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All Journal The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Oceana Biomedicina Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Spizaetus: Jurnal Biologi dan Pendidikan Biologi INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Oceana Biomedicina Journal Indonesian Journal of Cancer CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Svāsthya: Trends in General Medicine and Public Health Surabaya Biomedical Journal
Biutifasari, Verna
Fakultas Kedokteran Universitas Hang Tuah Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder Verna Biutifasari; Ni Komang Sri Dewi Untari; Pramita Anindya Nugraheni; Ronald Pratama Adiwinoto; Djatiwidodo Edi Pratiknya; Vendra Setiawan; Hartono Kahar; Betty Agustina Tambunan
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3358

Abstract

BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) are basic hematological indices used to assess inflammation and immune status. Hyperbaric oxygen (HBO) is known to enhance cerebral blood flow and reduce inflammation, however, not many studies have observed the its effect on BDNF level, SII, and SIRI in ASD subjects; therefore, this study was performed.METHODS: Fifteen ASD subjects were involved in this study and received HBO therapy 10 times within a 2-week period. The HBO therapy was performed by letting the subjects got into an isolated chamber filled with 100% oxygen and 1.3 ATA pressure for 60 minutes. Pre- and post-therapy blood samples were taken from subjects. BDNF level was measured with Enzyme Linked Immunosorbent Assay (ELISA), while neutrophils, monocytes, lymphocytes and platelets were measured by hematology analyzer for the calculation of SII and SIRI.RESULTS: Post-therapy BDNF level was higher than pre-therapy (1.84 ng/mL vs. 1.46 ng/mL; p=0.039). The increased in BDNF suggested reduced neuroinflammation and enhanced connections between neurons. Both post-therapy SII (672.4 vs. 359.4; p=0.005) and SIRI (1.3 vs. 0.7; p=0.009) were significantly lower than pre-therapy indexes. Decreased in SII and SIRI signified a reduction in neuroinflammation.CONCLUSION: HBO therapy increases BDNF level, also decreases SII and SIRI in ASD subjects. These results suggest that HBO has an effect on neuroinflammation, specifically in ameliorating inflammation.KEYWORDS: autism spectrum disorder, BDNF, SII, SIRI, hyperbaric oxygen therapy
Pengaruh Pemberian Gel Chitosan Dari Ekstrak Kulit Udang Vannamei (Litopenaeus Vannamei) Terhadap Angiogenesis Pada Tikus Jantan (Rattus Norvegicus) Pramana, Anak Agung Ngurah Gede Anggra; Rahadianto, Rahadianto; Biutifasari, Verna; Saputra, I Gede Agus Rio
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i1.56203

Abstract

Luka merupakan keadaan hilang atau rusaknya sebagian jaringan tubuh yang dapat disebabkan oleh trauma benda tajam atau tumpul, perubahan suhu, zat kimia, ledakan, sengatan listrik, atau gigitan serangga. Menurut WHO pada tahun 2018, Luka bakar adalah masalah kesehatan masyarakat global, yang menyebabkan sekitar 180.000 kematian setiap tahunnya. Kulit udang vannamei diketahui mengandung chitosan yang berpotensi dapat meningkatkan penyembuhan luka bakar. Tujuan penelitian ini untuk mengetahui pengaruh pemberian gel chitosan dari ekstrak kulit udang selama 7 hari secara topikal terhadap angiogenesis pada tikus jantan galur Wistar dengan luka bakar derajat II. Desain penelitian ini yang dilakukan di Laboratorium Biokimia Fakultas Kedokteran Universitas Hang Tuah Surabaya. rancangan penelitian ini adalah Post Test Only Control Group Design. Sampel yang digunakan adalah 18 ekor tikus jantan galur Wistar yang dibagi menjadi dua kelompok ; kelompok pertama, luka hanya dibiarkan sebagai kelompok kontrol. Kelompok kedua diberi gel chitosan dari ekstrak kulit udang secara topikal sebagai kelompok perlakuan, kemudian hari ke-8 tikus diambil jaringan kulitnya kemudian dibuat preparat histopatologi di Universitas Hang Tuah Surabaya. Tahap terakhir penelitian, dilakukan perhitungan jumlah angiogenesis. Data yang diperoleh dianalisis menggunakan uji statistik t dua sampel bebas. Hasil rerata jumlah angiogenesis pada kelompok kontrol sebanyak 3,83, pada kelompok perlakuan 6,72. Uji statistika uji t dua sampel bebas didapatkan hasil sebesar 0.001 (<0.05). Penelitian menunjukan bahwa terdapat pengaruh pemberian gel chitosan dari ekstrak kulit udang vannamei (litopenaeus vannamei) terhadap angiogenesis pada tikus jantan (rattus norvegicus) galur wistar dengan luka bakar derajat II.
The clinical value of systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) for predicting the occurrence of metastasis in patients with lung cancer Biutifasari, Verna; Hardjono, Ellen Angelique; Adiwinoto, Ronald Pratama; Hadi, Janto Poernomo
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in biomarkers, therapeutics, and probiotics: Recent updates in medical l
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.5628

