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All Journal Dentika Dental Journal Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease ODONTO Dental Journal Jurnal Penelitian Pendidikan Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Akuntansi dan Pajak Indonesian Journal of Chemistry Indonesian Journal of Dental Medicine Berkala Penelitian Hayati Odonto dental journal Bhakta Dental Journal Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis
Retno Pudji Rahayu
Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Curcumin in Turmeric (Curcuma longa L.) for Treatment of Oral Lichen Planus: A Narrative Review Purwaningrum, Vegananda Wahyu; Elizabeth, Laurencia Dwiamanda; Pratiwi, Chandrasasi Berlian; Nugraha, Ilyas Yakob Nurul; Setiawan, Kresna Erlangga; Maulina, Syafriaz Zulfa; Rahmah, Shafwa Aisha; Shallomitha, Aginta Gracia; Firjani, Putri Nabila; Supandji, Rafaelle Raditya; Salsabila, Alisya Rachel; Islamy, Azzahra Hasnur; Livesey, Gisele Nefertari Love; Masitoh, Hindun Fitria; Fadila, Okta Mulia Nur; Putri, Destiana Hardianti; Cinantya, Aulia Dian; Syahdiar, Aura Zalfa Ghassani; Wati, Sisca Meida; Rahayu, Retno Pudji; Budhy, Theresia Indah; Banerjee, Abhishek
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.40-43

Abstract

Background: Turmeric (Curcuma longa L.) has long been used as a traditional medicine. The primary active component of turmeric is curcumin. It has potential anti-inflammatory effects and high antioxidant activity. Curcumin contained in turmeric has been reported as an effective treatment for Oral lichen planus (OLP). OLP is a chronic autoimmune, inflammatory disease of the oral mucosa associated with systemic disease. This disease involves the skin and mucous membranes (mucocutaneous) of stratified squamous epithelium. Purpose: This narrative review conducted on Google Scholar, PubMed, Research Gate, and ScienceDirect databases aims to study the effectiveness of curcumin contained in Turmeric (C. longa L.)   in OLP treatment. Review(s): OLP is a condition of the oral mucosa that is a chronic autoimmune mucocutaneous disease. As many as 0.5% to 2.2% of cases of OLP occur in the adult population. Systemic and topical corticosteroid drugs are usually used to treat OLP. However, the use of these drugs has many side effects, so it needs searching for a new active substance to treat OLP. Curcumin is a hydrophobic polyphenol extracted from the rhizome of the herb Curcuma longa (turmeric), which has a low molecular weight. The repeated use of steroids can cause side effects that cause atrophy of the mucosa and candidiasis. One natural product that is superior to corticosteroids is curcumin. This is due to curcumin's anti-inflammatory, antioxidant, and chemopreventive properties in several diseases. Conclusion: This review suggests that OLP treatment using curcumin in Turmeric (C. longa L.)   is effective because curcumin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities, as well as immunomodulatory properties.
Unusual odontogenic keratocyst with impacted maxillary central incisor: A diagnosis challenge Purnamasari, Shinta; Marks, Luc A. M.; Devi Oktaviani, Paramita; Merlynike Leo, Leviena; Mulyawan, Indra; Rahayu, Retno Pudji; Saskianti, Tania
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 4 (2024): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i4.p298-304

Abstract

Background: Odontogenic keratocyst (OKC) is considered an odontogenic cyst, with the unique clinical characteristics of this entity being local destruction, aggressive behavior, a high recurrence rate, specific histopathologic features, and the tendency for multiple lesions when associated with syndromes. Odontogenic keratocyst accounts for 12–14% of all cysts in the jaws. Purpose: The aim of this case report is to present an unusual odontogenic keratocyst associated with impacted maxillary central incisor, case management of anterior maxilla odontogenic keratocyst involving an adjacent tooth, and its postoperative six-month follow-up. Case: A 13-year-old female patient was referred to the Universitas Airlangga Hospital with a complaint that her upper front teeth had not erupted. The parents revealed that the patient had suffered trauma from falling down the stairs at the age of four, i.e., eight years ago. Case Management: The cyst was enucleated together with the associated permanent upper right central incisor, retained deciduous upper right central incisor, the permanent upper right lateral incisor, and upper right canine. Post surgical treatment, the patient used a partial denture to increase her self-confidence. Conclusion: Enucleation of the cyst with extraction of the permanent teeth should be performed to avoid recurrence of the OKC. Periodic radiographic evaluation is required with long-term follow-up.
Immuno-expression analysis of VEGF and CD34 related to histological types of mandibular ameloblastoma Pradana, Septian; Kamadjaja, David Buntoro; Danoediningrat, Coen Pramono; Sumarta, Ni Putu Mira; Amir, Muhammad Subhan; Rahayu, Retno Pudji; Bhagat, James Antony
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p144-150

