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All Journal Jurnal Pendidikan Seni Rupa UG Journal Microbiology Indonesia Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Indonesian Journal of Cancer Universa Medicina Jurnal E-Bis: Ekonomi Bisnis Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Indian Journal of Forensic Medicine & Toxicology Jurnal Ilmu Keperawatan dan Kebidanan Jurnal Abdimas Bina Bangsa Jurnal Penelitian Inovatif Langit Biru: Jurnal Ilmiah Aviasi Indonesian Journal of Cancer Jurnal Mahasiswa Entrepreneur Journal of Global Research in Public Health

Herman Susanto

Divisi Onkologi Ginekologi, Departemen Obstetri Dan Ginekologi, Rumah Sakit Dr. Hasan Sadikin, Bandung

Author-ID : 395988

Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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Legal Assurance of Investor Dispute Settlement with Indigenous Law Communities in Legal Pluralism Perspective Susanto, Herman; Kristhy, Mutia Evi; Kristanto, Kiki
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 4, No 3 (2021): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i3.2104

With the enactment of Law Number 11 of 2020 concerning Job Creation, it has become a positive turning point in the Government's efforts to increase the number and value of investment in Indonesia while at the same time responding to challenges according to current developments with the method of resolving investment disputes by prioritizing deliberation and consensus up to the court mechanism. The purpose of this legal research is to analyze the legal certainty regarding the settlement of disputes between investors and indigenous peoples and to analyze the policies taken by the Government and Regional Governments in the context of resolving disputes in the perspective of legal pluralism. The research method used in this research is the normative legal method. According to the author, this is needed in order to provide guarantees for the basis of legal certainty, namely legal certainty and strengthening as well as the presence of the State in providing policy directions, commitments and joint responsibilities of the Government, Regional Governments in supporting and carrying out the process of forming laws and regulations that are in harmony and balance so that ensure the existence of public law and order in providing legal certainty in investing for investors, the community and the Government as well as the Regional Government in the context of improving regional economic development and community welfare in a fair and equitable manner.

PENGARUH PROGRAM PENCEGAHAN PENULARAN HIV (HUMAN IMMUNODEFICIENCY VIRUS) DARI IBU KE ANAK TERHADAP KEJADIAN HIV PADA ANAK DI RSUD R. SYAMSUDIN, SH KOTA SUKABUMI Rochmawati, Rochmawati; Effendi, Jusuf S.; Susanto, Herman; Susiarno, Hadi; Widjadjakusumah, Tony; Anwar, Anita Deborah
UG Journal Vol 14, No 3 (2020)
Publisher : Universitas Gunadarma

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Pada tahun 2015 terdapat 36,9 juta orang dengan HIV di seluruh du nia. Sebanyak 50% di antaranya adalah perempuan dan 2,1 juta anak berusia kurang dari 15 tahun. Penularan infeksi HIV dari ibu ke anak merupakan penyebab utama infeksi HIV pada anak usia di bawah 15 tahun. Penularan HIV dari ibu ke anak dapat dicegah denga n intervensi Pencegahan Penularan HIV dari Ibu ke Anak (PPIA). Penelitian ini menggunakan desain cohort retrospective nested cross sectional. Populasi dalam penelitian ini adalah data ibu hamil, bersalin, nifas dengan diagnosis HIV positif dan anaknya di RSUD R. Syamsudin, SH pada tahun 2011 - 2015. Analisis data menggunakan Chi Square dan Uji regresi logistik. Hasil penelitian didapatkan karakteristik subjek penelitian menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara umur dan pekerjaan dengan diagnosis anak HIV positif dan anak HIV negatif karena kedua nilai p > 0,05 (0,770 dan 0,308). Hasil analisis didapatkan bahwa terdapat pengaruh pemeriksaan ANC terpadu dan pengobatan ARV terhadap kejadian HIV pada anak (p < 0,05). Ibu yang menjalani pemeriksaan ANC terpadu yang tidak sesuai berisiko 10 kali (RR 10,5 IK 95% 1,510 -72,92) menularkan HIV pada anak dibandingkan yang menjalani ANC terpadu sesuai. Ibu yang mendapat pengobatan ARV yang tidak sesuai berisiko 12 kali (RR 12,139 IK 95% 1,742 -84,09) menularkan HIV pada anak dibandingkan dengan ibu yang mendapat pengobatan ARV yang sesuai. Faktor yang paling berpengaruh dalam program pencegahan penularan HIV dari ibu ke anak terhadap kejadian HIV pada anak yaitu pengobatan ARV

