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All Journal HAYATI Journal of Biosciences SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmiah Aplikasi Isotop Radiasi Microbiology Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Universa Medicina Indonesian Journal of Biotechnology and Biodiversity The Indonesian Journal of Infectious Diseases Eksakta : Berkala Ilmiah Bidang MIPA Majalah Kedokteran Andalas Health Information : Jurnal Penelitian Jurnal Ners East Asian Journal of Multidisciplinary Research (EAJMR) Journal of Comprehensive Science Makara Journal of Health Research Makara Journal of Science Journal of Clinical Microbiology and Infectious Diseases Indonesian Journal of Biomedicine and Clinical Sciences
Andi Yasmon
Department Of Microbiology, Faculty Of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Potential biomarkers of IFN-γ, IL-2 and CXCL9 for diagnosis of Q fever disease Purba, Hastuti Handayani S; Yasmon, Andi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.12991

Abstract

The pathogen responsible for Q fever disease, Coxiella burnetii, is a zoonosis classified as a pathogen due to its airborne transmission. The C. burnetii infection could be both acute or chronic in humans. The main and most common entry of the pathogens to the body is through the breathing of polluted aerosols containing a resistant substance similar to C. burnetii spores. This small cell variant (SCV) or spore-like morphotype is extremely stress-resistant, therefore inadequate treatment causes serious effects even death. Due to the diversity of clinical manifestations of Q fever and the presence of less specific and sensitive diagnoses for other diseases, multiple platforms for exploring Q fever biomarkers are required. Apart from serological studies to determine a biomarker for Q fever, it will be prudent to concentrate on the more appropriate cell-mediated immune response. This article discusses C. burnetii causing Q fever disease and how the host develops humoral and cellular immunity, particularly IFN-γ, IL-2 and CXCL9, as potential biomarkers for the diagnosis of Q fever disease.
High Risk Human Papillomavirus & Risk Factors for Cervical Cancer Agustini, Riani; Yasmon, Andi
Jurnal Ners Vol. 8 No. 2 (2024): OKTOBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i2.26220

Abstract

Cervical cancer is caused by the non-enveloped, Papillomavirus, or HPV, is an example of a double-stranded DNA virus.. According to the 2020 Global Cancer Observatory (GLOBOCAN) survey, a global study of female populations, cervical cancer is associated with a relatively high fatality rate. Cervical cancer is the second most prevalent form of the disease among women in Indonesia. Over 73% of instances of cervical cancer are known to be caused by high-risk HPV strains 16 and 18. The proteins E6 and E7 significantly prevent the tumor suppressors p53 and pRb from acting, which would otherwise cause cells to proliferate and become uncontrollably large. It is necessary to identify the risk factors that lead to cervical cancer in order to take the necessary preventive action.
Identification of Antiviral Compounds against Hepatitis C Virus (HCV) targeting NS3 Protein by Pharmacophore Modeling, Molecular Docking, and ADMET Approach Rahayu, Ratih; Erlina, Linda; Ratnoglik, Suratno Lulut; Yasmon, Andi; Fadilah; Paramita, Rafika Indah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 04 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss04/448

Abstract

Hepatitis C Virus (HCV) is a world health problem. HCV infection is initiated by various structural and non-structural proteins. The HCV NS3 protein has an important function in viral replication. The N-terminal domain of NS3 acts as a protease to process most of the viral polypeptides. NS3 also acts as an RNA helicase and NTPase and triggers liver fibrosis which accelerates the development of liver disease. Thus, this study aims to provide information on potential new antiviral candidates against HCV that target the NS3 protein. This study was conducted in-silico with a ligand-based and structure-based pharmacophore model to the cavity of the active protein site generated after virtual screening and molecular docking. The results of this study showed that three compounds, namely stigmasterol, gamma-mangostin, and erycristagallin, were found as HCV antiviral candidates that target the NS3 protein with a lower binding affinity than the native ligand. The binding energy of each compound is -9.23 Kcal/mol, -8.58 Kcal/mol, and -8.17 Kcal/mol. Based on ADMET analysis, the three compounds have high absorption in the small intestine. The cytotoxicity analysis of stigmasterol compounds is not potentially mutagenic, and the LD50 value of stigmasterol is also lower than other compounds.
Molecular Pathogenesis of Human Rhinovirus (HRV) Infection Murti, Anissa Wari; Andi Yasmon
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 04 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss04/540

