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KARAKTERISASI FARMAKOGNOSI DAUN FALOAK (Sterculia quadrifida R.Br): CHARACTERIZATION OF PHARMACOGNOSY OF FALOAC LEAVES (Sterculia quadrifida R.Br) Fahrauk Faramayuda; Julia Ratnawati; Akhirul Kahfi Syam
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.322

Abstract

Faloak secara empiris digunakan sebagai antimikroba, megobati penyakit tifus, mengatasi gangguan pada hati, laksatif, dan antimalaria. Faloak merupakan salah satu tumbuhan yang secara empiris digunakan sebagai obat tradisional di Nusa Tenggara Timur. Selanjutnya dari hasil penelitian ini dapat digunakan untuk studi dan pengembangan aktivitas biologi ekstrak daun faloak menjadi produk farmasi. Ekstraksi menggunakan cara maserasi dengan pelarut etanol dan menghasilkan rendemen 8,84% b/b. Parameter standarisasi ekstrak menunjukkan bobot jenis ekstrak 0,7543 ± 0,0060 g/mL, kadar sari larut air 54 ± 1,15% b/b, sari larut etanol 88,48 ± 1,05% b/b, kadar abu total 10,47 ± 0,16% b / b, abu larut air 8,01 ± 0,99% b / b, abu tidak larut asam 0,39 ± 0,03% b/b. Ekstrak etanol daun faloak mengandung flavonoid, kuinon, polifenol, steroid-triterpenoid, dan monoterpen-sesquiterpen. Ekstrak dianalisis kandungan kimianya menggunakan kromatografi lapis tipis (KLT) dengan fase diam silica F254 dan menggunakan fasa gerak n-heksana: etil asetat (1:1), hasilnya terdapat bercak dengan Rf 0,21 memberi warna biru pada UV 365 nm dan bercak hitam berlatar hijau pada UV 254 nm. Total kandungan flavonoid pada ekstrak etanol daun faloak 5,31 ± 0,29% b / b dan total kandungan polifenol 1,79 ± 0,03% b / b. Dari hasil karakterisasi ini bisa menjadi dasar pemgembangan tanaman faloak menjadi bahan baku obat tradisional terstandar dan acuan untuk melakukan uji aktivitas farmakologi.
Review: Flavonoid pada Tanaman Kumis Kucing (Orthosiphon stamineus Benth.): Review: Flavonoid Compounds in Orthosiphon stamineus Fahrauk Faramayuda; Silvy Julian; Ari Sr Windyaswari; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.862 KB) | DOI: 10.25026/mpc.v13i1.478

Abstract

Orthosiphon stamineus has long been used in traditional medicine in East India, Indo China, Southeast Asia, and tropical Australia, where this plant is usually found. Based on the color of the flowers and petals, Orthosiphon stamineus is classified into two varieties: white flowers (white varieties) and purple flowers (purple varieties). Orthosiphon stamineus has traditionally been used to treat hypertension, diabetes, bladder and kidney disorders, gallstones, gout, and rheumatism. The leaves of Orthosiphon stamineus were introduced to Europe and Japan as tea for health. The main compounds possessed by Orthosiphon stamineus are rosmarinic acid, eupatorium, and sinensetin. In addition, several studies have isolated the plant of Orthosiphon stamineus. This journal review aims to review studies related to the content of secondary metabolites, traditional uses, pharmacological activities, and levels of flavonoids contained in plants.
AKTIVITAS ANTIOKSIDAN POLIFENOL ASAM GALAT TEH HIJAU GAMBUNG MELALUI PENURUNAN KADAR MALONDIALDEHID TIKUS DIABETES MELITUS Iis Inayati Rakhmat; Fahrauk Faramayuda; Euis Reni Yuslianti
Medika Kartika : Jurnal Kedokteran dan Kesehatan 2018
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.647 KB)

