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All Journal CHEMISTRY PROGRESS Jurnal Natur Indonesia Techno: Jurnal Penelitian KOVALEN: Jurnal Riset Kimia IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Indonesia Chimica Acta Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Progres Kimia Sains Al-Kimia Indonesian Journal of Chemistry Jurnal Ilmu Alam dan Lingkungan Chemistry Indonesian Journal of Chemical Research Fullerene Journal of Chemistry Indobiosains Automotive Experiences Jurnal Pengabdian Papua Makara Journal of Science Journal of Community Health Provision Molekul: Jurnal Ilmiah Kimia Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Paulina Taba
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km 10, Tamalanrea, Makassar, 90245
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary Other

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A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents Karim, Harningsih; Azis, Arief; Ramadani, Ananda; Anita, Anita; Ahmad, Ahyar; Natsir, Hasnah; Taba, Paulina; Putri, Suriati Eka; Sarlan, Sarlan; Larekeng, Siti Halimah; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.90039

Abstract

Unique and varied bioactive compounds produced by the ocean have drawn attention and served as a focus for creating antibacterial and anti-inflammatory agents. As part of the approach for locating these research sources, databases such as PubMed, Science Direct, MDPI, Google Scholar, Springer Link, Web of Science, Scopus, and Wiley Online Library were used to identify completed studies. Numerous intriguing bioactive compounds have so far been isolated from marine bacteria. A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. This review summarizes several bacterial intracellular and extracellular bioactive compounds that have been applied as antibacterial and anti-inflammatory agents in 2016–2024, which we present in the form of structures, species sources, and evaluations of these compounds' antibacterial and anti-inflammatory activities. Therefore, this review article can be used as a recommendation for utilizing biomaterials from marine bacteria that are promising in the future for industrial-scale production of antibacterial and anti-inflammatory agents.
Optimasi Pertumbuhan Bakteri Laut Penghasil Protease Menggunakan Variasi Konsentrasi Media Skim Milk Modifikasi Anita, Anita; Natsir, Hasnah; Ahmad, Ahyar; Taba, Paulina; Karim, Harningsih
Indobiosains 2025: Volume 7 Nomor 1 Februari 2025
Publisher : Universitas PGRI Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31851/indobiosains.v7i1.17822

Abstract

This study aims to analyze the growth rate of marine bacteria producing protease using variations in the concentration of skim milk media and to observe the relationship between cell growth and enzyme activity. The study was conducted using three concentrations of skim milk media (1%, 2%, and 3%) and observation of growth and enzyme activity for 108 hours. The results showed that 1% skim milk concentration produced the largest proteolytic zone diameter (13.8 mm) with the fastest growth (1 day). Observations of cell growth patterns and enzyme activity showed that the highest enzyme activity (0.5933 U/mL) occurred in the early growth phase and decreased in subsequent phases even though cell growth increased. This indicates that there is no linear relationship between cell growth and enzyme activity in marine bacteria-producing protease, where enzyme production and activity are influenced by various complex factors such as physiological conditions of the cells and nutrient availability.
Anticancer Assay of Methanol Extract of Gracilaria salicornia Originating from the Hari Islands, Southeast Sulawesi, Against MCF-7 Cancer Cells Sernita, Sernita; Taba, Paulina; Sahidin, I; Soekamto, Nunuk Hariani
Journal of Community Health Provision Vol. 5 No. 1 (2025): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v5i1.553

