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The Effect of Variation in Polyvinylpyrrolidone (PVP) Concentration as a Binder in The Formulation of Curcumin Isolate Lozenges Yola Desnera Putri; Annisa Putri Dewantara; Yeyet Cahyati Sumirtapura; Adit Andriyannto
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tqs16n98

Background: The pharmaceutical industry continues to develop user-friendly dosage forms to improve patient compliance, especially for individuals who have difficulty swallowing conventional tablets. Lozenges are an alternative oral dosage form that does not require water and allows drug absorption through the oral mucosa, making them more practical and convenient. In lozenge formulation, polyvinylpyrrolidone (PVP) as a binder plays an important role in determining physical characteristics such as hardness, friability, and disintegration time. Objective: This study aimed to evaluate the effect of varying PVP concentrations on the physical characteristics of curcumin isolate lozenges and to determine the optimal formulation. Methods: An experimental method using wet granulation was applied with PVP concentrations of 1%; 2%; 3%; 4% and 5%. Evaluations included granule properties (moisture content, flow rate, angle of repose, compressibility index) and tablet properties (organoleptic characteristics, weight and size uniformity, hardness, friability, and disintegration time). Results: Increasing PVP concentration influenced tablet characteristics, particularly hardness, friability, and disintegration time. All formulations met the physical quality requirements for lozenges. The formulation containing 3% PVP showed the most balanced characteristics compared to others. Conclusion: PVP concentration affects the physical properties of curcumin lozenges, with 3% identified as the optimal concentration, indicating its potential as a practical alternative oral dosage form.

Formulation and Stability Evaluation of Sunscreen Cream: Utilization of Methyl Cinnamate Isolate from Alpinia galanga L. Rhizome as a Photoprotective Agent Yola Desnera Putri; Alidya Canticha Sari; Deby Tristiyanti; Adit Andriyannto
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43620

Methyl cinnamate isolate is an aromatic ester compound with a conjugated chromophore system capable of absorbing UV-B radiation, making it a promising candidate for sunscreen formulations. This study aimed to determine the optimum concentration of methyl cinnamate isolate based on its sun protection factor (SPF) and to develop a sunscreen cream with satisfactory physical stability. Methyl cinnamate isolate solutions were prepared at concentrations of 1000, 2000, 3000, 4000, and 5000 ppm and screened for SPF activity. The concentration yielding the highest SPF value was incorporated into cream formulations containing different stearic acid concentrations as an emulsifier (F1: 8% w/w and F2: 10% w/w). The resulting formulations were assessed for SPF, physical characteristics during 28 days of storage at room temperature, microbiological quality, and methyl cinnamate content under accelerated stability conditions (40 ± 2°C and 75 ± 5% RH). The isolate at 5000 ppm (0.5%) exhibited the highest SPF value of 33.49, corresponding to the ultra-protection category. Both formulations maintained acceptable physical characteristics throughout the storage period. At day 28, SPF values were 13.87 for F1 and 17.02 for F2, with F2 remaining within the ultra-protection category. After three months of accelerated stability testing, methyl cinnamate content was 47.62% in F1 and 68.32% in F2. Microbiological evaluation also revealed contamination based on total plate count and yeast–mold count analyses. These findings indicate that methyl cinnamate isolate has potential as a sunscreen active ingredient; however, further formulation optimization and preservative incorporation are required to improve chemical stability and microbiological quality.

PENINGKATAN KELARUTAN EKSTRAK ETANOL DAUN SIRIH MERAH (PIPER CROCATUM RUIZ & PAV.) MELALUI KOMPLEKSASI DENGAN β-SIKLODEKSTRIN Yola Desnera Putri; Princesa Elnovita Tierra; Sohadi Warya; Adit Andriyannto
ASSYIFA : Jurnal Ilmu Kesehatan Vol. 4 No. 2 (2026)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/ajk.v4i2.232

Red betel leaves (Piper crocatum Ruiz & Pav.) are rich in secondary metabolites, particularly flavonoids, which exhibit pharmacological potential such as antioxidant and antidiabetic properties. However, the low solubility of the extract poses a major challenge in drug formulation development. This study was designed to enhance the solubility of ethanol extract from red betel leaves by forming inclusion complexes with β-cyclodextrin using the kneading method, and further developing it into instant-dissolving granules. Extraction was performed via maceration technique with 70% ethanol as the solvent. Complexes were prepared by kneading at ratios of 1:1, 1:2, and 1:3 (extract:β-cyclodextrin). The resulting complexes were tested for solubility and formulated into granules through wet granulation. The extraction yielded 10.92% render. Kneading complex formation successfully increased solubility to 16.092% (F1), 27.844% (F2), and 36.302% (F3). Evaluation of the granules' physical properties showed parameters meeting standard requirements. The study concludes that β-cyclodextrin incorporation via kneading is effective in improving the solubility of red betel leaf extract and producing granules with optimal physical characteristics.

