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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) HAYATI Journal of Biosciences PHARMACON Jurnal Bios Logos Animal Production : Indonesian Journal of Animal Production Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Makara Journal of Science Heca Journal of Applied Sciences Malacca Pharmaceutics Health & Medical Sciences Journal of Educational Management and Learning Infolitika Journal of Data Science Grimsa Journal of Science Engineering and Technology Jurnal Inovasi Global Borneo Journal of Pharmacy
TRINA EKAWATI TALLEI
Faculty of Mathematics and Natural Sciences, Sam Ratulangi University Manado
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Heca Journal of Applied Sciences

 1 
Characterizing the Size Distribution of Silver Nanoparticles Biofabricated Using Calotropis gigantea from Geothermal Zone Kemala, Pati; Khairan, Khairan; Ramli, Muliadi; Mauer Idroes, Ghazi; Mirda, Erisna; Setya Ningsih, Diana; Tallei, Trina Ekawati; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.21

Abstract

This research aims to synthesize silver nanoparticles (AgNPs) using an aqueous leaf extract of Calotropis gigantea obtained from the geothermal manifestation Ie Seu-Um, Aceh Besar, Aceh Province, Indonesia. The C. gigantea leaf extract was mixed with AgNO3 solutions at concentrations of 2, 5, and 9 mM, respectively. The mixture was stirred at 80 rpm by a magnetic stirrer for 48 hours in the dark. The change in solution color indicated the reduction of Ag+ to Ag0. The resulting AgNPs synthesized using C. gigantea leaf extract (AgNPs-LCg) exhibited cloudy grey, reddish dark brown, and light brown colors when synthesized with AgNO3 concentrations of 2, 5, and 9 mM, respectively. The particle sizes of AgNPs-LCg had maximum frequencies at 246.98 nm (synthesized using AgNO3 2 mM), 93.02 nm (synthesized using AgNO3 5 mM), and 171.25 nm (synthesized using AgNO3 9 mM). The zeta potential values of AgNPs-LCg using 2, 5, and 9 mM AgNO3 were -41.9, -40.1, and -31.4 mV, respectively. Based on the solution color, nanoparticle size, and stability value of AgNPs, it can be concluded that the use of AgNO3 at 5 mM is optimal for the green synthesis process of AgNPs-LCg.
A Review on Mitochondrial Genome of Ants (Hymenoptera: Formicidae) Kolondam, Beivy Jonathan; Tallei, Trina Ekawati; Koneri, Roni; Abas, Abdul Hawil; Mamahit, Juliet Merry Eva
Heca Journal of Applied Sciences Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v1i2.74

Abstract

Ants, which are members of the Formicidae family, have been the subject of considerable scientific scrutiny due to their remarkable diversity and ecological importance. Extensive research endeavors have been directed towards understanding the complex behaviors and ecological responsibilities exhibited by these organisms. The advent of cutting-edge sequencing technology in recent times has sparked a significant breakthrough in the deciphering of mitochondrial genomes in many animals, including ants. The objective of this review paper is to provide an informative summary of the mitochondrial DNA of ants. Exploring the intricate structural aspects, we investigate the genetic diversity that exists in the mitochondrial genomes of ants. The investigation of evolutionary processes provides insight into the complex alterations that have shaped genomes throughout time. The broader ramifications of these genetic differences for the fields of ant biology and conservation are thoroughly considered. An examination is conducted on the structural characteristics, genetic variations, and evolutionary features of ant mitochondrial genomes, along with an investigation into their physiological impacts. As the molecular complexities of ant mitochondrial genomes are revealed, there is an opportunity to further explore their realm, leading to a more comprehensive comprehension of these extraordinary organisms.
Network Pharmacology Insights into Broccoli Microgreens for Prostate Cancer Wijaya, Puspita; Tallei, Trina Ekawati; Tendean, Lydia Estelina Naomi; Fatimawali, Fatimawali; Turalaki, Grace Lendawati Amelia; Purwanto, Diana Shintawati
Heca Journal of Applied Sciences Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v3i1.264

Abstract

Prostate cancer is a leading malignancy in men, ranking fourth globally and fifth in Indonesia (GLOBOCAN 2020). Conventional therapies, though available, are limited by high costs, side effects, and resistance, highlighting the need for accessible alternatives. Broccoli microgreens, rich in bioactive compounds, have shown potential in preventing and treating various cancers. This study hypothesized that bioactive compounds in broccoli microgreens interact with molecular targets involved in prostate cancer progression. To test this hypothesis, we employed a network pharmacology-based in silico approach to systematically explore these interactions and identify potential therapeutic mechanisms. Bioactive compounds in broccoli microgreens were identified using liquid chromatography-mass spectrometry (LC-MS) and analyzed via the PubChem database. The biological activities of these compounds were predicted using PASS Online, focusing on their capacity to modulate TP53 gene expression. Pharmacokinetic and toxicity evaluations were performed using ADMETLab 3.0 and Protox 3.0 to assess their safety and drug-like properties. Target proteins were identified through SwissTargetPrediction and GeneCards, while protein-protein interaction networks were constructed using STRING. The pharmacological network was visualized using Cytoscape to elucidate the molecular mechanisms of action. The analysis identified 528 relevant target proteins, with key roles attributed to SRC and EGFR, both critical in resistance to EGFR tyrosine kinase inhibitors and in regulating processes such as cell proliferation, apoptosis resistance, and metastatic potential. Through network pharmacology, bioactive compounds such as kaempferol and polydatin were identified as potential inhibitors of these targets, demonstrating their ability to modulate pathways essential to prostate cancer progression. In conclusion, broccoli microgreens contain bioactive compounds with potential pharmacological relevance for prostate cancer, particularly through their interaction with SRC and EGFR pathways, warranting further experimental validation.
Prostate Cancer Vaccines: Progress, Challenges, and Future Directions Runtunuwu, Stefanus Vicky Bernhard Elisa; Tallei, Trina Ekawati; Turalaki, Grace Lendawati Amelia
Heca Journal of Applied Sciences Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v3i1.263

