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All Journal Dentika Dental Journal Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease ODONTO Dental Journal Jurnal Penelitian Pendidikan Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Indonesian Journal of Chemistry Indonesian Journal of Dental Medicine Berkala Penelitian Hayati Eduvest - Journal of Universal Studies Odonto dental journal Bhakta Dental Journal Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis

Retno Pudji Rahayu

Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga

Author-ID : 355029

Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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ANALYSI S ON SECONDARY I NFECTI ON- TRI GGERI NG MICROORGANISMS IN HIV/AIDS PATIENTS AS A MODEL FOR POLICY CONTROL Rahayu, Retno Pudji; Nasronudin, Nasronudin; Indrawati, Retno; Widiyanti, Prihartini; Lukito, Bimo Dwi; Ferdiansyah, Ferdiansyah; Khairunisa, Siti Qomariyah; Mutamsari, Adiana; Kotaki, Tomohiro
Indonesian Journal of Tropical and Infectious Disease Vol. 5 No. 4 (2015)
Publisher : Institute of Topical Disease Universitas Airlangga

HIV infection is associated with immune-compromised and rising in opportunistic infection (secondary infection). Therefore, the number of mortality caused by HIV/AIDS is increasing. The use of ARV and development of HIV/AIDS management are expected to suppress the progress of HIV infection into AIDS and, therefore, the mortality can be diminished, while in fact most of the patients eventually suffer from AIDS due to secondary infection that commonly causes death. There should be a management by analysing microorganisms that trigger secondary infection. The method of this study was observational descriptive with cross sectional design. HIV infected blood samples were using ELISA Antibody (IgG and IgM) and Polymerase Chain Reaction (PCR) on laboratory test. The result showed correlation between HIV/AIDS severity and the amount and types of secondary infection. The most common secondary infections were toxoplasm (96.77%), hepatitis C (22.58%), tuberculosis (19.35%), and hepatitis B (3.22%). Other less frequent secondary infections, which were quite difficult to diagnose and not commonly found in Indonesia, were West Nile Virus (25.81%), Japanese Encephalitis Virus (3.22%), and Enterovirus (3.22%). Due to MDGs (Millenium Development Goals) target and the results above, researchers are highly demanded to contribute in decreasing mortality related to AIDS through early detection of secondary infection,including type of infection which have not been commonly found in Indonesia, such as West Nile Virus and Nipah Virus. The discovery of secondary infection in this study was not enough to suppress the occurrence of infection in HIV/AIDS patients. Antimicrobes and good nutrition are required. Moreover, there should be either a primary or secondary prophylaxis to prevent secondary infection that raises the number of mortality and morbidity of HIV/AIDS patients. The result of this study was to meet the target of MDGs by establishing new policies in handling HIV/AIDS infections and have potential as model for policy control in HIV/AIDS.

Stress-induced Oral Lichen Planus Immunopathogenesis and Potential Therapy: A Narrative Review Basalamah, Fatimah F.; Pramitha, Selviana R.; Pasaribu, Togu Andrie S.; Rahayu, Retno Pudji; Ayuningtyas, Nurina Febriyanti; Ernawati, Diah Savitri
Indonesian Journal of Dental Medicine Vol. 5 No. 2 (2022): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v5i2.2022.57-61

Background: Oral lichen planus is a chronic inflammatory condition that only involves in the oral cavity and is mediated by the cellular immune system. The etiology of OLP is unclear but autoreactive T lymphocytes are considered to play an important role in the development of OLP. Factors like stress and psychological anxiety have been associated with OLP but their roles in the development of OLP is yet explored. Purpose: To describe stress-induced OLP immunopathogenesis and therapeutic potential. Reviews: In the early stages, the mechanism of OLP involves the expression of keratinocyte antigens or exposure to an antigen in the form of self-peptide or heat shock protein (HSP). HSP90 is the most expressed heat shock protein in the basal layer of keratinocytes and plays a role in recruitment of cellular immune cells through the production of cytokines due to TLR2/4 and CD91 activation, inflammatory cell migration due to 4 integrin activation, and increased antigen presentation due to HSP90-peptide binding to MHC class I/II. Stress as a physiological response triggers the release of the hormone cortisol from the adrenal cortex and catecholamine hormones such as epinephrine/ adrenaline and norepinephrine/noradrenaline from the adrenal medulla. Catecholamines increase the migration of T lymphocyte cells through the interaction of integrins and integrin ligands on the endothelium through the expression of 2-integrin after binding to adrenergic receptors on the cell membrane. Conclusion: Oral lichen planus is a chronic inflammatory condition caused by various factors where stress increases the migration of T lymphocyte cells on the side that expresses self-peptides and antigens through the interaction of immune cells with catecholamines. Topical nonselective beta blockers can be supporting therapy in reducing pain and size of OLP lesions.