Abstract

Teh hijau dilaporkan mempunyai efek sebagai antidiabetes karena kandungan antioksidannya. Komplikasi diabetes berkaitan dengan terjadinya stres oksidatif akibat hiperglikemi persisten yang ditandai dengan peningkatan kadar malondialdehid. Aktivitas antioksidan selular dan kandungan polifenol terutama asam galat teh hijau asal Gambung Ciwidey Bandung masih belum banyak diketahui. Penelitian ini bertujuan mengetahui kandungan antioksidan asam galat serta penurunan malondialdehid teh hijau tikus diabetes. Metode penelitian adalah laboratorium eksperimental. Pengujian kandungan antioksidan kualitatif dengan uji fitokimia, pengujian kandungan asam galat kuantitatif metode pH diferensial ekivalen antosianin total, dan pengujian aktivitas antioksidan melalui penurunan kadar malondialdehid tikus diabetes metode TBARs. Tikus dibagi kedalam 5 kelompok (n=5) diberi perlakuan selama 14 hari peroral: Tikus kelompok I sebagai kontrol negatif, tikus kelompok II kontrol diabetes, tikus diabetes kelompok III dan IV diberi ekstrak etanol teh hijau 14,4 mg/hari dan 28,8 mg/hari serta tikus diabetes kelompok V diberi Vitamin C 3,6 mg/hari. Hasil penelitian menunjukkan bahwa ekstrak etanol teh hijau Gambung memiliki kandungan alkaloid, tanin, saponin, katekin, flavonoid, kuinon, dan asam galat 12,19 mg/L TAC. Kadar rerata malondialdehid darah kelompok teh hijau 28,8 mg/hari berbeda signifikan (P=0,012) dengan kelompok Vitamin C 3,6 mg/hari akan tetapi tidak ada perbedaan signifikan (P=0,087) apabila dibandingkan dengan kelompok yang diberi teh hijau 14,4 mg/hari. Pemberian teh hijau 28,8 mg/hari memberikan efek menguntungkan dibanding Vitamin C 3,6 mg/hari yang dibuktikan dengan penurunan kadar MDA kemungkinan karena kandungan antioksidan polifenol asam galat teh hijau sebagai scavenger radikal peroksil stres oksidatif pada tikus diabetes. DOI : 10.35990/mk.SE.PIT.X.p1-15
Comparison of Polyphenol Levels of Callus and Wild Type of Cat's Whiskers Plant ( Orthosiphon aristatus (Blume) Miq.) Purple Varieties Fahrauk Faramayuda; Soraya Riyanti; Ari Sri Widyaswari; Zaini Alfahmi; Sultan Salahudin Jamal; Totik Sri Mariani; Elfahmi Elfahmi; Sukrasno Sukrasno
Journal of Applied Agricultural Science and Technology Vol. 6 No. 2 (2022): Journal of Applied Agricultural Science and Technology
Publisher : Green Engineering Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.608 KB) | DOI: 10.55043/jaast.v6i2.51

Abstract

The cat's whiskers plant ( Orthosiphon aristatus (Blume) Miq) that grows in Indonesia has white flowers, purple flowers, and white flowers with purple patterns. The quality of the secondary metabolite content of each cat's whiskers plant is different because it depends on environmental influences such as rainfall or soil mineral content. Plant tissue culture methods such as callus culture or cell culture are used to overcome these obstacles because these methods do not depend on the environment and can produce secondary metabolites such as those produced by the original plant. Cat's whiskers contain the main secondary metabolite compounds: rosmarinic acid, eupatorin, and sinensetin. Rosmarinic acid belongs to the phenolic group, while sinensetin and eupatorin are flavonoids. This study aimed to determine the total levels of polyphenols and flavonoids in purple cat whiskers and determine the ratio of secondary metabolites of cat whiskers callus with wild-type plants—determination of polyphenol content using Folin Ciocalteau reagent. Determining flavonoid levels is based on colorimetry using AlCl 3 reagent, specific for flavone and flavonol compounds. The levels of polyphenols contained in the ethanolic extract of callus and cat whiskers of the purple variety were 16.056 ± 0.204 mgQE/g and 30.780 ± 0.425 mgQE/g, while the polyphenol content of the callus ethyl acetate extract and the purple variety of cat whiskers leaves was 15,489 ± 0.425 mgQE/g and 13,262 ± 0.044 mgQE/g. The levels of flavonoids contained in the ethanol extract of the cat whiskers leaf were 1.39±0.03 mgQE/g and callus 0.16±0.02 mgQE/g in the ethyl acetate extract of the leaves of the cat whiskers 2.16±0.012 mgQE/g and callus 2.24±0.010 mgQE/g. The polyphenols and flavonoids in the callus ethyl acetate extract were more significant than the ethyl acetate extract of the purple variety ( wild type ) cat whiskers leaf.
SOSIALISASI POTENSI TANAMAN KUMIS KUCING SEBAGAI IMUNOSTIMULAN YANG DAPAT DIGUNAKAN DIMASA PANDEMIK COVID-19 : PENJELASAN KHASIAT, PENANAMAN DAN PENGOLAHAN PASCA PANEN Faizal Hermanto; Akhirul kahfisyam; Suryani; Fahrauk Faramayuda
Jurnal Abditani Vol. 5 No. 2 (2022): Oktober
Publisher : FAKULTAS PERTANIAN UNIVERSITAS ALKHAIRAAT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/abditani.v5i2.152

