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All Journal Majalah Kedokteran Bandung Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Obstetri dan Ginekologi Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Gondo Mastutik
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
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Journal : Biomolecular and Health Science Journal

 1 
Distribution Genotype High Risk (HR) And Low Risk (LR) Human Papillomavirus (HPV) at Condyloma Acuminata Gondo Mastutik; Alphania Rahniayu; Dwi Murtiastutik; Afria Arista; Trisniartami Setyaningrum; Nabiha Missaoui; Suhartono Taat Putra
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26250

Abstract

Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%.  Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.
Analgesic Effect Study of Young Coconut Water (Cocos nucifera L.) on Mice (Mus musculus) Induced with Pain using Acetic Acid Dini Indah Berlianti; Danti Nur Indiastuti; Gondo Mastutik; Shaohong Lai
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30176

Abstract

Introduction: Pain signals tissue damage that is capable of reducing thequality of life. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are known as effective analgesic drugs which have various side effects, therefore natural minerals are used as an alternative medicine for pain and inflammation, one of which is known to be coconut water. Hence this research was conducted to find out the differences of the analgesic effect between young coconut water (Cocos nucifera L.) with non-selective and COX-2 selective NSAID on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.Methods: True experimental, conducted at the Pharmacology Laboratory in Faculty of Medicine of Airlangga University involving the sample of 48 mice (6 groups). The recorded data was tested using the oneway ANOVA methodology before then continued with the posthoc test of LSD.Results: The addition of young coconut water (Cocos nucifera L.) with the dosage of 3 ml/100gBW, 4 ml/100gBW, and 4.5 ml/100gBW of mice doesn't give any significant analgesic effect even though the analgesic protection percentage increases accordingly to its dosage (12.32%, 18.72%, 26.88%), but non-selective and COX-2 selective NSAID give significant analgesic effect (p<0.05) on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.Conclusion: There are differences in the analgesic effect of young coconut water (C. nucifera L.) with non-selective and COX-2 selective NSAID on mice induced with pain from acetic acid 0.6% 1 ml/100gBW of mice.
Co-Authors , Isnin Anang Marhana Afria Arista Afria Arista Afria Arista, Afria Agung Dwi Suprayitno Agus Santosa Agus Santosa Ali Rohman Alphania Rahniayu Aniek Meidi, Aniek Anny Setijo Rahaju, Anny Setijo Ariani, Grace Arifa Mustika Aryati , Aryati Aryati Aryati Aryati Aryati Bagus Setyoboedi Benediktus Yohan Bilqis Inayatillah Budi Harjanto Budi Harjanto Cempaka Harsa Sekarputri Dewi Sartika A. W. Dini Indah Berlianti Dwi Murtiastutik DYAH FAUZIAH, DYAH Erni J. Nelwan, Erni J. Erni Juwita Nelwan, Erni Juwita Faisal Amir Faisal Amir Faroek Hoesin Fira Soraya Heriyawati, Heriyawati Heru Fajar Trianto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Indiastuti, Danti Nur Iqhrammullah, Muhammad Isnin Anang Marhana Jennifer Susanto Juniastuti Juniastuti Khafidhotul Ilmiah Khafidhotul Ilmiah Kuntaman Kuntaman Kusumastuti , Etty Hary Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lasmauli Situmorang Leonita Agustin Hambalie M Hasinuddin Markus Kore Masyeni, Sri Mochamad Amin Mochamad Amin MOCHAMAD AMIN Muchlis AU Sofro Nabiha Missaoui Nila Kurniasari Nila Kurniasari Nurma Yuliyanasari, Nurma Poernomo Boedi Setiawan Prasetyo, Rizki Eko Purnama, Yugi Hari Chandra Purnomo, Windu Qonitatillah, Ana R. Tedjo Sasmono Rahmi Alia Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Renny I’tishom Ridholia Ridholia, Ridholia Rizki Eko Prasetyo S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Sasmono, R. Tedjo Shaohong Lai Sjahjenny Mustokoweni, Sjahjenny Sjamsul Arief Sofro, Muchlis AU Sofro, Muchlis AU. Sri Masyeni, Dewa Ayu Putri Suhartono Taat Putra Sunaryo Hardjowijoto Sutrisno Sutrisno Tamam Jauhar Trianto, Heru Fajar Trisniartami Setyaningrum Usman Hadi Willy Sandhika Windu Purnomo Wira Santoso Ongko Wiratama, Priangga Adi Yohan, Benediktus Yugi Hari Chandra Purnama