Abstract

Background: Increased expression of vascular endothelial growth factor (VEGF) and cluster of difference 34 (CD34) in ameloblastoma has been noted. Both proteins are markers of angiogenesis that play a role in supporting the growth of ameloblastoma. The existence of histopathological types of ameloblastoma allows for differences in behavioral and growth characteristics. Purpose: To evaluate the differences and correlation of VEGF and CD34 expression in histological types of ameloblastoma. Methods: This laboratory cross-sectional study uses total sampling from histological slides of mandibular ameloblastoma. Two observers manually quantified the immunohistochemical expression. The comparative data were analyzed statistically with the Kruskal–Wallis test (p < 0.05), while the correlative data were analyzed with Spearman’s rho (p<0.01). Results: 32 samples were obtained according to the inclusion criteria. The Kruskal–Wallis test showed significant differences in VEGF expression (p = 0.003) and CD34 expression (p = 0.026). The pairwise comparison test showed that VEGF expression in follicular ameloblastoma significantly differed from plexiform (p = 0.001) and combination (p = 0.002). The pairwise comparison test for CD34 expression showed a significant difference between follicular and combination ameloblastoma (p = 0.007). Spearman’s rho test showed a positive correlation (p = 0.001, r = 0.565) between markers. Conclusion: Follicular ameloblastoma expressed higher VEGF than plexiform and combination ameloblastoma. Follicular ameloblastoma expressed higher CD34 than combination types. CD34 expression is associated with VEGF in histological types of ameloblastoma.
ANTI-INFLAMMATORY POTENTIAL OF FUNGUS COMBS FROM INDO-MALAYAN TERMITE MACROTERMES GILVUS HAGEN MOUND: REVIEW ARTICLE Rahayu, Retno Pudji; Mulyani, Sri Wigati Mardi; Imannia, Ristya Sylva; Caesario, Jefferson; Loverita, Dyta; Nuzulistina, Elvin
Jurnal Biosains Pascasarjana Vol. 27 No. 1 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i1.2025.18-24

Abstract

There is evidence that termite colonies of the subfamily Termitomyces produce an unusual structure called a fungus comb, especially Termite mounds in Indo-Malaysian regions. This comb may include bioactive components that the termites use to investigate if they might aid in the body's inflammatory response. The anti-inflammatory potential, concentration, and bioavailability of fungal comb from the Indo-Malayan termite macrotermes gilvus Hagen mound will be further discussed in this research. We utilized databases to review the current evidence related to anti-inflammatory potential of fungus combs and termite macrotermes gilvus hagen mound. We discussed the most recent evidence of fungus combs and termite macrotermes gilvus mound regarding the anti-inflammatory potential, concentration, and bioavailability. This study concludes that ethyl acetate extract from fungus comb could enhance the immune system. Phenolic compounds have a positive effect on health indicators. These mechanisms may account for the decreased prevalence of chronic degenerative disorders in populations.
The effect of musa acuminata stem in increasing macrophage and neovascular cells of healing process Apriasari, Maharani Laillyza; Puspitasari, Dewi; Rahayu, Retno Pudji; Ernawati, Diah Savitri
Padjadjaran Journal of Dentistry Vol 30, No 2 (2018): July 2018
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.226 KB) | DOI: 10.24198/pjd.vol30no2.18324

Abstract

Introduction: Musa acuminata stem has both of imunostimulatory and imunosuppressant effects that are influenced by their concentrations. The study aimed to analyze the effect of Mauli banana stem extract (EMBS) to increase the number of macrophage and neovascular cells in traumatic ulcer healing. Methods: Rattus norvegicus of male Wistar strain  were used  as model of traumatic ulcer. The left buccal mucous was biopsied, then used the histopathology method to find the number of macrophage and neovascular cells. Results: EMBS gel was effected when administered at a concentration of 37.5% because it significantly increased the number of macrophage and neovascular cells in traumatic ulcer healing on the 3rd day to 5th days. Conclusion:  It can be concluded that EMBS within concentration of 37.5% can accelerate ulcer healing through the increasing  number of macrophage and neovascular cells.
Analisis pengaruh dana desa, alokasi dana desa, bagi hasil pajak dan retribusi, pendapatan asli desa dan luas wilayah terhadap belanja desa bidang pembangunan desa Rahayu, Retno Puji; Pratiwi, Desy Nur; Kusuma, Indra Lila
Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis Vol. 1 No. 3 (2024): Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis
Publisher : Nur Science Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/kurva.v1i3.1088

