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Viski Fitri Hendrawan
Faculty Of Veterinary Medicine, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Journal : Jurnal Medik Veteriner

 1 
The Effect of Black Cumin (Nigella sativa) on Histopathology of Liver and Kidney in Albino Rats with Organophosphate Exposure Hendrawan, Viski Fitri; Oktanella, Yudit; Firmawati, Aulia; Agustina, Galuh Chandra
Jurnal Medik Veteriner Vol. 6 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss1.2023.35-42

Abstract

This study aimed to determine the effect of black cumin extract (Nigella sativa) on the histopathological of the liver and kidneys in albino rats exposed to organophosphates. This study used 20 male mice divided into five treatment groups, i.e. (K-) without organophosphate and black cumin, (K+) induced by organophosphate 40 mg/kg BW, treatment group induced by organophosphate 40 mg/kg BW and black cumin extract as therapy (P1 ) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. Organophosphate administration for eight weeks and black seed extract therapy was given for three weeks then the mice were euthanized, the liver and kidney organs were taken for histopathological observation using Haematoxylin-Eosin (HE). Data were analyzed using OneWay ANOVA test followed by Tukey test. The results showed that there were significant differences between the treatment groups for liver and kidney damage (p<0,05). Hepatic degeneration and necrosis in the P2 and P3 groups differed from K+ with an average of 2,24±0,9, in the kidneys with an average of 2,52±0,8. It can be concluded that black cumin extract has a significant effect on improving the liver and kidneys in groups P3 (600 mg/kgBW).
Foot and Mouth Disease Impact on Milk Productivity and Quality in KUD Kertajaya, Kediri, Indonesia Oktanella, Yudit; Cahyani, Ayunda Ageng; Hendrawan, Viski Fitri; Nugroho, Widi; Agustina, Galuh Chandra
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.244-249

Abstract

One of the impacts of foot and mouth disease (FMD) on the dairy farming sector is decreasing the quantity and quality of milk production. This study aimed to determine the impact of FMD by observing the productivity and quality of fresh milk during FMD outbreaks. Sampling was performed to obtain productivity data before and during the FMD outbreak using the cluster sampling method in five areas in KUD Kertajaya, Kediri, Indonesia. The lactoscan test was used to analyze the quality of fresh milk from 50 positive samples. Based on the statistical analysis using the paired parametric T-test, it was reported that there was a significant difference in milk productivity before and during the FMD outbreak (p < 0,05). The results of the Lactoscan test on 50 positive samples showed an average fat content of 4,43%, solid nonfat (SNF) content of 8,54%, specific gravity of 1,028, lactose content of 4,67%, total solids content of 12,97%, added water content of 1,44 and freezing point of -0,54°C. In conclusion, the milk of dairy cows during the FMD outbreak often displayed a quality value of milk that met SNI requirements, despite the fact that there was a major decline in productivity.
Efficacy of Black Cumin (Nigella sativa) Ameliorate Organophosphate Toxicity in Pregnant Rats Based on Progesterone Levels and Fetal Bone Development Hendrawan, Viski Fitri; Agustina, Galuh Chandra; Aditya, Siska; Oktanella, Yudit; Firmawati, Aulia; Mariyam, Dewi
Jurnal Medik Veteriner Vol. 7 No. 1 (2024): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss1.2024.134-142

