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Profil fitokimia selada laut (Ulva lactuca) dan mikro alga filamen (Spirogyra sp) sebagai bahan alam bahari potensial dari perairan Indonesia Ari Sri Windyaswari; Elfahmi Elfahmi; Fahrauk Faramayuda; Soraya Riyanti; Oktiyas Muzaky Luthfi; Inna Puspa Ayu; Niken Tunjung Murti Pratiwi; Khairunisa Harizqi Nurul Husna; Ridzka Magfirah
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 2 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i2.288

Abstract

AbstrakPerairan Indonesia merupakan habitat bagi berbagai spesies makro dan mikro alga. Selada laut (Ulva lactuca) adalah salah satu makroalga hijau yang secara empiris digunakan sebagai makanan oleh masyarakat Indonesia yang hidup dipesisir pantai. Pada perairan tawar, ganggang hijau (Spirogyra porticalis) merupakan mikroalga filamen yang berperan penting sebagai bioindikator dalam sistem akuatik. Penelitian ini bertujuan untuk mengetahui profil fitokimia dari selada laut dan ganggang hijau yang tumbuh di perairan Indonesia. Hasil pengujian kualitatif pada selada laut (Ulva lactuca)  menunjukkan kandungan metabolit primer  dan sekunder berturut-turut adalah karbohidrat, alkaloid, flavonoid, mono dan seskuiterpenoid. Sementara itu ganggang hijau (Spirogyra porticalis) mengandung karbohidrat, protein, alkaloid, flavonoid, fenolik, tannin, kuinon, mono dan seskuiterpenoid. Pola kromatogram selada laut (Ulva lactuca) dan  ganggang hijau (Spirogyra porticalis) mendeteksi aktivitas antioksidan yang dimiliki oleh senyawa- metabolit sekunder  seperti fenol, tannin, flavonoid, mono dan seskuiterpenoid yang memiliki variasi kepolaran dari semi hingga polar. Hasil uji pendahuluan aktivitas antioksidan menggunakan metode dinamolisis menunjukkan selada laut (Ulva lactuca) dan  ganggang hijau (Spirogyra porticalis) memiliki aktivitas antioksidan dan berpotensi dikembangkan sebagai obat, suplemen, eksipien farmasi dan makanan nutrisi. Kata kunci: selada laut (Ulva lactuca), ganggang hijau (Spyrogyra porticalis), antioksidan, bahari, Indonesia. AbstractIndonesian waters are habitat for various macro and micro algae species. Sea lettuce Ulva lactuca is one of the green macroalgae that is empirically used as food by Indonesian people. In freshwater, green algae Spirogyra porticalis is filament microalgae that play an important role as bioindicators in the aquatic system. The aim of this research was to profiling the chemical constituent from native Indonesian sources, Ulva lactuca  and Spirogyra porticalis. The results of  Ulva lactuca  qualitative analysis showed the content of primary and secondary metabolites are carbohydrates, alkaloids, flavonoids, mono, and sesquiterpenoids, respectively. On the other hand, green algae Spirogyra porticalis carbohydrates, proteins, alkaloids, flavonoids, phenolics, tannins, quinones, mono, and sesquiterpenoids, respectively. The chromatogram pattern of sea lettuce Ulva lactuca and  Spirogyra porticalis showed the antioxidant activity caused by secondary metabolites such as phenol, tannin, flavonoids, mono and sesquiterpenoids which were various polarity. Preliminary test results of antioxidant activity with the dinamolysis method showed sea lettuce Ulva lactuca  and and green algae Spirogyra porticalis have antioxidant activity. It potentially developed as drugs, supplements, pharmaceutical excipients and nutritional foods. Keywords: sea lettuce Ulva lactuca, green microalgae Spyrogyra porticalis, antioxidant, marine, Indonesia,
PENENTUAN KANDUNGAN POLIFENOL TOTAL EKSTRAK METANOL KULIT BUAH RAMBUTAN RAPIAH (Nephelium lappaceum L.): DETERMINATION OF TOTAL POLYPHENOL CONTENT OF METHANOL EXTRACT RAMBUTAN RAPIAH FRUIT RIND (Nephelium lappaceum L.) Fahrauk Faramayuda; Oktovia El Shara; Julia Ratnawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i1.262

