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All Journal Biospecies Jurnal Biologi Udayana AL KAUNIYAH Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Biologi Universitas Andalas SEMIRATA 2015 Jurnal Riau Biologia Jurnal Pengabdian UntukMu NegeRI Jurnal Biologi Tropis Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Biosaintifika: Journal of Biology & Biology Education Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Riau Journal of Empowerment EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi dan Mikrobiologi Unri Conference Series: Community Engagement Current Research on Biosciences and Biotechnology Jurnal Media Informatika Bioscientiae, Jurnal ilmu ilmu Biologi JURNAL BIOLOGI PAPUA
Nery Sofiyanti
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Jurnal Media Informatika

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Antidepressant-like Effects of Young Areca Nut n-Hexane Extract Using Forced Swim Test in Mice Tested Individually Novianty, Riryn; Yuharmen, Yuharmen; Sofiyanti, Nery; Ya’la, Fitra Audhi
Jurnal Media Informatika Vol. 5 No. 3 (2024): Jurnal Media Informatika Edisi Mei - Agustus
Publisher : Jurnal Media Informatika

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Abstract

Depression is a common neuropsychiatric disorder that occurs in humans regardless of gender and age. Areca catechu, as a local plant, can be utilized as an antidepressant to treat depression. The current investigation aimed to determine the antidepressant action from an n-hexane extract of young areca nut using the Forced Swim Test (FST) as a standard method in screening antidepressants validated by the behavior of animals. Short-term medication or acute FST was performed by injecting mice with extract at doses 10 and 50 mg/kg, while the mice were treated with the best dose in long-term medication or sub-chronic FST. A day after the re-test on sub-chronic FST, toxicity test was performed. The extract at the dose of 50 mg/kg possessed antidepressant action during acute and sub-chronic FST. The results of the phytochemical analysis stated that the saponins and steroids present in the young areca nut n-hexane extract may be the active constituents that act as antidepressants. No toxic effects were detected from the young areca nut n-hexane extract in mice that had been injected for 7 consecutive days. n-Hexane extract from young areca nut presents antidepressant potential.
Co-Authors ', Trina , WULANDARI D , ZULHENDRA Afni Atika Marpaung Aminuyati Annisa Auliani Arini Arini Arise, Widya Nur Asih Rahayu Ajeng Agesti Asri Ria Lestari Asri Ria Lestari Awal Prichatin Kusumo Dewi Awal Prichatin Kusumo Dewi Berlyansah, Azizul DANIEL MUDIYARSO, DANIEL Desi Paramita Dewi Indriyani Roslim Dewi Indriyani Roslim Dewi, Awal Prichatin Kusumo Dhaniel Ridho Winata Dian Eka Indriani, Dian Eka Dian Indriyani Dien Septiani Dyah Iriani ENNIE CHAHYADI, ENNIE Ermi Ningsih ERWINA JULIANTARI, ERWINA Fadel Nugraha Fadli ' Febrian Lailatul Fitri Fitmawati ' Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitmawati Fitri, Febrian Lailatul Fitria, Rahmdani Fitriani K. U Haris Gunawan Haris Gunawan HAYATI, IBNA HENDRI WASITO Herman ' Ikhwan Taufik Indriani, Dwi Wahyu ISKA LESTARI, ISKA Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Isnaini Khairijon ' KOSUKE MIZUNO, KOSUKE L. FIBRIARTI, BERNADETA M. Yogi Riyantama Isjoni MARPAUNG, AFNI ATIKA Maya Sari Maya Sari Mayta Novaliza Isda Mayta Novaliza Isda Mellyasari Pangkey Muhammad Hamid Nanda Marlian Iriani NAPSIYAH, LUTHFI KHOTUN Nasri Baroroh Ninik Nihayatul Wahibah Ninik Nihayatul Wahibah Novianty, Riryn Nur Afdila Saputri Nurul Idani OSAMU KOZAN, OSAMU Paramita, Desi PRANATA, SYAFRONI Pranata, Syafroni Puji Lestari Putri Handayani Harahap Putri Intan Wahyuni Radith Mahatma Rafidah, Nurul Rissan suriatno Rodesia Mustika Roza Rodesia Mustika Roza Roza Elvyra Salpa Hartanto Silvera Devi Simbolon, Helda Simon Mangaratua Siska Sri Wahyuni, Siska Sri Siti Fatonah Slamet Prayogi Slamet Prayogi Sri Nur Kholifah Susi Supriani syafroni Pranata Syafroni Pranata Tami Oktari Tetty Marta Linda Via Andani Winata, Dhaniel Ridho Wirdayanti Wirdayanti Wulandari ' Ya'la, Fitra Audhi Ya’la, Fitra Audhi Yuharmen Yuharmen, Yuharmen Yulisa Resti Irawan Yulisa Resti Irawan Yundari, Yundari Yusfiati, Yusfiati YUSNA, MACHFIRA