KAJIAN PENGAMANAN PERIMETER DALAM MENUNJANG KEAMANAN PENERBANGAN DI BANDAR UDARA INTERNASIONAL ADI SOEMARMOSURAKARTA Amanda Nurma Hariyanti; Satiti Utami; Herman Susanto
Langit Biru: Jurnal Ilmiah Aviasi Vol 12 No 3 (2019): Langit Biru: Jurnal Ilmiah Aviasi
Publisher : Politeknik Penerbangan Indonesia Curug

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1150.118 KB)

The objektive of research to know and inspect connecting withthe safety and safety of flights at Adi Soemarmo International Airport is still found a variety of distractions that are there land boundaries or territories that are under the supervision of the airport. This limit is one that limits the area of aircraft movement, as well as air navigation equipment facilities and other important installations of all obstacles (obstacle) that can harm flight safety. With the current perimeter security, the perimeter fence at Adi Soemarmo International Airport has not functioned properly, namely to prevent psycology and physic, preventing intrusion and help detection/ Arrest, provide controlled doors/access for people and vehicles.It is directly or indirectly affects the safety of flights at Adi Soemarmo International Airport. To be able to realize optimal security at the perimeter of the Adi Soemarmo Intenational Airport, it is necessary to base the rules of flight that has been set, thereby supporting safe, smooth, convenient and efficient operation of aviation at Adi Soemarmo International Airport

Understanding Perinatal Mortality Causes in Indramayu Indonesia Sukriani, Wahidah; Hilmanto, Dany; Susanto, Herman
KEMAS: Jurnal Kesehatan Masyarakat Vol 17, No 3 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v17i3.24727

Perinatal mortality is a useful indicator for assessing pregnancy and delivery care. Indramayu was the fourth-highest perinatal mortality in West Java province in 2015. The cause of death can be prevented from several factors including health workers, patients, referrals, and the availability of healthcare facilities. This study aimed to analyze the causes of perinatal mortality in Indramayu. The Study found 375 perinatal deaths but only 296 cases have documents according to the inclusion criteria. Statistical analysis showed there was an association between maternal disease and referral delays with preventable perinatal mortality (p≤0.05). Maternal disease in Indramayu cannot early be detected due to the lack of antenatal care services and behavioral factors on choosing a helper contributed to referral delays. It is necessary to improve the quality of antenatal care services by doing minimum standard of antenatal care for early detection of maternal disease and improving health promotion about danger sign of pregnancy and choosing birth attendants to reduce referral delays.

Risk Factors Associated with Perinatal Mortality in West Java, Indonesia (Study in Karawang, Garut , Indramayu and Tasikmalaya City) Luh Nik Armini; Iin Prima Fitriah; Wahidah Sukriani; Sutriningsih; Farid Husin; Herman Susanto; Dany Hilmanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15835

Perinatal mortality is the death of a baby born at 28 weeks of gestation until less than 7 days afterbirth. Perinatal mortality is used to attribute causes of infant death to obstetric events such as stillbirth andinfant mortality in the first week of life. The purpose of this study was to describe the causes, periods, andrisk factors that influence perinatal mortality . The design of this study is the Sequential Explanatory MixedMethods , Research Quantitative designed with analytical methods conducted cross-sectiona l. Sampling wasdone by total sampling. 396 research sample data. The subjects in this study were parents, health workerswho were involved and understood about the causes of perinatal death and the person in charge of recordingand reporting perinatal deaths in health care facilities . 60.6% of the fatalities that occurred were preventabledeaths. Perinatal deaths that often occur are still births and early neonatal. At 2-21% perinatal kamtian, it iscarried out by non-health workers. The risk factors that affect perinatal mortality are pregnancy distance (p= 0.04 ) and comorbidities (p = 0.019).