Curcumin in Turmeric (Curcuma longa L.) for Treatment of Oral Lichen Planus: A Narrative Review Purwaningrum, Vegananda Wahyu; Elizabeth, Laurencia Dwiamanda; Pratiwi, Chandrasasi Berlian; Nugraha, Ilyas Yakob Nurul; Setiawan, Kresna Erlangga; Maulina, Syafriaz Zulfa; Rahmah, Shafwa Aisha; Shallomitha, Aginta Gracia; Firjani, Putri Nabila; Supandji, Rafaelle Raditya; Salsabila, Alisya Rachel; Islamy, Azzahra Hasnur; Livesey, Gisele Nefertari Love; Masitoh, Hindun Fitria; Fadila, Okta Mulia Nur; Putri, Destiana Hardianti; Cinantya, Aulia Dian; Syahdiar, Aura Zalfa Ghassani; Wati, Sisca Meida; Rahayu, Retno Pudji; Budhy, Theresia Indah; Banerjee, Abhishek
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.40-43

Background: Turmeric (Curcuma longa L.) has long been used as a traditional medicine. The primary active component of turmeric is curcumin. It has potential anti-inflammatory effects and high antioxidant activity. Curcumin contained in turmeric has been reported as an effective treatment for Oral lichen planus (OLP). OLP is a chronic autoimmune, inflammatory disease of the oral mucosa associated with systemic disease. This disease involves the skin and mucous membranes (mucocutaneous) of stratified squamous epithelium. Purpose: This narrative review conducted on Google Scholar, PubMed, Research Gate, and ScienceDirect databases aims to study the effectiveness of curcumin contained in Turmeric (C. longa L.) in OLP treatment. Review(s): OLP is a condition of the oral mucosa that is a chronic autoimmune mucocutaneous disease. As many as 0.5% to 2.2% of cases of OLP occur in the adult population. Systemic and topical corticosteroid drugs are usually used to treat OLP. However, the use of these drugs has many side effects, so it needs searching for a new active substance to treat OLP. Curcumin is a hydrophobic polyphenol extracted from the rhizome of the herb Curcuma longa (turmeric), which has a low molecular weight. The repeated use of steroids can cause side effects that cause atrophy of the mucosa and candidiasis. One natural product that is superior to corticosteroids is curcumin. This is due to curcumin's anti-inflammatory, antioxidant, and chemopreventive properties in several diseases. Conclusion: This review suggests that OLP treatment using curcumin in Turmeric (C. longa L.) is effective because curcumin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities, as well as immunomodulatory properties.

Unusual odontogenic keratocyst with impacted maxillary central incisor: A diagnosis challenge Purnamasari, Shinta; Marks, Luc A. M.; Devi Oktaviani, Paramita; Merlynike Leo, Leviena; Mulyawan, Indra; Rahayu, Retno Pudji; Saskianti, Tania
Dental Journal Vol. 57 No. 4 (2024): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i4.p298-304

Background: Odontogenic keratocyst (OKC) is considered an odontogenic cyst, with the unique clinical characteristics of this entity being local destruction, aggressive behavior, a high recurrence rate, specific histopathologic features, and the tendency for multiple lesions when associated with syndromes. Odontogenic keratocyst accounts for 12–14% of all cysts in the jaws. Purpose: The aim of this case report is to present an unusual odontogenic keratocyst associated with impacted maxillary central incisor, case management of anterior maxilla odontogenic keratocyst involving an adjacent tooth, and its postoperative six-month follow-up. Case: A 13-year-old female patient was referred to the Universitas Airlangga Hospital with a complaint that her upper front teeth had not erupted. The parents revealed that the patient had suffered trauma from falling down the stairs at the age of four, i.e., eight years ago. Case Management: The cyst was enucleated together with the associated permanent upper right central incisor, retained deciduous upper right central incisor, the permanent upper right lateral incisor, and upper right canine. Post surgical treatment, the patient used a partial denture to increase her self-confidence. Conclusion: Enucleation of the cyst with extraction of the permanent teeth should be performed to avoid recurrence of the OKC. Periodic radiographic evaluation is required with long-term follow-up.

