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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Anestesiologi Indonesia Jurnal Kedokteran Brawijaya Indonesian Journal of Urology Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Biosaintifika: Journal of Biology & Biology Education Media Medika Muda Amerta Nutrition Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research Berkala Penelitian Hayati Indonesian Journal of Cancer Berita Kedokteran Masyarakat
Ignatius Riwanto, Ignatius
Department Of Digestive Surgery, Faculty Of Medicine, Diponegoro University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Medica Hospitalia

 1 
Antioxidant and Anti-inflammatory effect of Graptophyllum pictum (L.) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids Azhar, Abu; Riwanto, Ignatius; Nugroho, Eriawan Agung; Susilaningsih, Neni; Prajoko, Yan Wisnu; Budiono, Parish; Prasetyo, Sigit Adi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.539 KB) | DOI: 10.36408/mhjcm.v7i2.515

Abstract

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory and plebotonic medicines, high fiber diet and changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory and plebotonic medicine) since its anti-inflammatory effect may be related to antioxidant property. ObjectiveTo elaborate the anti-inflammatory and anti-oxidant effect of GP on experimental hemorrhoid in male Wistar rats. MethodsA Randomized Controlled Trial Post-test only design in hemorrhoid-like rats using croton oil induced into the anus for 30 seconds each day for 3 consecutive days. 14 Wistar rats were randomly allocated into 2 groups. Group 1 got normal saline solution, while group 2 treated with GPE 100mg/Kg bw for 5 consecutive days. On the 9th experimental day, the blood was drawn for Elisa examination of COX-2 and SOD levels. As COX-2 and SOD normally distributed, pool t-test and product moment correlation was used for statistical analysis. Results All of Wistar rats were still alive. COX-2 levels (ng/ml) in the GPE group was 266.28±158.47, was significantly lower compared to control (595.21±68.92) (p=0.000). Serum SOD levels (ng/ml) in the GPE was 77.00±11.0, and was significantly higher than the control 28.00±4.00 (p=0.02). Correlation between COX-2 and SOD serum level was significantly strong negative correlation (p=0,000 and r=-0.842) Conclusions GPE at a dose of 100 mg/kg bw has antioxidant and anti-inflammatory effects on artificial hemorrhoids through decreased COX-2 levels, and elevated SOD levels. There is a strong negative correlation between SOD and COX-2 serum level. KeywordsGraptophyllum pictum, hemorrhoids, Croton oil, COX-2, SOD.
Pengaruh Pemberian Fenitoin Oral dan Vitamin C Oral terhadap Jumlah Kolagen dan Diameter pada Fistula Enterokutan Tikus Wistar: Effect Phenytoin and Vitamin C Therapy to Collagen Deposition and Diameter of Enterocutaneous Fistula in Wistar Rat Pambudi Utomo, Gede; Riwanto, Ignatius; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 3 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v9i3.766