Abstract

Saat ini diseluruh dunia masih terjadi pandemi covid-19. Penyakit yang disebabkan oleh virus dalam proses penyembuhan pada umumnya mengandalkan kekuatan pertahanan tubuh, sehingga diperlukan suatu senyawa yang dapat meningkatkan kerja sistem imun atau lebih dikenal imunostimulan. Berdasarkan hasil penelitian banyak tanaman obat yang berkhasiat sebagai imunostimulan salah satunya kumis kucing atau nama laiannya Orthosiphon aristatus. Selama ini kumis kucing terkenal dan banyak digunakan sebagai diuretik serta peluruh batu ginjal. Masyarakat belum banyak yang tahu bahwa kumis kucing memiliki potensi sebagai imunostimulan. Oleh karena itu perlu dilakukan upaya sosialisasi dan pelatihan potensi tanaman kumis kucing sebagai imunostimulan meliupti penjelasan khasiat, penanaman dan pengolahan pasca panen. Sosialisasi dilakukan pada paguyuban jamu manunggal kota cimahi dan umumnya pada masyarakat melalui video. Dari hasil sosialisasi, pemahaman para peserta paguyuban jamu manunggal tentang potensi tanaman kumis kucing sebelum diberikan materi dan pelatihan adalah 44 % dan sesudah diberikan materi naik menjadi 100 %. Pada kegiatan ini dilakukan pemberian bibit tanaman kumis kucing hasil kultur in vitro, bibit ini merupakan pengembangan hasil penelitian di Fakultas Farmasi UNJANI. Sosialisasi harus terus dilakukan pada skala lebih besar melalui video edukasi yang dibagikan pada media sosial.
Traditional uses, phytochemistry, pharmacology activity and plant tissue culture of ficus carica l. (a mini review) Fahrauk Faramayuda; Sigid Pamungkas Wicaksono; Akhirul Kahfi Syam; Soraya Riyanti; Ari Sri Windyaswari; Yeni Karlina; Elfahmi Elfahmi
Riset Informasi Kesehatan Vol 11 No 1 (2022): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.464 KB) | DOI: 10.30644/rik.v11i1.537

Abstract

Ficus carica L. or Figs plants are plants originating from the Middle East and the Mediterranean region, which then spread to various parts of the world through explorers who try to plant in various countries. Figs plants can grow in various habitats, including infertile rocky soils, forests, shrubs, and even hot dry soils. Figs plants have several varieties that can be distinguished from the shape of the stem, the shape of the leaves, and the fruit's color. Figs plants are widely used as traditional medicine for both leaves and fruit. Noted in several countries have used the Figs plant as one of the plants used for traditional medicine. Figs plants are widely used for antioxidants, anticancer, hepatoprotective, antidiabetic, antibacterial, antipyretic, antituberculosis, antispasmodic antiplatelet in several countries. Figs plants contain secondary metabolites of alkaloids, latexonins, phenols, and flavonoids. There is one method of multiplication of Figs plants that began to be widely used, namely plant tissue culture. Plant tissue culture is a method of propagation using tissue slices or parts of plants that are small and in aseptic conditions. Several studies have been obtained to trace figs plants by tissue culture methods using slices of leaves and shoots.
Peningkatan Kualitas Produk Paguyuban Jamu Manunggal Kota Cimahi Melalui Standardisasi Bahan Baku Fahrauk Faramayuda; Ari Sri Windyaswari; Ridwan Ilyas; Dhimas Ariya Wibiksana; Nursafira Khairunnisa Ismail; Reyhan Adriana Deris; Rifaz Muhammad Sukma; Tzazkia Febriyana Akbar; Chandani Nurul Hafizah; Rizka Khoirunnisa Guntina
AJAD : Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2 (2023): AUGUST 2023
Publisher : Lembaga Mitra Solusi Teknologi Informasi (L-MSTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59431/ajad.v3i2.185

