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Formulasi Dan Evaluasi Fisik Sediaan Tablet Allopurinol 100 Mg Menggunakan Pati Beras Merah (Oryza Nivara) Sebagai Bahan Pengikat Dengan Metode Granulasi Basah Siti Hujatul Hasanah; Agus Setiawan; Lucky Dita Agustiansyah; Dimas Danang Indriatmoko; Candra Junaedi
Jurnal Kesehatan Republik Indonesia Vol 2 No 9 (2025): JKRI - Agustus 2025
Publisher : PT. INOVASI TEKNOLOGI KOMPUTER

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Beras merah (Oryza nivara) umumnya hanya dikenal sebagai bahan pangan pokok. Padahal, beras ini mengandung komponen pati, yang terdiri atas amilosa dan amilopektin, dan berpotensi dimanfaatkan sebagai bahan pengikat dalam pembuatan tablet. Penelitian ini bertujuan mengevaluasi pengaruh penggunaan pati dari beras merah terhadap karakteristik fisik tablet allopurinol yang dibuat menggunakan metode granulasi basah. Penelitian ini bersifat eksperimental dengan empat variasi formula: satu formula menggunakan pengikat sintetis, sedangkan tiga lainnya memakai pati beras merah dengan konsentrasi berbeda. Formula 0 menggunakan PVP 8%, sementara Formula I, II, dan III masing-masing mengandung pati beras merah sebesar 8%, 12%, dan 16%. Evaluasi sifat fisik tablet menunjukkan bahwa penggunaan pati beras merah menghasilkan tablet dengan bobot dan ukuran yang seragam, kekerasan dalam rentang 4–8 kg, waktu hancur di bawah 15 menit, serta tingkat kerapuhan antara 0,5–1%. Analisis ANOVA menghasilkan nilai signifikansi p = 0,001, yang menunjukkan adanya perbedaan bermakna antar formula. Temuan ini mengindikasikan bahwa variasi konsentrasi pati beras merah memberikan pengaruh terhadap karakteristik fisik tablet allopurinol.
Potential Pharmaceutical Biotechnology Products in the Form of Formulations and Preparations of Telang Flower Kombucha Dish Soap (Clitoria ternatea L) as an Antibacterial from Beef (Bos taurus) Isolate Rezaldi, Firman; Nurvadilah, Eva; Junaedi, Candra; Somantri, Ucu Wandi; Fadillah, M. Fariz; Maritha, Vevi; Yenny, Ratna Fitry; Setyaji, Diyan Yunanto
Journal of Health and Nutrition Research Vol. 3 No. 1 (2024)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v3i1.237

Abstract

This research aims to see the potential of each formulation and preparation of dishwashing soap with the active ingredient telang flower kombucha in inhibiting the growth of pathogenic bacteria isolated from beef. This research is a laboratory experiment, namely by making a dishwashing soap base without the active substance of telang flower kombucha. Make a dishwashing soap base that adds the active substance of butterfly pea flower kombucha at concentrations of 20%, 30% and 40%. Biochemical identification results have shown that beef samples contain gram-positive bacteria in the form of Staphylococcus aureus and Listeria monocytogenes, as well as gram-negative bacteria in the form of Salmonella thyposa and Escherichia coli. The results of this research have also proven that pharmaceutical biotechnology products in the form of formulations and dishwashing soap preparations with the active ingredient telang flower kombucha have a positive correlation in inhibiting the growth of the four test bacteria. Based on the one-way ANOVA statistical test at each P value <0.05, it proves that telang flower kombucha dish soap at a concentration of 40% according to post hoc analysis is not significantly different from concentrations of 20% and 30% as a pharmaceutical and antibacterial biotechnology product. isolated from beef. The conclusion of this research is that the formulation and preparation of dishwashing soap at a concentration of 40% proved to be the most effective as a pharmaceutical biotechnology product in inhibiting the growth of the four test bacteria.
Rasionalitas Penggunaan Oains pada Pasien Osteoarthritis di Klinik Teluk Banten Candra Junaedi; Santi Endrawati; Dimas Danang Indriatmoko; Muhamad Parci
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 2 (2025): March: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i2.1163

