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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy Jurnal Penelitian Kimia Biology, Medicine, & Natural Product Chemistry Jurnal Kimia Riset Jurnal Zarah JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) SANITAS: Jurnal Teknologi dan Seni Kesehatan JURNAL PENDIDIKAN, SAINS DAN TEKNOLOGI Binawan Student Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Social Research Jurnal Ilmiah Farmasi Simplisia Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Esti Mumpuni, Esti
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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In Silico and In Vitro Antibiofilm Activity of Zingiber montanum Ethyl Acetate Fraction Against Propionibacterium acnes: Antibiofilm of Zingiber montanum Aji, Nur; Kumala, Shirly; Mumpuni, Esti; Rahmat, Deni
Journal of Tropical Life Science Vol. 15 No. 1 (2025)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/

Abstract

Propionibacterium acnes (P. acnes), a symbiotic bacterium involved in the development of acne, is recognized for its capacity to develop resistance due to its ability to generate biofilms. According to a previous investigation, the ethyl acetate fraction derived from Zingiber montanum exhibited anti-bacterial properties against P. acnes. Nevertheless, the causative role of biofilm formation in its resistance was not previously recognized. This study aims to ascertain the antibiofilm efficacy using in silico and in vivo methodologies. In this study, in silico examination utilized molecular docking to inhibit the quorum sensing mechanism by blocking the autoinducer 2 (AI-2) signal. The target protein was AI-2 binding periplasmic protein LuxP (PDB code: 4YRZ). Following that, an in vitro test was conducted using the crystal violet staining method, which was read using a microplate reader at a wavelength of 600 nm. The readings were expressed as percent inhibition and IC50. The in silico results showed that there were six compounds in the ethyl acetate fraction that have the potential to inhibit AI-2 signaling. Curcumin showed the highest inhibitory activity. Meanwhile, the in vitro results revealed that the ethyl acetate fraction of Z. montanum obtained the minimum biofilm inhibitory concentration (MBIC) of 2.5 % (w/v) and IC50 = 0.28 % (w/v). It can be concluded that the ethyl acetate fraction of Zingiber montanum could inhibit the biofilm formation of P. acnes.  
Co-Authors Achmad Daud, Rizqi Akbar Fandi Aey Fadilah, Yasin Aji, Nur Amalia . Andri Prasetiyo Audrey, Cresentia Budiati, Anarisa Dewi, Nidya Luciana Dhani, Muhammad Dian Ratih Laksmitawati Effionora Anwar Evi Susanti Fadillah, Almufti Fajar, In Rahmi Fatria Faridah Faridah HARI PURNOMO Hidayat, Andika Muhammad Humaedi, Aji Indriani, Aqilah Idelia intan permata sari KARTININGSIH, KARTININGSIH Krismayadi Krismayadi kurnia agustini Martati, Titiek Maryanto, Kenny Mawijaya, Agus Muhammad Luthfi Mulatsari, Esti Mutia Sari Wardana Natthawani, Amitta Noerfa, Tri Kumala Nurmayati, Adi Nursanti, Okta Panca Bayu Chandra, Pra Partomuan Simanjuntak Prasetyo, Andri Prasetyo Pristiyantoro, Pristiyantoro Purwanggana, Agus PUTRI WULANDARI Qodriah, Rahmatul R. Sapto Hendri Boedi Soesatyo Rahmadhani, Sekar Harsti RAHMAT, DENI Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Rasdianti, Putri Ratumakin, Monika Buka Kopon Raymond R. Tjandrawinata Rhahmadini, Yahdi Thia Saeful Amin, Saeful Sandayu, Feriza Sari Dewi, Rika Shirly Kumala Simanjuntak, Josua Donrio Siswandono, Siswandono Siung, Chris Nicholas Stephanie, Adiva Syabriena, Tarra Syamsi, Lusi Nursilawati Syamsudin Syamsudin Taqwa, Iqbal Ananda Titi Parwati, Titi Utami, Fajar Dwi Utami, Fit Indri Intan WAHYU WIDOWATI Yesi Desmiaty, Yesi Yogaswara, Amira Thufailla Yuliana, Agnes Zahra, Nurulita Az