Abstract

Marine macroalgae represent a promising but underexplored resource for anticancer drug discovery due to their diverse repertoire of bioactive secondary metabolites. Gracilaria salicornia, a red alga found abundantly in the waters surrounding the Hari Islands, Southeast Sulawesi, has not been previously studied for its cytotoxic potential. This study aimed to evaluate the phytochemical composition and anticancer activity of methanol extract from G. salicornia against MCF-7 human breast cancer cells. The algae were extracted using a gradient solvent system, with methanol selected for further testing due to its polarity and broad extraction capacity. Phytochemical screening revealed the presence of alkaloids, phenolics, and steroids/terpenoids—classes of compounds known for their cytotoxic, pro-apoptotic, and redox-modulatory properties. General toxicity was assessed using the Brine Shrimp Lethality Test (BSLT), with the extract demonstrating moderate toxicity (LC₅₀ = 561.26 mg/L), indicating the presence of bioactive constituents. Cytotoxicity against MCF-7 cells was evaluated using the MTT assay, yielding an IC₅₀ value of 414.6 mg/L. Although lower than the standard chemotherapeutic agent doxorubicin (IC₅₀ = 4.1 mg/L), the observed activity supports the hypothesis that G. salicornia contains compounds with therapeutic relevance. These findings suggest that G. salicornia harbors cytotoxic agents that act through diverse mechanisms, likely involving oxidative stress and hormonal regulation. While the crude extract exhibited only moderate activity, its phytochemical richness warrants further fractionation, isolation, and mechanism-of-action studies. This study provides foundational evidence for the potential of Indonesian marine algae in cancer drug discovery and highlights the need for continued exploration of native marine biodiversity as a source of novel chemotherapeutic agents.
Adsorption of Cu(II) Ions from Aqueous Solutions using a Magnetite Biochar Composite Material Ta'bi, Widi Aprilia; Taba, Paulina; Wahab, Abdul Wahid; Gappa, Maming; Zakir, Muhammad; Permatasari, Nur Umriani
Makara Journal of Science Vol. 29, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Water contamination from heavy metals, such as Cu(II) ions, poses severe threats to human health and the environment. This necessitates the development of efficient and eco-friendly treatment methods. In this study, a magnetite–biochar composite (MBC) was developed as an effective adsorbent for reducing Cu(II) ions from liquid waste. Biochar was produced through the pyrolysis of water hyacinth at 500 °C, while magnetite was synthesized using FeSO₄·7H₂O and FeCl₃·6H₂O with molar ratio of 1:2. The MBC was formed using a co-precipitation method and characterized by Fourier transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Brunauer–Emmett–Teller, and vibration sample magnetometer instruments. FTIR analysis confirmed the presence of Fe–O bonds, and XRD detected Fe₃O₄ peaks, confirming the successful integration of magnetite into the composite. The MBC exhibited a surface area of 72.54 m²/g and a saturation magnetization of 19.10 emu/g. Optimal Cu(II) ion adsorption occurred at pH 6 and a contact time of 60 min. Adsorption kinetics followed the pseudo-second-order model, and isothermal analysis aligned with the Sips model, indicating an adsorption capacity of 75.73 mg/g. These results demonstrate MBC’s excellent potential as a sustainable and effective adsorbent for treating Cu(II)-contaminated wastewater, offering an environmentally friendly solution to heavy metal pollution.
Synthesis and Characterization of MnO2 Nanoparticle Composite and Palm Kernel Shell-Based Activated Carbon as Supercapacitor Electrode Candidates Arif, Ainun Rezkiva; Zakir, Muhammad; Ahmad, Ahyar; Raya, Indah; Taba, Paulina; Rasyid, Herlina
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110797

Abstract

Palm kernel shells (PKS) are a biomass waste rich in carbon and low in ash content, making them suitable for conversion into supercapacitor electrode materials that support the principles of the blue economy and green technology. This study presents a novel synthesis approach for supercapacitor electrode materials by combining activated carbon derived from hydrothermally carbonized PKS biomass waste (AC-PKS) with MnO2 nanoparticles. Carbon activation in this study was carried out using chemical and physical activation approaches to produce a microporous structure with a high surface area. The AC-PKS/MnO2 composite was then synthesized through a redox reaction deposition using KMnO4 to create materials that exhibit potential properties between double-layer capacitance and pseudocapacitive behavior. Electrochemical testing with CV and GCD showed an increase in the specific capacitance of the AC-PKS/MnO2 composite of 67.85 and 46.91 F/g, respectively. These findings indicate the scientific contribution of combining biomass-derived activated carbon with metal oxides as a potential supercapacitor electrode. The implications of these results suggest that AC-PKS/MnO2 not only offers a sustainable material solution but also opens up opportunities for the development of high-capacity supercapacitor electrodes for future energy storage applications, particularly in renewable energy and environmentally friendly technologies.
Peningkatan Kapasitas Masyarakat Wala Kabupaten Sidrap dalam Inovasi Biopolimer Lokal “Kakatansea” Untuk Ekonomi Berkelanjutan Nur Umriani Permatasari; Nur Haedar; Paulina Taba; Djabal Nur Basir; Bulkis Musa; Prayiska Mariana Rapi; Nur Afni; Emmi Astuti; Novi Lestari; Nurmala Sari
JURNAL PENGABDIAN PAPUA Vol 9 No 3 (2025)
Publisher : LPPM Uncen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31957/jpp.v9i3.4911