Abstract

Systemic immune-inflammation index (SII) and prognostic nutritional index (PNI) serve as simple and practical tests that help indicate inflammatory and nutritional status to some extent. Lung cancer stands out as the most common contributor to cancer-related mortality globally. It is associated with an unfavorable prognosis. Most patients diagnosed with lung cancer have metastasis at the time of diagnosis. Prognostic heterogeneity of cancer patients causes the need for more prognostic biomarkers. This study aimed to evaluate the clinical value of SII and PNI in predicting metastasis in lung cancer patients. SII and PNI provides a prognostic value in lung cancer. Retrospective cross-sectional research was conducted in this study involving 138 data from medical records at the Inpatient and Outpatient Department of Pulmonology, RSPAL dr. Ramelan Surabaya in April 2019 to July 2023. Kolmogorov-Smirnov test, contingency coefficient test, and ROC analysis were done to analyze the data obtained. Patients with metastatic lung cancer had higher SII than those without metastasis. The group of patients with metastasis had an average SII of 5391.34 and a PNI of 40.11. The group of patients without metastasis had an average SII of 2849.52 and PNI of 43.05. Lung cancer metastasis was correlated significantly with SII but not with PNI. The cut-off value was determined using the ROC curve. The cut-off value for SII was 2198.54 (68.5% sensitivity and 58.7% specificity) and for PNI was 42.2 (62% sensitivity and 54.3% specificity). SII was correlated with lung cancer metastasis and may be a promising indicator predicting of metastasis. PNI showed no significant correlation with lung cancer metastasis.
Psychological Stress and Seborrheic Dermatitis Outcomes: Insights from a Clinical Cohort in Southeast Asia Brilliant , Fahridho Ramadhana; Biutifasari , Verna; Widjajanto , Hendra; Utami , Prawesty Diah; Adiwinoto, Ronald Pratama
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 1 (2025): June
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v6i1.278

Abstract

Seborrheic Dermatitis (DS) is a chronic skin disease that often occurs in areas rich in sebaceous glands, characterized by erythematous patches, plaques, and scales. Psychological factors, especially stress, will affect sebum production and colonization of Malassezia spp being the main cause of seborrheic dermatitis. Stress can increase skin inflammation and worsen DS symptoms. The severity of DS was assessed by the Seborrheic Dermatitis Area Severity Index (SDASI), while stress was measured by the Perceived Stress Scale (PSS). PSS is designed to measure the level of stress in everyday life. SDASI scale used to assess the severity of seborrheic dermatitis. The purpose of the study was to analyze the relationship between the level of stress measured using the Perceived Stress Scale (PSS) with the severity of seborrheic dermatitis evaluated through the Seborrheic Dermatitis Area Severity Index (SDASI). The study involved 51 patients who met the inclusion and exclusion criteria. Data collection was conducted through PSS questionnaires totaling 14 questions and SDASI assessment to measure the severity of DS. The results showed that most patients experienced very severe stress (88.2%) and the severity of severe SDASI (74.5%). The correlation between PSS and SDASI showed a p value of 0.010 (p < 0.05), which showed significant results between the level of stress with the severity of DS with correlation efficiency of 0.359..Stress can worsen the condition of seborrheic dermatitis in which an increase in PSS values is obtained.
Neutrophil–lymphocyte ratio as a predictor of dengue hemorrhagic fever severity in Indonesian pediatric patients: A Single-center retrospective study Dewi, I Gusti Ayu Ajeng Widia Kencana; Adiwinoto, Ronald Pratama; Rokhmadhoni Pikir, Rizqi; Rusli, Christina; Biutifasari, Verna; Diah Utami, Prawesty
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 4 (2025): July 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i4.104