Abstract

Tanaman rambutan rapiah (Nephelium lappaceum L.) merupakan tanaman yang tersebar luas di Indonesia. Konsumsi buah rambutan rapiah dapat meninggalkan limbah kulitnya yang cukup banyak. Kulit buah rambutan rapiah telah digunakan secara tradisional sebagai obat demam dan disentri. Kulit buah rambutan rapiah diketahui mengandung metabolit sekunder seperti polifenol, flavonoid, saponin, dan tanin. Penelitian sebelumnya melaporkan bahwa ekstrak metanol kulit buah rambutan memiliki aktivitas antioksidan yang kuat. Metabolit sekunder yang diduga memiliki aktivitas antioksidan adalah polifenol. Penelitian lebih lanjut perlu dilakukan, mengingat potensi kulit buah rambutan rapiah sebagai antioksidan kuat. Tujuan penelitian ini adalah untuk mengetahui kadar polifenol total ekstrak metanol kulit buah rambutan rapiah (Nephelium lappaceum L.). Penetapan kadar polifenol total dilakukan dengan menggunakan metode Folin Ciocalteu. Pereaksi Folin Ciocalteu akan bereaksi dengan gugus fenolik-hidroksil dan membentuk kompleks fosfotungstat-fosfomolibdat berwarna biru yang dapat dideteksi dengan spektrofotometer UV-Vis pada panjang gelombang 743,5 nm. Dari penelitian ini kadar polifenol total yang diperoleh adalah 0,2482±0,0401%.
KARAKTERISASI FARMAKOGNOSI DAUN FALOAK (Sterculia quadrifida R.Br): CHARACTERIZATION OF PHARMACOGNOSY OF FALOAC LEAVES (Sterculia quadrifida R.Br) Fahrauk Faramayuda; Julia Ratnawati; Akhirul Kahfi Syam
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.322

Abstract

Faloak secara empiris digunakan sebagai antimikroba, megobati penyakit tifus, mengatasi gangguan pada hati, laksatif, dan antimalaria. Faloak merupakan salah satu tumbuhan yang secara empiris digunakan sebagai obat tradisional di Nusa Tenggara Timur. Selanjutnya dari hasil penelitian ini dapat digunakan untuk studi dan pengembangan aktivitas biologi ekstrak daun faloak menjadi produk farmasi. Ekstraksi menggunakan cara maserasi dengan pelarut etanol dan menghasilkan rendemen 8,84% b/b. Parameter standarisasi ekstrak menunjukkan bobot jenis ekstrak 0,7543 ± 0,0060 g/mL, kadar sari larut air 54 ± 1,15% b/b, sari larut etanol 88,48 ± 1,05% b/b, kadar abu total 10,47 ± 0,16% b / b, abu larut air 8,01 ± 0,99% b / b, abu tidak larut asam 0,39 ± 0,03% b/b. Ekstrak etanol daun faloak mengandung flavonoid, kuinon, polifenol, steroid-triterpenoid, dan monoterpen-sesquiterpen. Ekstrak dianalisis kandungan kimianya menggunakan kromatografi lapis tipis (KLT) dengan fase diam silica F254 dan menggunakan fasa gerak n-heksana: etil asetat (1:1), hasilnya terdapat bercak dengan Rf 0,21 memberi warna biru pada UV 365 nm dan bercak hitam berlatar hijau pada UV 254 nm. Total kandungan flavonoid pada ekstrak etanol daun faloak 5,31 ± 0,29% b / b dan total kandungan polifenol 1,79 ± 0,03% b / b. Dari hasil karakterisasi ini bisa menjadi dasar pemgembangan tanaman faloak menjadi bahan baku obat tradisional terstandar dan acuan untuk melakukan uji aktivitas farmakologi.
ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY Fahrauk Faramayuda; Soraya Riyanti; Totik Sri Mariani; Rizka Khoirunnisa Guntina; Winda Nur Halimah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.977

Abstract

 One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.
EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.) Fahrauk Faramayuda; Ari Sri Windyaswari; Yeni Karlina; Muhamad Raihan Maulana; Rizka Khoirunnisa Guntina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.994

