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All Journal International Journal of Public Health Science (IJPHS) E-Jurnal Medika Udayana Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Jurnal Biomedika dan Kesehatan Afiasi : Jurnal Kesehatan Masyarakat Jurnal Midpro Jurnal Ners Community Development Journal: Jurnal Pengabdian Masyarakat Muhammadiyah Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Eduvest - Journal of Universal Studies Jurnal MedScientiae Journal of Educational Innovation and Public Health Jurnal MedScientiae Jurnal Kedokteran Meditek JCRIM (Journal of Current Research In Multidisciplinary)
Ade Dharmawan
Departemen Mikrobiologi Klinik, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia
Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Role Of Gut Microbiota, Firmicutes/Bacteroidetes Ratio, And Short Chain Fatty Acids In The Pathogenesis Of Type 2 Diabetes Mellitus Ade Dharmawan; Nicolas Layanto; Monica Cherlady Anastasia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53613

Abstract

AbstractThis study aims to understand the role of gut microbiota imbalance, specifically an increased ratio of Firmicutes to Bacteroidetes, in the pathogenesis of type 2 diabetes mellitus (T2DM). Using systematic literature review and thematic analysis. Data were collected from various scientific sources, including journal articles indexed in PubMed, Scopus, and ScienceDirect, this study explores how gut dysbiosis contributes to insulin resistance, impaired glucose metabolism, and chronic inflammation. The results show that changes in microbiota composition result in increased energy extraction from food, impaired gut barrier integrity, and altered production of short-chain fatty acids (SCFAs) such as butyrate, which play a role in glucose homeostasis and inflammation regulation. These findings also emphasize the potential of probiotic, prebiotic, and dietary modification interventions to restore microbiota balance, improve insulin sensitivity, and reduce oxidative stress. Overall, this study highlights the urgency of a personalized approach in the management of T2DM through modulation of the gut microbiota based on the latest clinical and mechanistic evidence.
Co-Authors Agus Cahyadi Amany, Hana Amirah Andini, KD Ayu Asti Anis Karuniawati Antoni, Marcel Cahyadi, Agus Cherlady Anastasia, Monica Christopher, Jeremy Clara Valentia Josephine Cleopas Martin Rumende Deby Deby Delly Chipta Lestari Devita, Arleen Dhimas Garin Dewa Agista Diana Wijaya Donna Mesina Pasaribu Donna Mesina Pasaribu Donna Mesina Rosadini Pasaribu Donna Mesina Rosadini Pasaribu Elena, Irene Maria Elisabeth D Harahap Elisabeth Harahap Farsida, Farsida Gratia Erlinda Tomasoa Guntur Darmawan Harahap, Elisabeth Henny Tannady Tan Henny Tannady Tan Heri Setiyo Bekti Husna, Ismalia Indriyani Indriyani Istia, Mieke Joseba Jeremy Christopher Kosasih, Audia Nizhma Nabila Krisna Fernanda Suryaputra Layanto, Nicolas Layanto, Nicolas Marcel Antoni Mardhia Mardhia Marpaung, Nurasi Lidya E. Marshell Tendean Monica Cherlady Anastasia Monica Cherlady Anastasia Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Nicolas Layanto Pasaribu, Donna Mesina Petri Damiani Petri Damiani Anindyajati Petri Damiani Anindyajati Pratiwi Pujilestari Sudarmono Rike Syahniar Rina, Veronica Rini Latifah Septiana, Yorisye Simanjuntak, Lasma Susi F. Sinsanta Sinsanta Suparto Suparto Suparto Suparto Tamara Atmogo Theresia Ervina Wani D Gunardi Wani Devita Gunardi Wani Devita Gunardi Widya Widya Wijaya, Jefri Wijaya, Pande I Gede Indra William Dharma Wijaya William William