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Journal : Reaktor

PRODUKSI ANTIBIOTIKA OLEH Bacillus subtilis M10 DALAM MEDIA UREA-SORBITOL Supartono Supartono; Nanik Wijayati; Lina Herlina; Enny Ratnaningsih
Reaktor Volume 13, Nomor 3, Juni 2011
Publisher : Dept. of Chemical Engineering, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.974 KB) | DOI: 10.14710/reaktor.13.3.185-193

Abstract

PRODUCTION OF ANTIBIOTICS BY Bacillus subtilis M10 IN UREA-SORBITOL MEDIUM. Infection diseases still become the main health problems that suffered by people in Indonesia. Besides, there were many pathogen bacteria found to be resistant to the some antibiotics. Therefore, the efforts to get a new antibiotic require to be done continuously. A new local strain of Bacillus subtilis BAC4 has been known producing an antibiotic that inhibit Serratia marcescens ATCC 27117 growth. To make efficient the local strain, mutation on Bacillus subtilis BAC4 was done by using acridine orange and a mutant cell of Bacillus subtilis M10 that overproduction for producing antibiotic was obtained. Nevertheless, the production kinetics of antibiotic by this mutant has not been reported. The objective of this research was to study the production kinetics of antibiotic by Bacillus subtilis M10 mutant. The production of antibiotic was conducted using batch fermentation and antibiotic assay was performed with agar absorption method using Serratia marcescens ATCC 27117 as bacteria assay. Research result provided that Bacillus subtilis M10 mutant with overproduction of antibiotic produced an antibiotic since 8th hour’s fermentation and optimum of it production was at 14th hours after inoculation.  Penyakit infeksi masih menjadi masalah yang utama diderita oleh masyarakat Indonesia. Di samping itu, banyak bakteri patogen yang ditemukan resisten terhadap beberapa antibiotika. Oleh karena itu, upaya-upaya untuk mendapatkan antibiotika baru perlu dilakukan secara terus-menerus. Suatu galur lokal baru Bacillus subtilis BAC4 teridentifikasi memproduksi senyawa antibiotika yang menghambat pertumbuhan Serratia marcescens ATCC27117. Untuk memberdayakan galur tersebut, terhadap Bacillus subtilis BAC4 dilakukan mutasi dengan larutan akridin oranye dan diperoleh mutan Bacillus subtilis M10 yang memproduksi antibiotika berlebihan. Namun, kinetika produksi antibiotika oleh Bacillus subtilis M10 belum pernah dilaporkan. Penelitian ini bertujuan untuk mempelajari kinetika produksi antibiotika oleh mutan Bacillus subtilis M10. Bacillus subtilis M10 difermentasikan ke dalam media urea-sorbitol dan diamati kemampuan produksi antibiotikanya menggunakan Serratia marcescens ATCC 2711 sebagai bakteri uji. Hasil penelitian menunjukkan bahwa mutan Bacillus subtilis M10 memproduksi antibiotika sejak jam ke 8, dan produksi optimumnya terjadi pada jam ke 14 setelah inokulasi.
