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All Journal Jurnal Ilmiah Farmasi PHARMACON Pharmascience Jurnal Kelautan Nasional Energi & Kelistrikan Jurnal Hilirisasi IPTEKS (JHI) Avant Garde As-Syar'i : Jurnal Bimbingan & Konseling Keluarga Marine Kreatif Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks An-Nidhom : Jurnal Manajemen Pendidikan Islam Jurnal Ilmiah Wahana Pendidikan JIKEM: Jurnal Ilmu Komputer, Ekonomi dan Manajemen Pharmaceutical And Biomedical Sciences Journal (PBSJ) Khatulistiwa: Jurnal Pendidikan dan Sosial Humaniora Jurnal Karya Pengabdian Teknik Mesin Journal of Creative Student Research Jurnal Publikasi Ilmu Manajemen Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan Jurnal Riset Rumpun Ilmu Ekonomi (JURRIE) Jurnal Manajemen Dan Bisnis Ekonomi Jurnal Riset Manajemen dan Ekonomi Jurnal Pengabdian Bersama Masyarakat Indonesia Guruku: Jurnal Pendidikan dan Sosial Humaniora (JIMBE) Alfihris: Jurnal Inspirasi Pendidikan Akuntansi: Jurnal Riset Ilmu Akuntansi Morfologi : Jurnal Ilmu Pendidikan, Bahasa, Sastra dan Budaya Jurnal Penelitian Ilmu Ekonomi dan Keuangan Syariah Perspektif: Jurnal Pendidikan dan Ilmu Bahasa Dharma Acariya Nusantara: Jurnal Pendidikan, Bahasa dan Budaya Jurnal Pendidikan, Bahasa dan Budaya Dinamika Pertanian Bilangan: Jurnal Ilmiah Matematika, Kebumian dan Angkasa Akhlak: Jurnal Pendidikan Agama Islam Dan Filsafat Jurnal Pendidikan dan Sosial Humaniora
Salman Salman
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences Transportation Veterinary Other

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Journal : Jurnal Ilmiah Farmasi

 1 
KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000 Erizal Zaini; Rahmi Nofita; Salman Salman; Ima Kurniati
Jurnal Ilmiah Farmasi Vol. 6 No. 1 (2009)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTSolid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG6000) were prepared by the melting method in order to increase the dissolution rates of this poorlywater-soluble compound. The temperature/composition phase diagram of binary system wasanalyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized lighthot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion techniquedecrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofenand polyethylene glycol 6000 respectively, which the results enhanced dissolution rates comparedto the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solidstate were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in soliddispersion.Keywords: solid dispersions, ibuprofen, polyethylene glycol 6000
Co-Authors AA Sudharmawan, AA ABDUL ROHMAN Aditya Alqamal Alianta Afni Putri Hairani Agus Dwi Catur Ahmad Tamrin Sikumbang Ahsanal Kasasiah Alfaridzi Ibnu Syamsudin Alinna Alinna Angga Prayuda Anisa Octavia Anisa Putri Ardana Annisah Rahma Palupi Arpillia Ariska Asyifa Yan Balqis Aysyah Lulu Fuadina Azhoma Gumala Azizah Tulfauziah Deprizon Deprizon Dhea Adrianda Dinda Nugrahan Dwiki Rahmadhana Elidahanum Husni Elsa Badriyah Encep Syarifudin Erizal Zaini Faiz Budi Hakim Fajar Fajar Fithri, Radhiyatul Fitri Ani Lubis Hardian Syahputra Hendry Sakke Tira, Hendry Sakke Henny Lucida Ima Kurniati Imel Ramelia Hudaya Indah Ayu Fitriani Indah Laily Hilmi Iskar Prayoga Ivan Idul Jana Junipranto Silitonga Kamila Kamila Khairunnisya Khairunnisya Latifatul Fajriyah M. Darul Amin Sitorus M. Fatih Naufal M. Qairul Rodzikin M. Rizky Hidayat Mally Ghinan Sholih Mally Sholih Meyer Nixon Nelwan Muhammad Rizky Najamuddin Najamuddin Nanda Putri Maileni Nurbaya Harahap Nurhabibah Harahap Nurjannah Nurjannah Nurlaila Hanum Puja Silvia Puti Andiny Radhiyatul Fitri Rahma Tilla Indah Rahmi Nofita Rani Sugiarti Rifka Rifka Rustini Rustini sakban sakban Sekar Ayu Maharani syaifuddin syaifuddin Syarif Ramadi Syolahudin Sahariawi T. Mauliyanda Tia Salsabilla Tiara Ramadhani Tibrani Tibrani Tsani Arsy Mura Tumarjiyanto Tumarjiyanto USWATUN HASANAH Wismanto Wismanto Yesung Allo Padang Yoanda Eka Putera Yufri Aldi Yusaini Kamal Yusnidar Siregar Yusrizal Yusrizal Zamzami Zulfa