Expression Of Osteoblasts In Periodontitis With Material Preservation Pocket Technique Gengigel® (Hyaluronic Acid 0.2%) Dwi Wahyu Indrawati; Ernie Maduratna Setyawatie; A. Retno Pudji Rahayu; Rizky Briliant Syah Manurung; Anis Khoirin Hayati
Eduvest - Journal of Universal Studies Vol. 4 No. 10 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i10.1503

Hyaluronic acid as a socket preservation material can absorb large amounts of hydration and regulate appropriate pressure in the surrounding tissue, resulting in expansion of the extracellular space. The socket preservation technique used is a solution to bone loss due to tooth extraction. However, research on the hyaluronic acid (Gengigel) material in sockets with periodontitis has not yet been clearly studied. In this study, we will see an increase in the number of osteoblasts in the alveolar bone after tooth extraction in Wistar rats with periodontitis. To determine the increase in the number of osteoblasts after administering Hyaluronic acid to the tooth sockets of Wistar rats with periodontitis. An increase in the number of osteoblast cells was observed using a multi-head light microscope in 5 areas of the preparation at 400x magnification. The measurement results from 5 areas are averaged and a calculation is obtained for one preparation. There are 2 groups that will be used in this research, namely the Control group (without treatment), HA (given Gengigel). Each group was tested at 14 and 21 days after administering the material. The research results showed that the Hyaluronic Acid (Gengigel) group had a higher number of osteoblast cells than the control group. The one-way ANOVA test showed an average significance result of 0.000 (p < 0.05) for all groups. This indicates that there was a significant change in each treatment group. Giving hyaluronic acid to the tooth sockets of Wistar rats with periodontitis can increase the number of osteoblast cells.

Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hilmy Irsyadi Hanif; Anis Fatimah Zafar; Astari Puteri; Sisca Meida Wati; Retno Pudji Rahayu
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.

Immuno-expression analysis of VEGF and CD34 related to histological types of mandibular ameloblastoma Pradana, Septian; Kamadjaja, David Buntoro; Danoediningrat, Coen Pramono; Sumarta, Ni Putu Mira; Amir, Muhammad Subhan; Rahayu, Retno Pudji; Bhagat, James Antony
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p144-150

Background: Increased expression of vascular endothelial growth factor (VEGF) and cluster of difference 34 (CD34) in ameloblastoma has been noted. Both proteins are markers of angiogenesis that play a role in supporting the growth of ameloblastoma. The existence of histopathological types of ameloblastoma allows for differences in behavioral and growth characteristics. Purpose: To evaluate the differences and correlation of VEGF and CD34 expression in histological types of ameloblastoma. Methods: This laboratory cross-sectional study uses total sampling from histological slides of mandibular ameloblastoma. Two observers manually quantified the immunohistochemical expression. The comparative data were analyzed statistically with the Kruskal–Wallis test (p < 0.05), while the correlative data were analyzed with Spearman’s rho (p<0.01). Results: 32 samples were obtained according to the inclusion criteria. The Kruskal–Wallis test showed significant differences in VEGF expression (p = 0.003) and CD34 expression (p = 0.026). The pairwise comparison test showed that VEGF expression in follicular ameloblastoma significantly differed from plexiform (p = 0.001) and combination (p = 0.002). The pairwise comparison test for CD34 expression showed a significant difference between follicular and combination ameloblastoma (p = 0.007). Spearman’s rho test showed a positive correlation (p = 0.001, r = 0.565) between markers. Conclusion: Follicular ameloblastoma expressed higher VEGF than plexiform and combination ameloblastoma. Follicular ameloblastoma expressed higher CD34 than combination types. CD34 expression is associated with VEGF in histological types of ameloblastoma.

ANTI-INFLAMMATORY POTENTIAL OF FUNGUS COMBS FROM INDO-MALAYAN TERMITE MACROTERMES GILVUS HAGEN MOUND: REVIEW ARTICLE Rahayu, Retno Pudji; Mulyani, Sri Wigati Mardi; Imannia, Ristya Sylva; Caesario, Jefferson; Loverita, Dyta; Nuzulistina, Elvin
Jurnal Biosains Pascasarjana Vol. 27 No. 1 (2025): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbp.v27i1.2025.18-24

There is evidence that termite colonies of the subfamily Termitomyces produce an unusual structure called a fungus comb, especially Termite mounds in Indo-Malaysian regions. This comb may include bioactive components that the termites use to investigate if they might aid in the body's inflammatory response. The anti-inflammatory potential, concentration, and bioavailability of fungal comb from the Indo-Malayan termite macrotermes gilvus Hagen mound will be further discussed in this research. We utilized databases to review the current evidence related to anti-inflammatory potential of fungus combs and termite macrotermes gilvus hagen mound. We discussed the most recent evidence of fungus combs and termite macrotermes gilvus mound regarding the anti-inflammatory potential, concentration, and bioavailability. This study concludes that ethyl acetate extract from fungus comb could enhance the immune system. Phenolic compounds have a positive effect on health indicators. These mechanisms may account for the decreased prevalence of chronic degenerative disorders in populations.