Abstract

Dengue hemorrhagic fever (DHF) is a significant health burden in Indonesia, necessitating reliable prognostic markers for early clinical intervention. The neutrophil‒lymphocyte ratio (NLR) has emerged as a potential biomarker for disease severity assessment, although its utility in pediatric populations requires further validation. This study aimed to to determine the relationship between the neutrophil‒lymphocyte ratio and DHF severity grade in pediatric patients and evaluate its potential as a prognostic indicator for clinical decision-making. This retrospective cross-sectional study analyzed 111 pediatric patients aged 5-14 years who were diagnosed with DHF at RSPAL Dr. Ramelan, Surabaya, between January 2022 and December 2024. Patients were classified according to the WHO severity grades (I-IV), with the NLR calculated from complete blood counts obtained during days 3-6 of illness. Statistical analysis with Spearman's rank correlation was used to examine the relationship between the NLR and disease severity. The study population predominantly demonstrated Grade I DHF (56.8%), followed by Grade II DHF (20.7%), Grade III DHF (18.0%), and Grade IV DHF (4.5%). Patients with lower severity grades (I-II) predominantly presented low NLR values (<1) in 46.0% and 47.8% of cases, respectively, whereas those with higher severity grades (III-IV) primarily presented normal NLR values (1-3) in 65.0% and 60.0% of cases, respectively. Spearman's correlation analysis revealed no statistically significant relationship between the NLR and DHF severity (ρ = 0.120, p = 0.208). The neutrophil‒lymphocyte ratio has limited utility as a standalone predictor of DHF severity in pediatric patients. These findings suggest the need for alternative biomarkers or composite indices for accurate prediction of pediatric DHF severity.
Heat Shock Protein (HSP) 70 dalam apoptosis dan inflamasi Biutifasari, Verna
Surabaya Biomedical Journal Vol. 1 No. 3 (2022): Mei
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i3.35

Abstract

Semua organisme menunjukkan respon homeostasis ketika organisme tersebut mengalami perubahan yang cepat dalam lingkungannya. Kemampuan organisme untuk beradaptasi atau menyesuaikan diri dengan lingkungan barunya sangat penting untuk kelangsungan hidup, dan kemungkinan merupakan kekuatan pendorong integral dalam evolusi. Heat shock protein (Hsp) adalah kelompok protein yang ekspresinya meningkat sebagai respons terhadap injuri. Hsp berfungsi sebagai molekul chaperone, degradasi protein, menghambat apoptosis. Peningkatan kadar Hsp terjadi setelah stres. Hsp mempunyai peran sentral dalam homeostasis seluler. Sistem penamaan atau nomenklatur Hsp berdasarkan berat molekulnya dan macam Hsp. Salah satu Hsp yang sering dipelajari adalah Hsp-70 Tujuan dari penulisan review ini adalah menjelaskan tentang Hsp serta peranan pada apoptosis dan inflamasi.
THE INTRAUTERINE DEVICE (IUD) USE AND BACTERIAL VAGINOSIS INCIDENCE, INSIGHTS FORM 2023 STUDY IN A SURABAYA, INDONESIA Biutifasari, Verna; Eka Fitriani Hafel; Prasetyadi , Frans O.H.; Adiwinoto, Ronald Pratama; Hardjono, Ellen Angelique
Indonesian Midwifery and Health Sciences Journal Vol. 9 No. 3 (2025): Indonesian Midwifery and Health Sciences Journal, July 2025
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v9i3.2025.243-254

Abstract

Background: The Intrauterine device (IUD) is one of the most widely used and effective long-term contraceptive methods, with a success rate exceeding 99%. However, prolonged copper IUD use has been associated with an increased risk of bacterial vaginosis (BV), with users reportedly 1.28 times more likely to develop BV than users of other contraceptive methods.This study aims to assess the association between IUD usage and the incidence of BV.  Methods: This cross-sectional analytic observational study included 50 participants using IUDs, recruited from three public health centers in Surabaya between May and December 2023. Vaginal swab samples from suspected BV cases were examined independently by two observers. Data were analyzed using the Chi-square test to assess associations and Cronbach's Alpha to evaluate inter-observer reliability, with significance set at p < 0.05.  Results: Most BV cases were found among women aged 30–39 years (40%) and among users of non-hormonal IUDs (76%). Based on Nugent scoring, 26 participants (52%) were diagnosed with definitive BV. The association between IUD use and BV incidence was not statistically significant (p = 0.090). Inter-observer reliability was high, with a Cronbach’s Alpha of 0.963. Conclusion: The study concludes that IUD use is not significantly associated with the occurrence of bacterial vaginosis, based on Nugent score evaluation.
The Antibacterial Activities of Piper betle and Allium cepa Extracts Against Staphylococcus aureus Setiawan, Vendra; Triono, Nathanel; Agustina, Astrid Karindra; Moira, Lovely Anastasia; Biutifasari, Verna; Budipramana, Krisyanti
Jurnal Penelitian Pendidikan IPA Vol 11 No 9 (2025): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i9.10850

