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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN JURNAL KIMIA SAINS DAN APLIKASI Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Medicine Poltekita : Jurnal Ilmu Kesehatan Indonesian Journal of Community Services Abdi Dosen : Jurnal Pengabdian Pada Masyarakat ARSY : Jurnal Aplikasi Riset kepada Masyarakat Jurnal Litbang Edusaintech Jurnal Pengabdian Masyarakat Kedokteran Jurnal Ilmiah Sultan Agung Gema Lingkungan Kesehatan International Journal of Cell and Biomedical Science Biosaintifika: Journal of Biology & Biology Education Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Titiek Sumarawati
Biomedic Departement, Faculty Of Medicine, Islam Sultan Agung University, Semarang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Sungkai Leaf Extract (Peronema canescens Jack) Reduces MDA Levels and Increases IL-10 Levels in MSG-Induced Wistar Rats Wahyudi, Wahyudi; Chodijah, Chodijah; Sumarawati, Titiek; Afrianti, Dina
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.3015

Abstract

The addition of Monosodium Glutamate (MSG) to ready-to-eat food can change eating habits, coupled with a lack of activity which can have an impact on health. MSG as a trigger for increased reactive oxygen species (ROS), causing systemic damage, the impact of excessive MSG consumption can be reduced by modifying the diet to contain high sources of antioxidants. Sungkai leaf extract can be an alternative as a natural antioxidant. Sungkai leaf extract antioxidants are expected to neutralize ROS thereby repairing cell damage. Objective: This study aims to determine how giving sungkai leaf extract affects MDA and IL-10 levels in MSG-induced mice. Method: Experimental research with a Randomized Post test only control group design. The total sample was 24 male Wistar rats divided into 4 groups. KN healthy mice, K(-) were given 1g MSG/rat, P1 was given 1g MSG/rat and 28mg sungkai leaf extract/rat, P2 was given 1g MSG/rat and 56mg sungkai leaf extract/rat. Results: The average results showed a decrease in MDA levels and an increase in IL-10 levels after treatment for 21 days, the One way Anova test followed by Post hoc LSD showed that each treatment group was significantly different from the control group where the MDA level in group P2 was 0, 07mg/ml ± 0.01 experienced a significant decrease compared to the KN group 0.07mg/ml ± 0.01 while IL-10 levels experienced a significant increase in the P1 group 130.10pg/ml ± 13.29 when compared to the KN group 60.43pg/ml ±17.40. Conclusion: Sungkai leaf extract (Penonema Canescens Jack) was able to reduce MDA levels at a dose of 56 mg/mouse in mice injected with 1gr MSG/rat and experienced a significant increase in IL-10 levels with a dose of 28 mg sungkai leaf extract/rat injected with 1gr MSG/rat.
Combination of Eucheuma Cottonii and Corticosteroids has a Superior Immunomodulatory Effect on Asthma Rizaldy, Rheza; Mulyani, Sri Priantini; Sumarawati, Titiek
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.3247

Abstract

Asthma prevalence has been increasing globally which is commonly treated using corticosteroid as gold standard treatment. However, corticosteroids have adverse effects and cases of corticosteroid-resistant asthma are emerging. Eucheuma cottonii (EC) has been shown to potentially attenuate inflammatory response in type I hypersensitivity. This study aimed to investigate the effect of Eucheuma cottonii extract and methylprednisolone combination on IL-4, IL-10, and histamine levels in Ovalbumin-induced asthma BALB/c mice. Thirty female BALB/c mice were randomly assigned to 6 groups : (1) Sham; (2) Ovalbumin-induced asthma mice; (3) Ovalbumin-induced asthma mice treated with methylprednisolone (MP) 0.24 mg/day; (4) Ovalbumin-induced asthma mice treated with EC extract 300 mg/kgBW/day; (5) Ovalbumin-induced asthma mice treated with combination of both. Treatments were given respectively for 7 days. Plasma IL-4, IL-10, and histamine levels were measured using ELISA method. The combination group showed both the lowest IL-4 levels (89.30 ± 1.37 pg/ml) and  the highest IL-10 levels (487.03 ± 20.57 pg/ml) compared to other asthma-like mouse groups (p = 0.001). No significant difference was observed in histamine levels among all treatments (p > 0.05). The administration of a combination of methylprednisolone and Eucheuma cottonii extract significantly affected plasma IL-4 and IL-10 levels compared to monotherapies. However, there was no significant difference in plasma histamine levels compared to monotherapies.
Penyuluhan bagi Kader PKK Desa Banjardowo tentang Potensi Tanaman Kemangi (Ocinum Sanctum Linn) terhadap Kesehatan Sumarawati, Titiek; Chodidjah, Chodidjah; Widayati, Eni; Soetoko, Anita Soraya
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.33-38

