Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

2.589

P-Index

This Author published in this journals

All Journal HAYATI Journal of Biosciences Jurnal Veteriner Microbiology Indonesia Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Sains dan Teknologi Farmasi Jurnal Media Gizi Indonesia (MGI) INDONESIAN JOURNAL OF PHARMACY Jurnal Komputer Terapan ANNALES BOGORIENSES FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Respirasi (JR) Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Layanan Masyarakat (Journal of Public Service) Narra J Jurnal Puruhita MEDICINUS Journal of Community Engagement in Health

HENI RACHMAWATI

School of Pharmacy, Institute of Technology Bandung. Jl. Ganesha, 10, Bandung 40132

Author-ID : 353987

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 34 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4

The Difference of Results in Abdomen and Anus Area Measurement With Non-Contact Infrared Thermometer Anna Surgean Veterini; Nancy Margarita Rehatta; Hamzah Hamzah; Widijiati Widijiati; Sarmanu Sarmanu; Subijanto Marto Soedarmo; Widodo Jatim Pudjirahardjo; Annis Catur Adi; Heni Rachmawati; I Ketut Sudiana
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Study about sepsis is chalenging to get the right therapeutic method. One clinical signs of the sepsis mice model is changes in body temperature. An easy way to examine body temperature is using infrared non-contact thermometer. The aim of this study is to compare the body temperature obtained from infrared non-contact thermometer at the abdomen and anus area. We used male Mus musculus mice, body weight of 25–30 grams, were divided into 2 groups (control and treated groups). In the control group, mice were injected with NaCl 0.9% solution, with the amount of NaCl volume equal to LPS. In the treated group, mice were injected with 2.5 mg/kgBW of LPS intraperitoneally. Body temperature measurement was measured in abdomen (tabd) and anus (tan) area. Body temperature was measured at 8th and 24th hour after LPS or NaCl injection. Body temperature value result using tabd was higher than tan. LPS injection to mice produced an increase in body temperature but was not significant when compared to the control group (8th and 24th hour). The mean difference between tabd and tan in 8th hour control groups respectively were 2.12oC. The mean difference between tabd and tan in 24th hour control groups 4.6oC. The mean difference in treated groups (8th hour) was 4.66oC, while it was 4.77oC in the 24th hour treated groups. LPS could caused vasodilation of the vessels, the measurement area of non contact-infrared thermometer will be the most important factor to be considered; tan may closer to the physiology condition.

PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN-ï¢-SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Citra Ariani Edityaningrum; Heni Rachmawati
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the ï¢-cyclodextrin forming curcumin-ï¢-cyclodextrin nanoparticle. The formula showed particle size of 156.8 Â± 38.3 nm, polydispersity indexof 0.174 Â± 0.026, and zeta potential of -17.3 ï‚± 0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively.

FORMULASI DAN KARAKTERISASI SEDIAAN NANOEMULSI VITAMIN A [Formulation and Characterization of Vitamin A Nanoemulsion] Annis Catur Adi; Nelly Setiawaty; Atsarina Anindya; Heni Rachmawati
Media Gizi Indonesia Vol. 14 No. 1 (2019): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Vitamin A is an essential nutrient to support the function of vision, growth, and immune system. Vitamin A cannot be synthesized in the body hence must be obtained through foods or supplements. However, oral administration of vitamin A is often hindered by poor absorption due to its hydrophobic nature and by its easily degradable nature by light and oxygen, particularly at high temperature. This study aimed to prepare a self-assembly vitamin A nanoemulsion with a high loading capacity to improve vitamin A absorption accross intestinal mucosa and to slow down its degradation process. The nanoemulsion was composed by glyceryl monooleate, Cremophor RH-40, and PEG 400 (1:8:1), then titrated with aqueous phase. The nanoemulsion characterization included globule size evaluation, size distribution, zeta potential, globule morphology, entrapment efficiency, physical and chemical stabilities, and ex vivo penetration test on New Zealand albino rabbit intestines. The vitamin A nanoemulsion was found to form transparent and nano-sized emulsions even when loaded with 16.67% vitamin A. The formula also produced 58.1±2.0 nm spherical globules with -0.69 mV zeta potential. Entrapment efficiency of vitamin A in the nanoemulsion was higher than 95%. The nanoemulsion shows stable after storage for 10 days at room temperature, as well as able to increase penetration rate compared to free vitamin A. Taken together, our established vitamin A nanoemulsion has a good stability and was proved to increase vitamin A absorption through intestinal mucosa while simultaneously decreased the vitamin A degradation rate.

