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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication Jurnal Kebidanan Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Farmasi Sains dan Komunitas Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Midwifery Journal: Jurnal Kebidanan UM. Mataram JSFK (Jurnal Sains Farmasi & Klinis) Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas YARSI Medical Journal Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Jurnal Sains Kebidanan Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Conferences of Medical Sciences Dies Natalis Kreativitas Pada Pengabdian Masyarakat (Krepa) Molekul: Jurnal Ilmiah Kimia Borneo Journal of Pharmacy Musyawarah: Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran Fajar: Media Komunikasi dan Informasi Pengabdian Kepada Masyarakat Folia Medica Indonesiana
Subandrate
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Serum Albumin and Globulin Levels in Pulmonary and Extrapulmonary Tuberculosis: A Cross-Sectional Study in Palembang Pearly Laurencia; Subandrate Subandrate; Sadakata Sinulingga; Dwi Indira Setyorini
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.333

Abstract

Introduction. Alterations in serum albumin and globulin reflect inflammatory responses in tuberculosis (TB), but evidence linking them to TB type remains inconsistent. This study investigated the association between serum albumin, globulin, albumin/globulin (A/G) ratio, and TB type (pulmonary [PTB] vs. extrapulmonary [EPTB]) in adult patients at Dr. Mohammad Hoesin Hospital, Palembang. Methods. A cross-sectional study was conducted among adult TB patients with measured serum albumin and globulin levels. TB type was categorized as PTB or EPTB. Associations were analyzed using chi-square tests, and prevalence ratios (PR) were calculated to quantify the strength of associations. Results. Among 251 patients, low serum albumin was more frequent in EPTB (41.7%) than in PTB (28.4%) (p = 0.006; PR = 1.802; 95% CI: 1.178–2.757), indicating EPTB patients were 1.8 times more likely to have low albumin. No significant association was observed for globulin: high globulin occurred in 56.7% of EPTB vs. 52.9% low-to-normal in PTB (p = 0.323; PR = 1.471; 95% CI: 0.682–3.174). Similarly, the A/G ratio showed no significant difference: low A/G ratio in 50% of PTB vs. 42.1% of EPTB (p = 0.676; PR = 1.376; 95% CI: 0.641–2.954). Conclusion. Lower serum albumin is significantly associated with EPTB compared to PTB, whereas globulin and the A/G ratio are not. Albumin may have potential as a supplementary clinical indicator of inflammatory status and disease manifestation in TB, though further longitudinal studies are warranted.
Inhibitory Effect of Ethanol Extract of Cherry Mistletoe Leaves (Dendrophthoe pentandra (L.) Miq) on Xanthine Oxidase Enzyme Hana Daini Sabathania; Subandrate Subandrate; Sadakata Sinulingga; Safyudin Safyudin; Liniyanti D Oswari; Fatmawati Fatmawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008252