Pemanfaatan Isolat Katekin dari Gambir (Uncaria Gambir Roxb.) pada Essence Sheet Mask: Kajian Stabilitas, Antioksidan dan Cemaran Mikroba Sediaan Yola Desnera Putri; Retty Azka Djumar Danawiria; Hesti Riasari; Adit Andriyannto
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar

Isolat katekin dari gambir (Uncaria gambir Roxb.) merupakan golongan polifenol yang memiliki aktivitas antioksidan tinggi melalui kemampuan menetralisir radikal bebas ROS. Dalam upaya memanfaatkan bioaktivitasnya, isolat katekin diformulasikan sebagai essence sheet mask yang mendukung penetrasi transdermal optimal untuk mengatasi penuaan dini, hiperpigmentasi, dan stres oksidatif jaringan kulit. Penelitian ini bertujuan mengembangkan dan mengkarakterisasi essence sheet mask berbasis katekin untuk aplikasi topikal inovatif, meliputi aktivitas antioksidan metode DPPH, stabilitas sediaan, cemaran mikroba (ALT dan AKK), serta penetapan kadar isolat katekin dalam sediaan essense sheet mask. Sediaan dibuat dalam dua formula, (F1, F2; rasio basis 2:1). Hasil uji DPPH menunjukkan nilai IC₅₀ asam askorbat sebesar 3,879 ppm dan isolat katekin 3,010 ppm. Setelah diformulasikan, aktivitas antioksidan isolat katekin menurun menjadi 64,066 ppm (F1) dan 50,565 ppm (F2), yang menunjukkan pengaruh matriks sediaan terhadap aktivitas bioaktif. Uji cemaran mikroba menunjukkan nilai ALT dan AKK berada di bawah batas maksimum (<10³), serta tidak terdeteksi Staphylococcus aureus dan Pseudomonas aeruginosa. Formulasi F1 dengan xanthan gum 0,2% menunjukkan stabilitas fisik yang optimal dan nilai IC₅₀ sebesar 96,049 ppm setelah penyimpanan 28 hari, serta kemampuan mempertahankan kadar zat aktif lebih baik dibandingkan F2. Dengan demikian, sediaan ini memenuhi standar stabilitas fisik dan mikrobiologis yang berpotensi sebagai alternatif antioksidan topikal.

Formulation and antibacterial activity of black mulberry fruit (Morus nigra L.) extract cream against cutibacterium acnes and staphylococcus epidermidis Yola Desnera Putri; Lisna Munawaroh; Ledianasari Ledianasari; Adit Andriyannto
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2338

Acne vulgaris is an inflammatory disorder of the pilosebaceous unit characterized by sebum overproduction, abnormal keratinization, microbial proliferation, and inflammation, with Propionibacterium acnes and Staphylococcus epidermidis as key contributing bacteria. To reduce the side effects associated with conventional acne therapies, natural ingredients have been explored as alternative approaches. Black mulberry (Morus nigra) fruit is one such natural source known to contain bioactive compounds, including flavonoids, tannins, and terpenoids, which possess antibacterial properties. This study aimed to develop and evaluate a topical cream formulation containing ethanolic extract of black mulberry fruit and to assess its antibacterial activity and physicochemical stability. The extract was obtained through 96% ethanol maceration and formulated into creams at concentrations of 1.25%, 2.5%, and 5%. Antibacterial activity was evaluated using the agar well diffusion method, while cream quality was assessed through organoleptic properties, homogeneity, pH, viscosity, spreadability, and centrifugation stability. The results showed that the extract exhibited strong antibacterial activity against both tested bacteria. All concentrations demonstrated inhibition zones categorized as strong, with a concentration-dependent increase in activity. At 1.25% inhibition zones against P. acnes were 11.7 ± 0.25 m, while against S. epidermidis were 11.9 ± 0.20 mm at day 28. All formulations showed acceptable physicochemical characteristics and remained stable during 28 days of storage. The novelty of this study lies in the development of a stable topical cream formulation of M. nigra extract with confirmed antibacterial activity, providing a potential plant-based alternative for anti-acne therapy.

Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Buah Murbei Hitam (Morus nigra L.) sebagai Antijerawat Yola Desnera Putri; Susi Sulastri; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1471

Acne is one of the most common skin disorders affecting various age groups, particularly adolescents, and is caused by inflammation of the pilosebaceous follicles associated with bacterial proliferation. The primary bacteria involved in acne pathogenesis are Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis). This study aimed to formulate an anti-acne gel containing ethanol extract of black mulberry (Morus nigra L.) fruit and to evaluate its antibacterial activity. The black mulberry fruit was extracted by maceration using 96% ethanol. The resulting extract was formulated into a Carbopol 940-based gel at three different concentrations: 1.25% (F1), 2.5% (F2), and 5% (F3). The formulated gels were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, antibacterial activity using the agar well diffusion method, and skin irritation using the Draize method. The results showed that the ethanol extract of black mulberry fruit exhibited antibacterial activity against P. acnes and S. epidermidis, with inhibition zone diameters of 12.0 ± 0.90 mm and 12.8 ± 0.59 mm, respectively, at a concentration of 1.25%, indicating strong antibacterial activity. After formulation into a gel, the highest antibacterial activity was observed in Formula 3 (F3) after 28 days of storage, with inhibition zone diameters of 15.1 ± 0.06 mm against P. acnes and 15.3 ± 0.10 mm against S. epidermidis. All formulations met the required physical evaluation parameters and showed no signs of irritation in a preliminary Draize irritation test during the observation period. Therefore, the ethanol extract of black mulberry fruit has the potential to be developed as a topical anti-acne gel with antibacterial activity against P. acnes and S. epidermidis.

Karakterisasi dan Uji Stabilitas Clay Mask Isolat Mangostin Sebagai Antijerawat Yola Desnera Putri; Shafa Nurul Fadilla; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1470

Acne is a common skin disorder affecting adolescents and young adults, characterized by inflammation of the pilosebaceous follicles associated with the proliferation of Propionibacterium acnes (P. acnes). The use of synthetic anti-acne agents may cause adverse effects, making natural products a promising alternative. This study aimed to evaluate the antibacterial activity of mangostin isolate against P. acnes, formulate it into a clay mask, and assess the antibacterial effectiveness of the resulting preparation. Antibacterial activity was evaluated using the disc diffusion method at mangostin isolate concentrations of 0.275%, 0.55%, and 1.1% (w/v). Clay mask formulations were prepared using a bentonite–kaolin base in four different formulations. The preparations were evaluated for organoleptic properties, pH, homogeneity, viscosity, drying time, spreadability, adhesiveness, and physical stability using the cycling test method. Antibacterial activity of the clay mask formulations was also assessed against P. acnes. The results showed that mangostin isolate at a concentration of 0.275% produced an inhibition zone diameter of 15.10 ± 0.64 mm, indicating strong antibacterial activity. All clay mask formulations met the required physical evaluation criteria and remained stable during the cycling test. Following formulation, antibacterial activity was retained, although the inhibition zone diameter decreased to the moderate category, ranging from 7.00 to 9.18 mm. These findings suggest that mangostin isolate has potential as a natural antibacterial active ingredient in anti-acne clay mask formulations

Aktivitas Antibakteri Ekstrak Etanol Buah, Daun, Dan Kulit Batang Limpasu (Baccaurea lanceolata (Miq.) MÃ¼ll.Arg.) dari Kalimantan Selatan Sani Nurlaela Fitriansyah; Yola Desnera Putri; Muhammad Haris; Rival Ferdiansyah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 15 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v15i2.3062

