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All Journal Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Journal of Pharmacopolium JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Midwifery and Nursing JURNAL FARMASIMED (JFM) Jurnal Ners Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Ilmiah Farmako Bahari Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech Current Research on Biosciences and Biotechnology Edu Masda Journal Jurnal Abdimas Kartika Wijayakusuma Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat (Jupemas) Usadha Journal of Pharmacy Pharmaceutical Science Journal ASSYIFA: Jurnal Ilmu Kesehatan
Yola Desnera Putri
Sekolah Tinggi Farmasi Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Buah Murbei Hitam (Morus nigra L.) sebagai Antijerawat Yola Desnera Putri; Susi Sulastri; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1471

Abstract

Acne is one of the most common skin disorders affecting various age groups, particularly adolescents, and is caused by inflammation of the pilosebaceous follicles associated with bacterial proliferation. The primary bacteria involved in acne pathogenesis are Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis). This study aimed to formulate an anti-acne gel containing ethanol extract of black mulberry (Morus nigra L.) fruit and to evaluate its antibacterial activity. The black mulberry fruit was extracted by maceration using 96% ethanol. The resulting extract was formulated into a Carbopol 940-based gel at three different concentrations: 1.25% (F1), 2.5% (F2), and 5% (F3). The formulated gels were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, antibacterial activity using the agar well diffusion method, and skin irritation using the Draize method. The results showed that the ethanol extract of black mulberry fruit exhibited antibacterial activity against P. acnes and S. epidermidis, with inhibition zone diameters of 12.0 ± 0.90 mm and 12.8 ± 0.59 mm, respectively, at a concentration of 1.25%, indicating strong antibacterial activity. After formulation into a gel, the highest antibacterial activity was observed in Formula 3 (F3) after 28 days of storage, with inhibition zone diameters of 15.1 ± 0.06 mm against P. acnes and 15.3 ± 0.10 mm against S. epidermidis. All formulations met the required physical evaluation parameters and showed no signs of irritation in a preliminary Draize irritation test during the observation period. Therefore, the ethanol extract of black mulberry fruit has the potential to be developed as a topical anti-acne gel with antibacterial activity against P. acnes and S. epidermidis.
Co-Authors Adit Andriyannto Adit Andriyannto Adit Andriyannto Alhamd, Mutiara Alidya Canticha Sari Aneu Nurdiana Angga Julianto Anisa D. Aryanti Anisa D. Aryanti, Anisa D. Annisa Putri Dewantara Ayuningtyas, Yudyana Aziza, Farradiba Nur Azkiani, Hani Amila Brilian, Alifa Deby Tristiyanti Diki Prayugo Wibowo Dytha Andri Deswati Fitri, Yova Amijaya Fitriani, Dewi Fatimah Giani Nurrahmawati Gustini, Sri Haruman Kartamihadrja Haruman Kartamihardja Haykal Firgy Saputra Hesti Riasari Holis Abdul Holik Holis Abdul Holik, Holis Abdul Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Intan Lisna Julianto, Angga K Sari, Nia Kartamihardja, Haruman Ledianasari Ledianasari Ledianasari Ledianasari Ledianasari, Ledianasari Ledianasari, Ledianasari Ledianasari, Ledianasari Lestari, Tyagita Dwi Linda Suci Ramdianti Lisna Munawaroh Lusi Fauziah Mardiah, Irma Marianta - Teresia Meisy Afdina Muhammad Haris Najwa Najwa Novitaria Br Sembiring Nur Asni Setiani P Legowo, Wahyu Princesa Elnovita Tierra Pupung Ismayadi Retty Azka Djumar Danawiria Revika Rachmaniar Riski Nur Utami Rival Ferdiansyah Sani Nurlaela Fitriansyah Septiya Hasanah Setyani, Fitri Shafa Nurul Fadilla Siswahyudianto Sohadi Warya Sohadi Warya Sohadi Warya Sriwidodo Sriwidodo Susi Sulastri Syarif Hamdani Trilestari, Rostika Dewi Wahyu Priyo Legowo Yeyet Cahyati Sumirtapura Yeyet Cahyati Sumirtapura Zakia Annisa