Abstract

One plant that can be used as an alternative treatment for hyperuricemia is the cherry plant. The usefulness of these plants is due to the secondary metabolite compounds that can inhibit the enzyme xanthine oxidase. Cherry mistletoe is thought to have the same flavonoids, saponins, alkaloids, terpenoids, and tannins as the cherry plant, which can act as inhibitors. The aim of the study was to determine the inhibitory effect of an ethanol extract of cherry mistletoe leaves on the xanthine oxidase enzyme. This study was conducted as  an in vitro experimental study. Cherry mistletoe leaves were extracted with 96% ethanol. The extract was done with phytochemical screening, followed by an inhibition test on the xanthine oxidase enzyme using a spectrophotometer at a wavelength of 400 nm. Allopurinol was a positive control. The ethanol extract of cherry mistletoe leaves contains flavonoids, saponins, alkaloids, terpenoids, and tannins. The IC50 value of the ethanol extract of cherry mistletoe leaves was 23.44 mg/L. The ethanol extract of cherry mistletoe leaves has an inhibitory effect on the xanthine oxidase enzyme with moderate activity. Accordingly, the cherry mistletoe leaf extract can be considered as an alternative inhibitor of the xanthine oxidase enzyme in the control of hyperuricemia.
Co-Authors Adiyatma Putra Mahardika Adma, Annes Claudia Ahmad, Zen Aldri Frinaldi Alexander Theo Yuda Salean Anggraini Tiara Septiyana Gunawan Aninditia, Fahira Aninditia, Fahira Annes C. Adma Aprilia Putri Arifin, Mutmainah Arrafi, Muhammad Hafizh Athiah, Medina Aulia Firdha Tariza Ayeshah A Rosdah Az Zahra, Fatihah Bebbi Arisya Kesumaputri Danang Bagus Untoro Dazakiah Dazakiah Dita Tri Ramadianti Dwi Indira Setyorini Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Dzakiyah, Dzakiyah Dzakiyah, Dzakiyah Eka Febri Zulissetiana Eka Handayani Oktharina Ella Amalia Ella Amalia, Ella Ellla Amalia Erial Bahar Erial Bahar Eva Syahriana Eva Syahriana Evlin Kohar Ezra Hans Soputra Fadel Fikri Suharto Fadel Fikri Suharto Fahira Aninditia Fahira Aninditia Faisal, Mia EPA Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Fifa Argentina Firdaus, Mutia Muthmainnah Galuh Anggraini Hana Daini Sabathania Hariyadi, Kusumo Hayati, Lusiya Hayati, Lusiya Hermansyah Hermansyah Hermansyah Hestiningsih, Tyas Hutabarat, Yosafat Beltsazar Iche Andriyani Liberty Iche Andriyani Liberty, Iche Andriyani Intan Rahma Dewi Irfannuddin Irfannuddin Irfannudin Irfannudin Irsan Saleh Izzah, Puspita Nurul Kohar, Evlin Kohar, Evlin Kusumo Hariyadi Kusumo Hariyadi Kusumo Hariyadi Kusumo Haryadi Liniyanti D Oswari Liniyanti D. Oswari Liniyanti D. Oswari Lusia Hayati M Fakhri Altiyan M Fitra Romadhon M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Mariana Mariana Mario Saputra Masayu Farah Diba Masayu Farah Diba Mediarty Mediarty Mediarty Mediarty Melina Indah Sari Mgs Irsan Saleh Mgs. Irsan Saleh Mgs. Irsan Saleh Mia EPA Faisal Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Mohamad Sadikin MOHAMAD SADIKIN Mohamad Sadikin Monanda, M Dias Athallah Monanda, M. Dias Athallah Muhammad Irsan Saleh Muniaty Sulam Ng Muthmainnah Arifin Mutiara Budi Azhar Naomi W Tioline Natasha, Amanda Ng, Muniaty Sulam Nita Parisa Nudhar, Lathifah Nur Azizah Nurul Windi Anggraini Nurul Windi Anggraini, Nurul Windi Oktalisa, Wenni Oktharina, Eka Handayani Oswari, Liniyanti Oswari, Liniyanti D Pearly Laurencia Permono, Trijoso Putriana Fuji Safitri Raafqi Ranasasmita Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Rasyid Rini Yana Rini Yana Rini Yana Rizki Andini Nawawi Romadhon, M Fitra Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Safyudin Saleh, Mgs. M. Irsan Salni Salni Salni Salni Salni Salni Salni Santosa, Dorothy Eunike Setyorini, Dwi Indira Soputra, Ezra Hans Soputra, Ezra Hans Sri Hartini Harianja Sri Nita Sri Nita Sri Nita, Sri SRI RAHAYU Sri Wahyuni Suly Auline Rusminan Susilawati Susilawati Susilawati Susilawati Susilawati, Susilawati Tri Suciati Trijoso Permono Trijoso Permono Triwani Triwani Untoro, Danang Bagus Untoro, Danang Bagus Yana, Rini Yudianita Kesuma, Yudianita Zen Hafy