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All Journal Jurnal Kedokteran Brawijaya Jurnal Kesehatan Reproduksi Nexus Kedokteran Klinik Universa Medicina Indonesian Journal of Medicine Journal of Health Promotion and Behavior Journal of Maternal and Child Health Proceedings of the International Conference on Nursing and Health Sciences Folia Medica Indonesiana
Supriyadi Hari Respati
Bagian Obgin FK UNS/ RSUD Dr. Moewardi, Jl. Kol. Sutarto 132 Surakarta
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Universa Medicina

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Recombinant vascular endothelial growth factor 121 decreases vascular cell adhesion molecule-1 in murine pre-eclampsia model placenta Sulistyowati, Sri; Sondakh, John Arianto; Yuliantara, Eric Edwin; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.192-198

Abstract

BackgroundPreeclampsia is one of the major contributors to maternal and fetal morbidity and mortality. Imbalance of soluble Fms-like tyrosine kinase (sFlt-1) as anti-angiogenic factor and vascular endothelial growth factor (VEGF) as pro-angiogenic factor plays a role in the pathogenesis of preeclampsia. Endothelial dysfunction in preeclampsia causes vascular cell adhesion molecule-1 (VCAM-1) to be expressed on its surface. This study aims to evaluate the effect of recombinant VEGF-121 on VCAM-1 expression in the placenta of a murine preeclampsia model. Methods An experimental analytical study conducted from February until March 2016 in the Biomedical Laboratory, Faculty of Veterinary Medicine, Airlangga University. The study sample consisted of 30 pregnant mice, divided into three groups, i.e. 10 normal pregnant mice, 10 mice with preeclampsia model and 10 mice with preeclampsia model and recombinant VEGF-121 therapy. All animals were subjected to immunohistochemical examination of VCAM-1 expression in their placentas. The results were assessed semiquantitatively according to a modified Remmele method. Data analysis was done using one-way ANOVA and Tukey’s multiple comparisons method. ResultsMean VCAM-1 expression in normal (0.97 ± 0.54%) murine placentas, compared with placentas (2.94 ± 0.96%) of murine preeclampsia models (p=0.000), while mean VCAM-1 expression in placentas of murine preeclampsia models with VEGF intervention was 2.14 ± 0.68% (p=0.030).Conclusion Recombinant VEGF-121 can reduce VCAM-1 expression in placentas of murine preeclampsia models. The present study has shown the potential benefits of VEGF therapy, justifying serious consideration of this therapeutic approach for use in women with preeclampsia.
Co-Authors -, Soetrisno - Adhi, Kresno Condro Adiyana, Febrian Andhika Alamsyah, Meuthia Ambar Mudigdo Antonius Budi Giri Bawono, Antonius Budi Giri Argyo Demartoto, Argyo Aris Sudiyanto Aristin, Okid Parama Arwiyantasari, Wida Rahma Astetri, Lini Bachnas, Muhammad Adrianes Bambang Eko Wiyono, Bambang Eko Bhisma Murti Carissa, Dinda Diffah Hanim Ediningtyas, Atifa Nadira Elita Rahmi Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fajriah, Asruria Sani Fitriawan, Ahmad Hermawan Udiyanto Heru Priyanto John Arianto Sondakh, John Arianto Kartikasari, Uswatun Khasanah Karuniawati, Benny Khoeronisa, Siti Kurniawan, Hendro Kusnadi, Noferi Laqif, Abdurahman Mahandaru, Araafi Hariza Miftahus Saadah, Miftahus Mubarokah, Rizka Innayatun Muhammad Adrianes Bachnas MUHAMMAD AGUS SUPRAYUDI Nababan, Ronald Nasrudin, Muhamad Nugroho, Muhammad Anggit Nurinasari, Hafi Nurul Husna Nutria Widya Purna Anggraini Nuur, Aliffudin Okid Parama Astirin Pella Todungbua', Prima Derry Pradana, Muhammad Denny Gagah Prasetya, Hanung Pujojati, Ferri Waluyo Wiwoho Rahmawati, Deni Nur Fauzia Rahmawati, Oktantia Dyah Rasyiid, Astika Ratna Diana Fransiska Ratnasari Dwi Cahyanti, Ratnasari Dwi Ratnasari, Affi Angelia Ridwan, Robert Rizkiani, Inne RUBEN DHARMAWAN Saputra, Ricky Bernadi Sesunan, Arfan Syahfani SITI MARYANI Soetrisno Kasan Wiharjo, Soetrisno Kasan Soetrisno Soetrisno Sri Mulyani Sri Sulistyowati Sulistywati, Sri Uki Retno Budihastuti Ulfah, Maharani Wiraswesty, Ika WISNU PRABOWO Yeni Andriani, Yeni Yuliani, Saffana Oka