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All Journal Pharmascience Jurnal Surya Medika Jukung (Jurnal Teknik Lingkungan) Al-Ard: Jurnal Teknik Lingkungan Jurnal Sehat Mandiri Jurnal Politikom Indonesiana Best Journal (Biology Education, Sains and Technology) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners HSG (Health Science Growth) Journal Jurnal Integrasi Kesehatan dan Sains Indonesian Journal of Community and Special Needs Education (IJCSNE) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Sustainable Community Service Journal of Pharmaceutical and Sciences. ASEAN Journal for Science and Engineering in Materials Preventif : Jurnal Kesehatan Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science
Sudarjat, Hadi
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Interaksi Warfarin dan Aspirin terhadap Risiko Perdarahan pada Pasien Penderita Penyakit Kardiovaskular Subekti, Firli Reisya; Nurhafidah, Zahra; Saputri, Jasmine Rahma; Adhwa'a Kaylla; Shadrina, Jahra Almas; Maharani, Puteri Rahma; Putri, Mukarromah Dita; Sudarjat, Hadi; Hilmi, Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1196

Abstract

Background: Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality; therefore, antithrombotic therapy such as warfarin and aspirin plays a crucial role in preventing thromboembolic events. The combination of these two agents provides a synergistic effect in inhibiting thrombus formation but significantly increases the risk of bleeding. Objective: To evaluate the impact of concominant ose of warfarin and aspirin on bleeding risk and its clinical benefits in patients with CVD. Methods: A systematic literature search was conducted using Google Scholar and Pubmed, with eligible studies analyzed. Result: The concomitant use of warfarin and aspirin increases the incidence of major bleeding without providing additional benefits in preventing stroke or myocardial infarction. Moreover, poor anticoagulation control further exacerbates this risk. Conclusion: The combination of warfarin and aspirin should be reserved only for patients with strong clinical indications, while warfarin monotherapy is safer for those with stable conditions. These findings emphasize the importance of individualized therapy evaluation and optimal INR monitoring to balance therapeutic benefits and bleeding risks.
Threatening Visual Warnings (TVWs) pada Kemasan Rokok terhadap Keinginan Berhenti Merokok Mally Ghinan Mally Ghinan; Hadi Sudarjat; Mayasari Mayasari
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 1 No. 1 (2020): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v1i1.4403

Abstract

Abstrak. Konsumsi tembakau pada rokok merupakan faktor risiko utama untuk berbagai macam penyakit seperti penyakit jantung dan kanker paru. Khususnya di Indonesia perokok dewasa mencapai 39,40% pada tahun 2016, untuk menurunkan rata-rata perokok tersebut maka salah satu strateginya adalah dengan menambahkan TVWs (Threatening Visual Warnings) pada kemasan rokok. Tujuan penelitian adalah menilai pengaruh iklan TVWs terhadap keinginan untuk berhenti merokok. Metode penelitian ini adalah crossectional dengan pengambilan data secara sekunder pada 60 responden masyarakat karawang dengan usia > 12 tahun. Data yang diperoleh kemudian diolah dengan menggunakan metode Chi Square dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan pada responden remaja putri tidamk ada hubungan TVWs dengan keinginan untuk berhenti merokok (nilai p 0,0256), sedangkan wanita dewasa, remaja putra dan pria dewasa terdapat hubungan TVWs dengan keinginan untuk berhenti merokok (nilai p berturut-turut 0,013, 0,001 dan 0,003). Kata kunci : Rokok, TVWs, dan Kemasan Rokok
Analisis Interaksi Senyawa Sinularin dan Turunannya terhadap Reseptor pada Kanker Payudara dengan Metode Penambatan Molekul: Analysis of the Interaction of Sinularin Compounds and Their Derivatives with Receptors in Breast Cancer by Molecular Docking Method Bismar Al Bara; Indah Laily Hilmi; Hadi Sudarjat
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 5 No. 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12945

Abstract

Over the past three decades, there have been thousands of women undergoing treatment with tamoxifen. But there is a decrease or even no response to the breast cancer chemotherapy treatment. This phenomenon can occur due to resistance. sinularin has potential as a cancer drug.This study aims to evaluate the interaction of sinularin compounds and its derivatives with breast cancer receptors such as estrogen receptor alpha with PDB code: 5W9C, progesterone receptor with PDB code: 1A28, and human epidermal growth factor receptor 2 using proteins with PDB code: 3PP0 using molecular docking methods to determine anticancer potential.This research method is in-silico research. The research was conducted by screening test compounds such as prediction of compound potential using PASS Online Server, prediction of physicochemical properties using SwissADME, and prediction of compound toxicity using ProTox 3.0. Then validation of the method using AutoDock Vina, Next molecular docking using AutoDock Vina, and visualization of molecular docking results using Biovia Discovery Studio Visualizer. The results showed that sinularin compounds and their derivatives showed anticancer potential through the PASS test, low toxicity, and compliance with the Lipinski Rule of Five. Method validation showed RMSD values ​​below 2.0 Å. In molecular docking, sinularin showed a binding affinity value with a value of -8.027 kcal/mol which was better than tamoxifen with a value of -7.61 kcal/mol, although still below the native ligand of estrogen receptor alpha with a value of -8.815 kcal/mol. Sinularin and its derivatives have potential as anticancer agents through interaction with ERα and HER-2. Keywords: Breast Cancer; Sinularin; Molecular Docking.
Co-Authors Adhwa'a Kaylla Advaita, Chalisya Vanya Affandhy , Adhwa’a Kaylla Affandhy, Adhwa'a Kaylla Affandhy, Adhwa’a Kaylla Ahsanal Kasasiah Asep Bayu Dani Nandiyanto Aulia Fashanah Hadining Aulia Hadining Balapadang, Rachel Noveriachristie Bismar Al Bara Daffa, Muhammad Naufal Dzannuba, Fadya Laila Dzannuba, Fadya Laila Dzannuba Laila Fadilah, Oca Nur Gina Lova Sari Gun Gun Gumilar Hadining, Aulia Herlaesa, Shofiatulfuadah Retnaningrum Hermawan, Deri Hilm, Inda Laily Hilmi , Indah Laily Hotimah, Alin Parliana Ilham, Febrian Dzikri Indah Laily Hilmi Indah Laily Hilmi Izzati, Maulia Keysha Feiruzyan Rafeifadattis Kusnadi Kusnadi, Kusnadi Lely Sulfiani Saula Linda Riski Sefrina Maharani, Puteri Rahma Mally G Sholih Mally G. Sholih Mally Ghinan Mally Ghinan Mally Ghinan Sholih Mayasari Mayasari Mierza, Vriezka Muini, Chantiara FM Munir Alinu Mulki Nadhira, Shafwa Faza Nandita Nuryanti Aulia Nazwa Rizkillah Nisa, Nasywa Khoirun Nurdin, Fitri Oktaviani Nurhafidah, Zahra Putri, Mukarromah Dita Rahma Maulida, Rahma Roudotul Jannah Salman Salman Saputri, Jasmine Rahma Shadrina , Jahra Almas Shadrina, Jahra Almas Sholih, Mally Ghinan Sri Anggraeni Subekti, Firli Reisya Syahrin, Esti Tresna, Muhammad Raka Verka Apriani Wardani, Aulia Yulianti Surasa, Triana Maudy