Abstract

This study aims to analyze the impact of the Village Fund Allocation, Village Fund, Revenue Sharing of Taxes and Levies, Village Original Income, and Area Size on Village Expenditure in the field of Village Development. This research utilizes quantitative methods and utilizes secondary data gained from the Village Information System of Sukoharjo Regency and the Central Bureau of Statistics. The villages in the Sukoharjo Regency comprise the study's population. Purposeful sampling technique was employed, yielding a resulting sample of 149 villages. The results showed that the Village Fund, Village Fund Allocation, and Village Original Income had a substantial impact on village expenditure in the field of village development. At the same time, the Revenue Sharing of Taxes and Levies and the area does not have a substantial impact on village spending in the field of village development.
Effect of freeze-dried platelet-rich plasma on FGF-2 and type I collagen expression in traumatic ulcers of diabetes mellitus: An in vivo study Riskayanti, Ni Putu; Radithia, Desiana; Maharani, Annissaqiella; Hendarti, Hening Tuti; Rahayu, Retno Pudji; Surboyo, Meircurius Dwi Condro; Ernawati, Diah Savitri
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p361-366

Abstract

Background: Diabetes mellitus is a chronic disease characterized by the pancreas’s inadequate production of insulin or the body’s impaired utilization of insulin, resulting in dysregulation of blood sugar levels. Diabetes mellitus causes prolonged wound healing due to decreased growth factors, including fibroblast growth factor 2 (FGF-2) and type I collagen. Purpose: This research analyzes the effect of topical administration of freeze-dried platelet-rich plasma (FD-PRP) on the healing process of traumatic ulcers in diabetic Wistar rats by increasing FGF-2 and type I collagen expression. Methods: Allogenic FD-PRP was obtained from the blood of 35 Wistar rats and 2% carboxymethyl cellulose (CMC) was added to make a gel formulation. Diabetes was induced in 30 Wistar rats using streptozotocin, followed by the creation of traumatic ulcers on the lower labial mucosa using a hot burnisher. The traumatic ulcers were then topically treated with FD-PRP gel in the treatment group and 2% CMC gel in the control group. Analysis of FGF-2 and type I collagen expression was performed through indirect immunohistochemical methods following treatment for 3, 5, and 7 days. Results: The expression of FGF-2 and type I collagen in the FD-PRP was higher than in the control group (p < 0.05). Conclusion: Topical application of FD-PRP plays an important role, especially in increasing the FGF-2 and type 1 collagen expression, in the healing process of traumatic ulcers in diabetic Wistar rats.
MORINGA OLEIFERA EXTRACT CAN INHIBIT GLOMERULUS DAMAGE OF RATTUS NOVERGICUS INJECTED CYCLOPHOSPHAMIDE Laurencia Dwiamanda Elizabeth; Budhy, Theresia Indah; Rahayu, Retno Pudji
Jurnal Biosains Pascasarjana Vol. 26 No. 1 (2024): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v26i1.2024.8-14

Abstract

Cyclophosphamide is a cytostatic used in chemotherapy. Cyclophosphamide has a toxic effect that causes damage to the kidneys. Moringa oleifera is a plant with high antioxidant activity. Its antioxidant content in the form of flavonoids and vitamin C which can inhibit glomerulus damage. Many studies have proven that Moringa oleifera contains high antioxidant activity. However, there has been no research about the potential of Moringa oleifera in inhibiting glomerulus damage that was injected with cyclophosphamide. The purpose of this study was to determine the potential of Moringa oleifera in inhibiting glomerulus damage in Rattus novergicus due to cyclophosphamide injection. This was a laboratory experiment with a post-test only control group design. This study used 18 Rattus norvegicus as samples which was divided into 3 sample groups namely K1 is the group that was only given NaCl, K2 was the group that was given NaCl and injected by cyclophosphamide, and the treatment group was given Moringa oleifera extract. Glomerulus histopathological preparations were stained with Hematoxylin Eosin. Data were analyzed statistically by the Kruskall Wallis and Mann-Whitney tests. The Mann-Whitney test showed significant difference between groups K1 and K2 and groups of P and K2 (p<0.05). There were no significant differences between K1 and P (p>0.05). Giving Moringa oleifera extract can inhibit the glomerular damage of Rattus novergicus, which is injected with cyclophosphamide.
Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hanif, Hilmy Irsyadi; Zafar, Anis Fatimah; Puteri, Astari; Wati, Sisca Meida; Rahayu, Retno Pudji
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i02.47