Limpasu merupakan tanaman yang berlimpah dari Kalimantan Selatan. Data empiris menunjukkan buah limpasu berpotensi untuk mengobati demam (karena infeksi), kesehatan kulit, dan antioksidan. Data ilmiah pendukung potensi limpasu sebagai anti-infeksi yang disebabkan bakteri masih minim. Penelitian ini bertujuan mendapatkan data ilmiah kandungan kimia secara kualitatif dan potensi ekstrak limpasu sebagai antibakteri. Bagian buah, daun, dan kulit batang limpasu diekstraksi menggunakan pelarut etanol 96% dengan soxhlet. Ekstrak cair diuapkan menggunakan rotary evaporator sehingga didapatkan ekstrak buah (EB), ekstrak daun (ED), dan ekstrak kulit batang limpasu (EKB). Pengujian aktivitas antibakteri dilakukan dengan metode difusi padat menggunakan kertas cakram. Bakteri yang diuji terdiri dari Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Propionibacterium acnes, dan Staphylococcus epidermidis. Hasil penelitian menunjukkan, ekstrak etanol buah limpasu merupakan ekstrak yang paling aktif terhadap bakteri B. subtilis, S. aureus, P. aeruginosa, E.coli, dan P. acnes dengan konsentrasi hambat minimum adalah 2,5% b/v dengan diameter secara berturut-turut 6,87; 7,60; 7,94; 8,80; dan 10,29 mm. Ekstrak etanol buah, daun, dan kulit batang limpasu secara umum positif mengandung alkaloid, flavonoid, tanin, dan saponin.

Optimiziation of Shampoo Formula Based on Natural Biosurfactant from Quinoa Extract (Chenopodium quinoa Willd.) Yola Desnera Putri; Zakia Annisa; Wahyu Priyo Legowo; Adit Andriyannto
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3452

Background: The use of natural ingredients in hair care products can provide an alternative approach to developing more environmentally friendly formulations. Quinoa (Chenopodium quinoa Willd.) extract contains compounds with potential as a natural biosurfactant. Objective: This study aimed to evaluate the biosurfactant activity of quinoa extract and determine the shampoo formula with optimal physical characteristics and stability. Methods: Quinoa extract was obtained by maceration and evaluated for biosurfactant activity based on surface tension and emulsification index (E24). Three shampoo formulas containing different concentrations of quinoa extract were prepared and evaluated for pH, viscosity, foam volume, homogeneity, and organoleptic properties during storage using the cycling test method.Results: Quinoa extract reduced the surface tension of water from 72 mN/m to 37.77 mN/m and showed an emulsification index of 36.66%. All shampoo formulas exhibited stable physical characteristics during the testing period and met the requirements of the Indonesian National Standard (SNI). Formula 2, containing 10% (w/v) quinoa extract and 3.75% (w/v) Cocamide MEA, demonstrated the most optimal overall physical characteristics and stability.Conclusion: Quinoa extract has potential as a natural biosurfactant in shampoo formulations. Formula 2 demonstrated optimal physical characteristics and stability during storage and may be further developed as a natural ingredient-based shampoo.

Karakterisasi dan Uji Stabilitas Clay Mask Isolat Mangostin Sebagai Antijerawat Yola Desnera Putri; Shafa Nurul Fadilla; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1470

Acne is a common skin disorder affecting adolescents and young adults, characterized by inflammation of the pilosebaceous follicles associated with the proliferation of Propionibacterium acnes (P. acnes). The use of synthetic anti-acne agents may cause adverse effects, making natural products a promising alternative. This study aimed to evaluate the antibacterial activity of mangostin isolate against P. acnes, formulate it into a clay mask, and assess the antibacterial effectiveness of the resulting preparation. Antibacterial activity was evaluated using the disc diffusion method at mangostin isolate concentrations of 0.275%, 0.55%, and 1.1% (w/v). Clay mask formulations were prepared using a bentonite–kaolin base in four different formulations. The preparations were evaluated for organoleptic properties, pH, homogeneity, viscosity, drying time, spreadability, adhesiveness, and physical stability using the cycling test method. Antibacterial activity of the clay mask formulations was also assessed against P. acnes. The results showed that mangostin isolate at a concentration of 0.275% produced an inhibition zone diameter of 15.10 ± 0.64 mm, indicating strong antibacterial activity. All clay mask formulations met the required physical evaluation criteria and remained stable during the cycling test. Following formulation, antibacterial activity was retained, although the inhibition zone diameter decreased to the moderate category, ranging from 7.00 to 9.18 mm. These findings suggest that mangostin isolate has potential as a natural antibacterial active ingredient in anti-acne clay mask formulations

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