Co-Authors - Jumaeri -, Solikhah A.A. Ketut Agung Cahyawan W Adi Suryanto Afifaturrochmah, Lutfi Agnes Juniarti Chastelyna, Agnes Juniarti Agung Tri Prasetya Agus Yuwono Ali Djamhuri Aluintany, Vitasha Geushiria Amalina, Nur Dina Anggriani, Frida Anggy Rinela Sulistya Rini, Anggy Rinela Sulistya Anita Harum Sari Antonius Tri Widodo Arief Rohman Arina Marissa, Arina Arofah, Barorotul Ulfah Aryono Adhi, Aryono Asbanu, Yoseanno Widi Anugrah Carnawi, Carnawi Christina Astutiningsih Christina Astutiningsih Didik Prasetyoko Drastisianti, Apriliana Dyah Rini Indriyanti Edy Cahyono Eko Budi Susatyo Ella Kusumastuti, Ella Ellianawati, Ellianawati Endang Susilaningsih Enny Ratnaningsih Enny Ratnaningsih Erika Wijayanti Ersanghono K. Ersanghono K., Ersanghono Ersanghono Kusuma Ersanghono Kusumo, Ersanghono F Widhi Mahatmanti Fanny Firman Syah, Fanny Firman Fathur Rokhman Fera Gustri Ariani, Fera Gustri Firstyarikha Habibah, Firstyarikha G, Agnesya Putri Harjito - Harjito Harjito Harjono Harjono Harmanto Harmanto Harno Dwi Pranowo Harno Dwi Pranowo Heri yanto Hertiana, Dita Setya Hertiana, Dita Setya Husna Amalana, Husna Hutasoit, Parpulungan Hutasoit, Parpulungan Iffani, Shinta Zulfa Ika Kusumawati Jayawarsa, A.A. Ketut Jumina Jumina Jumina Jumina Kasmadi Imam Supardi Kasmui -, Kasmui Kharomah, Kharomah Khofifah, Nur Kristianingsih, Desiagi Dwi Kurniasari, Laviona Tiara Kurniawati, Erlinda Eka Kusoro Siadi Kusoro Siadi Laily Isni Farikhati Langgeng Setyo Wibowo Lestari, Etika Ayu Lestari, Hartatik Sri Lestari, Nanda Ayu Lina Herlina Lina Herlina Lisa Amalia Suryana M. Agus Prayitno, M. Agus Machmudah - Margareta Dian Purnamasari, Margareta Dian Marsudi Marsudi Mar’attus Solihah Masturi Masturi Melykhatun, Rizka Ayu Mohammad Agus Prayitno Mohammad Agus Prayitno Muhammad Afif Muharom, Sidik Muharom, Sidik Murbangun Nuswowati Nasution, Annio Indah Lestari Nico Aditya Wijaya Nindya Ayu Lestari, Nindya Ayu Ningrum, Puji Nugroho, Imam Husnan Nuni Widiarti Nur Faizah Nur Hidayah Nur Kusuma Dewi Nurul Arifin Oktaviana, Sella Pangestika, Ria Rahayu Pratiwi, Khana Fitri Pratono, Ardiyana Prayitno, Mohammad Agus Purwodiningsih, Ristia Putra, Rizki Suhendar Putri, Syarafina Dirinda Rachmadiyono, Dwi Rahayu, Endah Fitriani Ratna Kumala Dewi Resti, Ade Ria Rahayu Pangestika, Ria Rahayu Ria Wulansarie, Ria Riva Ismawati, Riva Riva lsmawati, Riva Robi’ah Adawiyah, Robi’ah rohayati rohayati Rohmawati, Baiti Romawati, Carolina Romawati, Carolina Rosiyanah, Siti Ruliyanti, Tria S Mursiti Sabil, Muhammad Asnawi Salva Mutiara, Denisa Samuel Budi Wardana Kusuma, Samuel Budi Wardana Samuel Budi Wardhana Samuel Budi Wardhana Kusuma Saptorini - Saptorini Saptorini, Saptorini Septiyaningsih, Tri Shakin Ervita Oktaviyani Sigit Priatmoko Siti Anisa Rohmah Siti Handayani Siti Sundari Miswadi Solikhah Solikhah Sri Haryani Sri Haryani Sri Ngabekti Sri Sumartiningsih Sri Supanti Sri Susilogati Sri Susilogati Sumarti SRI WARDANI Suci Mulyati Sudarmin Sudarmin Sudarmin Sudarmin Supartono - Suprapto Suprapto Suprapto, Suprapto Surmatiningsih, Sri Susan Primadevi Susanto, Aris Tri Susanto, Aris Tri Sutikno Madnasri Suwito Eko Pramono Sya'idah, Fatin Atikah Nata Talitha Widiatningrum Tinasy, Nur Audiyah Titik Kushandayani Tri Handayani Triawan, Singgih Ade Triawan, Singgih Ade Triyono Triyono Triyono Triyono Tunggul Pawenang, Eram Ulya, Isnaeni Nurul Veronita, Fanna Veronita, Fanna Wahyuningtyas, Wulan Wara Dyah Pita Rengga Watoni, Edi Satria Wawan Wawan Widarti, Nuni Widya Hary Cahyati Wijianto, Wijianto Woro Sumarni Yayuk Tutiek Supriyanti Yeni Anita Sari yoga agung prabowo Yosepphiene Debbie Damayani Yuliyati, Tri Budi Yunita, Wulansari Zaenuri Zaenuri