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All Journal Dentika Dental Journal Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease ODONTO Dental Journal Jurnal Penelitian Pendidikan Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Akuntansi dan Pajak Smart Medical Journal Indonesian Journal of Chemistry Indonesian Journal of Dental Medicine Berkala Penelitian Hayati Eduvest - Journal of Universal Studies Odonto dental journal Bhakta Dental Journal Kurva: Jurnal Ekonomi Manajemen Keuangan dan Bisnis
Retno Pudji Rahayu
Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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THE EFFECTIVITY OF SCAFFOLD FROM ANADARA GRANOSA SHELL-STICHOPUS HERMANNI ON BLOOD VESSEL COUNTS AFTER TOOTH EXTRACTION Sari, Rima Parwati; Kusumawardani, Chaterina Dyah Nanik; Rahayu, Retno Pudji; Soedjarwo, Sri Agoes; Damaiyanti, Dian Widya
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.576 KB) | DOI: 10.30659/odj.8.2.11-17

Abstract

ABSTRACTBackground: Alveolar bone resorption can occur after tooth extraction. One source of bone scaffold material is hydroxyapatite and tricalcium phosphate (HA-TCP). The shell of Anadara granosa can be synthesized to be HA-TCP. Hyaluronic acid, which is widely contained in Stichopus hermanni, can stimulate endothelial progenitor cells for the healing process. Purpose: This research aims to prove the Effectivity of scaffold from Anadara granosa shell-Stichopus hermanni on blood vessel counts after tooth extraction. Methods: The sample in this study was male Wistar rats divided into four study groups randomly. Each group consists of 6 rats. Extraction was carried out on the mandibular first incisor, then was given gelatin as a placebo in the control group, treatment groups given scaffold from Anadara granosa shells (AG), and scaffold combination from Anadara granosa shells-Stichopus hermanni with concentrations of 0.4%-0.8%. (AGSH1-AGSH2). Development of HA-TCP synthesized from Anadara granosa combined with Stichopus hermanni extract for biomedical scaffolds using the freeze-dried method. Observations were made three days after tooth extraction. Data analysis has used one-way ANOVA followed by Tukey HSD (p<0.05). Results: The results of the ANOVA test followed by the HSD-Tukey test showed a significant difference between C (7.33±1.51) and AGSH1 (11.50±1.38), AGSH2 (21.17±1.94), AG (9.33±1.63) and AGSH1 with AGSH2, but between AG and, AGSH1 no significant differences.Conclusions: Combination scaffold from Anadara granosa shell and Stichopus hermanni 0.8% effectively increased blood vessel counts after tooth extraction.
Effect of freeze-dried platelet-rich plasma on FGF-2 and type I collagen expression in traumatic ulcers of diabetes mellitus: An in vivo study Ni Putu Riskayanti; Desiana Radithia; Annissaqiella Maharani; Hening Tuti Hendarti; Retno Pudji Rahayu; Meircurius Dwi Condro Surboyo; Diah Savitri Ernawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p361-366

Abstract

Background: Diabetes mellitus is a chronic disease characterized by the pancreas’s inadequate production of insulin or the body’s impaired utilization of insulin, resulting in dysregulation of blood sugar levels. Diabetes mellitus causes prolonged wound healing due to decreased growth factors, including fibroblast growth factor 2 (FGF-2) and type I collagen. Purpose: This research analyzes the effect of topical administration of freeze-dried platelet-rich plasma (FD-PRP) on the healing process of traumatic ulcers in diabetic Wistar rats by increasing FGF-2 and type I collagen expression. Methods: Allogenic FD-PRP was obtained from the blood of 35 Wistar rats and 2% carboxymethyl cellulose (CMC) was added to make a gel formulation. Diabetes was induced in 30 Wistar rats using streptozotocin, followed by the creation of traumatic ulcers on the lower labial mucosa using a hot burnisher. The traumatic ulcers were then topically treated with FD-PRP gel in the treatment group and 2% CMC gel in the control group. Analysis of FGF-2 and type I collagen expression was performed through indirect immunohistochemical methods following treatment for 3, 5, and 7 days. Results: The expression of FGF-2 and type I collagen in the FD-PRP was higher than in the control group (p < 0.05). Conclusion: Topical application of FD-PRP plays an important role, especially in increasing the FGF-2 and type 1 collagen expression, in the healing process of traumatic ulcers in diabetic Wistar rats.
Ashwagandha and Chronic Stress: A Review of Its Neuroimmune Modulatory Potential Iskandar, Assyfa Ulti; Rahayu, Retno Pudji; Ma'ruf, Anwar; Budhy, Theresia Indah
Smart Medical Journal Vol 8, No 2 (2025): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v8i2.105715