Abstract

The activity of the community of herbal medicine manunggal in Cimahi city, as the main partner, is to guide the processing of traditional medicines and the herbal medicine business. The proposing team held an initial meeting and socialization for members of the Jamu Manunggal community in the city of Cimahi on December 25, 2021, regarding counseling on planting, post-harvest processing, and the benefits of the cat's whiskers plant. From the results of these activities, several problems were identified: the raw materials for traditional medicines in the Jamu Manunggal Association needed to be better standardized. This activity aims to improve the quality of traditional medicinal products through standardization. The results of the drying shrinkage testing of the five medicinal raw materials met the standards in the Indonesian Herbal Pharmacopoeia. In testing the water-soluble ash content, the levels obtained were not too large illustrating the potential for minor contamination of traditional medicinal raw materials. The general conclusion is that the raw materials for traditional medicine in the Jamu Manunggal Association of Cimahi City have good quality.
ANALISIS METABOLIT SEKUNDER DARI KALUS RAMBUTAN Nephelium lappaceum L Fahrauk Faramayuda; Elfahmi Elfahmi; Weni Widy Astuti
Agric Vol. 33 No. 1 (2021)
Publisher : Fakultas Pertanian dan Bisnis, Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/agric.2021.v33.i1.p13-22

Abstract

Rambutan plant (Nephelium lappaceum L.) is a member of the Sapindaceae family. The rambutan plant is one of the natural ingredients that can be developed as traditional medicine. Rambutan peel has the potential for good antioxidant and anticancer activity. Rambutan fruit does not grow every time it needs efforts to produce the active substance in rambutan, using plant tissue culture techniques. The use of the correct variety of mediums and hormones at the right concentration is the key to thriving tissue culture. Explants derived from rambutan leaves were planted precisely on solid media Murashige and Skoog (MS) and WoddyPlant Medium (WPM) containing Indole-3-Butyric Acid (IBA) and Kinetin. After seven days, the callus was subcultured, then after 35 days, the subculture callus was collected and dried. Dry callus and rambutan leaves (Wild type) were macerated with n-hexane, ethyl acetate, and ethanol. The concentrated extract was then applied to a GF 254 silica gel plate with the mobile phase Toluene-Acetone (7: 3) and n-hexane-EthylAsetate (3: 7). The results showed that the concentration of IBA 2 ppm and kinetin three ppm was the best combination because it produced callus. TLC results of rambutan leave with plant tissue culture containing flavonoids and triterpenoids. This study provides new information regarding the induction of rambutan callus and can become the basis for producing active metabolites in rambutan with cell suspension culture development.
THE GROWTH OF PIMPINELLA ALPINA HOST CALLUS AT VARIOUS TREATMENTS OF PLANT GROWTH REGULATOR CONCENTRATIONS OF NAA. 2,4 D AND ITS COMBINATION WITH BAP Fahrauk Faramayuda; Muhammad Irwan; Akhirul Kahfi Syam
Agric Vol. 34 No. 2 (2022)
Publisher : Fakultas Pertanian dan Bisnis, Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/agric.2022.v34.i2.p171-182

Abstract

Purwaceng (Pimpinella alpina) is an herbal plant that has aphrodisiac, diuretic, and tonic properties. The imbalance between the growth and the exploitation of this plant makes it included in Appendix I (endangered), so its conservation will be crucial. One method of the conservation of this plant is tissue culture. This method is considered one way to induct the callus. The research objective is to find the effect of various treatments of plant growth regulator concentrations of NAA. 2,4 D and its combination with BAP on the growth of purwoceng callus. Concentration of plant growth regulator NAA (0.5 mg L-1, 1 mg L-1, 2 mg L-1), 2,4-D (0.4 mg L-1, 0.8 mg L-1, 1.2 mg L-1 ), a combination of NAA with BAP (0.5 mg L-1 NAA: 1 mg L-1 BAP, 1 mg L-1 NAA: 2 mg L-1 BAP, mg L-1 NAA: 3 mg L-1 BAP) and a combination of 2, 4- D with BAP (1 mg LL 2,4-D : 0.5 mg L BAP, 1 mg L-1 2,4-D : 1 mg L-1 BAP, 2 mg L-1 2,4-D : 1 mg L-1 BAP) into Murashige Skoog medium. Then purwaceng leaf explants were planted on the medium until the growth was seen. This research shows that the plant growth regulator concentration has a different influence on the growth of callus that is recognized by the day of callus induction, colour and callus texture. MS media with growth regulator 1.2 mg L-1 2,4-D can grow callus faster (17 days) with friable texture.
Sosialisasi Penanganan Pasca Panen Bahan Baku Rempah Obat Tradisional Fahrauk Faramayuda; Soraya Riyanti; Akhirul Kahfi Syam; Ari Sri Windyaswari; Yeni Karlina; Remare Halomoan Limbong; Anggita Esa Putri Fitrichia; Ananda Tunjung Pertiwi; Trialisa Aprilia; Ema Mutya; Renti Mutiara Dewi; Dwi Ayu Pratiwi; Usi Septiani; Esanda Zulfi Amedea; Yesi Wulandari; Adinda Fitriani; Ami Soega Dwigantina
Kawanad : Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 2 (2022): October
Publisher : Yayasan Kawanad

