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All Journal Vitek : Bidang Kedokteran Hewan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Sainstech Farma: Jurnal Ilmu Kefarmasian Proceeding of Mulawarman Pharmaceuticals Conferences Generics: Journal of Research in Pharmacy Sciences of Pharmacy Jurnal Pengabdian Masyarakat Bangsa Generics : Journal of Research in Pharmacy Jurnal Sains dan Kesehatan Berita Biologi
Lia Puspitasari
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Studi Molecular Docking Senyawa Flavonoid Quercetin Daun Mimba (Azadiracta indica A. Juss) sebagai Antidiabetes dan Antioksidan Lia Puspitasari; Bagas Apriliano Wijanarko; Saiful Bahri
Generics: Journal of Research in Pharmacy Vol 6, No 1 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i1.30124

Abstract

Daun mimba (Azadiracta indica A. Juss) merupakan tanaman obat yang banyak diteliti memiliki aktivitas antidiabetes dan antioksidan, namun kajian in silico yang secara spesifik mengevaluasi peran quersetin sebagai senyawa utamanya terhadap beberapa target molekuler kunci diabetes melitus masih terbatas. Oleh karena itu penelitian ini bertujuan untuk mengkaji potensi aktivitas quercetin terhadap Peroxisome Proliferator-Activated Receptors-Gamma (PPAR-?), Dipeptidyl Peptidase-4 (DPP-4), serta target yang berperan dalam pembentukan Reactive Oxygen Species (ROS) menggunakan pendekatan structure-based drug design melalui metode molecular docking. Hasil simulasi docking menunjukkan quersetin memiliki afinitas yang kuat dan stabil terhadap reseptor PPAR-y dan DPP-4, yang ditunjukkan oleh nilai energi ikatan bebas yang rendah dan pembentukan interaksi molekuler penting berupa ikatan hidrogen dan interaksi hidrofobik pada sisi aktif reseptor. Quersetin juga menunjukkan interaksi yang relevan dengan target protein terkait ROS, yang mengindikasikan potensi aktivitas antioksidan melalui penghambatan jalur pembentukan stress oksidatif. Berdasarkan profil afinitas ikatan dan pola interaksi molekuler tersebut, quersetin pada daun mimba berpotensi memiliki aktivitas antidiabetes melalui mekanisme aktivasi PPAR-y dan inhibisi DPP-4, serta berkontribusi dalam menurunkan stres oksidatif.
Chemometrics in Pharmaceutical Formulation: A Two-Decade Bibliometric Review (2005-2025) Puspitasari, Lia; Larasati, Rizky Dwi; Maharani, Zahra Ayu
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502568

Abstract

Chemometrics is essential in modern pharmaceutical development for enhancing analysis and quality control. Despite its importance, the evolutionary trajectory and thematic shifts of chemometrics within pharmaceutical formulation have not been comprehensively synthesized. This study aims to explore publication trends, scientific collaborations, and keywords in research related to the application of chemometrics to pharmaceutical formulations, using a bibliometric approach. Data were retrieved from Scopus (2005–2025) using a structured search strategy focusing on "pharmaceutical formulation", "drug formulation", and "pharmaceutical development". The search was limited to English-language original articles or reviews. Bibliometric mapping was performed using VOSviewer and the Bibliometrix R-package, applying a minimum keyword occurrence of 5, full counting method, and association strength normalization. A total of 516 documents were identified. Publications have increased significantly in the last decade, with research articles being the dominant document type. Egypt and the United States are the countries with the highest contribution and citation impact. The Journal of Pharmaceutical and Biomedical Analysis is ranked highest in terms of the number of publications and influence. Khan, Mansoor A., is the most productive author, while the Faculty of Pharmacy at Cairo University and the FDA are the most productive organizations. Keyword analysis revealed various main themes and a division into seven clusters, highlighting an evolutionary shift from traditional analysis toward Process Analytical Technology (PAT) and Quality by Design (QbD). These findings highlight the importance of cross-disciplinary collaboration and the potential for further exploration of novel approaches in pharmaceutical product development.
Co-Authors Amlius Thalib Amlius Thalib Astuti, Rini Budi Awal Prichatin Kusumo Azizah, Kholipia Bagas Apriliano Wijanarko Erwi Putri Setyaningsih Fatimi, Hana Anisa Febrina Mahmudah Finanti, Hanif Mifta Hajrah Hajrah Herdini Herdini Herman Herman Hery Yufrizal Hifna, Rifki Maulana Imam Prabowo, Imam Indriyani Indriyani Kharisma Novita Sari Kuncorojakti, Suryo Laode Rijai Larasati, Rizky Dwi Lisna Meylina Lita Rakhma Yustinasari Maharani, Zahra Ayu Mahendra, Raihan Bintang Manalu, Rosario Trijualiamos Moelyono M W Moelyono M W Munawarohthus Sholikha Natasya, Fauziah Cinta Nisa Naspiah Nugraha, Akbar Eka Nur Aripin, Iis Sumiyati Pribadi, Fitrawan Hernuza Rizky Andini Saiful Bahri Saptono Hadi, Saptono Suci Mareta Sulistiarini, Riski Syifa Fauziah Tamimah, Rifqah Alya Tarshan Sharma Suresh Ujang Suparman Usmarini, Razita Fathya Wahyuningtyas, Wahyuningtyas Yoppi Iskandar Zahir Thoriq -