Article Per Year (5 Year)
p-Index From 2021 - 2026
2.495
P-Index
This Author published in this journals
All Journal E-Jurnal Medika Udayana E-Journal Obstetric & Gynecology Udayana Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Health Sains International Journal of Social Service and Research Indonesian Journal of Perinatology Journal Research of Social Science, Economics, and Management
Ryan Saktika Mulyana
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
Cadmium Exposure and Preeclampsia: A Systematic Review of Environmental Risk in Pregnancy Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.951

Abstract

Objective: To systematically evaluate current scientific evidence on the association between cadmium (Cd) exposure and the risk of preeclampsia in pregnant women, and to explore underlying mechanisms and population-specific patterns.Methods: This systematic review was conducted according to PRISMA guidelines. Comprehensive literature searches were performed across PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar without time restriction, focusing on the past 15 years. Inclusion criteria encompassed original human studies measuring cadmium exposure—biological, dietary, or environmental—and reporting preeclampsia as an outcome. Risk of bias was assessed using the Newcastle-Ottawa Scale.Results: Twenty-five eligible studies were included, spanning case-control, cohort, and cross-sectional designs across diverse geographic regions. Most studies found a positive association between cadmium exposure and increased preeclampsia risk, though methodological heterogeneity exists. Proposed mechanisms include cadmium-induced oxidative stress, endothelial dysfunction, placental insufficiency, and hormonal dysregulation. Evidence also highlights differences in risk based on diet, region, and environmental regulation. However, inconsistencies in exposure metrics and population stratification remain.Conclusion: The cumulative evidence suggests cadmium is a plausible environmental risk factor for preeclampsia. Future research must standardize exposure assessments and address population-specific modifiers. This review provides critical groundwork for hypothesis-driven studies and policy frameworks addressing toxic metal exposure in maternal health.Paparan Kadmium dan Preeklampsia: Tinjauan Sistematis terhadap Risiko Lingkungan pada KehamilanAbstrakTujuan: Penelitian ini bertujuan untuk melakukan tinjauan sistematis terhadap bukti ilmiah terkini mengenai hubungan antara paparan kadmium (Cd) dan risiko preeklampsia pada ibu hamil, serta mengeksplorasi mekanisme biologis yang mendasari dan pola risiko spesifik populasi.Metode: Tinjauan sistematis ini disusun berdasarkan pedoman PRISMA. Pencarian literatur dilakukan secara menyeluruh melalui basis data PubMed, Scopus, Web of Science, ScienceDirect, dan Google Scholar tanpa batasan waktu, dengan fokus pada publikasi 15 tahun terakhir. Kriteria inklusi meliputi penelitian asli pada manusia yang mengukur paparan kadmium—baik secara biologis, dietetik, maupun lingkungan—dan melaporkan preeklampsia sebagai luaran. Risiko bias dinilai menggunakan Newcastle-Ottawa Scale.Hasil: Sebanyak 25 studi memenuhi kriteria dan dianalisis, mencakup desain studi kasus-kontrol, kohort, dan potong lintang dari berbagai wilayah geografis. Mayoritas studi menunjukkan adanya hubungan positif antara paparan kadmium dan peningkatan risiko preeklampsia, meskipun terdapat heterogenitas metodologis. Mekanisme yang diusulkan meliputi stres oksidatif akibat kadmium, disfungsi endotel, insufisiensi plasenta, dan disregulasi hormonal. Bukti juga menunjukkan perbedaan risiko berdasarkan pola diet, lokasi geografis, dan tingkat pengawasan lingkungan. Namun, masih terdapat ketidakkonsistenan dalam metrik paparan dan stratifikasi populasi.Kesimpulan: Bukti kumulatif mendukung bahwa kadmium merupakan faktor risiko lingkungan yang potensial terhadap preeklampsia. Penelitian selanjutnya perlu menstandarkan metode pengukuran paparan dan mempertimbangkan faktor-faktor spesifik populasi. Tinjauan ini memberikan landasan penting bagi studi berbasis hipotesis dan penyusunan kebijakan terkait paparan logam toksik dalam kesehatan maternal.Kata kunci: Komplikasi kehamilan; paparan kadmium; preeklampsia; stres oksidatif; toksikologi lingkungan
Blood Pressure Variability as a predictor of maternal and neonatal outcomes in preeclampsia Mulyana, Ryan Saktika; Pemayun, Tjokorda Gede Astawa; Narayani, Ida Ayu; Adikarya, I Putu Gede Danika; Pradnyaandara, I Gusti Bagus Mulia Agung; Paramyta, I Gusti Ayu Cintya
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.180-187

