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All Journal Dentika Dental Journal Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease ODONTO Dental Journal Jurnal Penelitian Pendidikan Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Akuntansi dan Pajak Indonesian Journal of Chemistry Indonesian Journal of Dental Medicine Berkala Penelitian Hayati Odonto dental journal Bhakta Dental Journal Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis
Retno Pudji Rahayu
Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : Bhakta Dental Journal

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Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hanif, Hilmy Irsyadi; Zafar, Anis Fatimah; Puteri, Astari; Wati, Sisca Meida; Rahayu, Retno Pudji
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i02.47

Abstract

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.
Co-Authors - UBSI Karawang, Djulaeha A. Toto Purnomo Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Sosiawan Aisah Faiz Bachmid Amir, Muhammad Subhan Aqsa Sjuhada Oki Ardyni Febri K Azhar, Imam Safari Banerjee, Abhishek Basalamah, Fatimah F. Bhagat, James Antony Bimo Dwi Lukito, Bimo Dwi Budi Utomo Caesario, Jefferson Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Cinantya, Aulia Dian Danoediningrat, Coen Pramono David B. Kamadjaja Desiana Radithia, Desiana Devi Oktaviani, Paramita Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Elizabeth, Laurencia Dwiamanda Elly Munadziroh Ernie Maduratna Setiawatie Fadila, Okta Mulia Nur Fedik Abdul Rantam Ferdiansyah Ferdiansyah Firjani, Putri Nabila Fitria Rahmitasari Hanif, Hilmy Irsyadi Hansen Kurniawan Haryono Utomo Hening Tuti Hendarti Imannia, Ristya Sylva Indra Lila Kusuma, Indra Lila Ira Arundina Islamy, Azzahra Hasnur Juniastuti Juniastuti Kharinna Widowati Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love LMS Kristiyanti, LMS Loverita, Dyta M. Qushay, M. Maharani Laillyza Apriasari Maharani, Annissaqiella Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Marks, Luc A. M. Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Maya Widyana Dewi Melathi, Harum Merlynike Leo, Leviena Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Ni Putu Mira Sumarta Nugraha, Ilyas Yakob Nurul Nurina Febriyanti Ayuningtyas Nuzulistina, Elvin Pasaribu, Togu Andrie S. Pramitha, Selviana R. Pratiwi, Chandrasasi Berlian Pratiwi, Desy Nur Prihartini Widiyanti Purwaningrum, Vegananda Wahyu Puspa Dila Rohmaniar Puteri, Astari Putri, Destiana Hardianti Rahmah, Shafwa Aisha Ramadan, Doaa Elsayed Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Riskayanti, Ni Putu S.Pd. M Kes I Ketut Sudiana . Saka Winias Salsabila, Alisya Rachel sari, Rima parwati Septian Pradana, Septian Setiawan, Kresna Erlangga Shallomitha, Aginta Gracia Sisca Meida Wati Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Sri Agoes Soedjarwo Sri Hernawati Sri Wigati Mardi Mulyani Supandji, Rafaelle Raditya Surboyo, Meircurius Dwi Condro Syahdiar, Aura Zalfa Ghassani Syamsulina Revianti Tania Saskianti Theresia Indah Budhy Sulisetyawati Titiek Berniyanti Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Yani Corvianindya Rahayu Yanty Wirza Zafar, Anis Fatimah