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Abdul Samad
Universitas Muhammadiayah Malang
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Journal : Journal Of World Science

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Brief Overview of MERS: Middle East Respiratory Syndrome Nadeem, Ayesha; Saeed, Hafiza Arshi; Talib, Ambreen; Shah, Rabbya Rayan; Atique, Rameen; Samad, Abdul
Journal of World Science Vol. 3 No. 11 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i11.1226

Abstract

Middle East Respiratory Syndrome (MERS) is a zoonotic disease caused by MERS-CoV, a beta coronavirus with a mortality rate of approximately 35%. The disease exhibits a wide range of clinical symptoms, from mild respiratory issues to severe conditions like multi-organ failure and pneumonia. Person-to-person transmission has led to significant hospital and community outbreaks, underscoring the urgent need for effective infection control measures. This study explores MERS-CoV's epidemiology, pathogenesis, and transmission dynamics, aiming to enhance understanding of its replication, spread, and control strategies due to limited pharmaceutical interventions. A comprehensive review of current literature was conducted, focusing on epidemiological data, genetic characteristics, and transmission patterns across affected regions, including the Middle East, Asia, Africa, and North America. Findings indicate that MERS-CoV originated from recombination events in the spike protein of African dromedaries and spread to the Arabian Peninsula via camels. The virus affects not only humans but also domestic animals like sheep, cattle, horses, and pigs, with global transmission facilitated by travelers, resulting in outbreaks in Asia and North America. Despite extensive research, no effective vaccines, antiviral drugs, or immune therapies control MERS-CoV. The findings emphasize the high pandemic potential of MERS-CoV due to its mortality rate and lack of effective treatments, highlighting the need for strict infection control and further research into viable therapeutic options.
Co-Authors A.A. Ketut Agung Cahyawan W Abdelslam Masoud Abobakr Amhabj Achmad Wicaksono AGUS MUCHSIN, AGUS Ahmad Ahmad Ahmad, Israr Alamsah, Andi Nour Ali, Javaid Amal A. R, Chaerul Andi Velahyati Baharuddin Andi Vita Sukmarini, Andi Vita Anggriani, Nining Anwar, Bushra Apriandi, Doni Areeb Ahmer ARIS ARIS, ARIS Arshi Saeed, Hafiza Atique, Rameen Ayen, Rosalina Yuliana Ayesha Muazzam Baharuddin, Andi Fathussalam Basri, Utari Nur Azizah Biradar, Ghufran Dendi Pratama Ernawan Setyono Erwin Rommel Febriana, Dina Febriansyah Febriansyah Fernanda, Muhammad Hafiz, Abdul Hamdani Hamdani Hamid, Muliyadi Hamid, Siti Hardiyanti Mustaina Handayani, Fransisca Heny Harnen Sulistyo Harnen Sulistyo, Harnen Hertati, Hertati Hossain, Md. Jakir Idris, Jabbar Karim, Ham Kartika MR, Galuh Nashrulloh Keerthana, K. B Kurniawati Kurniawati Kuswari, Zeta Lalitha Devi, A. Ludfi Djakfar Mishal Fatima Muanah, Muanah Muazzam, Ayesha Muh. Ikhsan, Muh. Muhammad Chaerul Muhammad Hamza Muhammad Khoiruddin Harahap Muhammad Ridwan Arif Muhammad Zain Kaleem Mujahid Mujahid, Mujahid Murni Murni Nadeem, Ayesha Nasta'in, Andi Firni Naveed, Areesha Naz, Irum Nurmadhani Fitri Suyuthi Nurnaningsih, Ratna Nurul Alam, AMM Pacitra, Silda Patel , Hrishitva Pradana, Syafa’at Anugrah Pusvitasari, Dwi Putra, Purniadi Rana, Tehreem reddi, Padmavathi Rezwan Shihab, Sk Rini Pebri Utari Ronia, Ronia Rosnaini Daga Saeed, Hafiza Arshi Sahbudin, Muhammad Samad, Mohammad Azwar Sania Tariq Shah, Rabbya Rayan Shehroz Ahmad Sohail, Muhammd Soomro, Hafeezullah Sree Hari, Y. Sri Wahyuningsih St. Rukaiyah Suci, Ida Ayu Sudirman L, Sudirman Sujatmiko Sujatmiko Sultana, Nahida Sung Vioary, Anddy SURIANI, LILIS Suryady, Dedy Sutrawati Syirril Ihromi, Syirril Talib, Ambreen Tariq, Imadullah Thomas, Ronald Wahidin, Ikhsan Waseem Akram Wicaksono, Achmad Yasmi, Yasmi Yusmanizar Yusmanizar Zahra, Maryam Zulkifli Zulkifli