Abstract

HIGHLIGHTS Increased blood pressure variability (BPV) in preeclampsia is associated with a higher risk of maternal complications, such as prolonged hospitalization and eclampsia, as well as neonatal complications, including low birth weight and the need for NICU admission. Incorporating BPV monitoring into routine prenatal care may improve early detection of high-risk cases, allowing for timely interventions to reduce adverse maternal and neonatal outcomes.   ABSTRACT Objective: Preeclampsia remains a major cause of maternal and perinatal morbidity and mortality worldwide. This study aimed to evaluate the impact of blood pressure variability (BPV) on maternal and neonatal outcomes in preeclamptic patients, emphasizing its potential role in clinical management. Materials and Methods: A retrospective cohort study was conducted on 40 preeclamptic patients treated at Prof. Dr. I.G.N.G Ngoerah Hospital, Denpasar, Bali, between January 2020 and December 2022. BPV was determined from serial systolic and diastolic blood pressure measurements during antenatal care. Maternal outcomes included length of hospitalization, preterm birth, premature rupture of membranes, eclampsia, postpartum hemorrhage, ICU admission, and composite adverse events. Neonatal outcomes included birth weight, Apgar scores, NICU admission, stillbirth, congenital anomalies, and neonatal death. Statistical analyses were performed using bivariate and multivariate logistic regression methods, with variables of p < 0.25 included in final models. Results: High BPV was significantly associated with increased maternal adverse events (adjusted OR 13.66; 95% CI 2.26–82.43; p = 0.004) and neonatal adverse outcomes (p = 0.011). Specifically, it correlated with low birth weight (p < 0.001), shorter birth length (p = 0.003), preterm birth (p = 0.003), and higher NICU admission rates (p = 0.005). No significant association was observed with fetal distress, intrauterine growth restriction, or neonatal death. The study achieved a statistical power of 86.7%. Conclusion:Increased BPV in preeclampsia is strongly linked to adverse maternal and neonatal outcomes. Routine BPV monitoring may serve as an important tool for early risk identification and improved obstetric management.
Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.236-248

Abstract

HIGHLIGHTS Perinatal ultraprocessed food (UPF) exposure disrupts maternal gut microbiota composition, increasing pro‑inflammatory taxa and systemic endotoxemia. Placental immune activation and oxidative stress represent key mediators linking maternal diet to fetal immune and metabolic programming. Neonatal outcomes include altered regulatory T‑cell development, Th2 immune skewing, allergic sensitization, and early metabolic risk. Integrated dietary counseling, microbiota‑targeted interventions, and public health policies are urgently needed to mitigate transgenerational immune health risks.   ABSTRACT Objective: To synthesize and critically evaluate evidence linking perinatal exposure to ultraprocessed foods (UPFs) with maternal gut dysbiosis, placental inflammation, and neonatal immune programming, and to identify translational implications for perinatal care. Materials and Methods: A systematic narrative review was conducted following PRISMA 2020 guidelines, without PROSPERO registration. Literature searches of major databases (2000–March 2025) identified 1,845 records. After screening and eligibility assessment, 20 studies were included. Study quality was appraised using validated tools, and data were synthesized thematically into evidence domains covering maternal microbiota, inflammatory pathways, placental changes, and neonatal immune outcomes. Results: Maternal UPF consumption was associated with gut dysbiosis characterized by reduced microbial diversity, increased pro-inflammatory taxa, and systemic endotoxemia. Elevated inflammatory biomarkers including lipopolysaccharide, interleukin‑6, tumor necrosis factor‑a, and C‑reactive protein were frequently reported. Limited placental studies revealed increased innate immune activation and oxidative stress. Neonatal immune alterations included regulatory T cell suppression, T helper 2 skewing, increased allergic sensitization, and metabolic programming changes. Evidence strength was highest for maternal gut dysbiosis and immune programming but limited for direct placental mechanisms. Translational opportunities include dietary counseling, microbiota-targeted interventions, and public health strategies aimed at improving maternal diet quality. Conclusion: Perinatal exposure to UPFs adversely impacts the maternal gut–placenta–fetal immune axis. Integrated dietary interventions and population-level nutrition policies are urgently needed to mitigate downstream transgenerational immune risk.
Co-Authors A. A. Ngurah Laksamana Yudha A.A. Ngurah Laksamana Yudha Adhi Pribadi Adikarya, I Putu Gede Danika Agustinus Darmawan Hariyanto Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alfonso Anggriawan Aloysius Suryawan Anak Agung Gede Putra Wiradnyana Anak Agung Ngurah Anantasika Andonotopo, Wiku Anom Suardika Bachnas, Muhammad Adrianes Bambang Rahardjo Cut Meurah Yeni Daniel H. Susanto de Liyis, Bryan Gervais Deantri, Fanny Denni Prasetyo Endang Sri Widiyanti Endang Sri Widiyanti Evert Solomon Pangkahila Hartanto Hartanto I Gde Sastra Winata I Made Darmayasa I Nyoman Gede Budiana I Nyoman Hariyasa Sanjaya I Wayan Artana Putra I Wayan Megadhana I Wayan Megadhana Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Jagannatha, Gusti Ngurah Prana Jaya Kusuma Julian Dewantiningrum Kamajaya, I Gusti Ngurah Agung Trisnu Kevin Agastya Duarsa Kirana, Ni Wayan Kartika Candra Kurjak, Asim Made Suyasa Jaya Mahastya, I Wayan Cahya Manuaba, Ida Bagus Gede Fajar Narayani, Ida Ayu Ni Kadek Mulyantari Ni Wayan Ariati Trisna Dewi Nicholas Renata Lazarosony Nuswil Bernolian Nyoman Bayu Mahendra Paramyta, I Gusti Ayu Cintya Pemayun, Tjokorda Gede Astawa Pradnyaandara, I Gusti Bagus Mulia Agung Pradnyana, I Wayan Agus Surya Pramono, Mochammad Besari Adi Putu Doster Mahayasa Rey Jauwerissa Sri Sulistyowati Stanojevic, Milan Surya, I Gede Ngurah Harry Wijaya Sutedja, Jane Carissa Theresia Monica Rahardjo Tjokorda Gde Agung Suwardewa Wibawa, I Bagus Satriya Wijaya Surya, I Gede Ngurah Harry William Alexander Setiawan Wiradnyana, Anak Agung Gede Putra