"COL-OCOLAN" DI DESA PERANTE, ASEMBAGUS-SITUBONDO Herman Susanto .; I Wayan Sudiarta, S.Pd,M.Si. .; Langen Bronto Sutrisno, S.Sn., M.A .
Jurnal Pendidikan Seni Rupa Undiksha Vol. 6 No. 2 (2016)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jjpsp.v6i2.8192

Penelitian ini bertujuan untuk mendeskripsikan (1) proses permainan Col-Ocolan Desa Perante, Asembagus, Situbondo, meliputi peserta, aturan main dan cara bermain, (2) bentuk dan rupa mainan Col-Ocolan Desa Perante, Asembagus, Situbondo. Meliputi proses terwujudnya bentuk Col-Ocolan serta mendeskripsikan rupa Col-Ocolan yang dibuat untuk dimainkan, dan yang dibuat untuk hiasan, (3) proses pembuatan mainan Col-Ocolan Desa Perante, Asembagus, Situbondo yang dibuat untuk dimainkan dan untuk hiasan dinding. Penelitian ini adalah penelitian deskriptif kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah observasi, wawancara, dan rekonstruksi. Hasil penelitian ini menunjukkan (1) peserta permainan Col-Ocolan di Desa Perante, Asembagus-Situbondo terdiri dari anak-anak berusia 4 sampai 15 tahun. Aturan main permainan Col-Ocolan di Desa Perante, Asembagus-Situbondo terdiri dari tiga aturan yaitu ghindhungan atau gendongan, kala nyambhi atau kalah bawa, dan kala push-up atau kalah push-up; (2) proses terwujudnya bentuk Col-Ocolan mengalami beberapa tahapan perkembangan bentuk dari phappana gheddeng atau pelepah pisang, bhungkana tebbhu atau batang tebu, dan bentuk akhir Col-Ocolan yang terbuat dari kayu. Bentuk Col-Ocolan, baik yang dibuat sebagai mainan maupun yang dibuat sebagai hiasan memiliki persamaan corak hias yaitu motif kartun dan motif bangun. Sedangkan pada bentuk Col-Ocolan tidak terlalu berbeda, perbedaan hanya terletak pada bagian ekor dan tebal badan, Col-Ocolan sebagai hiasanya dibuat lebih tipis dari Col-Ocolan yang dibuat sebagai mainan.; (3) Proses pembuatan Col-Ocolan sebagai mainanterdiri dari pemotongan kayu, pembentukan badan Col-Ocolan, penanaman besi, penghalusan, pembuatan ekor dan pengeleman, serta pewarnaan atau finishing. Sedangkan proses pembuatan Col-Ocolan sebagai hiasan terdiri dari pemotongan kayu, pembentukan badan Col-Ocolan, pembuatan ekor dan pengeleman, pengeboran, penghalusan, dan pewarnaan atau finishing. Kata Kunci : Col-Ocolan, bentuk, rupa, rekonstruksi This study aimed to describe (1) Describing the process a game of Col-Ocolan in Perante Village, Asembagus, Situbondo, including the player, rules of the game and how to play, (2) describing the forms and shapes of toys Col-Ocolan Perante Village, Asembagus, Situbondo. Covering the realization process of Col-Ocolan form and to describe such a Col-Ocolan are made for games, and that also made for decoration, (3) Describeing the process of making toys Col-Ocolan Perante Village, Asembagus, Situbondo are made for game and for wall decoration. This study was descriptive qualitative research. Data collection techniques used in this study is observation, interviews, and reconstruction. The results of this study showed (1) the player in the game of Col-Ocolan Perante Village, Asembagus-Situbondo consists of children aged 4 to 15 years. Rules of the game in the village of Col-Ocolan Perante, Asembagus-Situbondo consists of three rules that Ghindhungan or sling, Kala Nyambhi or lose bring, and Kala Push-ups or push-ups lose; (2) the realization of forms of Col-Ocolan experienced some form of developmental stages phappana gheddeng or banana skins, bhungkana tebbhu or sugarcane, and the final form Col-Ocolan made of wood. Col-Ocolan shape, well made as toys or created as decoration has similarities decorative patterns and motifs cartoon motifs wake. While the shape of Col-Ocolan not different, the only difference lies in the tail and thick body, Col-Ocolan as decoration made thinner than Col-Ocolan made as toys .; (3) The process of making Col-Ocolan such us from sawmill, Col-Ocolan entity formation, planting iron, refining, manufacture tail and gluing, and dyeing or finishing. While the process of making the Col-Ocolan as a decoration consisting of a cutting wood, entity shape of Col-Ocolan, manufacture tail and gluing, drilling, refining, and dyeing or finishing. keyword : Col-Ocolan, shape, appearance, reconstruction