Abstract

Human Rhinovirus (HRV) is a RNA virus belonging to the Picornaviriade family that most often causes acute respiratory infections (ARI). This virus can cause dangerous infections in children, people with chronic respiratory disorders, and individuals with low immunity. This virus can infect newborns six to eight  times and adults two to four times per year. In addition, HRV is the main cause of pneumonia and bronchiolitis which can worsen the symptoms of cystic fibrosis asthma. This article also discusses the development of the HRV replication process that occurs in the respiratory tract epithelium which takes place in several stages, starting with virus attachment and ending with the release of new virions. We also analyze the stages of neutralizing antibodies (nAbs) to prevent HRV infection. Currently, there are not any authorized antiviral drugs or HRV vaccination because this virus has highly variable antigenic sites. To develop a vaccine that can protect against various HRV serotypes, a consensus sequence that combines several strains is needed.
Immune Response to Capsular Polysaccharide of Streptococcus pneumoniae in Rabbits Immunized with Pneumococcal Conjugate Vaccine Zaenab; Tafroji, Wisnu; Salsabila, Korrie; Winarti, Yayah; Wulandari, I Gusti Ayu Inten; Yasmon, Andi; Safari, Dodi
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.642-648

Abstract

To evaluate the immune response of a rabbit model to polysaccharide capsules of Streptococcus pneumoniae after primary and booster immunization with pneumococcal conjugate vaccine. Rabbits were immunized with 0.25 ml of the 13-valent pneumococcal conjugate vaccine (PCV13) on Day 0, 7, and 14. Blood of rabbits was collected to measure the specific antibodies against the native polysaccharide capsules of S. pneumoniae serotypes 6B (Anti-Pn6BPS antibodies) and 19F (Anti-19FPS antibodies) using enzyme-linked immunosorbent assay (ELISA). The specific anti-Pn6BPS and anti-Pn19FPS antibodies in the immunized group increased significantly compared to the control rabbit after immunization (P<0.05). The highest titer of anti-Pn6BPS and anti-Pn19FPS antibodies were obtained on Day 21 and Day 28, respectively. The third immunization on Day 21 is a fairly high increase in specific antibodies against polysaccharide type 6B and type 19F. The highest antibody titers against polysaccharide capsules of S. pneumoniae were obtained after booster immunization.
West Sumatera curd effect on fecal IgA and IgG in BALB/c mice colon inflammation induced by dextran sodium sulphate Utami, Diah Dwi; Yasmon, Andi; Heri Wibowo; Maya Ulfah; Ibnu Agus Ariyanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17334

Abstract

Curd, a fermented buffalo milk product from West Sumatra, is known for its probiotic content. Probiotics are recognized for their health benefits, including potential advantages for inflammatory bowel disease (IBD). Previous studies have confirmed the probiotic status of curd. However, the effects of curd on the immunoglobulin response in colon inflammation are still not well understood. This study employs an experimental design to investigate the impact of curd on the levels of total immunoglobulins A (IgA) and G (IgG) in feces and analyze the correlation between total IgA levels in feces and IL-10 expression in serum and feces and total IgG levels in feces and TNF-α expression in serum and feces of BALB/c with colon inflammation. In the normal group, curd administration significantly increased total IgA levels in feces, indicating a potential modulation of the immune response. Conversely, in the inflammatory group, curd reduced total IgA levels, though this effect was not statistically significant. Similarly, while curd reduced total IgG levels in feces for both the normal and inflammatory groups, the reduction was not statistically significant. No significant relationships were found between total IgA levels in feces and IL-10 expression in serum and feces, nor between total IgG levels in feces and TNF-α expression in serum and feces.
Sampling of Sars-Cov-2 Covid-19 an Air Using the Impingement Method with Real-Time PCR as Detection Examination Tjampakasari, Conny Riana; Yasmon, Andi; Rosa, Yulia; Sjatha, Fithriyah
East Asian Journal of Multidisciplinary Research Vol. 3 No. 3 (2024): March 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i3.8651