The effect of musa acuminata stem in increasing macrophage and neovascular cells of healing process Apriasari, Maharani Laillyza; Puspitasari, Dewi; Rahayu, Retno Pudji; Ernawati, Diah Savitri
Padjadjaran Journal of Dentistry Vol 30, No 2 (2018): July 2018
Publisher : Faculty of Dentistry Universitas Padjadjaran

Introduction: Musa acuminata stem has both of imunostimulatory and imunosuppressant effects that are influenced by their concentrations. The study aimed to analyze the effect of Mauli banana stem extract (EMBS) to increase the number of macrophage and neovascular cells in traumatic ulcer healing. Methods: Rattus norvegicus of male Wistar strain were used as model of traumatic ulcer. The left buccal mucous was biopsied, then used the histopathology method to find the number of macrophage and neovascular cells. Results: EMBS gel was effected when administered at a concentration of 37.5% because it significantly increased the number of macrophage and neovascular cells in traumatic ulcer healing on the 3rd day to 5th days. Conclusion: It can be concluded that EMBS within concentration of 37.5% can accelerate ulcer healing through the increasing number of macrophage and neovascular cells.

Analisis pengaruh dana desa, alokasi dana desa, bagi hasil pajak dan retribusi, pendapatan asli desa dan luas wilayah terhadap belanja desa bidang pembangunan desa Rahayu, Retno Puji; Pratiwi, Desy Nur; Kusuma, Indra Lila
Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis Vol. 1 No. 3 (2024): Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis
Publisher : Nur Science Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/kurva.v1i3.1088

This study aims to analyze the impact of the Village Fund Allocation, Village Fund, Revenue Sharing of Taxes and Levies, Village Original Income, and Area Size on Village Expenditure in the field of Village Development. This research utilizes quantitative methods and utilizes secondary data gained from the Village Information System of Sukoharjo Regency and the Central Bureau of Statistics. The villages in the Sukoharjo Regency comprise the study's population. Purposeful sampling technique was employed, yielding a resulting sample of 149 villages. The results showed that the Village Fund, Village Fund Allocation, and Village Original Income had a substantial impact on village expenditure in the field of village development. At the same time, the Revenue Sharing of Taxes and Levies and the area does not have a substantial impact on village spending in the field of village development.

Co-Authors - UBSI Karawang, Djulaeha A. Toto Purnomo Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Sosiawan Aisah Faiz Bachmid Amir, Muhammad Subhan Anis Fatimah Zafar Anis Khoirin Hayati Aqsa Sjuhada Oki Ardyni Febri K Astari Puteri Azhar, Imam Safari Banerjee, Abhishek Basalamah, Fatimah F. Bhagat, James Antony Bimo Dwi Lukito, Bimo Dwi Budi Utomo Caesario, Jefferson Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Cinantya, Aulia Dian Danoediningrat, Coen Pramono David B. Kamadjaja Desiana Radithia, Desiana Devi Oktaviani, Paramita Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Doaa Elsayed Ramadan Dwi Wahyu Indrawati Elizabeth, Laurencia Dwiamanda Elly Munadziroh Ernie Maduratna Setiawatie Ernie Maduratna Setyawatie Fadila, Okta Mulia Nur Fedik Abdul Rantam Ferdiansyah Ferdiansyah Firjani, Putri Nabila Fitria Rahmitasari Hansen Kurniawan Haryono Utomo Hening Tuti Hendarti Hilmy Irsyadi Hanif Imannia, Ristya Sylva Indra Lila Kusuma, Indra Lila Ira Arundina Islamy, Azzahra Hasnur Juniastuti Juniastuti Kharinna Widowati Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love Loverita, Dyta M. Qushay, M. Maharani Laillyza Apriasari Maharani, Annissaqiella Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Marks, Luc A. M. Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Merlynike Leo, Leviena Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Ni Putu Mira Sumarta Nugraha, Ilyas Yakob Nurul Nurina Febriyanti Ayuningtyas Nuzulistina, Elvin Pasaribu, Togu Andrie S. Pramitha, Selviana R. Pratiwi, Chandrasasi Berlian Pratiwi, Desy Nur Prihartini Widiyanti Purwaningrum, Vegananda Wahyu Puspa Dila Rohmaniar Putri, Destiana Hardianti Rahmah, Shafwa Aisha Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Riskayanti, Ni Putu Rizky Briliant Syah Manurung S.Pd. M Kes I Ketut Sudiana . Saka Winias Salsabila, Alisya Rachel sari, Rima parwati Septian Pradana, Septian Setiawan, Kresna Erlangga Shallomitha, Aginta Gracia Sisca Meida Wati Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Sri Agoes Soedjarwo Sri Hernawati Sri Wigati Mardi Mulyani Supandji, Rafaelle Raditya Surboyo, Meircurius Dwi Condro Syahdiar, Aura Zalfa Ghassani Syamsulina Revianti Tania Saskianti Theresia Indah Budhy Theresia Indah Budhy Sulisetyawati Titiek Berniyanti Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Yani Corvianindya Rahayu Yanty Wirza

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