STATUS SOSIAL EKONOMI DENGAN LAMA MENYUSUI Islami Islami; Herman Susanto; Sri Endah Rahayuningsih
Jurnal Ilmu Keperawatan dan Kebidanan Vol 4, No 1 (2013): JURNAL ILMU KEPERAWATAN DAN KEBIDANAN
Publisher : Universitas Muhammadiyah Kudus

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Status sosial ekonomi merupakan salah satu faktor yang berkontribusi pada status kesehatan seseorang. Masyarakat dengan pendidikan dan sosial ekonomi yang rendah cenderung tidak memprioritaskan perilaku sehat seperti perilaku pencegahan penyakit, perilaku pemeliharaan kesehatan dan perilaku mencari pengobatan, termasuk perilaku pemberian ASI. Penelitia ini bertujuan untuk mengetahui korelasi status sosial ekonomi dengan lama menyusui. Metode penelitian ini adalah penelitian analitik dengan pendekatan observasional cross sectional. Populasi dalam penelitian ini adalah ibu menyusui di kecamatan Kaliwungu, Kota, Dawe, Jekulo dan Undaan Kabupaten Kudus yang memenuhi kriteria inklusi dengan teknik pengambilan sampel gugus bertahap dan diperoleh 140 responden. Penelitian ini dilaksanakan pada bulan Juli sampai September 2012. Data yang telah dikumpulkan dianalisis statistik univariabel, bivariabel dengan uji korelasi Lambda. Penghasilan dinilai berdasarakan jumlah biaya pengeluaran per bulan. Hasil yang diperoleh dalam penelitian ini adalah terdapat korelasi antara penghasilan dengan lama menyusui (r =0.393 p= <0.001), tidak terdapat korelasi antara pendidikan dengan lama menyusui (r = 0.075 p= 0.180) dan tidak terdapat korelasi antara pekerjaan dengan lama menyusui ( r = 0.047 p= 0.249). Simpulan dalam penelitian ini adalah tingkat pendidikan dan pekerjaan tidak memengaruhi lama menyusui, sedangkan penghasilan yang tinggi membuat ibu tidak mempunyai waktu yang cukup untuk menyusui.

ANALISIS PENYEBAB KEMATIAN PERINATAL DI KABUPATEN GARUT (STUDI EPIDEMIOLOGI DALAM UPAYA MENURUNKAN KEMATIAN PERINATAL DI PROVINSI JAWA BARAT) Iin Prima Fitriah; Dany Hilmanto; Herman Susanto; Hadi Susiarno; Eddy Fadlyana; Gustomo Panantro
Jurnal Ilmu Keperawatan dan Kebidanan Vol 10, No 1 (2019): JURNAL ILMU KEPERAWATAN DAN KEBIDANAN
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jikk.v10i1.533