Abstract

Tanaman Daun Kemangi (Ociumum sanctum Linn) mengandung banyak senyawa aktif seperti golongan alkaloid, terpenoid, fenolik, saponoid, tannin dan flavonoid yang terbukti mempunyai aktivitas sitotoksik, serta memiliki kadar nilai IC50 pada sel MCF-7 sebesar 6,95 µg/ml. Selain itu juga terbukti bahwa ekstrak etanol kemangi mempunyai aktivitas antioksidan yang sangat kuat. Tujuan pengabdian masyarakat ini adalah untuk mensosialisasikan terkait dengan hasil penelitian mengenai kandungan zat aktif dalam tanaman kemangi yang mempunyai potensi terhadap Kesehatan. Kelurahan banjardowo merupakan desa binaan Fakultas kedokteran universitas islam sultan Agung sehingga lokasi ini dipilih untuk mensosialisasikan hasil penelitian tentang tanaman kemangi mengingat banyaknya manfaat bagi Kesehatan dan meningkatkan pengetahuan ibu ibu. Metode penyuluhan yang digunakan adalah Metode ceramah dan diskusi kelompok, para ibu ibu kader PKK kelurahan BanjarDowo yang mengikuti penyuluhan sebanyak 23 orang, usia 41- 60 tahun sebanyak 16 orang dan usia 25 – 40 tahun sebanyak 7 orang. Hasil analisis nilai pretest dan postest peserta menunjukan terdapat kenaikan nilai rerata peserta pada postest, yaitu 6,70±1,8, dimana sebelum kegiatan penyuluhan dimulai nilai rerata peserta hanya mencapai angka 4,78±1,9. Dari analisis statistik menunjukan adanya perbedaan yang bermakna antara nilai pretest dan postest peserta dengan nilai p=0,000. Dengan pemberian penyuluhan pada kader PKK di kelurahan Banjardowo tentang potensi tanaman kemangi terhadap Kesehatan menunjukkan hasil adanya nilai peningkatan pengetahuan peserta sebelum diberi penyuluhan dan sesudah penyuluhan.The basil leaf plant (Ociumum sanctum Linn) contains many active compounds such as alkaloids, terpenoids, phenolics, saponoids, tannins and flavonoids which have been proven to have cytotoxic activity, and have an IC50 value in MCF-7 cells of 6.95 µg/ml. Apart from that, it has also been proven that basil ethanol extract has very strong antioxidant activity. The aim of this community service is to disseminate research results regarding the content of active substances in basil plants which have potential for health. Banjardowo sub-district is a village supported by the Faculty of Medicine, Sultan Agung Islamic University, so this location was chosen to disseminate the results of research on basil plants considering the many benefits for health and increasing mothers' knowledge. The counseling method used was the lecture and group discussion method, 23 people from PKK cadres from BanjarDowo sub-district took part in the counseling, 16 people aged 41-60 years and 7 people aged 25-40 years. The results of the analysis of participants' pretest and posttest scores showed that there was an increase in the participants' average score on the posttest, namely 6.70 ± 1.8, where before the counseling activities began, the participants' average score only reached 4.78 ± 1.9. Statistical analysis shows that there is a significant difference between the participants' pretest and posttest scores with a p value = 0.000. By providing counseling to PKK cadres in the Banjardowo sub-district about the potential of basil plants for health, the results showed that there was a value in increasing participants' knowledge before being given the counseling and after the counseling.
Tingkat Pengetahuan Penyakit Diabetes Mellitus pada Lansia Peserta BPJS di Klinik Mugi Sehat Jatingaleh Semarang Chodidjah, Chodidjah; Sumarawati, Titiek; Soetoko, Anita Soraya
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.1-5