DEVELOPMENT AND CHARACTERIZATION OF POLYCLONAL ANTIBODY OF RECOMBINANT HUMAN INTERFERON Α2B IN NEW ZEALAND WHITE RABBIT Heni Rachmawati
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

We have developed recombinant wild type and mutant human interferon α2b (rhIFNα2b) from synthetic gene in Escherichia coli. To identify the successful product of the proteins, immunology-based assay was suggested due to specificity for characterization. This work was aimed to develop and characterize rhIFNα2b polyclonal antibody generated in White New Zealand rabbits. The rhIFNα2b was overproduced in Escherichia coli BL21 containing rhIFNα2b synthetic gene in pET32b.The protein was obtained as inclusion bodies, refolded, purified using nickel affinity chromatography, and characterized using polyacrylamide gel electrophoresis. The purified rhIFNα2b protein was injected into rabbits for 21 days. Absorption of E.coli antibody was done using total E. coli protein to remove antibody againts host cell. The generation of antibody was monitored using dot blot and Western blot methods and quantified using Enzyme Linked Immunsorbant Assay (ELISA). To do so, rhIFNa2b was used as an antigen. The result showed that the rhIFNα2b was produced as a His-tag protein fusion of 33kDa in size. The results of dot blot and Western blot analyses strongly indicated that antibody against rhIFNα2b was generated and specifically recognized rhIFNα2b. ELISA showed that the titer of the polyclonal anti-rhIFNα2b was 1:10.000. In conclusion, polyclonal antibody spesifically against rhIFNα2b protein was successfully detected with high titer after 21 days after rabbit immunization.

INFLUENCE OF STABILIZERS IN MELOXICAM NANOCRYSTAL FORMATION AND ITS APPLICATION ON SUSPENSION ORAL DOSAGE FORM Magdalena Yuni Kristanti; Rachmat Mauludin; Heni Rachmawati
Indonesian Journal of Pharmacy Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Meloxicam is a non steroid anti inflammatory drug that is classified as Biopharmaceutics Classification System (BCS) class II. Meloxicam is poorly soluble in water, therefore its solubility would be the rate limiting step for drug absorption. This study was conducted to improve meloxicam solubility using nanotechnology approach. Meloxicam nanocrystal was prepared using high pressure homogenization technique. Several stabilizers were investigated for suitable nanocrystal production. Formulation of suspension on the meloxicam nanocrystal was developed. Short physical stability was performed to assess the potential use of the stabilizer. Nanocrystal containing 10% meloxicam and 5% PVP K25 was formed faster with better physical stability compared to other stabilizers (xanthan gum, HPMC 2910 type 603 dan 645). Meloxicam nanocyrstal suspension containing meloxicam nanocrystal with stabilizer 5% or 10% of PVP K25 showed excellent particle size stability (with particle size 466.6nm and 486.9nm) and dissolution rate compared to reference product (without nanonization). Particle size and dissolution rate of meloxicam nanocrystal suspensions (containing 5% or 10% of PVP K25) were stable after storage for 30 days at room temperature. Kinetic solubility of meloxicam nanocrystal was three times higher than that of meloxicam. According to XRD profile, there was no differences in crystallinity between meloxicam and meloxicam nanocrystal.Key words: meloxicam, high pressure homogenizer, nanocrystal,dissolution rate, kinetic solubility

