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All Journal Journal of Food and Pharmaceutical Science Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Pascapanen Pertanian Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal Indonesian Journal of Chemical Science Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Food and Pharmaceutical Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia
Nanang Fakhrudin, Nanang
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta, Indonesia, 55281.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory. Nurrochmad, Arief; Wirasti, Wirasti; Dirman, Arifin; Lukitaningsih, Endang; Rahmawati, Adillah; Fakhrudin, Nanang
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1362.529 KB) | DOI: 10.14499/indonesianjpharm29iss4pp188

Abstract

Brown macroalgae (BM) which contain fucoxanthin exhibited high antioxidant activity. This study was performed to examine antioxidant, anti-collagenase, anti-elastase, anti-tyrosinase activities, and effect on cell viability of Human Dermal Fibroblast adult (HDFa) of BM, Turbinaria decurrens Bory. T. decurrens dried powder were macerated by ethanol to obtain extract (ETD) and was fractination by column chromatography to obtain fraction (FTD). Fucoxanthin content was determined using HPLC. The antioxidant activities, anti-collagenase, anti-elastase, and tyrosinase inhibitory assay were performed. The effect of ETD and fucoxanthin standard on cell viability were conducted on HDFa cell-induced by hydrogen peroxide (H2O2). The HPLC analysis showed that ETD and FTD contain fucoxanthin of 284.9±3.3µg/g and of 653.4±30.6µg/g dry-weight, respectively. The antioxidant assay showed that ETD and FTD produced high antioxidant activity by ferric reducing antioxidant power (FRAP) and b-carotene bleaching (BCB) methods that were comparable to fucoxanthin. ETD exhibited significantly higher tyrosinase inhibitory than kojic acid (p<0.01), while FTD had a comparable effect to kojic acid. The result also revealed that ETD and FTD produced anti-elastase and anti-collagenase (matrix metalloproteinase-1 (MMP-1). Fucoxanthin and ETD were able to maintain cell viability on HDFa cell-induced H2O2. This study suggests that T. decurrens may be effective to prevent skin aging and wrinkle formation, possibly through the antioxidant activity and maintain cell viability of fibroblast. 
The Effect of Ursolic Acid from Plantago Lanceolata Leaves on Leukocytes Migration and Chemokines Level Nanang Fakhrudin; Yuvianti Dwi Franyoto; Eny Dwi Astuti; Arief Nurrochmad; Subagus Wahyuono
Indonesian Journal of Pharmacy Vol 30 No 4, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1130.954 KB) | DOI: 10.14499/indonesianjpharm30iss4pp252

Abstract

Initially considered as a normal body response to injury, inflammation is currently known as a major event contributing to the development of many human disorders. Many drugs and bioactive molecules have been discovered from medicinal plants and the number is still growing by time. Among those medicinal plants used in folk medicines, Plantago lanceolata is used to cure inflammatory-related diseases. In our previous study, we showed that the n-hexane insoluble fraction of P. lanceolata leaves (HIF) demonstrated a potent anti-inflammatory activity by inhibiting leukocytes migration in mice. This study aimed to identify the anti-inflammatory compound from the HIF and to investigate the effect on the chemokines level. P. lanceolata leaves were initially macerated with dichloromethane. The dried extract was partitioned using n-hexane to obtain n-hexane soluble fraction (HSF) and n-hexane insoluble fraction (HIF). Both fractions were evaluated for their anti-inflammatory activities in thioglycollate-induced leukocyte migration. The active fraction (HIF) was subjected to preparative thin-layer chromatography (TLC) to isolate the major compound. The structure of the compound was identified based on NMR, IR, and Mass spectra. Moreover, we investigated the effect of the compound on the level of chemokines responsible for leukocytes migration. The active compound was identified as ursolic acid, based on its spectral data. Ursolic acid at the dose of 30, 60, and 120mg/kg BW inhibited leukocyte migration and reduced chemokines level (IL-8 and MCP-1).
Co-Authors Abdul Rohman Agustinus Widodo Akhmad Khumaidi Anak Agung Gede Sugianthara Andayana Puspitasari Gani Andayana Puspitasari Gani Argandita Meiftasari Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arifah, Mitsalina Fildzah Ayu Ina Solichah Chelvin Ari Kusnanto Dirman, Arifin Djoko Santosa Ediati Sasmito Efendi Efendi Eka Kumalasari Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Eny Dwi Astuti Febrianti, Dwi Rizki Gani, Andayana Puspitasari Gharsina Ghaisani Yumni Hifdzur Rashif Rija’i Ika Puspitaningrum Ika Puspitasari Indah Hastuti Ipang Djunarko Jovanita Fara Addina Kahfi Nur Fatimah Khoerul Anwar KRISNA KHARISMA PERTIWI Kusnanto, Chelvin Ari Laras Widawaty Putri Mar'uf, Muhammad Muhammad Hafizh Ridho Muthi Ikawati Ni'ma, Neli Syahida Niah, Rakhmadhan Nimas Ayu Kurniailla Nita Testikawati Nita Testikawati Normilawati Oktariani Pramiastuti Peni Susilowati Putri Peni Susilowati Putri, Peni Susilowati Puji Astuti Rahmawati, Adillah Ratih Anggar Kusumaningtyas Riris Istighfari Jenie Riski, Akhmad Rusydan, Azka M. Rusydan, Azka Muhammad Sari Rosiati Nur Khasanah Sigit Hartomo Siluh Astuti Siluh Astuti Siluh Putu Yuni Astuti Sitarina Widyarini Soda Farida Sofa Farida Sofa Farida Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sutomo Sutomo Sutomo Sutomo T. N. Syaifullah Sulaiman Tahoangako, Sarmadhan Saputra Tatang Irianti Teuku Nanda Saifullah Sulaiman Tiaravista, Amanda Gita Widhihastuti, Endah Wirasti, Wirasti Yuli Widiyastuti Yuvianti Dwi Franyoto