Abstract

Oil palm (Elaeis guineensis Jacq.) is a plant that is native to Africa and South America. This plant can grow well in tropical areas, such as Indonesia. Indonesia is currently one of the largest producers of palm oil worldwide. As the area of palm oil plantations increases, the potential for waste from this plant continues to increase. The potential for palm oil leaf waste production in Indonesia is 658 kg dry matter/hectare/year. Palm oil leaf waste has been widely processed into organic fertilizers and animal feeds. This plant has the potential to be developed into a source of traditional medicinal ingredients. Based on the abundant sources of palm oil leaves and their pharmacological potential, palm oil leaves can be used as a source of raw materials for traditional medicine. This study aimed to compare the antioxidant activities of oil palm leaf extracts obtained by maceration and reflux to determine which extraction method produces the best antioxidant activity. Extraction was carried out using 70% ethanol solvent by maceration and reflux. The results of the phytochemical screening showed that oil palm leaves contain flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpene-sesquiterpenes. Antioxidant activity using a UV-Visible spectrophotometer with DPPH free radicals showed that the extract obtained by maceration and reflux methods had IC50 values of 46.61 ± 1.76 ug/mL and 55.21 ± 2.91 ug/mL respectively. Therefore, extraction by maceration produces a better antioxidant activity.  Keywords: Palm leaves; Traditional medicine; Extraction; Active compound stability; Antioxidant
Penyuluhan Manfaat Tanaman Obat Tradisional dan Pengelolaan Website Paguyuban Jamu Manunggal Kota Cimahi Faramayuda, Fahrauk; Ilyas, Ridwan; Paramita, Veronika Santi; Windyaswari, Ari Sri; Ismail, Nursafira Khairunnisa; Akbar, Tzazkia Febriyana; Putri, Dhiffa Namira Alifia; Adriana, Reyhan
AJAD : Jurnal Pengabdian kepada Masyarakat Vol. 4 No. 3 (2024): DECEMBER 2024
Publisher : Divisi Riset, Lembaga Mitra Solusi Teknologi Informasi (L-MSTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59431/ajad.v4i3.378

Abstract

Paguyuban Jamu Manunggal Cimahi is located at Gang M. Ardjo No.224. Based on the initial survey, the problem was identified that knowledge about the benefits of traditional medicinal plants was still limited. In addition, the sales of products are still ineffective because the marketing is still carried out conventionally. This underlies the need for counseling on the benefits of traditional medicinal plants and website management at Paguyuban Jamu Manunggal which aims to increase the knowledge of the participants and to expand the target market. The counseling activity was carried out on October 08, 2023 which began with a pre-test, presentation, post-test, and workshop. Based on the test results, it can be concluded that the counseling activities can significantly increase the knowledge of the participants, this is indicated by the average value of the pre-test and post-test which was originally 60 to 95.3.
Formulation and Physical Evaluation of Orthosiphon aristatus Leaf Extract Granule Preparation as Herbal Beverage Candidate Al-Hakim, Nur Achsan; Nur Fauziyyah, Salma Alifia; Purnamasari, Nira; Faramayuda, Fahrauk
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91009

Abstract

Developing Orthosiphon aristatus (Blume) Miq. leaf extract of purple varieties into granule dosage forms is expected to facilitate consumption, storage, and can extend the shelf life of the product. This study aims to develop the formulation and evaluation of granule preparations of O. aristatus leaf extract of purple varieties, with a comparison of lactose and maltodextrin fillers to produce the best formula. The granule dosage forms were prepared using wet granulation method. Furthermore, the variation of granule preparation formula consists of F1 (extract with lactose), F2 (extract with maltodextrin), F3 (extract with a combination of lactose and maltodextrin 1:1), F4 (freeze dried extract with lactose), F5 (freeze dried extract with maltodextrin), and F6 (freeze dried extract with a combination of lactose and maltodextrin 1:1). The physical evaluation of granules comprised moisture content testing, flowability, compressibility index, particle size distribution, and granule dissolving time. Results from the physical evaluation of granules over 28 days of storage indicated that all six formulas met the criteria for good granules, with F3 emerging as the optimal formula due to its superior physical stability and visually appealing appearance upon dissolution. To conclude, this study demonstrates that O. aristatus leaf extract can be effectively formulated into instant granule preparations suitable for herbal beverage or alternative medicine. Moreover, by modifying the filler material, the physical stability of the granule preparation can be maintained.
REVIEW: PLANTS WITH REPELLENT ACTIVITY Purnama, Uwan; Faramayuda, Fahrauk
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1174

