticity, pH and air content. Validation of the analytical method for testing the uniformity of paracetamol content of gummy candy using a UV-Vis spectrophotometer includes the parameters of accuracy, precision, specificity, linearity, LOD and LOQ. The researchers discovered that the amount of gelatin and carrageenan in paracetamol gummy candy preparations affected the elasticity, pH, and water content. Carrageenan has a dominant influence on boosting pH and water content, while gelatin has a dominant effect on improving flexibility. The best formula had 599,226 mg of gelatin and 400,774 mg of carrageenan.
Co-Authors Aji Wahyu Wahiddatul Djakiah Ana Indrayati Aris Tri Jaka Harjanta, Aris Tri Ayu anindia Ayu Rachmawati Bambang Agus Herlambang, Bambang Bowo Sugiharto Destik Wulandari Dewi Ekowati Dwi Ningsih Erna Irawan, Erna Febrian Murti Dewanto Ferina Dyah Prastiyanti Fitriana Noor Khayati Fradine, Chossy Harlita Harlita Haryo Kusumo Heryani, Monalisa I MADE ARTIKA I Made Artika Irawan, Ira Ismi Rahmawati Ismi Rahmawati Isna Jati Asiyah Juliana, Dara Kristina Simanjuntak, Kristina Simanjuntak Kusumo, Haryo Maharani, Novita Mandasari, Mitha Oktavia Marlina, Dian Mega Novita Mega Novita Ningsih, dwi - Nisa, Zaitun Pradana, Arsita Pradana, Arsitya Rahmawati, Ismi Rahmawati, Ismi - Reny Pratiwi Reny Pratiwi Rizky Bimantara HA Ryan Werytama Saputra Saputra, Ryan Werytama Setyaningsih, Widiastuti Simanjuntak, Kristina Siti Aisiyah Sri Hayati, Sri Sri Rejeki Handayani Sri Rejeki Handayani, Sri Rejeki Suharyanto Suharyanto Supriyono Supriyono Supriyono Supriyono Tanzila Rahmi Tita Novarini Tiwuk Susantiningsih Tri Panji Turahman, Taufik Turahman, Taufik Vicky Agus Arwanda Widiastuti Setyaningsih Wulandari, Destik ‪Arlina Dhian Sulistyowati‬