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All Journal Biospecies Jurnal Biologi Udayana AL KAUNIYAH Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Biologi Universitas Andalas SEMIRATA 2015 Jurnal Riau Biologia Jurnal Pengabdian UntukMu NegeRI Jurnal Biologi Tropis Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Riau Journal of Empowerment EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi dan Mikrobiologi Unri Conference Series: Community Engagement Current Research on Biosciences and Biotechnology Jurnal Media Informatika Bioscientiae, Jurnal ilmu ilmu Biologi JURNAL BIOLOGI PAPUA
Nery Sofiyanti
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Current Research on Biosciences and Biotechnology

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Potential antidepressant activity of n-hexane extract from old Areca catechu Nut by reducing depressive-like state in Swiss albino male mice Novianty, Riryn; Yuharmen; Sofiyanti, Nery; Indriani, Dwi Wahyu; Wasito, Hendri; Ya'la, Fitra Audhi
Current Research on Biosciences and Biotechnology Vol. 6 No. 1 (2024)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2024.6.1/6NKD6D9X

Abstract

Depression is a psychological disorder caused by an imbalance of neurotransmitters that can be managed with antidepressants. One of the local plants with the potential as an antidepressant is areca nut. However, its’ antidepressant effects in nonpolar solvents have not been studied recently. Equipping the extract to animals sub-chronically could mimic the clinical antidepressant treatment. Thus, the current investigation studied the antidepressant action of the hexane extract of old areca nut by utilizing acute and sub-chronic FST. This research started with extracted areca nut using n-hexane and continued with phytochemical tests. During FST, the animals were treated with n-hexane extract (50 and 100 mg/kg), fluoxetine (20 mg/kg), and saline (0.1 mL/20 g). The phytochemical test of the extract showed positive results from the content of secondary metabolites, namely saponins and steroids. n-Hexane extract at a dose of 50 mg/kg gave the best action in decreasing the immobility period. After sub-chronic medication, the secondary metabolites of the extract did not induce any toxic effects. This study’s findings imply that depression may be treated with conventional medicine, such as old areca nut extract.
Co-Authors ', Trina , WULANDARI D , ZULHENDRA Afni Atika Marpaung Aminuyati Annisa Auliani Arini Arini Arise, Widya Nur Asih Rahayu Ajeng Agesti Asri Ria Lestari Asri Ria Lestari Awal Prichatin Kusumo Dewi Awal Prichatin Kusumo Dewi Berlyansah, Azizul DANIEL MUDIYARSO, DANIEL Desi Paramita Dewi Indriyani Roslim Dewi Indriyani Roslim Dewi, Awal Prichatin Kusumo Dhaniel Ridho Winata Dian Eka Indriani, Dian Eka Dian Indriyani Dien Septiani Dyah Iriani ENNIE CHAHYADI, ENNIE Ermi Ningsih ERWINA JULIANTARI, ERWINA Fadel Nugraha Fadli ' Febrian Lailatul Fitri Fitmawati ' Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitri, Febrian Lailatul Fitria, Rahmdani Fitriani K. U Haris Gunawan Haris Gunawan HAYATI, IBNA HENDRI WASITO Herman ' Ikhwan Taufik Indriani, Dwi Wahyu ISKA LESTARI, ISKA Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Khairijon ' KOSUKE MIZUNO, KOSUKE L. FIBRIARTI, BERNADETA M. Yogi Riyantama Isjoni MARPAUNG, AFNI ATIKA Maya Sari Maya Sari Mayta Novaliza Isda Mayta Novaliza Isda Mellyasari Pangkey Muhammad Hamid Nanda Marlian Iriani NAPSIYAH, LUTHFI KHOTUN Nasri Baroroh Ninik Nihayatul Wahibah Ninik Nihayatul Wahibah Novianty, Riryn Nur Afdila Saputri Nurul Idani OSAMU KOZAN, OSAMU Paramita, Desi PRANATA, SYAFRONI Pranata, Syafroni Puji Lestari Putri Handayani Harahap Putri Intan Wahyuni Radith Mahatma Rafidah, Nurul Rissan suriatno Rodesia Mustika Roza Rodesia Mustika Roza Roza Elvyra Salpa Hartanto Silvera Devi Simbolon, Helda Simon Mangaratua Siska Sri Wahyuni, Siska Sri Siti Fatonah Slamet Prayogi Slamet Prayogi Sri Nur Kholifah Susi Supriani Syafroni Pranata syafroni Pranata Tami Oktari Tetty Marta Linda Via Andani Winata, Dhaniel Ridho Wirdayanti Wirdayanti Wulandari ' Ya'la, Fitra Audhi Ya’la, Fitra Audhi Yuharmen Yuharmen, Yuharmen Yulisa Resti Irawan Yulisa Resti Irawan Yundari, Yundari Yusfiati, Yusfiati YUSNA, MACHFIRA