Abstract

Diabetes mellitus (DM) merupakan penyakit degeneratif atau gangguan metabolisme kronis dengan multi etiologi yang ditandai dengan tingginya kadar gula darah disertai dengan gangguan metabolisme karbohidrat, lipid dan protein sebagai akibat insufisiensi insulin. Klinik Mugi Sehat Jatingaleh merupakan klinik yang melayani peserta BPJS dan tiap bulan dilakukan kegiatan penyuluhan kesehatan bagi lansia penderita Diabetes Mellitus, maka masyarakat lansia peserta BPJS di klinik Mugi Sehat Jatingaleh perlu diberi penyuluhan tentang. Mengenal penyakit Diabetes Mellitus. Metode Penelitian 26 peserta BPJS di Klinik Mugi Sehat Jl. Jatingaleh Semarang sebagai responden dilakukan pretest sebelum diberi penyuluhan post tes setelah penyuluhan, untuk mengetahui tingkat pengetahuan tentang pentingnya pengetahuan penyakit Diabetes Mellitus bagi lansia peserta BPJS di Klinik mugi Sehat Jatingaleh Semarang serta di bagi leaflet untuk belajar menghitung kebutuhan kalori. Hasil pemahaman peserta meningkat setelah di berikan penyuluhan. Kesimpulan Peserta BPJS Lansia yang menderita Diabetes Mellitus memahami dan dapat menghitung kebutuhan kalori untuk mengontrol kadar gula darah.Diabetes mellitus (DM) is a degenerative disease or chronic metabolic disorder with multiple etiologies characterized by blood sugar levels accompanied by metabolic, lipid and protein disorders as a result of insulin insufficiency. Mugi Sehat Jatingaleh Clinic is a clinic that serves BPJS participants and every month health counseling activities are carried out for the elderly with Diabetes Mellitus, so the elderly people who are BPJS participants at the Mugi Sehat Jatingaleh clinic need to be given counseling about. Knowing Diabetes Mellitus. Research Methods 26 BPJS participants at the Mugi Sehat Clinic Jl. Jatingaleh Semarang as a respondent did a pretest before being given counseling after counseling, to determine the level of knowledge about the importance of knowledge about Diabetes Mellitus for the elderly BPJS participants at the Mugi Sehat Clinic Jatingaleh Semarang and distributed leaflets to learn to calculate calorie needs. The results of participants' understanding increased after being given counseling. Conclusion BPJS Elderly participants who suffer from Diabetes Mellitus understand and can calculate calorie needs to control blood sugar levels.
INTRODUCTION TO NUTRITION AND EXCERSICE ON PKK CADRES DURING THE COVID-19 PANDEMIC TIME IN GAJI VILLAGE, DEMAK Sumarawati, Titiek; Chodidjah, Chodidjah; Widayanti, Eni; Fatmawati, Dina
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 6 No. 3 (2022): SEPTEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.962 KB) | DOI: 10.32832/abdidos.v6i3.1262

Abstract

Corona Virus Disease 2019 or commonly abbreviated as COVID-19 is an infectious disease caused by SARS-CoV-2. People with COVID-19 may experience fever, dry cough, and difficulty breathing. With the outbreak, the government gives appealed to the community to leave the house as necessary, work from home and maintain health. Salary village is a village located in Demak Regency, Central Java. Public knowledge about the COVID 19 pandemic is still limited, most people do not know that nutrition and physical exercise can improve the body's immune system and prevent COVID 19 disease. Community service is carried out in Gaji Village due to low public knowledge about nutrition and physical exercise (exercise) during the Covid 19 pandemic. Activities were carried out by providing pre and post-tests, counseling to increase public knowledge, and measuring Body Mass Index with 23 participants. Knowledge about Covid 19 increased but not very significantly while increasing knowledge about nutrition and physical exercise experienced a significant increase among the pre and post-test participants. The results of the BMI measurement of 23 respondents had an ideal body weight of 9 people (39.13 %), overweight 12 people (52.17%), and 2 people obese (8.70%). BMI ideal body weight 39.13%; overweight 52.17% and 8.70% fat.
Exosomes from Hypoxic Mesenchymal Stem Cells Enhance TGF-β Expression and Promote Collagen Regeneration in Wistar Rats with Collagen Loss Kusumawardani, Ade Ifalliah Putri; Subchan, Prasetyowati; Sumarawati, Titiek; Setiawan, Eko
Molecular and Cellular Biomedical Sciences Vol 9, No 3 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i3.647