Abstract

Prostate cancer remains a major contributor to cancer-related deaths in men, with its incidence rising significantly with age. Conventional treatment modalities, including surgery, radiation therapy, hormonal therapy, and chemotherapy, often face limitations such as treatment resistance, disease recurrence, and considerable side effects. These challenges have sparked growing interest in novel approaches like immunotherapy, which leverages the immune system to combat cancer. Among these, vaccine-based immunotherapy has emerged as a promising strategy, aiming to generate precise immune responses against tumor-specific antigens. Advances in immunology, molecular targeting, and vaccine development have demonstrated encouraging results in terms of safety and immunogenicity. Nevertheless, obstacles such as tumor heterogeneity, immune escape mechanisms, and limited efficacy in advanced stages of the disease continue to hinder progress. The aim of this review is to examine the current landscape of prostate cancer vaccine development, with a focus on advancements in molecular target identification, optimization of vaccine technologies, and the evaluation of combination therapy strategies. Findings from clinical trials have shed light on both the opportunities and challenges of vaccine-based therapies. Synergistic approaches involving immune checkpoint inhibitors, radiotherapy, and androgen deprivation therapy have shown potential to amplify immune responses and mitigate resistance mechanisms. Additionally, emerging technologies such as bioinformatics and artificial intelligence are revolutionizing vaccine development by enabling the discovery of patient-specific neoantigens and the creation of tailored vaccine formulations. Despite these breakthroughs, achieving consistent therapeutic outcomes remains challenging, particularly in metastatic and castration-resistant cases. Future directions in the field include developing personalized cancer vaccines, adopting adaptive clinical trial designs, and employing innovative endpoints to streamline translation into clinical practice. In summary, while prostate cancer vaccine development has advanced significantly, addressing critical barriers like tumor heterogeneity and immune evasion and embracing emerging technologies are essential for optimizing personalized vaccines and improving treatment outcomes.
Co-Authors Abas, Abdul Hawil Adikila, Gregorius Giani Angelina Stevany Regina Masengi Antasionasti, Irma Any Aryani Arifin, Mulyani Asep Rusyana Azzania Fibriani Balansa, Endrile Golmen Barasarathi , Jayanthi BEIVY JONATHAN KOLONDAM Celik, Ismail Daniel Febrian Sengkey Dantje Tarore Diah - Kusumawaty Diah Puspitasari Dian Handayani Diana Setya Ningsih, Diana Didik Priyandoko Dolongtelide, Jeclin Inebel Dzikrina, Hanina El-Shazly, Mohamed Elly Suoth Emran, Talha Bin Erwin Wantasen Estevam, Ethiene Castellucci Faisal, Farassa Rani Fatimawali . Florencia N. Sompie Ghazi Mauer Idroes Halimatushadyah, Ernie Hariyanto, Yuanita Amalia Herny E.I. Simbala Hizir Sofyan Idroes, Ghifari Maulana Illah Sailah Irvanizam, Irvanizam Jein Rinny Leke, Jein Rinny Kalalo, Marko Jeremia Kemala, Pati Kepel, Billy Johnson Khairan Khairan Laksono Trisnantoro Lala, Andi Lydia E. N. Tendean, Lydia E. N. Mamahit, Juliet Merry Eva Martha Marie Kaseke Masengi, Kyoko Itsuko Etsuko Gabriela Maulana, Aga Maulydia, Nur Balqis Mirda, Erisna Moh. Yani Mohd Fauzi, Fazlin Monoarfa, Alexander James Muliadi Ramli Musdalifah, Annisa Nabila, Fiki Farah Niode, Nurdjannah Jane Nurul Faridah, Nurul Patwekar, Mohsina Paulina yamlean Pendong, Christa Hana Angle Purukan, Christy Purwanto, Diana Shintawati Rahman, Sunarti Abd Ratte, Titah Amelia Rinaldi Idroes Rizkia, Tatsa Roni Koneri Runtunuwu, Stefanus Vicky Bernhard Elisa Salaki, Christina Leta Salaswati, Salaswati Sambul, Alwin Melkie Sari, Nadia Warda Sekar Sasmita, Novi Reandy Siampa, Jainer Pasca Sri Sudewi, Sri Takawaian, Agrita Feisilia Tamala, Yulianida Tania, Adinda Dwi Tendean, Lydia Estelina Naomi Teuku Rizky Noviandy Tumilaar, Sefren Geiner Turalaki, Grace Lendawati Amelia Unsratdianto Sompie, Sherwin Reinaldo Utami, Wulandari Putri Wawo, Arsianita Ester Wijaya, Puspita Wungouw, Herlina Ineke Surjane Zuchra Helwani, Zuchra Zulkarnain Jalil