Kematian perinatal berhubungan dengan peristiwa obstetri seperti lahir mati dan kematian neonatal dini. Kasus kematian bayi di Kabupaten Garut menduduki peringkat kedua tertinggi kematian bayi di Jawa Barat. Berbagai upaya dilakukan untuk menurunkan kasus kematian perinatal namun, belum memperlihatkan hasil maksimal. Tujuan penelitian adalah menganalisis penyebab kematian perinatal yang dapat dicegah. Rancangan penelitian ini adalah Sequential Explanatory Mixed Method. Tahap pertama melakukan teknik kuantitatif dengan studi dokumentasi terhadap dokumen Otopsi Verbal Perinatal (OVP) berjumlah 78 kasus. Uji statistik menggunakan fisher exact. Tahap kedua dengan teknik kualitatif dengan indepth interview pada empat orang keluarga bayi yang meninggal, dua orang petugas kesehatan dan dua orang penanggungjawab pencatatan dan pelaporan dan Focus Group Discussion (FGD) pada satu orang kepala seksi kesehatan keluarga Dinas Kesehatan Kabupaten Garut dan empat orang bidan koordinator puskesmas. Penelitian dilaksanakan bulan Oktober sampai November 2016. Hasil penelitian menunjukkan terdapat hubungan jarak kelahiran, penyakit penyerta, ketersediaan fasilitas dan rujukan dengan kematian perinatal yang dapat dicegah (p<0,05). Jarak kelahiran dan penyakit penyerta masih berkontribusi terhadap kematian perinatal yang dapat dicegah terkait dengan keterbatasan pengetahuan ibu dan juga deteksi dini baik tingkat keluarga maupun tenaga kesehatan, sedangkan ketersediaan fasilitas kesehatan terkait dengan keterbatasan alat dan sumber daya manusia kesehatan. Sebagian besar kematian perinatal dapat dicegah. Perlu kerjasama semua elemen masyarakat maupun pemerintah dalam upaya menurunkan kematian perinatal yang dapat dicegah.

Peran Serum IL-6 dan CA-125 Prabedah sebagai Prediktor Resektabilitas Tumor pada Kanker Ovarium Tipe Epitel ANDI KURNIADI; YUDI M HIDAYAT; DODI SUARDI; HERMAN SUSANTO; GATOT N.A.W; HERU PRAYITNO
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