Abstract

Background: Ultraviolet B (UVB) exposure triggers reactive oxygen species (ROS) formation, inhibits procollagen synthesis via the transforming growth factor-beta (TGF-β)/Smad pathway, and leads to collagen loss. Exosomes derived from hypoxia-conditioned mesenchymal stem cells (EH-MSCs) are more effective than those from normoxic MSCs due to their higher content of miRNAs and cytokines with anti-inflammatory and regenerative properties. This study aims to evaluate the effect of EH-MSC injection on TGF- β levels and collagen density in Wistar male rats with UVB-induced collagen loss. Materials and methods: This in vivo experimental study used a post-test only control group design with 30 rats, divided into five groups: Healthy group, 0.9% NaCl-treated group, hyaluronic acid (HA)-treated group, 200μL EH-MSC-treated group, and 300μL EH-MSC-treated group. TGF-β levels were analyzed using ELISA, while collagen density was assessed with Masson trichrome staining.Results: Highest mean TGF-β levels were observed in the 300μL EH-MSC-treated group (155.56±99.84 pg/mL), while the highest collagen density was found in the Healthy group (23.07±1.81 pg/mL). Mann-Whitney test indicated a significant increase (p=0.008) in TGF-β levels in treatment groups compared to the 0.9% NaCl-treated group. Post Hoc LSD Tamhane test for collagen density also showed a significant increase (p=0.000) in treatment groups compared to the 0.9% NaCl-treated group. Conclusion: EH-MSC injection significantly increased TGF-β levels and collagen density, indicating its potential for promoting skin repair in UVB-induced collagen loss.Keywords: EH-MSC, collagen loss, TGF-β, collagen density 
Hubungan Pola EKG Infark dan Iskemik dengan Derajat Stenosis Berdasarkan Gensini Score Rohman, Fatuh; Abduh, Saugi; Sumarawati, Titiek
Jurnal Kesehatan Andalas Vol. 14 No. 3 (2025): November 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v14i3.2646

Abstract

Myocardial infarction and ischemia are progressive manifestations of coronary heart disease due to coronary artery stenosis. ECG examination can be an initial tool for detecting infarction and ischemia. However, it has relatively low sensitivity and specificity in detecting arterial stenosis. Objective: To determine the relationship between infarction and ischemic ECG patterns with the degree of stenosis based on the Gensini score and risk factors that influence the degree of stenosis. Methods: This observational analytical study employed a cross-sectional design, utilizing secondary data from medical records at RSI Sultan Agung Semarang from January 2018 to December 2023. The degree of stenosis was calculated using the Gensini score method. Results: A total of 500 patient data were analyzed using a Chi-square test to examine ischemic and infarction ECG patterns in relation to the degree of stenosis, yielding a p-value of 0.001 and a contingency coefficient of 0.15. Conclusion: A significant relationship was found between infarction and ischemic ECG patterns, as well as the degree of stenosis, based on the Gensini score, with a very weak correlation strength. Keywords: degree of stenosis, Gensini score, infarction, ischemic
Co-Authors Abdul, Moh Saugi Agung Putra aisah, wipi sari Alamsyah Alamsyah Amalina, Nur Dina Anggraeni, Gilda Putri Aning Susilowati Anita Soetoko Anita Soraya Soetoko Azza, Afa Al Catur Retno Lestari Chodidjah Chodidjah Chodidjah Chodidjah Chodidjah CHODIJAH, CHODIJAH Danis Pertiwi Dina Afrianti1 Dina Fatmawati Eko Setiawan Eni Widayati Fristiani, Yeni Hadi Sarosa Haitamy, Mohammad Nurrizki Hermansyah, Dedi Ibrahim, Sugeng Isna Hudaya, Isna Jessika, Cleveria Joko Wahyu Wibowo Joko Wahyu Widodo Joko Wahyu Widodo Kusumawardani, Ade Ifalliah Putri Laili, Ni'mah Hidayatul M. Saugi Abduh Maharani, Sahara Maulidia, Meli Minidian Fasitasari Muhar, Adi Muradi Muliatul Jannah, Muliatul Mulyani, Sri Priantini Nafi'a, Zidni Ilman Nenik Faozah noven afiyata Pramukarso, Dodik Tugasworo Pramukarso Prasetyowati Subchan, Prasetyowati Purmawanti, Sri Purwaningsih, Hesti Purwito Soegeng Purwito Soegeng Rahim, Denasa Dwi Sopandita Riyanto, Anwar Rizaldy, Rheza Rohman, Fatuh Roy, Adryan Saugi Abduh Saugi Abduh Setyo Trisnadi Setyo Trisnadi Shofa Chaasani Siti Thomas Siti Thomas Zulaikhah Siti Thomas Zulaikhah Soraya, Anita Sri Priyantini Sulistyo, Sona Syaifullah Syaifullah Taskworo, Dodik Taufiqurrachman Nasihu Taufiqurrachman Nasihun Taufiqurrachman Nasihun Taufiqurrachman Taufiqurrachman Taufiqurrahman Nasihun, Taufiqurrahman Utami, Wulan Dyah W, Joko Wahyu Wahyudi Wahyudi Widayanti, Eni Yustianingsih, Vivi Zulaikah, Siti Thomas