Tablet of captopril with a cross-linked system of alginate Sukmadjaja Asyarie; Heni Rachmawati; Pricillia Sinambela
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Captopril has a short biological half life (1-3h) and has been used for long-term treatment of hypertension. The properties of captopril such as freely water-soluble and instability in intestinal environment lead to the difficulty of developing captopril as a sustained-release preparation. . In this study, sustained-release of captopril was prepared with a matrix system using sodium alginat as a polymeric forming-matrix. The ratio of sodium alginat and captopril was 1:2. Matrix system was obtained by forming alginate cross-linked with a various concentration of calcium acetate. Xanthan gum was used to help cross-linked reaction. Tablet was prepared by wet granulation and the dissolution test was performed in HCl 0.01 N, paddle method, 100 rpm, for 12 h. Although release profile of captopril from all formula developed were different, the release of captopril sustained up 12 h. Formula containing 30 % of xanthan gum and 40 % of sodium alginate showed the best release profile of captopril and the hardness of tablets do not influence to the release of captopril. Tablet of captopril with a crosslinked system of alginate sustained the release of captopril until 12 h .Key words: captopril, sustained-release, sodium alginat, calcium acetat.

Optimization of Human Interferon α2b Soluble Protein Overproduction and Primary Recovery of Its Inclusion Bodies RATIH ASMANA NINGRUM; DEBBIE SOFIE RETNONINGRUM; YEYET CAHYATI; HENI RACHMAWATI
Microbiology Indonesia Vol. 5 No. 1 (2011): March 2011
Publisher : Indonesian Society for microbiology

The hIFN2b open reading frame has been constructed and overexpressed in Escherichia coli BL21(DE3). The yields of protein purified using nickel column from inclusion bodies (IB) and total soluble proteins were 3.46 mg and 2.57 mg in 1 L culture, respectively. This research was aimed to obtain optimal condition for high level overproduction of soluble hIFNα2b as well as primary recovery of hIFN2b from IB. We used two different conditions for obtaining soluble protein, i.e. induction temperatures and inducer concentrations, and three different conditions for inclusion bodies, i.e. centrifugation speeds, washing and solubilizing buffers. Induction using 0.5 mM of isopropyl thiogalactopyranoside at 25 °C yielded 8.9 mg hIFN2b in 1 L culture. The best recovery of IB was achieved when 10 000 g was applied for centrifugation, 1% Triton X-100 in 50 mM Tris Cl pH 8.0 as washing buffer, and 8M guanidine HCl in 50 mM Tris Cl pH 8.0 containing 800 mM 2-mercaptoethanol as solubilizing buffer were used. At this optimal condition the yield of hIFN2b from IB was 28.85 mg in 1 L culture. The total recovery of hIFNα2b at optimal condition was 50% from IB and 14% from soluble protein. hIFN2b from IB was refolded by 9 d dialysis in refolding buffer (0.2 mM EDTA, 0.25 mM ditiothreitol, 50 mM Tris and 0.4 M urea pH 8.0).

Community Empowerment Through Sulfur Soap Preparation for Dermatitis Prevention Amirah Adlia; Sakinah Aljuffrie; Annis Catur Adi; Deandra Ardya Regitasari; Vidya Anggarini Rahmasari; Heni Rachmawati
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 1 No. 2 (2019): December 2019
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Background: As a country with a tropical climate, Indonesia has the risk to have many disease problems, such as skin disorder or dermatitis. Dermatitis is an either acute, sub-acute, or chronic inflammatory skin disease. One of therapies is using sulfur compound. Purpose: The objective of this program was to improve public awareness of Tulungagung Regency on the importance of health care, to train people preparing soap containing sulfur, and to help the people to empower the economic community through home industry initiation. Methods: This program was done by motivation generating, counseling, advocacy, and education. The activities were performed through counseling about skin diseases, causes, the prevention and treatment of the disease with sulfur soap, demonstration and providing training to the community about sulfur soap. Results: The training on handmade soap preparation was conducted at the Village Hall of Mojosari, Kauman, Tulungagung, on July 28-29th 2019 and was attended by 20 female participants. The socialization programme was carried out by providing technical guidance, visual exposure of materials, packaging training through small groups. Conclusion: This training program of soap containing sulfur preparation attracted public attention to gain the science, knowledge, and skill increase business motivation, knowledge, and community skills as well as motivation generation to apply a simple technology of soap containing sulfur manufacturing.