Abstract

The community service program "Enhancing the Capacity of the Wala Community in Sidrap Regency through the Local Biopolymer Innovation 'Kakatansea' for Sustainable Economy" aims to evaluate the effectiveness of interventions in improving community capacity. The main activities include providing education on the utilization of seaweed as an environmentally friendly biopolymer raw material for food and non-food products; training in producing edible coating spray from seaweed polysaccharides to extend the shelf life of local products; training in making modified tempeh from peanuts and seaweed to improve nutrition and shelf life; and training in making environmentally friendly soap with seaweed extract for skin health and economic value. The program involved 50 participants, using a quantitative approach with paired t-test analysis on pre- and post-intervention questionnaire data, measuring understanding, knowledge, and skills through ten key indicators. The results showed a significant increase in the average participant capacity score from 21.06 (pre) to 21.82 (post), with a statistically significant difference (p=0.000; t=-3.882; df=49). This indicates the program’s success in increasing understanding of biopolymers, production processes, product benefits, successful practices, and independent skills. Although the pre- and post-intervention correlation was not significant (r=0.240; p=0.093), the overall increase confirms a positive impact. In conclusion, this program was effective in enhancing the capacity of the Wala community in biopolymer innovation, laying a foundation for sustainable economic development. 
Co-Authors Abd. Wahid Wahab Abdul Karim Abdul Wahid Wahab Abdul Wahid Wahab Abubakar, Andi Nur Fitriani Ahmad Fudhail  Majid Ahmad Zaini Ahyar Ahmad Alfian Noor Alfian Noor Amin, Ida Ifdaliah Andi Arwita Gau Andi Muhammad Anshar Andi Suciati Andi Yanti Puspita Sari Anita Anita Arfah, Rugaiyah A. Arfiani Nur Arif, Ainun Rezkiva Azis, Hijrah A. Bulkis Musa Burhanuddinnur, Muhammad Djabal Nur Basir, Djabal Djasmawati Mahmud Emma Suryati Emmi Astuti Fadliah, Fadliah Fatahu, Fatahu Fausan Sullahi Firdaus Firdaus Firdaus Firdaus Firdaus, Firdaus Gappa, Maming Graine Moran Harningsih Karim Harningsih Karim Hasnah Natsir Hasnah Natsir Hazirin Zubair Hazirin Zubair, Hazirin I W. Sutapa Indah Raya Indah Raya Indrawati Patabang Irfandi, Rizal Jarnuzi Gunlazuardi Kasturiasih, Ni Putu Khairunnur, Siti La Kolo Malimongan M Maming Maming Gaffar, Maming Miftahul Jannah Miftahul Jannah Misriyani Misriyani Muh. Bachri Amran Muhammad Qaddafi Muhammad Zakir Muhammad Zakir Munadi, Rachmin Musa, Bulkis Novi Lestari Nunuk Hariani Soekamto Nunuk Soekamto Nur Afni Nur Haedar Nur Umriani Permatasari NURAENI, ANDI Nuritasari Azis Nurmala Sari Nursiah La Nafie Nursiah La Nafie Nursiah La Nafie Nursiah La Nafie Nursiah La Nafie Parmitha, Nadya Yuli Permatasari, Nur Umriani Prastawa Budi Prastawa Budi Prayiska Mariana Rapi Putri, Tri Widayati Ramadani, Ananda Rasyid, Herlina Ridwan, Irham Pratama Rino R. Mukti Romi Anto Rosalinda Zeniona Maarebia Ruslan Ruslan Russell F. Howe S, Giovanno Alvin Saefuddin ., Saefuddin Sahidin . Sahriani Ali Samriani Samriani Sari, Andi Y.P. Sarlan, Sarlan Seniwati Dali Seniwati Dali Sernita, Sernita SITI HALIMAH LAREKENG, SITI HALIMAH Sopiarini, Putri St. Fauziah Sulistiani Jarre Suriati Eka Putri Syaharuddin Kasim Syahruddin Kasim Syamsiar, Syamsiar Syarifuddin Liong Syarifuddin Liong Ta'bi, Widi Aprilia Tahril Tanasal A.M Tjodi Harlim Triana Febrianti Yasser, M Yusafir Hala Zarlina ., Zarlina