Abstract

Latar Belakang : Enterocutaneous fistula (ECF) adalah salah satu tantangan bagi banyak ahli bedah di dunia. Meskipun terdapat perkembangan dalam perawatan medis dan tekhnik operasi, namun morbiditas dan mortalitas terkait ECF masih tinggi. Keberhasilan dalam tatalaksana ECF memerlukan perawatan yang komprehensif dan sumber daya yang mahal, dimana tidak terjangkau oleh sebagian masyarakat Indonesia. Fenitoin dan Vitamin C adalah obat yang murah dan telah menunjukan manfaat baik dalam penyembuhan luka. Tujuan : Penelitian ini bertujuan untuk mengetahui apakah pemberian fenitoin dan vitamin C akan meningkatkan kolagenisasi dan menurunkan diameter ECF pada tikus wistar. Kemudian untuk mengevaluasi apakah pemberian kombinasi fenitoin dan vitamin C memberikan hasil yang lebih baik dibandingkan pemberian tunggal fenitoin atau fitamin C Metode : Peneliti membuat caecostoma sebagai model ECF pada 24 ekor tikus. Tikus kemudian dibagi menjadi empat kelompok perlakuan dengan : perawatan NaCl,  Kombinasi fenitoin-vitamin C, Fenitoin saja dan Vitamin C saja. Pengamatan hasil dilakukan pada hari ke-7 dengan mengamati deposisi kolagen dan mengukur diameter ECF. Hasil : Penelitian ini menunjukan perbedaan kolagenisasi dan penurunan diameter ECF bermakna secara statistik (p<0.05) pada tiap kelompok perlakuan jika dibandingkan kelompok kontrol (5,521 + 2,552 %; 9,395 ± 0,582 mm). Penelitian ini juga mengungkapkan bahwa pemberian kombinasi fenitoin dengan vitamin C (28,110 ± 6,535 %; 5,742 ± 0,394 mm) memberikan hasil yang lebih baik (p<0.05) dibanding pemberian tunggal fenitoin (15,448 ± 5,184 %; 8,101 ± 0,822 mm) atau vitamin C (19,118 ± 4,190 %; 6,883 ± 0,744 mm). Kesimpulan : Kami menyimpulkan baik fenitoin maupun vitamin C memiliki efek baik dalam penyembuhan ECF. Pemberian kombinasi Fenitoin dan vitamin C terbukti lebih bermanfaat dibandingkan pemberian tunggal. Kata Kunci :  Enterocutaneous fistula, Fenitoin, Vitamin C, kolagen, Diameter fistula
Assessing the Inter-observer Agreement of Electrocardiography Interpretation in the Elderly Surgical Patients: A Cross-Sectional Study Mupangati, Yudo Murti; Setyawan, Henry; Soejono, Czeresna Heriawan; Gasem, Muhammad Hussein; Riwanto, Ignatius
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.969

Abstract

Background: Electrocardiography (ECG) is an essential objective diagnosis tool, specifically for the elderly who are about to undergo surgery. From the examination results, it is possible to determine the presence of a heart condition that could impair the surgical outcome. Furthermore, the examination is slightly influenced by the subjectivity of observers. Purpose: To evaluate the inter-observer agreement on the reader of a 12-lead ECG on elderly patients subjected to elective surgery. Method: A consequential ECG examination was conducted on elderly patients who underwent elective surgery at Dr. Kariadi Hospital  Semarang between July and November 2021. Two junior internist observers were independently involved in reading the ECG results in different places. The inter-observer reliability analysis used kappa statistics to determine consistency between observers. Result: Analysis was carried out on 193 patients aged  60-87 years old, with a prevalence of abnormal ECG was 33.7%. Kappa Conformity Value was 0.864 (95 % CI: 0.790-0.938,  p<0.001). Conclusion: The value of agreement between junior internists in ECG interpretation among elderly surgical patients is good (kappa value  >0.8). Even though the observers are junior internist, the result of the interpretation with a high kappa is considered to have reliable validity.
Factors Associated with Survival Rate in Biliary Atresia Patients Following Kasai Surgery Prasetyo, Agung Aji; Basyar, Edwin; Wibisono, Agoes; Wardhani, Avriana Pety; Rachmawati, Banundari; Riwanto, Ignatius
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1059

Abstract

Introduction: Biliary atresia is the most frequent cause of obstructive jaundice leading to liver fibrosis, end-stage liver disease, and death. Kasai surgery offers a bridge to attenuate liver fibrosis progression through reconstruction of the biliary system. The success of the Kasai procedure depends on the presence of jaundice, age at the time of surgery, clay-colored stool, and bilirubin counts. Aim: This study aimed to investigate and predict the death incidence of Biliary atresia patients following Kasai Surgery in our institution. Method: We conducted a case-control study from March 2020 to January 2022 at Kariadi General Hospital, Semarang, Indonesia. We collected data related to gender, age at surgery, albumin level pre and post-surgery, total and direct bilirubin before and after surgery, and the presence of ascites. Bivariate analysis using the Chi-Square test with OR (95% CI) was performed to analyze the risk factors in BA patients following the Kasai procedure. Results: 19 patients with biliary atresia underwent the Kasai procedure with a survival rate of 68.4%. Bilirubin levels ≥10 mg/dL before (p=0.033, OR 11.25) and after (p=0.025, OR 11.00) the Kasai procedure, and the presence of ascites (p=0.005) were significant factors associated with mortality cases. However, a combined multivariate analysis of these factors did not show any significant relationship with outcomes. Conclusion: Bilirubin exceeding 10 mg/dL before and after the Kasai procedure and the presence of Ascites was a marker for poor outcomes for biliary atresia patients following the Kasai procedure
Sleeve Gastrectomy And Liver Cyst Unroofing In Morbid Obesity With Multiple Liver Cysts: A Case Report Mughni, Abdul; Renata, Bella; Nugrahadi, Dimas Erlangga; Pemayun, Tjokorda Gde Dalem; Rudiman, Reno; Riwanto, Ignatius
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1110