Abstract

Introduction: Chronic stress disrupts neuroimmune homeostasis, driving neuroinflammation and neuronal damage. Despite growing interest in natural interventions, comprehensive reviews on ashwagandha’s dual neuro-immunomodulatory mechanisms remain limited. This review examines ashwagandha’s potential in mitigating chronic stress-induced neuroimmune dysregulation.Methods: A review was conducted by searching PubMed, Scopus, and Google Scholar for relevant preclinical and clinical studies published between 2015 and 2025. Studies were selected based on their focus on Ashwagandha’s effects on the hypothalamic–pituitary–adrenal (HPA) axis, cytokine expression, oxidative stress, and neuroprotection. Data were extracted and synthesized thematically.Results: Ashwagandha was found to downregulate pro-inflammatory cytokines (TNF-α, IL-6), inhibit NF-κB signaling, and enhance antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT). Clinical and animal studies reported cortisol reduction, attenuation of microglial activation, increased brain-derived neurotrophic factor (BDNF) levels, improved T-cell proliferation and NK cell activity, and restoration of Th1/Th2 balance. These mechanisms were associated with improved mood, cognition, and stress resilience.Conclusion: Ashwagandha demonstrates multimodal neuroimmune modulation, offering a promising natural therapeutic for stress-related disorders. Standardized extracts warrant further investigation for clinical translation.
Co-Authors - UBSI Karawang, Djulaeha A. Toto Purnomo Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Sosiawan Aisah Faiz Bachmid Amir, Muhammad Subhan Anis Khoirin Hayati Annissaqiella Maharani Aqsa Sjuhada Oki Ardyni Febri K Astari Puteri Azhar, Imam Safari Banerjee, Abhishek Basalamah, Fatimah F. Bhagat, James Antony Bimo Dwi Lukito, Bimo Dwi Budi Utomo Caesario, Jefferson Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Cinantya, Aulia Dian Damaiyanti, Dian Widya Danoediningrat, Coen Pramono David Buntoro Kamandjaja Desiana Radithia, Desiana Devi Oktaviani, Paramita Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Elizabeth, Laurencia Dwiamanda Elly Munadziroh Ernie Maduratna Setiawatie Fadila, Okta Mulia Nur Fedik Abdul Rantam Ferdiansyah Ferdiansyah Firjani, Putri Nabila Fitria Rahmitasari Hanif, Hilmy Irsyadi Hansen Kurniawan Haryono Utomo Hening Tuti Hendarti Imannia, Ristya Sylva Indra Lila Kusuma, Indra Lila Indrawati, Dwi Wahyu Ira Arundina Iskandar, Assyfa Ulti Islamy, Azzahra Hasnur Juniastuti Juniastuti Kharinna Widowati Kusumawardani, Chaterina Dyah Nanik Laurencia Dwiamanda Elizabeth Livesey, Gisele Nefertari Love LMS Kristiyanti, LMS Loverita, Dyta M. Qushay, M. Ma'ruf, Anwar Maharani Laillyza Apriasari Manurung, Rizky Briliant Syah Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Marks, Luc A. M. Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Maya Widyana Dewi Melathi, Harum Merlynike Leo, Leviena Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Ni Putu Mira Sumarta Ni Putu Riskayanti Nugraha, Ilyas Yakob Nurul Nurina Febriyanti Ayuningtyas Nuzulistina, Elvin Pasaribu, Togu Andrie S. Pramitha, Selviana R. Pratiwi, Chandrasasi Berlian Pratiwi, Desy Nur Prihartini Widiyanti Purwaningrum, Vegananda Wahyu Putri, Destiana Hardianti Rahmah, Shafwa Aisha Ramadan, Doaa Elsayed Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Rima Parwati Sari, Rima Parwati Rohmaniar, Puspa Dila S.Pd. M Kes I Ketut Sudiana . Saka Winias Salsabila, Alisya Rachel sari, Rima parwati Septian Pradana, Septian Setiawan, Kresna Erlangga Setyawatie, Ernie Maduratna Shallomitha, Aginta Gracia Sisca Meida Wati Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah Soedjarwo, Sri Agoes Sri Agoes Soedjarwo Sri Hernawati Sri Wigati Mardi Mulyani Supandji, Rafaelle Raditya Surboyo, Meircurius Dwi Condro Syahdiar, Aura Zalfa Ghassani Syamsulina Revianti Tania Saskianti Theresia Indah Budhy Sulisetyawati Titiek Berniyanti Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Yani Corvianindya Rahayu Yanty Wirza Zafar, Anis Fatimah