Abstract

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.
ANALISIS EFEKTIVITAS PELAKSANAAN BANTUAN TUNAI LANGSUNG (BLT) Dewi, Maya Widyana; Rahayu, Retno Puji; Melathi, Harum; Kristiyanti, LMS
Jurnal Akuntansi dan Pajak Vol. 25 No. 1 (2024): JAP : Vol. 25, No. 1, Februari 2024 - Juli 2024
Publisher : ITB AAS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The implementation of development programs is directed at improving the social welfare of the community so that they can live properly and be able to develop themselves, so that they can carry out their social functions. Poverty is one of the social inequalities that must be overcome when development is carried out. The Direct Cash Transfer (BLT) program is one of the government initiatives aimed at improving people's welfare. The objective to be achieved in this research is to determine the effectiveness of the implementation of the Direct Cash Transfer (BLT). In this study, researchers used descriptive data analysis techniques by collecting data by conducting interviews, observation, documentation and literature. The implementation of BLT distribution in Lumbungkerep village showed less than optimal results, namely in the indicators of targeting accuracy and benefit accuracy. The cause of the lack of targeting accuracy was poor coordination between levels of government regarding BLT recipient data. There were also allegations of nepotism that occurred in the selection process of BLT recipient candidates. Meanwhile, the cause of the non-optimized accuracy of benefits was that the BLT funds were not used in accordance with the purpose of the BLT funds themselves, but to cover other needs besides primary needs.
Co-Authors - UBSI Karawang, Djulaeha A. Toto Purnomo Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Sosiawan Aisah Faiz Bachmid Amir, Muhammad Subhan Aqsa Sjuhada Oki Ardyni Febri K Azhar, Imam Safari Banerjee, Abhishek Basalamah, Fatimah F. Bhagat, James Antony Bimo Dwi Lukito, Bimo Dwi Budi Utomo Caesario, Jefferson Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Cinantya, Aulia Dian Danoediningrat, Coen Pramono David B. Kamadjaja Desiana Radithia, Desiana Devi Oktaviani, Paramita Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Elizabeth, Laurencia Dwiamanda Elly Munadziroh Ernie Maduratna Setiawatie Fadila, Okta Mulia Nur Fedik Abdul Rantam Ferdiansyah Ferdiansyah Firjani, Putri Nabila Fitria Rahmitasari Hanif, Hilmy Irsyadi Hansen Kurniawan Haryono Utomo Hening Tuti Hendarti Imannia, Ristya Sylva Indra Lila Kusuma, Indra Lila Ira Arundina Islamy, Azzahra Hasnur Juniastuti Juniastuti Kharinna Widowati Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love LMS Kristiyanti, LMS Loverita, Dyta M. Qushay, M. Maharani Laillyza Apriasari Maharani, Annissaqiella Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Marks, Luc A. M. Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Maya Widyana Dewi Melathi, Harum Merlynike Leo, Leviena Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Ni Putu Mira Sumarta Nugraha, Ilyas Yakob Nurul Nurina Febriyanti Ayuningtyas Nuzulistina, Elvin Pasaribu, Togu Andrie S. Pramitha, Selviana R. Pratiwi, Chandrasasi Berlian Pratiwi, Desy Nur Prihartini Widiyanti Purwaningrum, Vegananda Wahyu Puspa Dila Rohmaniar Puteri, Astari Putri, Destiana Hardianti Rahmah, Shafwa Aisha Ramadan, Doaa Elsayed Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Riskayanti, Ni Putu S.Pd. M Kes I Ketut Sudiana . Saka Winias Salsabila, Alisya Rachel sari, Rima parwati Septian Pradana, Septian Setiawan, Kresna Erlangga Shallomitha, Aginta Gracia Sisca Meida Wati Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Sri Agoes Soedjarwo Sri Hernawati Sri Wigati Mardi Mulyani Supandji, Rafaelle Raditya Surboyo, Meircurius Dwi Condro Syahdiar, Aura Zalfa Ghassani Syamsulina Revianti Tania Saskianti Theresia Indah Budhy Sulisetyawati Titiek Berniyanti Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Yani Corvianindya Rahayu Yanty Wirza Zafar, Anis Fatimah