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All Journal Jurnal Surya Medika Jukung (Jurnal Teknik Lingkungan) Al-Ard: Jurnal Teknik Lingkungan Jurnal Sehat Mandiri Jurnal Politikom Indonesiana Best Journal (Biology Education, Sains and Technology) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners HSG (Health Science Growth) Journal Jurnal Integrasi Kesehatan dan Sains Indonesian Journal of Community and Special Needs Education (IJCSNE) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Sustainable Community Service Journal of Pharmaceutical and Sciences. ASEAN Journal for Science and Engineering in Materials Preventif : Jurnal Kesehatan Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science Journal of Pharmascience
Sudarjat, Hadi
Universitas Singaperbangsa Karawang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Analisis Interaksi Senyawa Sinularin dan Turunannya terhadap Reseptor pada Kanker Payudara dengan Metode Penambatan Molekul: Analysis of the Interaction of Sinularin Compounds and Their Derivatives with Receptors in Breast Cancer by Molecular Docking Method Bismar Al Bara; Indah Laily Hilmi; Hadi Sudarjat
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 5 No. 2 (2024): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v5i2.12945

Abstract

Over the past three decades, there have been thousands of women undergoing treatment with tamoxifen. But there is a decrease or even no response to the breast cancer chemotherapy treatment. This phenomenon can occur due to resistance. sinularin has potential as a cancer drug.This study aims to evaluate the interaction of sinularin compounds and its derivatives with breast cancer receptors such as estrogen receptor alpha with PDB code: 5W9C, progesterone receptor with PDB code: 1A28, and human epidermal growth factor receptor 2 using proteins with PDB code: 3PP0 using molecular docking methods to determine anticancer potential.This research method is in-silico research. The research was conducted by screening test compounds such as prediction of compound potential using PASS Online Server, prediction of physicochemical properties using SwissADME, and prediction of compound toxicity using ProTox 3.0. Then validation of the method using AutoDock Vina, Next molecular docking using AutoDock Vina, and visualization of molecular docking results using Biovia Discovery Studio Visualizer. The results showed that sinularin compounds and their derivatives showed anticancer potential through the PASS test, low toxicity, and compliance with the Lipinski Rule of Five. Method validation showed RMSD values ​​below 2.0 Å. In molecular docking, sinularin showed a binding affinity value with a value of -8.027 kcal/mol which was better than tamoxifen with a value of -7.61 kcal/mol, although still below the native ligand of estrogen receptor alpha with a value of -8.815 kcal/mol. Sinularin and its derivatives have potential as anticancer agents through interaction with ERα and HER-2. Keywords: Breast Cancer; Sinularin; Molecular Docking.
Analisis Rhodamin B pada Kerupuk Seblak Prasmanan di Sekitar Universitas Singaperbangsa Karawang Kampus 1 Chalisya Vanya Advaita; Vriezka Mierza; Hadi Sudarjat
Journal of Pharmascience Vol. 12 No. 1 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.19358

Abstract

Rhodamin B merupakan pewarna yang tidak boleh digunakan sebagai bahan tambahan pangan (BTP).  Konsumsi Rhodamin B dapat menimbulkan efek racun, gangguan fungsi organ hingga kanker. Seblak prasmanan merupakan seblak dengan variasi kerupuk berwarna. Penelitian ini bertujuan untuk mengidentifkasi Rhodamin B pada kerupuk seblak prasmanan yang dijual di sekitar Universitas Singaperbangsa Karawang kampus 1. Analisis kualitatif dan kuantitatif pada penelitian ini menggunakan metode KLT dengan eluen N-butanol, etil asetat dan ammonia 10% (10:4:5) dan spektrofotometri UV-Vis dengan diawali validasi metode. Hasil uji kualitatif menunjukkan 1 dari 12 sampel positif mengandung Rhodamin B dengan nilai Rf 0,94 dan nilai Rf baku Rhodamin B 0,80. Hasil uji validasi menunjukkan bahwa metode ini baik untuk mengidentifikasi Rhodamin B pada kerupuk dengan nilai parameter korelasi (r) = 0,9999; LOQ 0,2748 mg/L; LOD 0,0842 mg/L; %RSD 0,233%; % recovery 114,725% (konsentrasi 4 mg/L), 108,76% (konsentrasi 5 mg/L) dan 100,117% (konsentrasi 6 mg/L). Berdasarkan hasil analisis diketahui 12 sampel positif mengandung Rhodamin B dengan % kadar (b/b) yang relatif kecil yaitu 0,000476% (A1); 0,000883% (B1); 0,00126% (C1); 0,000277% (A2); 0,00045% (B2); 0,00069% (C2); 0,000577% (A3); 0,0013% (B3); 0,001141% (C3); 0,000377% (A4); 0,000347% (B4) dan 0,00142% (C4).
Interaksi Warfarin dan Aspirin terhadap Risiko Perdarahan pada Pasien Penderita Penyakit Kardiovaskular Firli Reisya Subekti; Zahra Nurhafidah; Jasmine Rahma Saputri; Adhwa'a Kaylla; Jahra Almas Shadrina; Puteri Rahma Maharani; Mukarromah Dita Putri; Hadi Sudarjat; Indah Laily Hilmi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1196