Abstract

Background: Obesity has become a major global health issue which leads to various complications, including hepatic diseases. However, we found a rare case of morbid obesity and symptomatic multiple liver cysts. Aim: This article aims to represent a rare case of morbid obesity and multiple liver cysts surgically managed by sleeve gastrectomy and liver cyst unroofing which were performed in a single surgery. Case report: 41-year-old female presented with morbid obesity and blunt intermittent abdominal pain in the right upper quadrant. Stage II hypertension, tenderness on the right upper quadrant of the abdomen and epigastrium were found in clinical assessment. Lipid profiles were shown to be elevated. Abdominal CT revealed fatty liver and multiple cystic lesions in all hepatic segments. Discussion: Non-parasitic liver cysts affect 2-18% of the global population, with a higher prevalence in females possibly due to hormonal factors. Obesity is associated with hormonal alterations, potentially leading to increased secretion of FSH and LH. Conclusion: Sleeve gastrectomy and liver cyst unroofing may be considered as a treatment strategy for patients with morbid obesity and multiple liver cysts.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Mughni Agung Aji Prasetyo, Agung Aji Agung Pribadi Agung Putra Anindita Soetadji Ar, Ardiyana Azhar, Abu Bahrudin Bahrudin Banundari Rachmawati Baskoro, Adhi Gunawan Bernadus Parish Budiono Budi Mulyono Bulandari, Beatrice LA. Catharina Suharti Christyana, To Lidwina Prillya Indra Czeresna Heriawan Soejono Dody Novrial, Dody Dwi Pudjonarko Edi Dharmana Edwin Basyar Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Ernestia, Henrita Fuadi, Ahmad F. Gasem, Muhammad Hussein Hardhono Susanto Henry Setyawan Susanto Henry Setyawan Susanto Heri Nugroho Hermawan Istiadi Ibrahim, Sugeng Indra Wijaya Irawan, Andry Iwan Vanca Saragih Kosnayani, Ai Sri Kristanti, Alberta Widya Kurniawati, Yovie Lisyani Budipardigdo Suromo Mario Sadar Bernitho Hutagalung Meita Hendrianingtyas Muniroh, Muflihatul Mupangati, Yudo Murti Neni Susilaningsih Nugrahadi, Dimas Erlangga Nugroho, Trilaksana Nur Anna Chalimah Sadyah Pambudi Utomo, Gede Parish Budiono Prabowo, Erik Prawara, Ananta Sidhi Purnomo, Hery D. Radityo Prakoso Rampengan, Derren DCH. Renata, Bella Reno Rudiman Respati, Danendra RK. Satrio Adi Wicaksono Satyagraha, Muhammad Thifan Sebong, Perigrinus H Sefri Noventi Sofia Selamat Budijitno Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Suhartono, Suhartono Suharyo Hadisaputro Sutanto, Eviana Budiartanti Sutiman B Sumitro Sutiman B. Sumitro Tjandra, Kevin C. Tjitradinata, Cynthia Tjokorda Gde Dalem Pemayun Tri Indah Winarni Trilaksana Nugroho Wardhani, Avriana Pety Wibisono, Agoes Yan Wisnu Prajoko