Abstract

Osteoarthritis is a type of arthritis that occurs in the area around the joints because the cartilage that protects the ends of the bones begins to break down accompanied by reactive changes at the edges of the joints which can cause pain and difficulty moving. Drug use is said to be rational if the patient receives treatment that is in accordance with clinical needs, namely correct diagnosis, correct drug selection, correct indication, correct dose, correct method of administration, and correct patient. This research aims to use a descriptive analysis design for observational research. The research design used was quantitative research to determine the rationality of using NSAIDs anti-pain medication in osteoarthritis patients undergoing treatment at the Klinik Teluk Banten. The rationality results in this research are, 100% correct diagnosis, 100% correct indication. 100% correct choice of drug, 89% correct dose, 100% correct method of administration, 94% correct patient for Osteoarthritis at Klinik Teluk Banten.
DAMPAK PENERAPAN KEBIJAKAN E-CATALOGUE TAHUN 2023 TERHADAP POLA PENGADAAN OBAT DI RSUD dr. DRADJAT PRAWIRANEGARA: IMPACT OF 2023 E-CATALOGUE POLICY ON DRUG PROCUREMENT PATTERNS AT RSUD dr. DRADJAT PRAWIRANEGARA Junaedi, Candra; Anggriani, Yusi; Abillah, Syamsudin; Sari, Ratna Permana
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/zra0nq53

Abstract

Pengadaan obat di rumah sakit merupakan aspek penting dalam menjamin kelancaran pelayanan kesehatan kepada masyarakat. Dengan kemajuan teknologi dan regulasi pemerintah, pengadaan obat kini dilakukan secara menyeluruh melalui sistem e-Purchasing menggunakan e-Catalogue. Penelitian ini bertujuan mengevaluasi pengadaan obat e-Catalogue dan non e-Catalogue sebelum dan sesudah penerapan kebijakan e-Catalogue tahun 2023 di RSUD dr. Dradjat Prawiranegara Serang. Penelitian ini menggunakan pendekatan observasional analitik dengan data retrospektif tahun 2022-2023. Data obat e-Catalogue diperoleh dari LKPP dan obat non e-Catalogue dari SIMRS. Analisis dilakukan secara univariat dengan metode deskriptif yang ditampilkan pada gambar dan tabel. Hasil menunjukkan bahwa secara keseluruhan pengadaan obat melalui e-Catalogue pada tahun 2023 meningkat dan pengadaan non e-Catalogue menurun. Sedangkan pengadaan obat generik meningkat dari 66,62% menjadi 70,20% dan pengadaan obat non e-Catalogue nama dagang meningkat dari 51,81% menjadi 64,67%. Waktu tunggu pengadaan obat e-Catalogue pada tahun 2023 tercatat lebih lama, yaitu sekitar 103 hari, dibandingkan obat non e-Catalogue sekitar 17 hari. Namun, waktu tunggu obat e-Catalogue pada 2023 lebih cepat dibandingkan tahun 2022 yang mencapai 121 hari. Terdapat delapan penolakan obat (50% karena persediaan, 25% syarat minimum, 12,5% harga, 12,5% negosiasi). Kesimpulan pengadaan obat e-Catalogue dan non e-Catalogue periode 2022-2023 dipengaruhi oleh implementasi kebijakan pengadaan obat tahun 2023
Formulasi Dan Aktivitas Antioksidan Sediaan Masker Mata Hidrogel Dari Sari Umbi Wortel (Daucus Carota L.) Nurhayati, Nina; Novi, Cory; Junaedi, Candra
Journal of Chemistry Sciences and Education Vol 2 No 02 (2025): Journal of Chemistry Sciences and Education
Publisher : PT. Pubsains Nur Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69606/jcse.v2i02.363