The success of ovarian cancer therapy is determined by optimal cytoreduction performed prior to chemotherapy. Maximum residual tumor after cytoreduction and before chemotherapy is essential for prognosis. Factors affecting tumor mass resectability are the surgeon, location of the mass, ascites more than 1000 mL, carcinomatosis, mass in lymph nodes more than 1 cm, mass at the liver parenchym, large mass up to diaphragm and pre-operative CA-125 > 500 MIU / L will increase the likelihood of suboptimal cytoreduction. IL-6 and CA-125 play a role in the occurrence of those factors, so both examinations are expected to improve the prediction of cytoreduction resectability and determine the appropriate choice for the treatment of ovarian cancer, either cytoreduction or neoadjuvant chemotherapy.The design of this study is cross sectional that is by examining patients suspected of ovarian malignancy, checking for their preoperative IL-6 and CA-125 levels and their resectability. Data analysis done by univariat and bivariate. For categorical data tested by chi-square test or Exact Fisher test, significance test used unpaired T test or Mann Whitney test. Analysis of numerical variables by numerical using Pearson correlation analysis or Spearman correlation analysis as well as correlation between numerical variables with nominal variables using Eta Correlation test. The data obtained is recorded in a special form and then processed with SPSS version 24.0 for WindowsPatients collected during the study period were 54, where only 36 people met the inclusion and exclusion criteria. It was found that most subjects were aged 40-64 years (77.8%), mean value of CA-125 for suboptimal cytoreduction group was higher than optimal cytoreduction (1099,75 + 1242,555 vs 311,23 + 160,165), which is statistically significant, p = 0,000 (p value <0,05), CA 125 cut off point in this research was 432 with sensitivity value of 72,2% and specificity value of 77,88%. The mean value of IL-6 for the suboptimal cytoreduced group was greater than the optimized cytoreduction (137.72 + 107.658 VS 62.20 + 66.330), which is statistically significant, p = 0.009 (p value <0.05), IL-6 cut off point at this study was 64.9 with a sensitivity of 72.2% and a specificity of 72.2 %. There was a positive correlation with a strong correlation strength between CA-125 levels and the operating outcome, p = 0.012 (p <0.05), there was a positive correlation with a small correlation strength between IL-6 levels and the outcome of surgery, p = 0,016 (p <0,05) and there was correlation between IL-6 and CA-125 presurgery with operating outcome (suboptimal and optimal cytoreduction) with cut off point 418,5 with sensitivity value 88.9% and specificity value 72,2% .Conclusion: There is a correlation between the levels of IL-6 and CA-125 and ovarian cancer resectability. ABSTRAKKeberhasilan terapi kanker ovarium ditentukan oleh optimalnya sitoreduksi yang dilakukan sebelum pemberian kemoterapi. Maksimal residual tumor setelah sitoreduksi dan sebelum kemoterapi sangat penting untuk prognosis. Faktor -faktor yang mempengaruhi resektabilitas massa tumor adalah operator, lokasi massa, asites lebih dari 1000 mL, karsinomatosis, massa di limfa lebih dari 1 cm, massa diparenkim hati, massa yang besar sampai ke diafragma dan kadar CA-125 pre-operatif > 500 mIU/L akan meningkatkan kemungkinan sitoreduksi suboptimal. IL-6 dan CA-125 berperan peran dalam terjadinya faktor – faktor tersebut, sehingga pemeriksaan kedua-duanya diharapkan dapat meningkatkan prediksi resektabilitas sitoreduksi dan menentukan pilihan tatalaksana kanker ovarium yang tepat yaitu sitoreduksi atau kemoterapi neoajuvan.Rancangan penelitian ini adalah cross sectional yaitu dengan melakukan pemeriksaan kadar IL-6 dan CA-125 prabedah penderita tersangka keganasan ovarium kemudian dilihat resektabilitasnya.. Analisis data dilakukan secara univariat dan bivariate. Untuk data kategorik diuji dengan uji chi-square atau uji Exact Fisher , Uji kemaknaan digunakan uji T tidak berpasangan atau uji Mann Whitney. Analisis variabel numerik dengan numerik menggunakan analisis korelasi Pearson atau analisis korelasi Spearman serta korelasi antara variabel numerik dengan variabel nominal menggunakan uji Korelasi Eta. Data yang diperoleh dicatat dalam formulir khusus kemudian diolah dengan program SPSS versi 24.0 forWindowsPasien yang berhasil dikumpulkan selama periode penelitian sebanyak 54 orang, yang memenuhi kriteria inklusi dan ekslusi hanya 36 orang. diperoleh data bahwa subjek terbanyak adalah usia 40 – 64 tahun (77,8%), Nilai rerata CA-125 untuk kelompok sitoreduksi suboptimal lebih besar dibandingkan dengan sitoreduksi optimal (1099,75 + 1242,555 VS 311,23 + 160,165 ) bermakna secara statistik p = 0,000 (nilai p < 0,05), cut off point CA 125 pada penelitian ini adalah 432 dengan nilai sensitivitas 72,2% dan nilai spesifisitas 77,88%. Nilai rerata IL-6 untuk kelompok sitoreduksi suboptimal lebih besar dibandingkan dengan sitoreduksi optimal (137,72 + 107,658 VS 62,20 + 66,330) bermakna secara statistik p = 0,009 (nilai p < 0,05), cut off point IL-6 pada penelitian ini adalah 64,9 dengan sensitivitas 72,2% dan spesifisitas 72,2%%. Terdapat korelasi positif dengan kekuatan korelasi yang cukup kuat antara kadar CA-125 dengan luaran operasi p = 0,012 (p < 0,05), terdapat korelasi positif dengan kekuatan korelasi yang kecil (tidak erat) antara kadar IL-6 dengan luaran operasi, p = 0,016 (p < 0,05) dan terdapat korelasi antara kadar IL-6 dan CA-125 prabedah dengan luaran operasi (sitoreduksi suboptimal dan optimal ) dengan cut off point 418,5 dengan nilai sensitivitas 88.9% dan nilai spesifisitas 72,2%.Simpulan : Terdapat korelasi antara kadar IL-6 dan CA-125 prabedah dengan resektabilitas kanker ovarium