Abstract

Background: Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality; therefore, antithrombotic therapy such as warfarin and aspirin plays a crucial role in preventing thromboembolic events. The combination of these two agents provides a synergistic effect in inhibiting thrombus formation but significantly increases the risk of bleeding. Objective: To evaluate the impact of concominant ose of warfarin and aspirin on bleeding risk and its clinical benefits in patients with CVD. Methods: A systematic literature search was conducted using Google Scholar and Pubmed, with eligible studies analyzed. Result: The concomitant use of warfarin and aspirin increases the incidence of major bleeding without providing additional benefits in preventing stroke or myocardial infarction. Moreover, poor anticoagulation control further exacerbates this risk. Conclusion: The combination of warfarin and aspirin should be reserved only for patients with strong clinical indications, while warfarin monotherapy is safer for those with stable conditions. These findings emphasize the importance of individualized therapy evaluation and optimal INR monitoring to balance therapeutic benefits and bleeding risks.
Literature Review: Efektivitas Konseling Farmasi Terhadap Kepatuhan Minum Obat pada Pasien Diabetes Melitus Tipe 2: Literature Review: Effectiveness of Pharmacist Counseling on Compliance with Taking Medication in Diabetes Mellitus Type 2 Patients Fitri Otaviani Nurdin; Indah Laily Hilmi; Hadi Sudarjat; Triana Maudy Yulianti Surasa
Jurnal Surya Medika (JSM) Vol. 12 No. 1 (2026): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v12i1.8614

Abstract

Diabetes Melitus (DM) tipe 2 merupakan penyakit metabolik kronis yang memerlukan pengobatan seumur hidup. Salah satu faktor yang memengaruhi keberhasilan terapi DM adalah tingkat kepatuhan pasien terhadap pengobatan. Ketidakpatuhan ini sering kali disebabkan oleh kurangnya pemahaman pasien tentang pentingnya pengobatan jangka panjang. Tujuan: mengevaluasi efektivitas konseling farmasis dalam meningkatkan kepatuhan penggunaan obat pada pasien diabetes mellitus tipe 2. Metode yang digunakan adalah narrative review terhadap artikel yang membahas dampak konseling terhadap kepatuhan pasien. Hasil: Analisis 10 artikel memperlihatkan konseling oleh farmasis secara signifikan meningkatkan kepatuhan pengobatan, menurunkan kadar gula darah, serta memperbaiki hasil klinis secara keseluruhan. Kesimpulan: konseling farmasis merupakan intervensi yang efektif dalam meningkatkan kepatuhan pengobatan dan kontrol glukosa darah, yang berpotensi meningkatkan kualitas hidup pasien diabetes.
Co-Authors Adhwa'a Kaylla Advaita, Chalisya Vanya Affandhy , Adhwa’a Kaylla Affandhy, Adhwa'a Kaylla Affandhy, Adhwa’a Kaylla Ahsanal Kasasiah Asep Bayu Dani Nandiyanto Aulia Fashanah Hadining Aulia Hadining Balapadang, Rachel Noveriachristie Bismar Al Bara Chalisya Vanya Advaita Daffa, Muhammad Naufal Dzannuba, Fadya Laila Dzannuba, Fadya Laila Dzannuba Laila Fadilah, Oca Nur Firli Reisya Subekti Fitri Otaviani Nurdin Gina Lova Sari Gun Gun Gumilar Hadining, Aulia Herlaesa, Shofiatulfuadah Retnaningrum Hermawan, Deri Hilm, Inda Laily Hilmi , Indah Laily Hotimah, Alin Parliana Ilham, Febrian Dzikri Indah Laily Hilmi Indah Laily Hilmi Izzati, Maulia Jahra Almas Shadrina Jasmine Rahma Saputri Keysha Feiruzyan Rafeifadattis Kusnadi Kusnadi, Kusnadi Lely Sulfiani Saula Linda Riski Sefrina Mally G Sholih Mally G. Sholih Mally Ghinan Mally Ghinan Mally Ghinan Sholih Mayasari Mayasari Mierza, Vriezka Muini, Chantiara FM Mukarromah Dita Putri Munir Alinu Mulki Nadhira, Shafwa Faza Nandita Nuryanti Aulia Nazwa Rizkillah Nisa, Nasywa Khoirun Nurdin, Fitri Oktaviani Nurhafidah, Zahra Puteri Rahma Maharani Rahma Maulida, Rahma Roudotul Jannah Salman Salman Shadrina , Jahra Almas Shadrina, Jahra Almas Sholih, Mally Ghinan Sri Anggraeni Syahrin, Esti Tresna, Muhammad Raka Triana Maudy Yulianti Surasa Verka Apriani Vriezka Mierza Wardani, Aulia Yulianti Surasa, Triana Maudy Zahra Nurhafidah