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All Journal Jurnal Veteriner Media Kedokteran Hewan Jurnal Medik Veteriner JURNAL KAJIAN VETERINER Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology journal of Basic Medical Veterinary Journal of Fisheries & Marine
Widiyatno, Thomas Valentinus
Departemen Patologi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Medik Veteriner

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The Efficacy of Madeira Vine Leaf Extract Combined with Turmeric Rhizome Extract Gel Topically on Second-Degree Burn Wound in Albino Rats Hisyam, Mirza Atikah Madarina; Yuniarti, Wiwik Misaco; Theresia, Sis Wisnuarti; Yudaniayanti, Ira Sari; Lukiswanto, Bambang Sektiari; Sudjarwo, Sri Agus; Widiyatno, Thomas Valentinus
Jurnal Medik Veteriner Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Scien
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss3.2023.91-98

Abstract

Burns is now considered one of the most destructive forms of trauma affecting humans and animals. This study aimed to determine the effect of Madeira vine leaf extract combined with 2% Turmeric rhizome extract (MVLTR) gel administered topically on second-degree burn wound in albino rats based on the number of fibroblasts. A total of 25 male rats weighed 200–300 grams were divided into five groups i.e. (C-) was normal skin, (C+) was burn and treated using 1% silver sulfadiazine, (T1) was burn and treated using 1.25% MVLTR gel, (T2) was burn and treated using 2.5% MVLTR gel, and (T3) was burn and treated using 5% MVLTR gel. The burn wound was performed on the right gluteus of rats, and the therapy was applied twice a day topically, starting after the burn wounds were made. Skin samples were collected on day 15. The histopathological examination was performed by counting fibroblast cells and then analyzed using One-way ANOVA, continued with the Duncan test. Based on the results showed that the C- group was significantly different compared to C+, T1, T2, and T3 groups. C+ had a significant difference with the T1 and T3 groups, meanwhile not significantly different from the T2 group. T2 was not significantly different from the C+ and T3 groups. In conclusion, MVLTR gel at 5% concentration has the potential to be an effective treatment for second-degree burns, as indicated by the increased number of fibroblasts.
Efficacy of Sauropus androgynous Leaves Extract Gel on Burn Wound Healing in Albino Rats Panggabean, Rosenna Tiara; Sudjarwo, Sri Agus; Ma'ruf, Anwar; Widiyatno, Thomas Valentinus; Yudaniayanti, Ira Sari; Kurnijasanti, Rochmah; Khairullah, Aswin Rafif
Jurnal Medik Veteriner Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Scien
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss3.2023.107-115

Abstract

Burns not only damage skin locally but generally affect the body system and have been related as the secondary cause of death. Burns can be effectively treated with a topical drug to prevent chronic inflammation. Burn wound healing is really important for ensuring overall health and well-being. This study aimed to determine the effect of Sauropus androgynous leaves extract gel on the number of fibroblasts, fibrocytes, and collagen density on burn wound healing in albino rats. A total of 50 male albino rats were randomly divided into five groups i.e. (C-) was normal skin, (C+) was skin burn treated with placebo, (T1) was skin burn treated with 2.5% of S. androgynous leaves extract gel, (T2) was skin burn treated with 5% of S. androgynous leaves extract gel, and (T3) was skin burn treated with 10% of S. androgynous leaves extract the gel. The amount of 25 albino rats' skin samples were collected on the 8th day, and the remaining samples were collected on the 15th day. The results showed that 10% of S. androgynous leaves extract gel improved faster, as indicated by the increased number of fibroblasts, fibrocytes, and collagen density. This study can be concluded that 10% of S. androgynous leaves extract gel was the effective dosage to increase the number of fibroblasts, fibrocytes, and collagen density in burn wound healing.
Co-Authors Abdul Samik, Abdul Aksono HP., Eduardus Bimo Amirotul Azhimah Anindya, Afifatus Arianto, Intan Diah Safitri Arief Budiman Arimbi Bambang Poernomo Bambang Sektiari Lukiswanto Boedi Setiawan Cahyono, Shahani Azpriyanne Dellavia, Yolanda Eka Pramyrtha Hestianah, Eka Pramyrtha Eko Agus Suyono Fedik Abdul Rantam Hana Eliyani Hani Plumeriastuti Hestiana, Eka Pramyrtha Hidajati, Nove Hidayatik, Nanik Hisyam, Mirza Atikah Madarina Ira Sari Yudaniayanti Iwan Sahrial Hamid Kadek Rachmawati Khairullah, Aswin Rafif Kuncorojakti, Suryo Lastoaji, Firman Lianny Nangoi Lilik Maslachah Lovela, Aprinda Ratna Lucia Tri Suwanti, Lucia Tri Ma'ruf, Anwar Mahendra Pujiyanto Meles, Dewa Ketut Mochamad Donny Koerniawan Nidom, Chairul Anwar Nugrahani, Anggi Dwi Nunuk Dyah Retno Lastuti Panggabean, Rosenna Tiara Poedji Hastutiek Prambudi, Dhimas Toni Angger Pratama, Ricki Putri, Mirtanti Kiswandi Renaldi, Nogi Rochmah Kurnijasanti Santoso, Kuncoro Puguh Sri Pantja Madyawati, Sri Pantja Sukmanadi, Mohammad Theresia, Sis Wisnuarti Ulfah Juniarti Siregar Wiwik Misaco Yuniarti Yeni Dhamayanti Yusuf, Anang Zhaza Afililla