Abstract

Carrots (Daucus carota L.) are a root vegetable that contains high levels of antioxidants and can be used as a base ingredient in masks. Carrots contain antioxidants such as vitamin C and vitamin A, which can act as skin moisturizers. This study aims to develop a hydrogel eye mask formulation from carrot root extract and test its antioxidant activity using the 1,1-diphenyl-2-picrylhydrazil (DPPH) method. Carrot root extract was formulated into hydrogel eye mask preparations Basis, F1, and F2. Evaluation of the hydrogel eye mask preparations included organoleptic observation, storage stability test, adhesion test, pH test, and hydrogel eye mask shrinkage test. The results showed that the carrot root hydrogel eye masks had antioxidant activity with an average IC50 value of 1167.67 ppm for Basis, 163.63 ppm for F1, and 145.94 ppm for F2. The formulation of hydrogel eye masks from carrot root extract at concentrations of Basis, F1, and F2 had good properties, namely pH, storage stability, adhesion test, mask shrinkage, color, odor, and shape that met the requirements for topical preparations.
Pelatihan Pembuatan Produk Herbal sebagai Upaya Pemanfaatan Potensi Lokal Desa Sukalangu Kabupaten Pandeglang Ucu Wandi Somantri; Candra Junaedi; Fachrudin Perdana; Tarso Rudiana; Nenden Suciyati Sartika; Tuti Rostianti Maulani; Irwan Irwan; Irwanto Irwanto; Ditta Ahmad Herviana; Nur Thooyibah; Widiya Putri; Frida Elasjulia
Jurnal Pengabdian Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v5i3.5896

Abstract

The community service activities carried out in Sukalangu Village, Pandeglang Regency, had the main objective of increasing the utilization of local potential through the development of useful and economic herbal products. The potential of herbal plants in this village is quite abundant, but their utilization is still limited to traditional use for household needs. Therefore, a systematic effort is needed to enable the community to process them into products with added value. The implementation method of the activities included counseling on the benefits of herbal plants for health, technical demonstrations of making simple herbal products such as health drinks and traditional potions, and participatory assistance in the production process. The results of the activities showed a significant increase in community knowledge, with a 40% increase in understanding of the types, benefits, and processing methods of herbs. In addition, technical skills in mixing and processing herbs increased by 50% based on pre- and post-training evaluations. Furthermore, community interest and motivation to develop herbal-based businesses also grew, as demonstrated by the formation of small groups of residents who took the initiative to produce herbal products as household businesses. Other impacts that emerged were increased individual capacity, collective awareness to protect and utilize natural potential, and the opening of sustainable local economic opportunities. Overall, this activity makes a real contribution to supporting the independence of village communities through the utilization of local resources based on traditional wisdom.
Edukasi Efek Samping Obat dan Resiko Penggunaan Obat yang Salah di Pantiasuhan Hasanudin Pandeglang Sofi Nurmay Stiani; Yusransyah Yusransyah; Eneng Elda Ernawati; Baha Udin; Sumarlin US; Muhamad Ichsan Fahlevy; Candra Junaedi; Fajrin Noviyanto
Jurnal IPTEK Bagi Masyarakat Vol 5 No 1 (2025)
Publisher : Ali Institute of Research and Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55537/j-ibm.v5i1.1117

Abstract

Penggunaan obat yang tidak tepat dapat menimbulkan efek samping yang merugikan, terutama di kalangan masyarakat dengan akses informasi yang terbatas seperti orang yang tinggal di panti asuhan. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan penghuni Panti Asuhan Hasanudin Pandeglang mengenai efek samping obat dan risiko penggunaan obat yang salah melalui kegiatan pemberian edukasi. Metode yang digunakan adalah penyuluhan kesehatan disertai dengan diskusi tanya jawab serta evaluasi pretest dan posttest menggunakan kuesioner pengetahuan. Kuesioner tersebut dirancang untuk mengukur pemahaman peserta terhadap materi yang disampaikan sebelum dan sesudah edukasi. Jumlah peserta pada kegiatan ini sebanyak 57 peserta. Hasil evaluasi menunjukkan adanya peningkatan signifikan pada skor pengetahuan peserta setelah dilakukan penyuluhan. Hal tersebut membuktikan bahwa kegiatan edukasi ini efektif dalam meningkatkan kesadaran dan pemahaman mengenai penggunaan obat yang aman. Kegiatan ini diharapkan dapat menjadi model edukasi kesehatan serupa di lingkungan panti asuhan lainnya untuk mencegah penggunaan obat yang tidak rasional.