Abstract

Black cumin (Nigella sativa), also referred to as black cumin, is a versatile herbal treatment that has recently grown in popularity, it contains antimicrobial, antibacterial, antifungal, anti-inflammatory, analgesic, antipyretic, antiparasitic, antihistamine, antihypertensive, antitumor, anticancer, antidiabetic, and anti-asthmatic properties are just a few of the positive and pharmacological effects of active ingredients in black cumin, such as thymoquinone and other compounds. This study aimed to evaluate black cumin activity ameliorates organophosphate toxicity in pregnant rats based on progesterone levels and fetal bone development. In this study, pregnant albino rats were divided into five treatment groups i.e. (K-) placebo; (K+) treated an organophosphate; treated an organophosphate and black cumin extract at a dose of (P1) 200 mg/kg BW, (P2) 400 mg/kg BW, and (P3) 600 mg/kg BW. The progesterone levels serum and fetal bone development were evaluated and calculated using ANOVA followed by Turkey. The results showed that P2 and P3 groups significantly increase in progesterone levels compared to K+ and P1 groups. Fetal bone was also reported increase in the growth of caudal vertebrae. In conclusion, 400 mg/kg BW of black cumin could ameliorated progesterone levels and fetal bone development in pregnant rats with organophosphate toxicity.
Role of Cryoprotectants in Preventing Quality Loss of Goat Oocytes after Warming by Examining Insulin-Like Growth Factor-1 and Bone Morphogenetic Protein-15 Expression Shabira, Zahra; Widjiati, Widjiati; Rimayanti, Rimayanti; Lestari, Tita Damayanti; Safitri, Erma; Mafruchati, Maslichah; Hendrawan, Viski Fitri
Jurnal Medik Veteriner Vol. 8 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss1.2025.175-182

Abstract

This research aimed to assess the efficacy of ethylene glycol-sucrose as an alternative cryoprotectant compared to commercial cryoprotectants by focusing on the expression of insulin-like growth factor-1 (IGF-1) and bone morphogenetic protein-15 (BMP-15) in goat oocyte cumulus complexes after warming with identification using the immunocytochemical analysis. Maturated oocytes were divided into 3 groups, i.e., (C) the control group followed by an immunocytochemical examination, and two treatment groups, i.e., (P1) was exposed to a commercial cryoprotectant for 15 minutes, then placed in a hemistraw and dipped in liquid nitrogen, and (P2) was exposed to 30% ethylene glycol and 1 M sucrose for 15 minutes, then placed in a hemistraw and dipped in liquid nitrogen. The results revealed divergent responses in IGF-1 (CG = 9.00 ± 3.00; P1 = 9.50 ± 3.20; P2 = 4.67 ± 0.94) and BMP-15 (CG = 10.50 ± 3.35; P1 = 9.50 ± 2.69; P2 = 5.50 ± 3.64) expression patterns, possibly influenced by the two cryoprotectant abilities and oocytes performing their permeabilities to cryoprotectant solution. We concluded that each cryoprotectant is necessary to mitigate the adverse impact on gene expression in oocytes so that we can use it for reproductive technologies.
Co-Authors Aditya, Siska Adrenalin, Sruti Listra Agustina, Galuh Candra Agustina, Galuh Chandra Amri, Indah Amalia Andre Giovanni Aprilia, Rizka Muizzu Asri Nurul Huda Assifa Mardiyah, Fraya Budiono Cahyani, Ayunda Ageng Chanif Mahdi Chanif Mahdi Dameanti, Fidi Nur Aini Eka Puji Desi Wulansari Desi Wulansari Dhea Salsabila Erma Safitri Firmawati, Aulia Galuh Chandra Agustina Hendrawan Soetanto Intan Firdha Olien N. A. I. Kamulyan, Ujiati Khamalt, Nursalsabila Khoirus Viestaria Lesmana, Muhammad Arfan Mafruchati, Maslichah Mariyam, Dewi Nurul Luthfiana Pudji Srianto Rahim, Nurul Insyirah Residiwati, Gretania Rimayanti Rimayanti Ritonga, Azra Salsabila Shabira, Zahra Siska Aditya Sruti Listra Adrenalin Suherni Susilowati Tita Damayanti Lestari Tuska, Habib Syaiful Arif Ujiati Kamulyan Widi Nugroho Widjiati Widjiati Widjiati Widjiati, Widjiati Yesica, Reza Yudit Oktanela Yudit Oktanella, Yudit