Abstract

Mosquitoes are vectors of illnesses, such as encephalitis, dengue, filariasis, intestinal sickness, and encephalitis. These diseases have become epidemics in Indonesia and around the world. Natural repellents are alternatives for preventing mosquito-borne diseases that are safe, easily degradable, and eco-friendly. This review aimed to identify compounds in plants with mosquito repellent activity. Data were obtained from national and international journals using search platforms, including PubMed, Scholar, SciDirect, and Hindawi. This review focuses on plants with repellent activity, their resulting repellent activity, the content of bioactive compounds, and the mosquito species used. Many plants contain naturally occurring compounds that can repel mosquitoes. Following scientific research, 14 bioactive compounds have been shown to have repellent activity in plants. Keywords: repellent, volatile oil, mosquitos, bioactive compounds, narrative literature review
ANTIOXIDANT ACTIVITY OF COMBINATION OF WHITE-PURPLE Orthosiphon aristatus (Blume) Miq HERB EXTRACT AND Stevia rebaudiana Bertoni USING FRAP METHOD Faramayuda, Fahrauk; Syam, Akhirul Kahfi; Putri, Dhiffa Namira Alifia; Ismail, Nursafira Khairunnisa; Akbar, Tzazkia Febriyana; Farhan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1612

Abstract

Oxidative stress is caused by an increase or decrease in the antioxidant defense activity. Orthosiphon aristatus (Blume) Miq and Stevia are two plants that contain antioxidant compounds and can bind free radical compounds. The combination of Orthosiphon aristatus (Blume) Miq and Stevia was expected to increase antioxidant activity. This study aimed to determine the antioxidant activity of a combination of the Orthosiphon aristatus (Blume) Miq white-purple variety and Stevia rebaudiana Bertoni extract. Antioxidant activity was tested using the FRAP method with a UV-visible spectrophotometer at a wavelength of 710 nm. The results of phytochemical screening showed that both plant extracts and dry material contained secondary metabolite compounds, including flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpenes-sesquiterpenes. A qualitative test relating to antioxidants using TLC showed positive antioxidant activity, which was proven by the presence of green or blue light on the TLC plates. This was due to electron transfer in the compound, which reduced Fe3+ to Fe2+. On the other hand, quantitative measurements using the FRAP method showed the antioxidant capacity values consecutively, F1 combination extract (1:1) of 43.725 mg of QE/g extract, F2 combination extract (2:1) of 57.963 mg of QE/g extract, and combination extract of F3 (3:1) of 64.849 mg of QE/g extract. The extract combination of F3 showed the best formula, with a value of 64.849 mg QE/g extract.  Keywords: Orthosiphon aristatus (Blume) Miq, Stevia, antioxidants, FRAP
Pelatihan Pembuatan Serbuk Jamu Instan sebagai Model Pemberdayaan UMKM di Kota Cimahi Faramayuda, Fahrauk; Windyaswari, Ari Sri
Room of Civil Society Development Vol. 4 No. 4 (2025): Room of Civil Society Development
Publisher : Lembaga Riset dan Inovasi Masyarakat Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59110/rcsd.734