COMMUNITY EMPOWERMENT IN PINEAPPLE AGROINDUSTRY WASTE UTILIZATION AS AN INGREDIENT OF SNACKS IN SUBANG DISTRICTS Annis Catur Adi; Mahmud Aditya Rifqi; Deandra Ardya Regitasari; Vidya Anggarini Rahmasari; Wizara Salisa; Heni Rachmawati
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 2 No. 2 (2020): DECEMBER 2020
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Background:The development of agro-industry in Indonesia remains facing many obstacles. In addition to the environmental wasteproblem, the low ability to process products leads to their low added value, as faced bypineapple agro-industry associationin Barokah Agro Lestari (BAL). This community service activity is important to improve beneficial and economical value of pineapple agro-industry. Purpose: This activity aims to reduce the environmental burdenof pineapple agro-industry by product by implementing technology to give its added value as well as providing a healthy snack alternative for society. Method: This community service activity is carried out through counseling, training and education related to waste product of pineapple. These activities included the preparation phase, the selection of organic waste of pineapple, bioactive component testing, testing of nutrients and food formulation. Results:The community service program was conducted at PT Karya Masyarakat Mandiri in Subang District and attended by 30 pineapple farmers from Cirangkong village, gathered in Barokah Agro Lestari (BAL). Training was done by administering stages of activity systemically, exposure of the material using visual methods, cooking demonstration for the training activities of processing and product development. Conclusion: Community service activities and training in processing the pineapple stem waste can be a means of empowering local communities. Processing organic waste into food products help improving the community skills and motivation for business development through organic waste treatment.

PENGEMBANGAN SISTEM PEMBAWA ALBUMIN NANOPARTIKEL UNTUK SILIMARIN DAN KAJIAN SIFAT FISIK SERTA PROFIL PELEPASANNYA SECARA IN VITRO Rini Ambarwati; Heni Rachmawati
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 7, No 2 (2017): Fitofarmaka Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Silimarin merupakan senyawa flavonolignan yang berasal dari tumbuhan Silybum marianum (Asteraceae). Silimarin memiliki efek farmakologi sebagai antikanker dan hepatoprotektor, tetapi senyawa ini memiliki kelarutan yang rendah dalam air. Tujuan penelitian ini adalah mengembangkan formulasi silimarin dalam sistem pembawa nano dengan teknik desolvasi. Pembawa yang digunakan adalah serum albumin (bovine serum albumin/BSA). Kombinasi silimarin dalam BSA diharapkan dapat meningkatkan efikasi silimarin sebagai anti kanker karena permeabilitas BSA yang lebih baik pada sel kanker. Evaluasi standar terhadap nanopartikel silimarin-BSA meliputi ukuran dan distribusi ukuran partikel, zeta potensial, morfologi nanopartikel, kristalinitas, sifat termal, spektroskopi inframerah, efisiensi penjeratan serta profil pelepasan silimarin dari BSA nanopartikel pada 2 media berbeda (HCl 0,1 N PBS pH 7,4). Nanopartikel BSA- silimarin memiliki ukuran partikel 174,23 13,94 nm; distribusi ukuran partikel 0,185 0,052; efisiensi penjeratan 90,54 0,098 %; loading capacity 30,18 0,036 % dan zeta potensial -1,62 mV. Hasil analisis menggunakan DSC (differential scanning calorimetry), XRD (X-ray diffraction) dan spektroskopi inframerah menunjukan bahwa nanopartikel silimarin berhasil terenkapsulasi di dalam nanopartikel BSA, dan BSA-silimarin memiliki bentuk amorf. Setelah 1 jam uji pelepasan, terdapat sebanyak 21,89% silimarin terlepas dalam HCl 0,1 N dan 54,84% silimarin terlepas dalam PBS pH 7,4 sehingga dapat disimpulkan bahwa silimarin-BSA memiliki kelarutan yang baik dalam air. Oleh karena itu, perlu dilakukan pengujian lebih lanjut untuk mengkaji akt ivitas serta perilaku silimarin-BSA in vivo untuk mengkonfirmasi data in vitro.