Abstract

Examination of airborne microbial for SARS-CoV-2, Coronavirus Disease 2019 (Covid-19) has not been widely developed. Whether this virus is airborne is still an unanswered question. This preliminary study was to evaluate the presence of the Covid-19 in the air. The study was conducted on 4 rooms, which are laboratory rooms used for Covid-19 activities. The impingement which is an active method used for air sampling, while the detection was carried out through a molecular approach using RT real-time  PCR. The overall Covid-19 virus was not found in the room being examined. Four rooms gave CT values above the positive control, that is administration room (CT 30.44), BSL room (CT 30.23), BSC (CT 30.69 ) and waiting room (CT 35.61). No found SARS-CoV-2 Covid-19 in air using the impingement method with real-time PCR as detection examination in the room being examination.  Preliminary study shown SARS-CoV-2 Covid-19 can not transmitted through the air. Research needs to be done with more sampling as continuation of this study.
Co-Authors . Andriansjah Abror Irsan Ade P.R. Simaremare Agustini, Riani Anis Anis Anis Karuniawati Ardiana Kusumaningrum Ariyani Kiranasari ASRI SULFIANTI Beti Ernawati Dewi Budiman Bela Burhanuddin Burhanuddin Burhanuddin Burhanuddin Delly Chipta Lestari Delly Chipta Lestari Dewi Murniati Diah Dwi Utami Diana Natalia Diana Natalia Efendi, Ida Effendi, Ida Effiana Effiana Effiana, Effiana Elisabeth D. Harahap Elisna Syahruddin Erlina, Linda Fadilah Fadilah Fadilah FERA IBIRAHIM Fera Ibrahim Fithriyah Fithriyah Fithriyah Fithriyah Fithriyah Fithriyah Gultom, Desy A. Hanifah, Rifdah Heri Wibowo Ibnu Agus Ariyanto Ika Ningsih Junita Indarti Ketut Tuti Parwati Linosefa Linosefa Lisnawati Rachmadi Lola Febriana Dewi Louisa Ivana Utami Lucky H Moehario Mardhia, Mardhia Mardhia, Mardhia Mardiastuti H Wahid Maria L. Rosilawati Maria L. Rosilawati Maria Lina R. Maria Lina Rosilawati Maya Ulfah Moehario, Lucky Hartati Murti, Anissa Wari Ni Made Adi Tarini Ni Nengah Dwi Fatmawati Normasari Normasari Oktania Sandra Puspita Paramita, Rafika Indah Pramita G. Dwipoerwantoro Pratiwi Pujilestari Sudarmono Purba, Hastuti Handayani S Purnomosidi, Muhammad Abhi Rahayu, Ratih Ratnoglik, Suratno Lulut Rela Febriani Ria Kodariah Rosa, Yulia Rudyanto Sedono Safari, Dodi Salsabila, Korrie Samsuridjal Djauzi Sari Rahmayanti Simon Yosonegoro Liem SJATHA, FITHRIYAH Sudarmo, Fitrahwati Tafroji, Wisnu Teguh Sarry Hartono Thomas Robertus Tjampakasari, Conny Riana Utami, Diah Dwi VIVI SETIAWATY Winarti, Yayah Wresti Indriatmi B. Makes Wulandari, I Gusti Ayu Inten Yeva Rosana Yulia Rosa Saharman YULIANTY MUHAYAR Yusmaniar Yusmaniar Zaenab