Abstract

Banyak pelaku usaha jamu di Indonesia menghadapi kendala dalam meningkatkan kualitas produk akibat keterbatasan keterampilan teknis dan pengetahuan pengolahan tanaman obat. Kegiatan pengabdian ini bertujuan untuk meningkatkan pengetahuan dan keterampilan komunitas usaha jamu di Kota Cimahi melalui pelatihan pembuatan serbuk instan. Metode pelaksanaan meliputi penyuluhan, praktik langsung, serta evaluasi melalui pre-test dan post-test yang diikuti oleh 37 peserta. Analisis data dilakukan dengan membandingkan rata-rata skor pre-test dan post-test, disertai dokumentasi lapangan. Hasil menunjukkan adanya peningkatan rata-rata skor dari 6,05 menjadi 6,41 atau sebesar 5,8%. Peserta juga berhasil menghasilkan produk serbuk instan berbahan jahe, kunyit, dan beras kencur, yang sebagian telah memperoleh izin edar sederhana berupa SPP-IRT. Selain itu, pelatihan berdampak pada peningkatan kapasitas produksi mitra serta kepercayaan diri peserta dalam memasarkan produk. Dengan demikian, pelatihan ini dapat dipandang sebagai model intervensi awal yang efektif untuk memperkuat daya saing UMKM jamu lokal, yang keberlanjutannya memerlukan dukungan pendampingan dan strategi pemasaran modern.
Co-Authors Adella Shindy Pratiwi Adely, Alyaa Muliahati Adinda Fitriani Adriana, Reyhan Akbar, Tzazkia Febriyana Akhirul Kahfi Syam Amedea, Esanda Zulfi Ami Soega Dwigantina Amirah Mohd Gazzali Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Aprilia, Trialisa Ari Sr Windyaswari Ari Sri Widyaswari Ari Sri Windyaswari Ayu, Inna Puspa Bambang WIJIANTO Chandani Nurul Hafizah Citra Permata Sari Defanie Sophi Nurfadhilah dessy ratnasari Dewi, Renti Mutiara Dhimas Ariya Wibiksana Dinda Choirunnisa Dinda Siti Nurhalizah Dumanauw, Jovie Mien Dwi Ayu Pratiwi Dwi Nurahmanto Dwigantina, Ami Soega Dyah Nur Azizah, Dyah Nur Elfahmi Elfahmi Elfahmi Elfahmi Elfahmi Elfahmi, Elfahmi Ema Mutya Endang Kumolowati Esanda Zulfi Amedea Euis Reni Yuslianti Evi Umayah Ulfa Faizal Hermanto Fania Mufti Mufidah Farhan Fikri Alatas Fitriani, Adinda Fitrichia, Anggita Esa Putri Iis Inayati Rakhmat Ismail, Nursafira Khairunnisa Jaka Permana Julia Ratnawati Julia Ratnawati Khairunisa Harizqi Nurul Husna Limbong, Remare Halomoan Lina Winarti Liquw Rontos Liza Pratiwi Melani, Putri Dwi Mentari Suci Indah Lestari Muhamad Raihan Maulana Muhammad Hilmi Afthoni Muhammad Irwan Mutya, Ema Niken Tunjung Murti Pratiwi Nira Purnamasari, Nira Nur Achsan Al-Hakim Nur Fauziyyah, Salma Alifia Nurhayati, Viola Aditya Nursafira Khairunnisa Ismail Nurul Wahdaniah Andi Wajuanna Oktiyas Muzaky Luthfi Oktovia El Shara Olva Nurnissa Krissakti Osama Al Hafiz Paramita, Veronika Santi Pertiwi, Ananda Tunjung Pratiwi, Dwi Ayu Purnama, Uwan Purwoko, Agus Putri Fatimatuz Zahro Putri, Dhiffa Namira Alifia Ramelan, Riska Sigit Remare Halomoan Limbong Renti Mutiara Dewi Reyhan Adriana Deris Rian Maulana Muttaqin Ridwan Ilyas Ridzka Magfirah Rifaz Muhammad Sukma Riska Sigit Ramelan RIZKA KHOIRUNNISA GUNTINA, RIZKA KHOIRUNNISA Septiani, Usi Sigid Pamungkas Wicaksono Silvy Julian Siti Muslichah Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sufyan Zainul Arifin Sugiyanto Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sultan Salahudin Jamal Sundani Nurono Soewandhi SURYANI Susi Sunarty Sigalingging Suwidjiyo Pramono Tety Lutfia Totik Sri Mariani Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Trialisa Aprilia Tzazkia Febriyana Akbar Usi Septiani Viola Aditya Nurhayati Wayan Puspita Dewi Weni Widy Astuti Winda Nur Halimah Wulandari, Yesi Yeni Karlina Yeni Karlina Yeni Karlina, Yeni Yenni Karlina Yesi Desmiaty, Yesi Yesi Wulandari Zaini Alfahmi Zaza Nurahmadanti