Co-Authors Abdillah, Oktaviardi Bityasmawan Agustiyanti, Dian Fitria Alfan Danny Arbianto Ali Iqbal Tawakal Ali Iqbal Tawakal Amalia, Riezki Ambarwati, Rini Amirah Adlia Amirah Adlia Amirah Adlia Anna Smdyah Putri Anna Surgean Veterini Anna Surgean Veterini Annis Catur Adi Arbianto, Alfan Danny Arini Setiawati Asrul Muhamad Fuad Asrul Muhamad Fuad, Asrul Muhamad Atsarina Anindya Bambang Wahjuprajitno Citra Ariani Edityaningrum, Citra Damar Rasti Adhika Deandra Ardya Regitasari Deandra Ardya Regitasari DEBBIE SOFIE RETNONINGRUM Debbie Sofie Retnoningrum DEBBIE SOFIE RETNONINGRUM Dewi Esti Restiani Dian Fitria Agustiyanti Dwiyatna, Archie Arman Emyr Reisha Ishaura Estherina Juliana Marbun, Estherina Juliana Farapti Farapti Fathrizqita Aghnia Raudhany Fatona Suraya, Fatona Ferry Iskandar Fibriani, Azzania Hamzah Hamzah Herdiani Sulistyo Putri Hidayat, Erzi I Ketut Adnyana Irda Fidrianny Isaura, Emyr Reisha Iskandar, Fery Jessie S. Pamudji Kusnandar Anggadiredja Leonny Yulita Hartiadi Lili Fitriani Magdalena Yuni Kristanti Maharani, Dita Galuh Mahmud Aditya Rifqi Marlina Indriastuti Meirawan, Rizky Fajar Muhammad mahrus zain Nancy Margarita Rehatta Nelly Setiawaty Nuthathai Sutthiwong Pambudi, Sabar Permatasari, Fitri A. Permatasari, Fitri Aulia Pricillia Sinambela Putri, Dea Mayang Yulia Rachmad Suhanda Rachmadani, Nisa Amanda Rachmat Mauludin Rahmah, Ainur Rahmana E. Kartasasmita Rahmana E. Kartasasmita Rasyidi, Mohammad Fahmi RATIH ASMANA NINGRUM Rehatta, Nancy Margarita Resmi, Juniar Kalpika Restiani, Dewi Esti Rika Hartati Rini Ambarwati S.Pd. M Kes I Ketut Sudiana . Sabar Pambudi Safira Prisya Dewi Sakinah Aljuffrie Salisa, Wizara Santika, Arum Sinda Sari, Ririn Andika Sarmanu, Sarmanu Satuman Satuman Shafiqah Adam Siti Fatimah Zahro Soetomo, Meilisa Keizia Sophi Damayanti Subijanto Marto Soedarmo Subijanto Marto Soedarmo Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sulistiawan, Soni Sunarso Taharuddin, Audrey Angelina Putri Tarwadi Tarwadi Tarwadi, Tarwadi Tjandrawati Mozef Tri Suciati Vidya Anggarini Rahmasari Vidya Anggarini Rahmasari Wenda Novayani Wibowo, Indra Widijiati Widijiati Widjiati Widjiati Widodo Jatim P Widodo Jatim Pudjirahardjo Widodo, Ferri Wijayanti, Ni PAD. Wizara Salisa Wizara Salisa Wizara Salisa Yeyet C. Sumirtapura YEYET CAHYATI Yogie Handoko

Title

Found 34 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 34 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 34 Documents
Search