Abstract

Indonesia rich in biodiversity, both animals and plants. This is known as ethnobotany. Local people learn to use natural herbs to meet their daily needs, and some commonly used herbs are Piper betle (betel leaf) and Allium cepa (red onion). They often use P. betle or A. cepa to cure various skin infections, one of which is furuncles. This study aimed to explore ethanol extracts of P. betle, A. cepa, and their combination against Staphylococcus aureus, the main bacterial cause of furuncles, using petri dish. The inhibition zones in petri dishes were measured using a caliper to evaluate the antibacterial efficacy. Each sample was tested with 3 replicates and kanamycin was used as positive control. The P. betle extract exhibited the strongest inhibitory effect with an inhibition zone of 17.70 ± 0.30 mm, followed by P. betle and A. cepa with ratio 1:1 produced an inhibition zone of 15.63 ± 0.58 mm. The ethanol extract of A. cepa showed the lowest inhibition zone only 14.38 ± 0.35 mm and this inhibition zone was similar to that of kanamycin as positive control.
In Silico Bahan Aktif Epigallocatechin Gallate dari Sargassum cristaefolium untuk Menghambat Pembentukan Interleukin 1B pada Sindroma Mata Kering Faiq, Muhammad Nabil; Pasaribu, Irma A.; Jauhar, Tamam; Biutifasari, Verna
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 6 No 3 (2025): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v6i3.528

Abstract

Dry eye syndrome is a multifactorial condition that disrupts the tear film and ocular surface, causing discomfort, visual disturbances, and damage to the ocular surface. Sargassum cristaefolium, a brown alga found in Indonesia, contains the active compound Epigallocatechin gallate (EGCG), which has anti-inflammatory potential. EGCG can inactivate interleukin-1B signaling, thereby triggering the activation of MMPs that play a role in epithelial barrier degradation and maintaining lubrication of the corneal surface. EGCG also exhibits functions comparable to Cyclosporin A, a drug used for dry eye syndrome. This study aims to determine the performance of EGCG in suppressing interleukin-1B to inhibit the production and activation of MMPs through an in-silico approach. The method involves several stages, namely molecular docking, ADME prediction, and toxicity prediction of the active compound EGCG. EGCG is predicted to have potential equivalent to Cyclosporin A in inhibiting interleukin-1B. EGCG shows advantages such as good distribution in blood plasma, no effect on CYP3A4 enzymes, and no influence on OCT2 substrates. In addition, EGCG has a slower excretion rate, is non-mutagenic, does not cause skin sensitization, and is non-hepatotoxic. Thus, EGCG found in Sargassum cristaefolium may serve as an anti-inflammatory agent and inhibit interleukin-1B protein in dry eye syndrome through in silico mechanisms.
Co-Authors Adnyana , I Made Dwi Mertha Agustina, Astrid Karindra Arundani, Prima Betty Agustina Tambunan Bimantara, Riza Fajar Brilliant , Fahridho Ramadhana Budipramana, Krisyanti Dewi, I Gusti Ayu Ajeng Widia Kencana Diah Utami, Prawesty Djatiwidodo Edi Pratiknya Eka Fitriani Hafel Faiq, Muhammad Nabil Hadi, Janto Poernomo Hardjono, Ellen Angelique Hartono Kahar, Hartono Haryati, Tallia Irawati, Ade Jauhar, Tamam Ketut Edy Sudiarta LEONI Moira, Lovely Anastasia Ni Komang Sri Dewi Untari NI KOMANG SRI DEWI UNTARI Pasaribu, Irma A. Peppy Nawangsasi Pramana, Anak Agung Ngurah Gede Anggra Pramita Anindya Nugraheni Prasetyadi , Frans O.H. Pratama A., Ronald Rahadianto, Rahadianto Rokhmadhoni Pikir, Rizqi Ronald Pratama Adiwinoto Ronald Pratama Adiwinoto Rusli, Christina Saputra, I Gede Agus Rio Sari, Arine Talitha Setiawan, Vendra Tamam Jauhar Triono, Nathanel Utami , Prawesty Diah Vendra Setiawan VIRA AULIA KUSUMA WARDANI Wahyu Prasasti Mutiadesi Wibowo, Prajogo Widjajanto , Hendra Wienta Diarsvitri Yudadi, Redemptus Zenjaya, Kellyn Trycia