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56347/kjpkm.v1i2.52

Abstract

Community service activities carried out by students of Universitas Jenderal Achmad Yani were carried out on August 29, 2022, taking place in a medicinal plant garden, Faculty of Pharmacy, Universitas Jenderal Achmad Yani which was attended by UMKM Spice Nusantara Bandung participants. The socialization carried out was the presentation and delivery of post-harvest processing materials (wet sorting, washing, drying, and dry sorting) and the standardization of traditional raw materials. Conventional medicine is a form of treatment efforts in the community to support health which is currently being recommended by the government. Communities can use the toga as an economical and efficient measure to maintain body immunity because the community can obtain and use the toga quickly and simply to maintain family health. The postharvest process greatly determines the existence of active compounds that are efficacious for treatment. Incorrect postharvest management can change, reduce, or destroy the active substance of a plant into a substance that has no therapeutic effect and can even endanger health. The results of the participant's level of understanding were carried out post-test with the results of what is the purpose of post-harvest processing (100%), the sequence of post-harvest processing (80%), what is the general drying temperature (100%), a medicinal plant has good quality and efficacy then we need to know (80%), and what is the function of the washing process (90%) with the conclusion that socialization activities can significantly increase the knowledge of participants from MSMEs regarding planting, post-harvest processing, and the properties of medicinal plants significantly.
Co-Authors Adella Shindy Pratiwi Adely, Alyaa Muliahati Adinda Fitriani Adriana, Reyhan Akbar, Tzazkia Febriyana Akhirul Kahfi Syam Amedea, Esanda Zulfi Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Aprilia, Trialisa Ari Sr Windyaswari Ari Sri Widyaswari Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Ayu, Inna Puspa Chandani Nurul Hafizah Choirunnisa, Dinda dessy ratnasari Dewi, Renti Mutiara Dhimas Ariya Wibiksana Dwi Ayu Pratiwi Dwigantina, Ami Soega Dyah Nur Azizah, Dyah Nur Elfahmi Elfahmi Elfahmi Elfahmi, Elfahmi Ema Mutya Endang Kumolowati Esanda Zulfi Amedea Euis Reni Yuslianti Faizal Hermanto Farhan Fikri Alatas Fitriani, Adinda Fitrichia, Anggita Esa Putri Iis Inayati Rakhmat Ismail, Nursafira Khairunnisa Jaka Permana Jovie Mien Dumanauw Julia Ratnawati Julia Ratnawati Khairunisa Harizqi Nurul Husna Limbong, Remare Halomoan Melani, Putri Dwi Muhamad Raihan Maulana Muhammad Irwan Mutya, Ema Niken Tunjung Murti Pratiwi Nira Purnamasari, Nira Nur Achsan Al-Hakim Nur Fauziyyah, Salma Alifia Nurhalizah, Dinda Siti Nurhayati, Viola Aditya Nursafira Khairunnisa Ismail Oktiyas Muzaky Luthfi Oktovia El Shara Paramita, Veronika Santi Pertiwi, Ananda Tunjung Pratiwi, Dwi Ayu Purnama, Uwan Purwoko, Agus Putri, Dhiffa Namira Alifia Ramelan, Riska Sigit Remare Halomoan Limbong Renti Mutiara Dewi Reyhan Adriana Deris Ridwan Ilyas Ridzka Magfirah Rifaz Muhammad Sukma Riska Sigit Ramelan Rizka Khoirunnisa Guntina Rizka Khoirunnisa Guntina Septiani, Usi Sigid Pamungkas Wicaksono Silvy Julian Siti Muslichah Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sufyan Zainul Arifin Sugiyanto Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sultan Salahudin Jamal SURYANI Suwidjiyo Pramono Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Trialisa Aprilia Tzazkia Febriyana Akbar Usi Septiani Viola Aditya Nurhayati Weni Widy Astuti Winda Nur Halimah Wulandari, Yesi Yeni Karlina Yeni Karlina Yeni Karlina, Yeni Yenni Karlina, Yenni Yesi Desmiaty, Yesi Yesi Wulandari Yuslianti, Euis Reni Zaini Alfahmi