Cloning, Expression and Bioinformatic Analysis of Human Papillomavirus Type 52 L1 Capsid Gene from Indonesian Patient SONY SUHANDONO; DEWI AYU KENCANA UNGU; TATI KRISTIANTI; EDHYANA SAHIRATMADJA; HERMAN SUSANTO
Microbiology Indonesia Vol. 8 No. 3 (2014): September 2014
Publisher : Indonesian Society for microbiology

Human papillomavirus (HPV) type 52 is the most prevalent type for causing cervical cancer in Indonesian population. Cervical cancer becomes the most common cancer suffered by Indonesian women. Prevention of HPV infection can be achieved using HPV virus-like particle (VLP) vaccine derived from L1 major capsid protein. Â This study aimed to clone and analyze HPV-52 L1 gene. DNA obtained from biopsy of a cervical cancer patient was amplified using specific primers designed from Asian originated HPV-52 L1 gene available in the GenBank. The isolated HPV-52 L1 gene sequence was submitted to GenBank with accession number [KF225497]. Expression of HPV-52 L1 gene was performed using pRSET/EmGFPEscherichia coli expression vector. We analyzed and compared the HPV-52 L1 gene expressions from recombinant E.coli BL21 (DE3) that had been induced for 3 hours with 1 mM IPTG and without induction. The protein was expressed in insoluble form. We performed the following bioinformatic analyses: construction of phlyogenetic tree, T-cell epitopes prediction and 3D proteins structure modelling. We utilized the following softwares: MEGA5 for phylogenetic tree, IEDBann for MHC prediction, CLC DNA Workbench 6.5 for hydrophobicity analysis and PDB-Viewer Deep for 3D protein structure analysis. The phylogenetic tree which was developed based on [KF225497] sequence showed that it shared a branch with Asian countries (Philippines and Thailand). The deduced amino acid sequences of the predicted epitopes that were consistent in all of the programs were 259GTLGDPVPGDLYIQGS274 and 345KKESTYKNE353. This information may be useful to design diagnostic strategies and vaccine suitable for Indonesian population.

Co-Authors Afandi Charles, Afandi Amanda Nurma Hariyanti Anandayu Pradita Andi Kurniadi, Andi Ani Melani Maskoen Anita Deborah Anwar Arief, Mohammad Yahya Ariyantiningsih, Febri Birgitta M. Dewayani, Birgitta M. Cynthia Kurniawan Dany Hilmanto DEWI AYU KENCANA UNGU Dodi Suardi Eddy Fadlyana EDHYANA SAHIRATMADJA Edhyana Sahiratmadja Farid Farid, Farid Farid Husin Fitri Rahmi Fadhilah Fitriah, Iin Prima Gatot N.A. Winarno GATOT N.A.W Gustomo Panantro Hanifa, Fanni Henry Riyandi Herri S. Sastramihardja HERU PRAYITNO Heru Prayitno HIDAYAT, YUDI M Hidayati, Arum I Wayan Sudiarta Islami - Islami Islami Islami, Islami Jusuf S. Effendi Karmila, Linda Kristanto, Kiki Kristhy, Mutia Evi Langen Bronto Sutrisno Luh Nik Armini N.A.W, GATOT Panantro, Gustomo Ratu Safitri Rochmawati Rochmawati Satiti Utami Soesanti, Arum SONY SUHANDONO SONY SUHANDONO Sri Endah Rahayuningsih Susiarno, Hadi Susila Candra Sutriningsih Tanaya, Olivia Tarsikah, Tarsikah TATI KRISTIANTI Wahidah Sukriani Widjadjakusumah, Tony YUDI M HIDAYAT Yundari, Yundari

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